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Clinical Practice Guideline of Integrative Chinese and Western Medicine for Acute Myocardial Infarction

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Chinese Journal of Integrative Medicine 2020年第7期26卷 539-551页

作者： LIAO Peng-da CHEN Ke-ji ge jun-bo ZHANG Min-zhou Guangdong Provincial Hospital of Chinese Medicine Guangzhou(510120)China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou(510120)China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing(100091)China Shanghai Institute of Cardiovascular Diseases Zhongshan HospitalFudan UniversityShanghai(200032)China

With increasing morbidity and mortality,acute myocardial infarction(AMI)has become one of the major causes of human death,leading to heavy burdens to individuals,families and *** researches have found that though large amount of resources and great effort were devoted,no significant improvements were achieved in reducing the in-hospital mortality of AMI ***,extensive studies about Chinese medicine(CM)have found that CM has special advantages in treating AMI ***,there is no standardized and unified clinical practice guideline(CPG)of CM for ***,a CPG with strict standard and generally acknowledgement is urgent to be *** guideline was developed following the methodological process established by the World Health Organization Handbook for Guideline *** search on clinical evidences including systematic review(SR),randomized controlled trial(RCT),observational study and case reports was launched,covering evidence of CM for AMI on several aspects,such as diagnosis,CM patterns,CM interventions on AMI and complications,cardiac rehabilitation and clinical pathway ***,the application of Grading of Recommendations Assessment,Development and Evaluation(GRADE)approach enabled the evaluation of evidence and formulation of grade of recommendation(GOR)and level of evidence(LOE).With the help of GOR and LOE,this CPG recommends the integrative CM and WM treatment method in AMI patients and provides useful information on medical decision for clinical physicians.

关键词： acute myocardial infarction integrative Chinese and Western medicine clinical practice guideline

gender difference in patients with acute myocardial infarction treated by primary percutaneous coronary intervention in drug-eluting stent era

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Chinese Medical Journal 2010年第7期123卷 776-777页

作者： ge jun-bo Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai 200032 China

Primary percutaneous coronary intervention （PCI） has been the standard of care for patients with acuteST-elevation myocardial infarction hours of symptom onset in modem and applications of robust （STEMI） within 12 era.1＇2 The advances anti-platelet and anti-coagulation medicines further improve the outcome of STEMI patients undergoing primary PCI^3 ,and

关键词： era stent coronary intervention treated acute myocardial infarction gender differences advances and applications PCI especially effective interest improve robust modern women male data care DES

Preinfarction angina： old story initiates new attention

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Chinese Medical Journal 2012年第6期125卷 968-969页

作者： ge jun-bo Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai 200032China

Since first report by Murry et alI in 1986, the role of ischemia preconditioning before sustained coronary occlusion in protecting myocardium and reducing infarct size has been identified in animal studies. The mechanism underlying the endogenous cardioprotective effects of ischemia preconditioning is complex and may involve humoral, neural, or a combination of both, with adenosine, different signaling pathways involving bradykinin, protein kinases and K（ATP） channels.

关键词： preinfarction angina ST-elevation myocardial infarction percutaneous coronary intervention

Six-month clinical outcomes of Firebird 2TM sirolimus-eluting stent implantation in real-world patients with coronary artery diseases

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Chinese Medical Journal 2011年第6期124卷 831-835页

作者： ge jun-bo ZHANG Feng QIAN Ju-ying ge Lei LIU Xue-bo ZHOU jun Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai 200032 China

Background The Firebird 2TM sirolimus-eluting stent （Firebird 2 stent） is a second-generation sirolimus-eluting stent which has a cobalt-chromium alloy stent platform, a brand new bracket structure, and two layers of styrene-butylenes-styrene polymer coatings with better biocompatibility. The Firebird 2TM cObalt-Chromium alloy sirolimus-elUting Stent registry （FOCUS registry） aimed to evaluate the safety and efficacy of the Firebird 2 stent in patients with coronary artery disease in daily *** The FOCUS registry is a prospective, non-randomized, international multi-center, single-arm clinical *** March 2009 and February 2010, 5084 patients receiving at least 1 Firebird 2 stent during daily clinical practice at 83 medical centers were *** Of the 5084 patients enrolled in the registry, 5077 and 5058 were respectively available for 30 days and 6 months follow-up. The 30-day rate of major adverse cardiac events （MACE） was 1.20%, including 13 cardiac deaths, 46 non-fatal myocardial infarction （MI）, and 6 target vessel revascularization （TVR）. At 6 months follow-up, the rate of MACE was 1.80%. There were 32 cardiac deaths, 48 non-fatal MI, and 15 TVR. According to the Academic Research Consortium definition, definite/probable stent thrombosis （ST） occurred in 0.43% （22/5058） of patients, including 8 cases of acute ST, 11 subacute ST, and 3 late *** The Firebird 2 stent showed the promising efficacy and safety at 30 days and 6 months in a real-world population of patients with coronary artery diseases.

关键词： sirolimus-eluting stent percutaneous coronary intervention coronary artery disease cobalt-chromium alloy

Late stent malapposition and marked positive vessel remodeling after sirolimus-eluting coronary stent implantation

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Chinese Medical Journal 2006年第4期119卷 349-350页

作者： ZHANG Feng QIAN Ju-ying ge jun-bo Department of Cardiology Zhongshan Hospital Fudan University Shanghai 200032 China

It has been reported that positive remodeling, regression of neointimal hyperplasia, and late malapposition are associated with brachytherapy, one of the approaches to prevent first-time and recurrent in-stent restenosis. Recently, some drug-eluting stents have been demonstrated to dramatically reduce restenosis rates. Despite these promising results, these drug-eluting stents may have the same potential risks as brachytherapy, with some similarities between the 2 technologies in anti-proliferative effects on vascular smooth muscle cells and endothelial cells. We reported a case of late stent malapposition and marked positive vessel remodeling after sirolimus-eluting coronary stent implantation.

关键词： late stent malapposition vessel remodeling intravascular ultrasound

Rapid development of late stent malappositon and coronary aneurysm following implantation of a paclitaxel-eluting coronary stent

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Chinese Medical Journal 2007年第7期120卷 614-616页

作者： ZHANG Feng QIAN Ju-ying ge jun-bo Department of Cardiology Zhongshan Hospital Fudan University Shanghai 200032 China

Late stent malapposition （LSM）, an unusual intravascular ultrasound （IVUS） finding at follow-up,has been reported to be more common alter drug-eluting stem （DES） implantation than after bare metal stent （BMS） implantation. However, there has been no clear elucidation of time course and mechanism. We reported a case who developed LSM and coronary aneurysm very early after paclitaxel-eluting stent （PES） implantation. A review of the literature reveals no previous report describing rapid development of LSM and coronary aneurysm after PES implantation.

关键词： late stent malapposition drug-eluting stent vessel remodeling

Acute myocardial infarction due to myocardial bridge

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Chinese Medical Journal 2012年第19期125卷 3589-3590页

作者： LI Zhao-feng YANG Shu-guang ge jun-bo Department of Cardiology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Cardiology No. 88 Hospital of People's Liberation Army Tai'an Shandong 271000 China

Myocardial bridge （MB） is regarded as a common .anatomic variant rather than a congenital conditionanomaly, defined as the intrainyocardial course of a portion of the coronary artery. It was first mentioned by Rayman in 1737 and first described by Grainicianu in the early 1920s. The current gold standard tor diagnosing MB is coronary angiography with the typical systolic compression of the epicardial coronary vessel （milking effect）.

关键词： myocardial bridge myocardial infarction, coronary, angiography

Wire trapping technique combined with retrograde approach for recanalization of chronic total occlusion

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Chinese Medical Journal 2008年第17期121卷 1753-1756页

作者： ge jun-bo ZHANG Feng ge Lei QIAN Ju-ying WANG Hao Department of Cardiology Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases Shanghai 200032 China

Coronary chronic total occlusion （CTO）, defined as a ,total occlusion of duration 〉3 months, remains a technical challenge for the interventional cardiologists. The major limitation in percutaneous coronary intervention （PCI） of CTO is the inability to penetrate and cross the occlusion with a guidewire. It was reported that the immediate angiographic success rate varied from 50% to 70% using the standard antegrade techniques.1 To improve this suboptimal success rate, the authors firstly introduced retrograde approach through the collateral channels as a novel technique and successfully recanalized a left main CTO using this technique when demonstrating the live cases in Transcatheter Cardiovascular Therapeutics （TCT） 2005. Recently, modified techniques based on the retrograde approach have demonstrated that this approach could provide a high success rate with PCI.3-5 In the present report, we described a new method, wire trapping technique combined with retrograde approach, which was applied successfully in three patients with CTO.

关键词： chronic total occlusion retrograde approach wire trapping coronary angioplasty

Pravastatin activates platelet nitric oxide synthase (NOS) in patients with type 2 diabetes mellitus and NOS activation is accompanied by serine phosphorylation

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Chinese Medical Journal 2005年第19期118卷 1654-1657页

作者： YAO Kang XU Biao Gao Ling ge jun-bo Shanghai Institute of Cardiovascular Disease Zhongshan HospitalFudan University Shanghai 200032 China Department of Cardiovascular Disease Gulou Hospital NanjingUniversity Nanjing 210008 China

Statins cause reductions in myocardial infarction and also morbidity and mortality of type 2diabetes related to atheromatous disease and its thrombotic complications beyond those predicted by reductions in low density lipoprotein cholesterol （LDL） It has been suggested that the protective mechanism （s） may relate to improved endothelial function and/or antithrombotic effects, but the mechanism is not clear.

关键词： platelet HMG-CoA reductase inhibitors type 2 diabetes mellitus nitric oxide synthase