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Molecular Plant 2014年第7期7卷 1252-1255页

作者： juan manuel Pérez-Ruiz manuel Guinea Leonor Puerto-Galán Francisco Javier Cejudo Instituto de Bioquímica Vegetal y Fotosíntesis Universidad de Sevilla-Consejo Superior de Investigaciones Científicas 41092-Sevilla Spain Umea Plant Science Centre Department of Plant Physiology Umea University S-901 87 Umea Sweden

Dear Editor, The synthesis of tetrapyrroles, including chlorophylls, is central for chloroplast function. The metabolic pathway of tetrapyrrole biosynthesis in Arabidopsis is initiated with the formation of amino levulinic acid （ALA）, which is con- verted by a series of common reactions to protoporphy- tin IX （Proto IX）（Tanaka et al., 2011）. Then the pathway diverges into two branches： the synthesis of heme/bilin and chlorophylls. The insertion of Mg2＋ into Proto IX, cata- lyzed by Mg-chelatase, is the first committed reaction of the chlorophyll branch and is considered a key step for the regulation of the whole pathway. Mg-chelatase is a het- erotrimeric enzyme composed of subunits CHLI, CHLD, and CHLH, the reaction mechanism of which has been estab- lished. It is a two-step process consisting in the Mg-ATP- dependent activation of the enzyme, which implies the formation of a ternary complex of subunits CHLI and CHLD with ATP-Mg2＋, and Mg2＋ chelation, which is catalyzed by CHLH driven by ATP hydrolysis, CHLI providing ATPase activity to the complex （Tanaka et al., 2011）. In Arabidopsis, CHLH and CHLD are encoded by single genes, whereas two genes, CHLI-I and CHLI-2, encode the two isoforms of CHLI.

关键词： synthesis of tetrapyrroles chlorophylls Arabidopsis

A summary of Copepoda:synthesis,trends,and ecological impacts

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Journal of Oceanology and Limnology 2023年第3期41卷 1050-1072页

作者： Vinod VAKATI juan manuel FUENTES-REINÉS Pengbin WANG Jun WANG Steven DODSWORTH Key Laboratory of Conservation and Utilization of Fish Resources College of Life SciencesNeijiang Normal UniversityNeijiang 641100China Universidad del Magdalena Grupo de Investigación en Biodiversidad y Ecología AplicadaSanta Marta AA 731Colombia Key Laboratory of Marine Ecosystem Dynamics the Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Fourth Institute of Oceanography Ministry of Natural ResourcesBeihai 536000China Department of Life Science College of Natural SciencesHanyang UniversitySeoul 04763Republic of Korea School of Biological Sciences University of PortsmouthPortsmouth PO12DYUnited Kingdom

Copepoda are one of the most significant animal groups present in aquatic ***,evolutionary biologists,and biotechnologists continue to test new methods to study the application of Copepoda as model organisms in various fields of pure and applied science,from evolution and ecology to aquaculture as live feed,as biological control of mosquito larvae,as biological indicators of water and sediment quality,in environmental monitoring and as a source of protein in the food *** paper reviews the current progress and trends within copepod research from a number of different *** emphasize the importance of Copepoda and the necessity of strengthening research on various topics related to copepod biology,some of which are of great significance to local sustainable development.

关键词： bioindicators aquaculture pollutants eutrophication nutrition halotolerance

Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

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Translational Neurodegeneration 2019年第1期8卷 111-125页

作者： José Aguareles juan Paraíso-Luna Belén Palomares Raquel Bajo-Grañeras Carmen Navarrete Andrea Ruiz-Calvo Daniel garcía-Rincón Elena garcía-Taboada manuel Guzmán Eduardo Muñoz Ismael Galve-Roperh Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS) Ctra.Colmenar Viejokm9100 MadridSpain Departamento de Bioquímica y Biología Molecular and Instituto Universitario de Investigación Neuroquímica Universidad ComplutenseMadridSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) MadridSpain Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC) CórdobaSpain Departamento de Biología Celular Fisiología e InmunologíaUniversidad de CórdobaCórdobaSpain Hospital Universitario Reina Sofía CórdobaSpain Emerald Health Pharmaceuticals San DiegoUSA

Background:The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular *** cannabinoid actions in the nervous system are mediated by CB1 receptors,which can elicit psychotropic effects,but other targets devoid of psychotropic activity,including CB2 and nuclear PPARγreceptors,can also be the target of specific ***:We investigated the pro-neurogenic potential of the synthetic cannabigerol derivative,VCE-003.2,in striatal neurodegeneration by using adeno-associated viral expression of mutant huntingtin in vivo and mouse embryonic stem cell differentiation in ***:Oral administration of VCE-003.2 protected striatal medium spiny neurons from mutant huntingtin-induced damage,attenuated neuroinflammation and improved motor ***-003.2 bioavailability was characterized and the potential undesired side effects were evaluated by analyzing hepatotoxicity after chronic ***-003.2 promoted subventricular zone progenitor mobilization,increased doublecortin-positive migrating neuroblasts towards the injured area,and enhanced effective ***,we demonstrated the proneurogenic activity of VCE-003.2 in embryonic stem ***-003.2 was able to increase neuroblast formation and striatal-like CTIP2-mediated ***:The cannabigerol derivative VCE-003.2 improves subventricular zone-derived neurogenesis in response to mutant huntingtin-induced neurodegeneration,and is neuroprotective by oral administration.

关键词： Cannabinoid Huntingtin Neurodegeneration Neurogenesis PPAR

Short-term outcomes of robotic liver resection: An initial singleinstitution experience

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World Journal of Hepatology 2022年第1期14卷 224-233页

作者： manuel Durán Javier Briceño Ana Padial Ferdinando Massimiliano Anelli juan manuel Sánchez-Hidalgo María Dolores Ayllón Rafael Calleja-Lozano Carmen garcía-Gaitan Unit of Hepatobiliary Surgery and Liver Transplantation General and Digestive Surgery DepartmentReina Sofia University HospitalCordoba 14004Spain GC18 Translational Research in Surgery of Solid Organ Transplantation Maimonides Biomedical Research InstituteCórdoba 14004Spain GE09 Research in Peritoneal and Retroperitoneal Oncological Surgery Maimonides Biomedical Research InstituteCórdoba 14004Spain Department of Anesthesiology and Resuscitation Reina Sofia University HospitalCordoba 14004Spain

BACKGROUND Liver surgery has traditionally been characterized by the complexity of its procedures and potentially high rates of morbidity and mortality in inexperienced *** robotic approach has gradually been introduced in liver surgery and has increased notably in recent ***,few centers currently perform robotic liver surgery and experiences in robot-assisted surgical procedures continue to be limited compared to the laparoscopic *** To analyze the outcomes and feasibility of an initial robotic liver program implemented in an experienced laparoscopic hepatobiliary *** A total of forty consecutive patients underwent robotic liver resection(da Vinci Xi,***,United States)between June 2019 and January *** were prospectively followed and retrospectively *** characteristics and perioperative and short-term outcomes were *** are expressed as mean and standard *** study was approved by the Institutional Review *** The mean age of patients was 59.55 years,of which 18(45%)were *** mean body mass index was 29.41 kg/m^(2).Nine patients(22.5%)were *** were divided by type of resection as follows:Ten segmentectomies,three wedge resections,ten left lateral sectionectomies,six bisegmentectomies(two VVI bisegmentectomies and four IVb-V bisegmentectomies),two right anterior sectionectomies,five left hepatectomies and two right *** lesions occurred in twenty-nine(72.5%)of the *** mean operative time was 258.11 min and two patients were transfused intraoperatively(5%).Inflow occlusion was used in thirty cases(75%)and the mean total clamping time was 32.62 *** was a single conversion due to uncontrollable *** postoperative complications(Clavien–Dindo>Ⅲb)occurred in three patients(7.5%)and mortality in one(2.5%).No patient required readmission to the *** mean hospital stay was 5.6 *** Althou

关键词： Robotics Hepatectomy Minimally invasive surgery Liver surgery Da vinci

Oxidative stress in the hydrophilic medium of algae and invertebrates

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BIOCELL 2016年第1期40卷 35-38页

作者： GABRIELA MALANGA PAULA MARIELA GONZALEZ juan manuel OSTERA SUSANA PUNTARULO Instituto de Bioquímica y Medicina Molecular(IBIMOL)-Universidad de Buenos Aires(UBA) CONICETFisicoquímicaFacultad de Farmacia y BioquímicaJunín 956(C1113AAD)Buenos Aires.Argentina.

The harmful effects of the reactive species may be due to the increase in their steady state concentration either by the enhancement of their production rates and/or the decrease of their consumption rate by antioxidant *** ascorbyl radical(A^(·))can be considered as a final product of radical oxidative transformations of ascorbate(AH^(-)).The ratio A^(·)content/AH^(-)content(A^(·)/AH^(-))has been widely used as an interesting tool to estimate mild to moderate oxidative transformations,providing a quick and simple method of diagnosis of stress in the hydrophilic cellular *** aim of this work was to summarize studies on the cellular oxidative condition in algae and invertebrates by assessing the A^(·)/AH^(-)ratio under environmentally changing *** use of indices of oxidative stress increasingly sensitive and,somewhat more specific,can bring a new light to the still unknown world of oxidative responses in marine organisms.

关键词： algae ascorbyl/ascorbate ratio invertebrates oxidative stress

Hybrid Security Assessment Methodology for Web Applications

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Computer Modeling in Engineering & Sciences 2021年第1期126卷 89-124页

作者： Roddy A.Correa juan Ramon Bermejo Higuera Javier Bermejo Higuera juan Antonio SiciliaMontalvo manuel Sanchez Rubio A.Alberto Magrenan Universidad Tecnica Particular de Loja San Cayetano AltoLojaEcuador Escuela Superior de Ingenieria y Tecnologia Universidad Internacional de La RiojaLogrono26006Spain Universidad de la Rioja Logrono26006Spain

This study presents a methodology to evaluate and prevent security vulnerabilities issues for web *** analysis process is based on the use of techniques and tools that allow to perform security assessments of white box and black box,to carry out the security validation of a web application in an agile and precise *** objective of the methodology is to take advantage of the synergies of semi-automatic static and dynamic security analysis tools and manual *** one of the phases contemplated in the methodology is supported by security analysis tools of different degrees of coverage,so that the results generated in one phase are used as feed for the following phases in order to get an optimized global security analysis *** methodology can be used as part of other more general methodologies that do not cover how to use static and dynamic analysis tools in the implementation and testing phases of a Secure Software Development Life Cycle(SSDLC).A practical application of the methodology to analyze the security of a real web application demonstrates its effectiveness by obtaining a better optimized vulnerability detection result against the true and false positive *** analysis with manual checking is used to audit the results,24.6 per cent of security vulnerabilities reported by the static analysis has been checked and it allows to study which vulnerabilities can be directly exploited *** phase is very important because it permits that each reported vulnerability can be checked by a dynamic second tool to confirm whether a vulnerability is true or false positive and it allows to study which vulnerabilities can be directly exploited *** analysis finds six(6)additional critical *** control analysis finds other five(5)important vulnerabilities such as Insufficient Protected Passwords or Weak Password Policy and Excessive Authentication Attacks,two vulnerabilities that permit brute force at

关键词： Web applications security vulnerability weakness security analysis white box black box interactive application security testing static application security testing dynamic application security testing

Introduction to the Special Issue on Recent Advances on Deep Learning for Medical Signal Analysis

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Computer Modeling in Engineering & Sciences 2021年第8期128卷 399-401页

作者： Yu-Dong Zhang Zhengchao Dong juan manuel Gorriz Carlo Cattani Ming Yang School of Informatics University of LeicesterLeicesterLE17RHUK Molecular Imaging and Neuropathology Division Columbia University and New York State Psychiatric InstituteNew YorkNY 10032USA Department of Psychiatry Cambridge UniversityCambridgeCB21TNUK Department of Signal Theory Networking and CommunicationsUniversity of GranadaGranadaSpain Engineering School(DEIM) University of TusciaViterboLazio01100Italy Department of Radiology Children’s Hospital of Nanjing Medical UniversityNanjing210008China

Over the past years,deep learning has established itself as a powerful tool across a broad spectrum of domains,e.g.,prediction,classification,detection,segmentation,diagnosis,interpretation,reconstruction,*** deep neural networks initially found nurture in the computer vision community,they have quickly spread over medical imaging applications.

关键词： has initially Deep

GIS-based study of the evolution of the IGN's strong motion network of mainland Spain and the balearics

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Geodesy and Geodynamics 2021年第4期12卷 279-287页

作者： Jose-Lazaro Amaro-Mellado Daniel Anton juan-manuel Alcalde Instituto Geografico Nacional Servicio Regional en AndaluciaSeville 41013Spain Departamento de Ingenierfa Grafica Universidad de SevillaSeville 41092Spain Research Group TEP970:Innovacion Tecnoldgica Sistemas de Modelado 3D y Diagnosis Energetica en Patrimonio y Edificacidn'Departamento de Expresion Grafica e Ingenieria en la EdificacionEscuela Tecnica Superior de Ingenieria de EdificacionUniversidad de Sevilla4A Reina Mercedes AvenueSeville 41012Spain The Creative and Virtual Technologies Research Laboratory School of ArchitectureDesign and the Built EnvironmentNottingham Trent University50 Shakespeare StreetNottingham NG14FQUK Escuela Superior de Ingenieria y Tecnologia Universidad Intemacional de La Rioja737 La Paz AvenueLogrono 26006Spain Instituto Geografico Nacional Red Sismica NacionalMadrid 28003Spain

In some countries with seismicity,an adequate detection network is essential to assess seismic *** Instituto Geografico Nacional(National Geographic Institute/IGN)of Spain manages a strong motion network distributed throughout the whole country and an earthquake detection network composed of velocity *** paper aims at studying the development of the strong motion network of the Spanish National Seismic Network(focusing on mainland Spain and the Balearics)in the last three decades.A Geographic Information System(GIS)has been implemented to integrate the attributes from the IGN’s database concerning the earthquake catalogue,seismograph and accelerometer networks,which enabled to analyse the data and map the distribution of detection equipments in the *** irregularly distributed Spanish strong motion network was greatly expanded from 1990 to *** the past decade,it developed at a slower rate,but more modern technology was implemented.

关键词： Strong motion Accelerometer network Spanish national seismic network Earthquake catalogue GIS

Conical tank level control using fractional order PID controllers： a simulated and experimental study

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Control Theory and Technology 2016年第4期14卷 369-384页

作者： Cristian JAUREGUI manuel A. DUARTE-MERMOUD Rodrigo OROSTICA juan Carlos TRAVIESO-TORRES Orlando BEYTIA Electrical Engineering Department and Advanced Mining Technology Center Universidad de Chile Av. Tupper 2007 Casilla 412-3 Santiago Chile Industrial Technologies Department Technological Faculty Universidad de Santiago de Chile Av. El Belloto 3735 Santiago Chile

In this paper, simulated and experimental results on the conical tank level control are presented. PI/PID controllers of integer order （IO） as well as of fractional order （FO） are studied and compared. The tuning parameters are obtained first by using root locus （RL） and Ziegler and Nichols methods, for comparison purposes. Next, particle swarm optimization （PSO） is employed to determine the optimal controllers＇ parameters using as fitness function the integral of the absolute value of tracking error （IAE）. From the experimental results it is concluded that PI/FOPI are the controllers presenting the lowest IAE indexes, whereas PID/FOPID controllers present the lowest energy consumption by the control signal.

关键词： Level control conical tank PID control fractional PID control experimental control

National assessment of the evolution of forest fragmentation in Mexico

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Journal of Forestry Research 2011年第2期22卷 167-174页

作者： Rafael Moreno-Sanchez Francisco Moreno-Sanchez juan manuel Torres-Rojo University of Colorado Denver Department of Geography and Environmental SciencesCampus Box 172 P.O.Box 173364DenverCO 80217-3364USA Instituto Nacional de Investigaciones Forestales y Agropecuarias(INIFAP) Av Progreso #5CoyoacánMéxico D.F.04100México Centro de Investigación y Docencia Económicas(CIDE) Carretera México-Toluca 3655Col.Lomas de Santa FeMéxicoD.F.01210México

This paper presents assessments of the fragmentation of the temperate and tropical forests in Mexico at the national level for two dates 1993 and *** study was based on land use and vegetation cover data sets scale 1：250,*** broad forest types（Temperate Forests and Tropical Forests） and five more specific forest types（Broadleaf Forests,and Coniferous Forests;Tropical Dry Deciduous Forests,Tropical Sub-evergreen Forests,and Tropical Evergreen Forests） were defined to conduct the *** 3.3 was used to estimate nine metrics of the spatial pattern of the forests for each forest type and date *** results indicate that the land cover transitions that have occurred between 1993 and 2002 have resulted in more isolated forest patches with simpler shapes in both the Temperate and Tropical *** remaining Tropical Forest patches have become smaller and more *** contrast,the remaining Temperate Forest patches are fewer and on average *** the more specific forest types defined in this study,the Broadleaf Forests have the highest indicators of *** these forests are usually embedded or adjacent to Coniferous *** more concern for conservation purposes are the high values of fragmentation metrics found for the Tropical Evergreen Forests and Tropical Dry Deciduous Forests,because these forest types are usually surrounded by non-forest land covers or anthropogenic land uses.

关键词： forest fragmentation Mexico FragStats.