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Nociceptors and Macrophages in Bacterial Meningitis:Partners in Crime?

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Neuroscience Bulletin 2024年第3期40卷 418-420页

作者： Fang gao Hongzhen Hu The Kimberly and Eric J.Waldman Department of Dermatology Icahn School of Medicine at Mount SinaiNew York NY10029USA The Nash Family Department of Neuroscience Icahn School of Medicine at Mount SinaiNew York NY10029USA The Mark Lebwohl Center for Neuroinfammation and Sensation Icahn School of Medicine at Mount SinaiNew York NY10029USA Friedman Brain Institute Icahn School of Medicine at Mount SinaiNew York NY10029USA

Bacterial meningitis is a serious and potentially life-threatening infection that affects the protective layers surrounding the brain and spinal cord,known as the *** types of bacteria,including Streptococcus pneumoniae,Neisseria meningitidis,and Haemophilus influenzae,can cause this *** populations,such as infants,children,immunocompromised adults,and the elderly,are particularly vulnerable to these *** of bacterial meningitis can manifest suddenly and may include high fever,severe and persistent headache,stiff neck,vomiting,sensitivity to light,and confusion or changes in mental state[1,2].Identifying these symptoms in infants can be more challenging and may lead to long-term disability or death[3].Despite the effectiveness of vaccines,it is crucial to understand how bacteria invade the brain and how our innate immune system responds to infection(Fig.1).

关键词： protective infection suddenly

Three-dimensional porous In_(2)O_(3) arrays for self-powered transparent solar-blind photodetectors with high responsivity and excellent spectral selectivity

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Nano Research 2024年第5期17卷 4471-4477页

作者： Nana Zhang Xinyu gao Haoran Guan Simin Sun Jiaming Liu Zhitao Shao Qiyue gao Yuan Zhang Ruyu Sun Guang Yang Feng gao Wei Feng College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China

Transparent solar-blind ultraviolet photodetectors(SBUV PDs)have extensive applications in versatile scenarios,such as optical ***,it is still challenging to simultaneously achieve high responsivity,high transparency,and satisfying self-powered ***,we demonstrated high-performance,transparent,and self-powered photoelectrochemical-type(PEC)SBUV PDs based on vertically grown ultrathin In_(2)O_(3) nanosheet arrays(NAs)with a three-dimensional(3D)porous *** 3D porous structure simultaneously improves the transmittance in the visible light region,accelerates interfacial reaction kinetics,and promotes photogenerated carrier *** performance of In_(2)O_(3) NAs photoanodes exceeds most reported self-powered PEC SBUV PDs,exhibiting a high transmittance of approximately 80%in the visible light region,a high responsivity of 86.15 mA/W for 254 nm light irradiation,a fast response speed of 15/18 ms,and good multicycle *** In_(2)O_(3) NAs also show excellent spectral selectivity with an ultrahigh solar-blind rejection ratio of 1319.30,attributed to the quantum confinement effect induced by the ultrathin feature(2-3 nm).Furthermore,In_(2)O_(3) NAs photoanodes show good capability in underwater optical *** work demonstrated that a 3D porous structure is a powerful strategy to synchronously achieve high responsivity and transparency and provides a new perspective for designing high-performance,transparent,and self-powered PEC SBUV PDs.

关键词： In_(2)O_(3) three-dimensional porous transparent photoelectrochemical solar-blind photodetectors

Sonodynamic therapy for the treatment of atherosclerosis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 666-677页

作者： Yan Zhang Ying Yang Yudi Feng Xueyan gao Liping Pei Xiaopan Li Bingxin gao Lin Liu Chengzeng Wang Shuochen gao The Department of Ultrasound The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China The Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China

Atherosclerosis(AS)is a chronic inflammatory disease of large and medium-sized arteries that leads to ischemic heart disease,stroke,and peripheral vascular *** the current treatments,mortality and disability still remain *** therapy(SDT),a non-invasive and localized methodology,has been developed as a promising new treatment for inhibiting atherosclerotic progression and stabilizing *** progress has been made through cell and animal assays,as well as clinical *** example,the effect of SDT on apoptosis and autophagy of cells in AS,especially macrophages,and the concept of non-lethal SDT has also been *** this review,we summarize the ultrasonic parameters and known sonosensitizers utilized in SDT for AS;we elaborate on SDT's therapeutic effects and mechanisms in terms of macrophages,T lymphocytes,neovascularization,smooth muscle cells,lipid,extracellular matrix and efferocytosis within plaques;additionally,we discuss the safety of SDT.A comprehensive summary of the confirmed effects of SDT on AS is conducted to establish a framework for future researchers.

关键词： Atherosclerosis Sonodynamic therapy Sonosensitizer Ultrasound Reactive oxygen species

颈前咽后入路病灶清除联合后路寰枢椎融合治疗寰枢椎结核的疗效观察

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中华医学杂志 2016年第19期96卷 1495-1499页

作者：高延征邢帅高坤施新革张敬乙余正红康永生河南省人民医院郑州大学人民医院骨科郑州450003 郑州市骨科医院脊柱外科

目的评估颈前咽后入路病灶清除联合后路寰枢椎融合治疗寰枢椎结核的疗效。方法回顾分析2005年2月至2013年2月郑州大学人民医院骨科接受颈前咽后入路病灶清除联合后路寰枢椎融合治疗的寰枢椎结核患者7例的临床资料；男3例，女4例。术前... 详细信息

目的评估颈前咽后入路病灶清除联合后路寰枢椎融合治疗寰枢椎结核的疗效。方法回顾分析2005年2月至2013年2月郑州大学人民医院骨科接受颈前咽后入路病灶清除联合后路寰枢椎融合治疗的寰枢椎结核患者7例的临床资料；男3例，女4例。术前和末次随访时采用日本骨科学会颈椎功能评分（JOA）、颈椎残障指数（NDI）和Frankel分级进行神经功能评价并计算末次随访JOA评分改善率。末次随访时，采用Odom’s分级评估临床疗效；术前及末次随访通过影像学检查评估内固定及植骨融合情况。结果术后12个月7例均获骨性融合，17—21个月结核病变均达到临床治愈；末次随访时，JOA评分由术前的（11．1±0．7）分上升到（15．3±0．5）分（P〈0．05）；NDI评分由术前的（34．0±4．6）分下降到（10．1±1．3）分（P〈0．05）。末次随访，按Odom’s标准评价，优5例，良1例，可1例，Frankel分级均由D级上升至E级。结论对于寰枢椎的临床治疗，颈前咽后入路病灶清除联合后路寰枢椎融合，配合局部抗结核药物应用，临床疗效确切，病灶清除彻底，是治疗寰枢椎结核的一种可靠方式。

关键词：寰枢关节脊柱融合术结核,脊柱颈前咽后入路

OnFractional(g,f,n′,m)-Critical Covered Graphs

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Journal of the Operations Research Society of China 2024年第2期12卷 446-460页

作者： Wei gao Wei-Fan Wang School of Information Science and Technology Yunnan Normal UniversityKunming 650500YunnanChina Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina

The main contribution in this article is threefold:(1)we show the necessary and sufficient condition for graphs to be fractional(g,f)-covered which can be expressed in different forms,and extended to fractional(g,f,m)-covered graphs;(2)the concept of fractional-critical covered graph is put forward and its necessary and sufficient condition is given;(3)we present the degree condition for a graph to be fractional(g,f,n′,m)-critical covered,and show that degree bound is sharp when m is ***,the related result in fractional(a,b,n′,m)-critical covered setting is also verified.

关键词： Network Fractional factor Data transmission Fractional covered graph Fractional critical covered graph

谷胱甘肽在激素诱导的BMSCs功能失调中的作用

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中国修复重建外科杂志 2018年第1期32卷 91-98页

作者：代志鹏郑稼高延征刘珂杨述华许伟华河南省人民医院骨科郑州450003 华中科技大学同济医学院附属协和医院骨科武汉430022

目的探讨抗氧化剂谷胱甘肽(glutathione,GSH)对激素诱导的人BMSCs成脂、成骨关键因子表达水平的影响。方法取3例股骨颈骨折患者股骨近端骨髓,采用密度梯度离心联合贴壁法进行BMSCs的分离、培养和纯化。取第3代BMSCs分为5组:A组,单纯BMSC... 详细信息

目的探讨抗氧化剂谷胱甘肽(glutathione,GSH)对激素诱导的人BMSCs成脂、成骨关键因子表达水平的影响。方法取3例股骨颈骨折患者股骨近端骨髓,采用密度梯度离心联合贴壁法进行BMSCs的分离、培养和纯化。取第3代BMSCs分为5组:A组,单纯BMSCs组(1×10~5个/mL);B组,BMSCs(1×10~5个/mL)+10μmol/L地塞米松;C组,BMSCs(1×10~5个/mL)+10μmol/L地塞米松+5μmol/L GSH;D组,BMSCs(1×10~5个/mL)+10μmol/L地塞米松+10μmol/L GSH;E组,BMSCs(1×10~5个/mL)+10μmol/L地塞米松+50μmol/L GSH。培养7 d,采用流式细胞仪检测细胞内活性氧水平,RT-PCR检测细胞内超氧化物歧化酶(superoxide dismutase,SOD)和过氧化氢酶(Catalase)mRNA表达水平,实时荧光定量PCR检测成脂转录因子过氧化物酶体增殖激活受体γ(peroxisome proliferator-activated receptorsγ,PPAR-γ)、CCAAT增强结合蛋白(CCAAT/enhancer-binding family of proteins,C/EBP)和成骨转录因子Runx2、ALP基因表达情况;培养21 d,采用油红O染色观察细胞成脂分化情况,Western blot检测相关蛋白表达水平。结果 B组细胞内活性氧水平显著高于其余各组,C组高于A、D、E组,D、E组高于A组(P0.05)。B组油红O染色阳性细胞明显多于其余各组,C、D、E、A组依次减少,各组吸光度(A)值比较差异均有统计学意义(P0.05)。实时荧光定量PCR检测示,B组PPAR-γ、C/EBP m RNA相对表达量显著高于其余各组(P0.05)。B组Runx2、ALP m RNA相对表达量显著低于其余各组,C组低于A、D、E组,D、E组低于A组,差异均有统计学意义(P0.05)。Western blot检测示,B组PPAR-γ、C/EBP蛋白相对表达量较其余各组显著提高,C、D、E、A组呈逐渐下降趋势,组间比较差异均有统计学意义(P<0.05);B组Runx2、ALP蛋白相对表达量较其余各组显著下降,C、D、E、A组呈逐渐上升趋势,组间比较差异均有统计学意义(P<0.05)。结论 GSH可通过降低细胞内活性氧水平抑制人BMSCs成脂分化,增强成骨分化;在一定范围内,GSH浓度越高,效果越明显。

关键词：股骨头坏死 BMSCs 活性氧成骨分化成脂分化谷胱甘肽

Spatiotemporal pattern of climate change in the China-Myanmar Economic Corridor from 1901 to 2018

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Journal of Mountain Science 2024年第1期21卷 131-145页

作者： YANG Xiaoliu LI Yungang gao Lu Institute of Geography Fujian Normal UniversityFuzhou 350117China School of Geographical Sciences Fujian Normal UniversityFuzhou 350117China Institute of International Rivers and Eco-Security Yunnan UniversityKunming 650500China Fujian Provincial Engineering Research Center for Monitoring and Accessing Terrestrial Disasters Fujian Normal UniversityFuzhou 350117China Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350117China

The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security.

关键词： China-Myanmar Economic Corridor CRU Air temperature Precipitation Spatiotemporal pattern

Potential role of hippocampal neurogenesis in spinal cord injury induced post-trauma depression

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Neural Regeneration Research 2024年第10期19卷 2144-2156页

作者： Ying Ma Yue Qiao Xiang gao Spinal Cord and Brain Injury Research Group Stark Neuroscience Research InstituteIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neurology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The largescale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. Yet, few basic studies have been conducted to address the potential molecular mechanisms. One of possible factors underlying the depression is the reduction of adult hippocampal neurogenesis which may come from less physical activity, social isolation, chronic pain, and elevated neuroinflammation after spinal cord injury. However, there is no clear consensus yet. In this review, we will first summarize the alteration of hippocampal neurogenesis post-spinal cord injury. Then, we will discuss possible mechanisms underlie this important spinal cord injury consequence. Finally, we will outline the potential therapeutic options aimed at enhancing hippocampal neurogenesis to ameliorate depression.

关键词： antidepressants chronic pain depression exercise hippocampal neurogenesis inflammation inhibition neuroinflammation physical activity deficits social isolation spinal cord injury

Study on thermal cycling ageing resistance of performances of polypropylene/elastomer/boron nitride nanocomposites for high voltage direct current cable insulation

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HIGH VOLTAGE 2024年第3期9卷 556-565页

作者： Li, Jing gao, Yu Song, Zheng Liu, Baixin Guo, Chenyi Chen, Yu gao, Junguo Du, Boxue Tianjin Univ Sch Elect & Informat Engn Tianjin Peoples R China State Grid Tianjin Chengxi Elect Power Supply Bran Tianjin Peoples R China Xi An Jiao Tong Univ State Key Lab Elect Insulat & Power Equipment Xian Peoples R China Harbin Univ Sci & Technol Key Lab Engn Dielect & Its Applicat Minist Educ Harbin Peoples R China

The influences of thermal cycling ageing on structures and insulation performances of polypropylene (PP)/elastomer/boron nitride (BN) nanocomposites are investigated. The Melt blending method was used to prepare the nanocomposites, in which propylene-based elastomer (PBE) or ethylene-octene copolymer elastomer (EOC) was contained for comparison. Then, the samples were treated using a thermal cycling process with a temperature range from -30 to 150 degrees C, and the number of thermal cycles was set from 0 to 15. Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry and X-ray diffraction measurements were taken to facilitate the comprehension of structural changes. Additionally, measurements were taken to assess the trap distribution and direct current (DC) breakdown strength of the samples. The obtained results revealed that following thermal cycling ageing, the morphology and crystallinity of PP/PBE/BN remained almost unchanged. In contrast, PP/EOC/BN exhibited substantial microstructural damage accompanied by a significant reduction in crystallinity. As the number of thermal cycles increased, the trap level and DC breakdown strength of PP/PBE/BN were maintained at high levels, while those of PP/EOC/BN initially remained stable but then experienced a sharp decline. It is suggested that the addition of BN nanoparticles enhances the thermal cycling ageing resistance of the PP/PBE blend, whereas it weakens this resistance of the PP/EOC blend.

关键词： POLYPROPYLENE IRRADIATION BEHAVIOR DEGRADATION