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Single-centre study comparing standard apical dissection with a modified technique to facilitate vesico-urethral anastomosis during laparoscopic radical prostatectomy

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Asian Journal of Andrology 2011年第3期13卷 494-498,515页

作者： Xin gao xiao-Yong Pu jie Si-Tu Wen-Tao Huang Department of Urology the Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China

A modified apical dissection of the prostate to improve the efficiency of vesico-urethral anastomosis （VUA） in laparoscopic radical prostatectomy （LRP） was reported. A total of 42 patients were randomly selected and enrolled in this study. A standard LRP was performed in 21 patients （group 1）, whereas a novel, modified apical dissection of the prostate in LRP was performed in another 21 patients （group 2）. Surgical data, total operative time, VUA time, extravasation rate, catheterisation time, occurrence of anastomotic strictures, and the early and late continence rates were analysed statistically. No differences in clinical or pathological characteristics were determined between the two groups. The total operative time, VUA time, blood loss and catheterisation time were lower in group 2, which received the novel, modified technique compared with group 1, which received the standard technique to dissect the apex of the prostate （P〈0.01 for each variable）. Regarding the extravasation rate and the occurrence of anastomotic strictures, no significant differences were found between the two groups （P〉0.0.05 for each）. After catheter removal, a statistically significant difference in the continence rates was present at 3 and 30 days post operation in the two groups （P〈0.01, respectively）. At 90 days post operation, the difference, although still present, was no longer statistically significant （P〉0.05）. The novel, modified apical dissection of the prostate facilitates the VUA and significantly improves the efficacy of the procedure and early restoration of continence.

关键词： continence laparoscopic technique radical prostatectomy vesico-urethral anastomosis

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可利霉素产生菌中糖基转移酶基因ssp803的功能鉴定及酶学特性分析

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中国医药生物技术 2024年第5期19卷 432-442页

作者：高晓杰李可萌赫卫清中国医学科学院北京协和医学院医药生物技术研究所卫健委抗生素生物工程重点实验室/医科院合成生物学重点实验室

目的通过体内基因阻断和体外酶促反应鉴定可利霉素产生菌中糖基转移酶基因ssp803功能和酶学特性，以及与可利霉素生物合成的关系。方法在可利霉素产生菌54-IA中利用CRISPR-Cas9基因编辑系统敲除ssp803基因，将组成型启动子kasOp*控制... 详细信息

目的通过体内基因阻断和体外酶促反应鉴定可利霉素产生菌中糖基转移酶基因ssp803功能和酶学特性，以及与可利霉素生物合成的关系。方法在可利霉素产生菌54-IA中利用CRISPR-Cas9基因编辑系统敲除ssp803基因，将组成型启动子kasOp*控制的ssp803及其同源基因oleD分别转化到54-IA和?803变株中进行回复和高表达实验，通过HPLC分析?803变株、回复株和高表达株中可利霉素主组分异戊酰螺旋霉素的产量变化。再将ssp803基因连接至冷休克表达载体pColdI上，利用大肠杆菌Transetta(DE3)中进行表达和纯化。以大环内酯类抗生素为糖苷配体和以UDP-葡萄糖为供体进行Ssp803催化反应，通过HPLC-MS检测酶催化后的产物，通过UDP-Glo试剂盒测定Ssp803的酶促动力学参数。结果利用PCR筛选出了ssp803基因框内缺失突变株?803，在?803中异戊酰螺旋霉素产量与54-IA出发菌株相似，而在54-IA和?803中高表达ssp803完整基因时，异戊酰螺旋霉素的含量明显下降，导入高表达oleD基因的质粒后产量下降得更多。通过体外酶促反应证实Ssp803催化的最适温度是37℃，最适pH是9.06。Ssp803对所测的大环内酯类抗生素都具有糖基化失活作用，对异戊酰螺旋霉素I等16元环的大环内酯类抗生素的催化活性要低于14元环大环内酯类抗生素，对索利霉素的催化效率最高。结论 Ssp803对大环内酯类抗生素具有糖基化失活作用，对14元环大环内酯类抗生素的活性更高，最适底物是索利霉素；在可利霉素产生菌中高表达ssp803和oleD基因会抑制异戊酰螺旋霉素的生物合成。

关键词：糖基转移酶可利霉素异戊酰螺旋霉素大环内酯类抗生素

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Theoretical and numerical study on reinforcing effect of rock-bolt through composite soft rock-mass

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Journal of Central South University 2018年第10期25卷 2512-2522页

作者： ZHAO Zeng-hui gao xiao-jie TAN Yun-liang MA Qing State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology College of Mining and Safety Engineering Shandong University of Science and Technology

Anchoring mechanism and failure characteristics of composite soft rock with weak interface usually exhibit remarkable difference from those in single rock *** order to fully understand the reinforcement mechanism of composite soft roof in western mining area of China,a mechanical model of composite soft rock with weak interface and rock bolt which considering the transverse shear sliding between different rock layers was established *** anchoring effect was quantified by a factor defined as anchoring effect coefficient and its evolution equation was further deduced based on the deformation relationship and homogenized distribution assumption of stress acting on composite ***,the numerical simulation model of composite soft rock with shear joint was prompted by finite element *** detailed analysis were carried out for the deformation features,stress distribution and failure behavior of rock mass and rock bolt near the joint under transverse *** theoretical result indicates that the anchoring effect of rock-bolt through weak joint changes with the working status of rock mass and closely relates with the physical and geometric parameters of rock mass and rock *** the numerical results,the bending deformation of rock bolt accurately characterized by Doseresp model is mainly concentrated between two plastic hinges near the shear *** maximum tensile and compression stresses distribute in the plastic ***,the maximum shear stress appears at the positions of joint *** failure zones of composite rock are produced firstly at the joint surface due to the reaction of rock *** above results laid a theoretical and computational foundation for further study of anchorage failure in composite soft rock.

关键词： composite soft rock anchorage evolution equation numerical model plastic hinge

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中药结合腹针治疗老年卒中后睡眠障碍临床观察

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湖北中医药大学学报 2024年第2期26卷 76-78页

作者：郝建雯赵华婧韩玫高晓杰赵辉河北省退役军人总医院河北邢台054000

目的观察中药结合腹针治疗老年卒中后睡眠障碍(PSSD)患者临床疗效。方法将我院老年PSSD患者200例随机分为治疗组与对照组各100例。对照组服用右佐匹克隆治疗,治疗组在对照组的治疗基础上采用中药、腹针治疗。比较两组总有效率,匹兹堡... 详细信息

目的观察中药结合腹针治疗老年卒中后睡眠障碍(PSSD)患者临床疗效。方法将我院老年PSSD患者200例随机分为治疗组与对照组各100例。对照组服用右佐匹克隆治疗,治疗组在对照组的治疗基础上采用中药、腹针治疗。比较两组总有效率,匹兹堡睡眠质量指数量表(PQSI)、失眠严重程度指数量表(ISI)、临床痴呆评定量表(CDR)评分,睡眠时间、觉醒时间、觉醒次数,汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分。结果治疗后,治疗组总有效率高于对照组(P<0.05)。两组PSQI、ISI、CDR评分均低于治疗前,治疗组PSQI、ISI、CDR评分均低于对照组(P<0.05);两组睡眠时间均高于治疗前,觉醒时间、觉醒次数均低于治疗前,治疗组睡眠时间高于对照组,觉醒时间、觉醒次数低于对照组(P<0.05);两组HAMD、HAMA评分均低于治疗前,治疗组HAMD、HAMA评分低于对照组(P<0.05)。结论中药结合腹针治疗老年PSSD患者临床疗效显著,能提高睡眠质量,缓解失眠和痴呆,改善抑郁和焦虑。

关键词：卒中老年睡眠障碍中药腹针临床疗效

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Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： xiao-Bao Wu Jun-Xiu Shi Yi-Ming Ou Hua-jie Jiang Yi-Jun Fang Qi-Ming Wang Quan gao jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

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Characteristics and stability of oxide+carbonitride in H13 steel at 1250℃

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Journal of Iron and Steel Research International 2024年第1期31卷 134-142页

作者： xiao-lin Sun Han-jie Guo Jing Guo Fei Wang Dong Xu gao-yang Song Shuai Wang School of Materials Science and Engineering Hebei University of EngineeringHandan056038HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China High Temperature Materials Research Institute Central Iron and Steel Research Institute Co.Ltd.Beijing100081China Technology Innovation Center for High Quality Cold Heading Steel of Hebei Province Hebei University of EngineeringHandan056038HebeiChina

The morphology,size,quantity,and composition of complex oxide+carbonitride in H13 steel held at 1250℃for 5,10,and 15 h were *** results show that the ratio and number of complex carbonitrides with cores in H13 steel are gradually increased when holding at 1250℃compared with those in the original H13 steel,and the core size *** are one or more oxide cores in(Ti_(x),V_(1-x))(Cy,N_(1-y)),including xCaO·zAl_(2)O_(3),xCaO·yMgO·zAl_(2)O_(3),and CaO after holding at 1250℃,in addition to MgO·Al_(2)O_(3)and Al_(2)O_(3)in the original *** equilibrium temperature for(Ti_(x),V_(1-x))(Cy,N_(1-y))precipitation at the solidification front and decomposition in the solid state was theoretically analyzed,which was affected by the x value and the product of Ti and N contents in H13 ***,the composition of(Ti_(x),V_(1-x))(Cy,N_(1-y))is influenced by the oxide *** is convinced that(Ti_(x),V_(1-x))(Cy,N_(1-y))with oxide cores has a higher stability,especially for oxides with a high Al_(2)O_(3)*** treatment at high temperature facilitates a more reasonable analysis of oxide+carbonitride,and the generation mechanism of oxide+carbonitride was discussed.

关键词： Complex carbonitride Decomposition Oxide core Characteristic Stability

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Lignin-reinforced PVDF electrolyte for dendrite-free quasi-solid-state Li metal battery

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Rare Metals 2024年第3期43卷 1006-1016页

作者： Xin-Yang Chen Xue-jie gao Han-Yan Wu Yu-Long Liu xiao-Fei Yang Run-Cang Sun Center for Lignocellulosic Chemistry and Biomaterials College of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian116034China Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China School of Chemistry Northeast Normal UniversityChangchun130024China

Quasi-solid-state lithium metal batteries(QSSLMBs)assembled with polyvinylidene fluoride(PVDF)are a promising class of next-generation rechargeable batteries due to their safety,high energy density,and superior interfacial ***,PVDF has a series of inherent drawbacks such as low ionic conductivity,ease of crystallization,and hydrophobic character that leading to poor cell *** tackle these issues,a lignin-reinforced PVDF electrolyte is proposed in this work to solve these drawbacks of PVDF and enhance the comprehensive performance of *** lithophilic polar groups of lignin can promote uniform deposition of Li on the *** with the improved mechanical properties can efficiently prevent Li dendrites penetration through the *** addition,more active sites provided by lignin can also enhance Li^(+)transport and lead to a faster electrochemical reaction *** from the ingenious design,Li symmetric cells with 5%lignin-PVDF quasi-solid-state electrolyte can operate for 900 h at a high current density/capacity of 5 mA·cm^(-2)/5 mAh·cm^(-2),while shortcircuiting occurs after 56 h for the counterpart(pure PVDF).Moreover,a full cell of Li/5%lignin-PVDF/LFP cell demonstrates a high capacity of 96.2 mAh·g^(-1)after 2000 cycles at 10 *** work is expected to open up promising opportunities to develop other high-energy/power-density QSSLMBs.

关键词： Quasi-solid-state electrolyte Lignin PVDF Dendrite-free Li metal battery

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An Efficient Multi-objective Approach Based on Golden Jackal Search for Dynamic Economic Emission Dispatch

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Journal of Bionic Engineering 2024年第3期21卷 1541-1566页

作者： Keyu Zhong Fen xiao Xieping gao Key Laboratory of Computing and Stochastic Mathematics of Ministry of Education Hunan Normal UniversityChangsha410081China School of Mathematics and Statistics Hunan Normal UniversityChangsha410081China School of Computer Science Xiangtan UniversityXiangtan411105China Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing Hunan Normal UniversityChangsha410081China

Dynamic Economic Emission Dispatch(DEED)aims to optimize control over fuel cost and pollution emission,two conflicting objectives,by scheduling the output power of various units at specific *** many methods well-performed on the DEED problem,most of them fail to achieve expected results in practice due to a lack of effective trade-off mechanisms between the convergence and diversity of non-dominated optimal dispatching *** address this issue,a new multi-objective solver called Multi-Objective Golden Jackal Optimization(MOGJO)algorithm is proposed to cope with the DEED *** proposed algorithm first stores non-dominated optimal solutions found so far into an ***,it chooses the best dispatching solution from the archive as the leader through a selection mechanism designed based on elite selection strategy and Euclidean distance index *** mechanism can guide the algorithm to search for better dispatching solutions in the direction of reducing fuel costs and pollutant ***,the basic golden jackal optimization algorithm has the drawback of insufficient search,which hinders its ability to effectively discover more Pareto *** this end,a non-linear control parameter based on the cosine function is introduced to enhance global exploration of the dispatching space,thus improving the efficiency of finding the optimal dispatching *** proposed MOGJO is evaluated on the latest CEC benchmark test functions,and its superiority over the state-of-the-art multi-objective optimizers is highlighted by performance ***,empirical results on 5-unit,10-unit,IEEE 30-bus,and 30-unit systems show that the MOGJO can provide competitive compromise scheduling solutions compared to published DEED ***,in the analysis of the Pareto dominance relationship and the Euclidean distance index,the optimal dispatching solutions provided by MOGJO are the closest to the ideal solutions for minimizing fuel costs

关键词： Dynamic economic emission dispatch Multi-objective optimization Golden jackal Euclidean distance index

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APFA:Ameliorated Pathfinder Algorithm for Engineering Applications

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Journal of Bionic Engineering 2024年第3期21卷 1592-1616页

Pathfinder algorithm(PFA)is a swarm intelligent optimization algorithm inspired by the collective activity behavior of swarm animals,imitating the leader in the population to guide followers in finding the best food *** algorithm has the characteristics of a simple structure and high ***,PFA faces challenges such as insufficient population diversity and susceptibility to local optima due to its inability to effectively balance the exploration and exploitation *** paper proposes an Ameliorated Pathfinder Algorithm called APFA to solve complex engineering optimization ***,a guidance mechanism based on multiple elite individuals is presented to enhance the global search capability of the ***,to improve the exploration efficiency of the algorithm,the Logistic chaos mapping is introduced to help the algorithm find more high-quality potential solutions while avoiding the worst ***,a comprehensive following strategy is designed to avoid the algorithm falling into local optima and further improve the convergence *** three strategies achieve an effective balance between exploration and exploitation overall,thus improving the optimization performance of the *** performance evaluation,APFA is validated by the CEC2022 benchmark test set and five engineering optimization problems,and compared with the state-of-the-art metaheuristic *** numerical experimental results demonstrated the superiority of APFA.

关键词： Pathfinder algorithm Swarm intelligent Metaheuristic Engineering problems

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A compact route for efficient production of high-purity β-Ga2O3 powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： xiao-Wei Zhou gao-jie Chen Liang Xu Zhi-Jun Shao Cheng Yang Yong-Pan Tian Zhuo Zhao School of Metallurgical Engineering Anhui University of Technology Low-Carbon Research Institute Anhui University of Technology

The present study has proposed a compact process for the production of high-purity β-Ga2O3powder by simply using gallium metal and water as the raw materials. The process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product of β-Ga2O3. Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization. X-ray diffractometer（XRD）, scanning electron microscopy（SEM）, thermogravimetryDdifferential scanning calorimetry（TG-DSC） and X-ray photoelectron spectroscopy（XPS） were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH to β-Ga2O3by calcination. Chemical analysis of the final product of β-Ga2O3obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry（ICP-MS）, and the results showed that the contents of the representative impurities such as Ni, Cu, In, Mn, Co, Zn and Cr are obviously lower than the requirement of 5N β-Ga2O3standard, exhibiting excellent application prospect of the proposed process to produce high-purity β-Ga2O3.

关键词： Calcination Hydrothermal synthesis Purity Reaction mechanism β-Ga2O3

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