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Blocking beta 2-adrenergic receptor inhibits dendrite ramification in a mouse model of Alzheimer's disease

Neural Regeneration Research 2017年第9期12卷 1499-1506页

作者： Qin Wu Jin-xia Sun xiang-he Song Jing Wang Cun-quan Xiong Fei-xiang Teng Cui-xiang gao Jiangsu Key Laboratory of Brain Disease Bioinformation Xuzhou Medical College College of Medical Technology Jiangsu Vocational College of Medicine

Dendrite ramification affects synaptic strength and plays a crucial role in memory. Previous studies revealed a correlation between beta 2-adrenergic receptor dysfunction and Alzheimer＇s disease （AD）, although the mechanism involved is still poorly understood. The current study investigated the potential effect of the selective β2-adrenergic receptor antagonist, ICI 118551 （ICI）, on Aβ deposits and AD-related cognitive impairment. Morris water maze test results demonstrated that the performance of AD-transgenic （TG） mice treated with ICI （AD-TG/ICI） was significantly poorer compared with NaCl-treated AD-TG mice （AD-TG/NaCl）, suggesting that β2-adrenergic receptor blockage by ICI might reduce the learning and memory abilities of mice. Golgi staining and immunohistochemical staining revealed that blockage of the β2-adrenergic receptor by ICI treatment decreased the number of dendritic branches, and ICI treatment in AD-TG mice decreased the expression of hippocampal synaptophysin and synapsin 1. Western blot assay results showed that the blockage of β2-adrener- gic receptor increased amyloid-β accumulation by downregulating hippocampal a-secretase activity and increasing the phosphorylation of amyloid precursor protein. These findings suggest that blocking the β2-adrenergic receptor inhibits dendrite ramification of hippocampal neurons in a mouse model of AD.

关键词： nerve regeneration neurodegeneration beta-2 adrenergic receptor Alzheimer's disease amyloid-β ICI 118551 cognitive function dendrite ramification synapsin 1 synaptophysin a-secretase amyloid precursor protein neural regeneration

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Design and test of the bilateral throwing soil-covering device for straw mulching machine in orchards

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International Journal of Agricultural and Biological Engineering 2023年第1期16卷 162-171页

作者： Xinhua Zhu xiang gao Xudong Li Shaojie Xu College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100ShaanxiChina Weichai Lovol Heavy Industry Co. Ltd.Weifang 261200ShandongChina

Aiming to lack the function of soil covering in the developed orchard straw mulching machine(OSM),a kind of bilateral counter-throwing soil-covering device was developed to eliminate the orchard fire risk caused by the straw *** soil-covering device was suspended at the rear of the *** core component was a pair of throwing wheels installed on both sides of a *** motors drove the throwing wheels to take soil on-site and cover the straw *** adjustment range of the space between the throwing wheels on both sides was 1.4-2.1 *** on the analysis of soil-covering quantity,soil-covering width,thickness uniformity of soil layer,and power consumption,the key parameters such as the radius,the number of the vane,and the minimum rotation speed of the throwing wheels were *** was proved that the thickness uniformity of the soil layer by bilateral counter-throwing was better than by unilateral,and bottom throwing was better than top *** blade of the soil cutter consisted of a straight blade and a curved blade,and the sliding-cutting angle was 14°-40°.The field test results showed the soil-covering device had good performance with a width of 1.4-2.2 m,a thickness of the soil-covering layer(TSL)of 23.2-40.7 mm,a standard deviation(SD)of 1.4-2.9 mm,width uniformity of 100%,and leakage rate of *** established model,between the thickness of soil-covering layer and trenching depth,throwing angle,and rotation speed of the throwing wheels,has a determination coefficient of 0.9757 and can be used to guide the operating *** soil cutter reduced the power consumption and impact load of the throwing wheels by 64.77%and 60.88%,*** work provides a type of new equipment for the mechanization technology of straw mulching in arid and semi-arid orchards.

关键词： orchard straw mulching mechanization soil-covering device counter-throwing uniformity

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Foldamer-Derived Preorganized Bi- and Tri-zinc Porphyrin Tweezers for a Pentafluorobenzene-bearing Pyridine Guest： The Binding Pattern Study

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Chinese Journal of Chemistry 2013年第5期31卷 582-588页

作者： Changzhi Li Xin Zhao xiang gao Quanrui Wang Zhanting Li Department of Chemistry Fudan University Shanghai 200433 China ghanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

By introducing two and three zinc porphyrin units to one side of hydrogen bonding-induced aromatic amide foldamers, two new molecular tweezers 1 and 2 have been prepared. To explore new possible binding patterns, a leucine-based pyridine ligand 3 that bears a pentafluorophenyl group has been prepared. UV-Vis and IH NMR ex- periments reveal that 1 and 2 favorably complex one or two molecules of 3. UV-Vis titration experiments show that the apparent association constants of the complexes of the zinc porphyrin units of the two receptors and 3 are con- siderably higher than that of the complex between a simple control zinc porphyrin and 3. In the presence of excess of 3, the left zinc porphyrin unit of 1 and 2 can bind one more molecule of 3, which is, however, stabilized only by the single Zn-N coordination.

关键词： molecular recognition foldamer hydrogen bonding coordination porphyrin

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Naphthalene decomposition in a DC corona radical shower discharge

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第1期12卷 71-77页

作者： Ming-jiang NI Xu SHEN xiang gao Zu-liang WU Hao LU State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China College of Environmental Science and Engineering Zhejiang Gongshang University Hangzhou 310015 China Division of Combustion Physics Lund University S-22100 Lund Sweden

The naphthalene decomposition in a corona radical shower discharge (CRS) was investigated, with attention paid to the influences of voltage and initial naphthalene density. The OH emission spectra were investigated so as to know the naphthalene decomposing process. The by-products were analyzed and a decomposing theory in discharge was proposed. The results showed that higher voltage and relative humidity were effective on decomposition. The initial concentration affected the decomposing efficiency of naphthalene. When the initial naphthalene density was 17 mg/m3, the decomposition rate was found to be 70% under 14 kV. The main by-products were carbon dioxide and water. However, a small amount of carbonic oxide, 1,2-ethanediol and acetaldehyde were found due to the incomplete oxidization.

关键词： Naphthalene decomposition Corona Discharge OH radical

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Microstructural evolution of Al-Si coating and its influence on high temperature tribological behavior of ultra-high strength steel against H13 steel

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Journal of Iron and Steel Research International 2017年第10期24卷 1048-1058页

作者： Meng-xuan Guo Kai-xiang gao Wu-rong Wang Xi-cheng Wei School of Materials Science and Engineering Shanghai UniversityShanghai 200072China

Al-Si coated ultra-high strength steel（UHSS）has been commonly applied in hot stamping *** influence of austenitizing temperature on microstructure of Al-Si coating of UHSS during hot stamping process and its tribological behavior against H13 steel under elevated temperature were simulatively *** austenitizing temperature of Al-Si coated UHSS and its microstructual evolution were confirmed and analyzed by differential scanning calorimetry and scanning electron microscopy.A novel approach to tribological testing by replicating hot stamping process temperature history was *** show that the hard and stable phases Fe_2Al_5＋FeAl_2 formed on Al-Si coating surface after exposure to 930°C for 5 min,which was found to be correlated to the tribological behavior of *** friction coefficient of coated steel was more stable and higher than that of uncoated *** main wear mechanism of Al-Si coated UHSS was adhesion wear,while abrasive wear was dominant for the uncoated UHSS.

关键词： Hot stamping Al-Si coating Ultra-high strength steel Intermetallic compound Diffusion Friction coefficient Adhesive wear

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The role of immune cells in obesogenic memory

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Cellular & Molecular Immunology 2020年第8期17卷 884-886页

作者： Minli Sun Shang Zheng xiang gao Zhaoyu Lin MOE Key Laboratory of Model Animals for Disease Study Model Animal Research CenterState Key Laboratory of Pharmaceutical BiotechnologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing University210061NanjingChina

Obesity is a serious chronic disease and worldwide public health *** to data from the World Health Organization(WHO),more than 650 million adults in the world were obese and three times more individuals were overweight in *** is associated with type II diabetes,hepatic steatosis,cardiovascular diseases,systemic chronic inflammation,and at least 13 types of ***,few effective remedies are available for *** major problem is that most patients suffer from weight regain 2–3 years after obesity treatments,such as obesity drugs,lifestyle interventions(including exercise,diet restrictions,and diet modification),and bariatric *** with weight regain,most of the initial beneficial changes in metabolomic and transcriptomic profiles dissipate,including insulin sensitivity,the level of adipokines and blood *** phenomenon has been defined as“obesogenic memory”.1,2 Obesogenic memory causes repeated weight loss and gain along with obesity therapy,which is called“weight cycling”,leading to a worse healthy status than would result from simple obesity.3,4.

关键词： obesity drugs inflammation

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Synthesis and Primary Research on Antitumor Activity of Three New Panaxadiol Fatty Acid Esters

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Chemical Research in Chinese Universities 2007年第2期23卷 176-182页

作者： ZHANG Chun-hong LI xiang-gao gao Yu-gang ZHANG Lian-xue FU Xue-qi Academy of Chinese Traditiorial Medicine Jilin Agricultural University Changchun 130118 P. R. China Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Jilin University Changchun 130021 P. R. China

For making use of Ginseng resources that exhibit an antitumor activity and for finding new anticancer drugs, three new fatty acid ester compounds： 3/β-acetoxy panaxadiol （ Ⅰ ）, 3β-palmitic acid aceloxy panaxadiol （ Ⅱ ） , and 3β-octadecanoic acid aceloxy panaxadiol（ Ⅰ , Ⅱ, and m） were synthesized with panaxadiol, diacetyl oxide, palmityl chloride and stearyl chloride, and their structures were determined via MS, ^13C NMR, IR, TLC, and so on. The molar yields of the three compounds are 75.14%, 79. 08%, and 72. 57%, respectively. Meanwhile, the antitumor activity of the three new panaxadiol fatty acid ester derivatives and panaxadiol was compared by using the method of MTT. Tumor cell used was Vero cell line. Positive control was 5-FU, blank was an RPMI1640 culture medium, negative control was an RPMI1640 culture medium and the solvent for drugs to be tested. Compound Ⅰ has the strongest antitumor activity followed by panaxadiol; compounds Ⅱ and Ⅲ have similar and weakest antitumor activities. Furthermore, the antitumor activities of the panaxadiol fatty acid ester derivatives show positive correlation with the concentration of the test group, but show no relationship with the molecular weight of fatty acid. The methods that are used to synthesize the three compounds with high yields and strong antitumor activities are simple and show a great potential for meeting the needs of industrial manufacture of these drugs.

关键词： Synthesis Panaxadiol fatty acid esters Anti-tumor activity

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Synthesis and Properties of Novel Luminescent Compounds Containing Triphenylamine and Bipyridine Units

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Chemical Research in Chinese Universities 2012年第2期28卷 313-318页

作者： LU Hai-jun LI xiang-gao WANG Shi-rong gao Wen-zheng WANG Sha-sha School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072P.R.China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018P.R.China

Blue luminescent compounds T1―T4 containing triphenylamine donors,bipyridine acceptors and olefinic linkers were synthesized and characterized by 1 H NMR,13 C NMR and high resolution mass spectrometry（HRMS）.Four compounds T1―T4 exhibit excellent solubility in common solvents and good film forming *** chemical calculations show that compounds T1―T4 have asymmetric linear structures and the proper highest occupied molecular orbital（HOMO） *** UV-Vis absorption and fluorescence emission spectra of the four compounds in dilute chloroform solutions and on the solid films were *** reveals that compounds T1―T4 exhibit similar spectral behavior,suggesting that these compounds can form amorphous state in solid *** calculated absorption and emission spectra of compounds T1―T4 are in good agreement with experimentally determined *** T1―T4 have absolute fluorescence quantum yield above 17% in dilute chloroform *** compounds possess high glass-transition temperature（T g） exceeding 97 ℃ and the maximum T g is 155.28 ℃ for compound *** voltammetry measurements show that these compounds have proper HOMO levels in a range of-5.01―-5.13 eV for hole *** properties of compounds T1―T4 indicate that these compounds are candidates for the application in organic light-emitting devices（OLEDs） as hole-transporting materials（HTMs）.

关键词： Luminescent compound Triphenylamine Bipyridine Hole-transporting material

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Morphodynamic Characteristics and Medium-Term Simulation of the North-South Passage Under the Impact of the Yangtze Estuary Deepwater Navigation Channel Project

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China Ocean Engineering 2020年第2期34卷 198-209页

作者： JIAO Jian DOU Xi-ping gao xiang-yu DING Lei YANG Xiao-yu Key Laboratory of Port Waterway and Sedimentation Engineering of MOTNanjing Hydraulic Research InstituteNanjing 210029China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China

The morphological evolution characteristics of the North-South Passage area since the construction of the Yangtze Estuary Deepwater Navigation Channel Project(DNCP)are analyzed on the basis of the measured data.A twodimensional morphodynamics numerical model of the Yangtze Estuary is established to verify the morphological evolution of the North-South Passage under the influence of the DNCP and to predict the future evolution in the next 40 *** analysis shows that the North Passage has experienced rapid adjustment stages and adaptive stages after the construction of the *** erosion occurred along the main channel,and slow siltation could be observed in the area between the *** South Passage showed a state of upper section erosion and down section *** present,the whole South Passage is in a slight erosion *** to the numerical model,the eroding and silting speed of the North Passage will slow down in the *** present state that erosion occurs in the main channel and siltation occurs between the groins will *** South Passage will still maintain upper section erosion and down section deposition in the *** to the main channel erosion of the North Passage and siltation of the South Passage,the sediment division ratio of the North Passage will increase in the future but still be smaller than 50%.After morphological evolution of 40 years,the direction of residual sediment transport caused by M2 and M4 tidal components in the North Passage has not changed,but the transport rate will *** is considered that the morphological evolution of the North-South Passage could reach a relatively stable state after 40 years.

关键词： Yangtze Estuary numerical model morphology tidal current sediment transport deepwater navigation channel project(DNCP)

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Phase matched scanning optical parametric chirped pulse amplification based on pump beam deflection

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Chinese Physics B 2021年第10期30卷 351-355页

作者： Rong Ye Huining Dong Xianyun Wu xiang gao College of Physics and Engineering Chengdu Normal UniversityChengdu 611130China College of Science Southwest University of Science and TechnologyMianyang 621010China

Combined with the optical beam deflection,a novel approach of phase matched broadband scanning optical parametric chirped pulse amplification(OPCPA)was *** this scheme,there was no superfluous operations to the chirped signal pulse which propagated in a changeless direction straightforward,but the pump beam were deflected in space with time by passing through a KTN crystal,which was applied with varied driving *** theories of phase matching of each chirped signal frequency based on pump beam deflection was analyzed *** the type-I amplification of chirped signal with 800 nm central wavelength and 20 nm bandwidth pumped by 532 nm in BBO crystal was simulated as a case in *** simulation results showed that the spectral distribution of chirped signal pulse was almost the same as the initial form,i.e.,there was nearly no narrowing on the amplified spectrum by using of the scanning OPCPA based on pump beam *** addition,the simulations demonstrated that it was worth minimizing the voltage deviation applied to KTN crystal as much as possible for the sake of better waveform,larger bandwidth and higher conversion efficiency of amplified signal pulse in the proposed scanning OPCPA.

关键词： optical parametric chirped pulse amplification optical beam deflection phase matching scanning KTN crystal

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