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Orbital pacing and secular evolution of lake-level changes reconstructed by sedimentary noise modeling during the Early Jurassic icehouses-(super)greenhouses

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Science China Earth Sciences 2024年第1期67卷 252-267页

作者： Meng li Xin li Stephen P.HESSELBO Mingjie li wenjin liu Wei WU Jienan PAN Ruizhen gao School of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China Camborne School of Mines and Environment and Sustainability Institute University of ExeterPenryn TR109FEUnited Kingdom Qinghai No.105 Coal Geological Exploration Team Xining 810000China

Lake-level changes can significantly affect paleoenvironmental evolution,resource occurrence,terrestrial carbon budget,and biodiversity in continental *** is one of the most critical factors controlling lake-level *** of the Early Jurassic has been evidenced by oscillating icehouses to(super)greenhouses with interrupted intermittent extreme climatic events(hyperthermal and cooling),e.g.,the Toarcian oceanic anoxic event(~183 Ma)and the late Pliensbachian cooling event(~185 Ma).Lake-level evolution and hydrologic cycling on Earth’s surface during the Early Jurassic icehouses-to-(super)greenhouses are thus far poorly understood due to a lack of continuous high-resolution nonmarine *** we present a super-long nonmarine lake level record for this pivotal interval from the early Pliensbachian to Toarcian by sedimentary noise modeling,and construct a 16.7-Myr-long astronomical time scale(174.2 Ma to 190.9 Ma)based on cyclostratigraphy analysis of rock color datasets(CIE b*)of the Qaidam *** results document lake-level oscillations on a 5-to 10-million-year(Myr)scale which shows a pronounced correlation with long-term climate variation and extreme climatic events,and 1-to 2.5-Myr-scale lake-level changes that are prominently paced by the 2.4-Myr long-eccentricity forcing and the 1.2-Myr obliquity *** the Pliensbachian Stage,the 1.2-Myr-scale lake-level changes are in phase with the coeval sealevel *** forced growth and decay of the ephemeral or permanent ice sheets in polar regions are interpreted to control the synchronous ups-and-downs of continental lake level and global sea ***,during the Toarcian ice-free greenhouses to(super)greenhouses,the 1.2-Myr-scale lake-level variations show an anti-phase relationship with global sea level,indicating a‘seesaw’interaction between continental reservoirs(lakes and groundwater)and global *** 2.4-Myr longeccentricity cycles mainly regulate variation

关键词： Milankovitch cycles Orbital forcing Sedimentary noise model Lake level Continental basins

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Portable hydrogel-based tri-channel fluorescence sensor array for visual detection of multiple explosives

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Nano Research 2024年第7期17卷 6483-6492页

作者： wenxing gao wenfeng liu Saijin Huang lin Wang Yingying Jian Yutong li Weiwei Wu li Shang State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China School of Advanced Materials and Nanotechnology Xidian UniversityXi'an 710126China Honors College Northwestern Polytechnical UniversityXi'an 710119China

The identification and detection of various types of explosives are essential for human health and environmental ***-based sensing approach offers significant advantages in detecting multi-analytes simultaneously,thereby holding great potential in identifying multiple ***,we report a tri-channel fluorescence array composed of three distinct fluorescence probes based on gold nanoclusters and nicotinamide adenine dinucleotide with well-separated emission *** the specific interactions of explosives with different fluorescent probes and the yielded response patterns,seven explosives can be successfully distinguished with 100%*** particular,the sensor array exhibits excellent performance in the quantitative analysis of individual explosive and the differentiation of multiple explosive *** facilitate the field detection towards practical application,the tri-channel fluorescence array was further integrated with polymer *** fabricated portable hydrogel-based array sensors can not only visually identify seven different explosives by their distinct fluorescence color change,but also enable quantitative detection based on linear discriminant analysis(LDA)together with a *** study illustrates the great potential of hydrogel-based fluorescence sensor array as robust sensors for explosives,which also holds significant promise for the development of portable explosive devices towards practical application.

关键词： sensor array gold nanoclusters explosives fluorescence hydrogels

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Piezoelectric film promotes skin wound healing with enhanced collagen deposition and vessels regeneration via upregulation of PI3K/AKT

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Nano Research 2024年第8期17卷 7461-7478页

作者： Qi Xu Wufei Dai Peizhe li Qinglin li Zhen gao Xiaoli Wu Wei liu wenbo Wang Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Research Institute of Plastic Surgery Shandong Second Medical UniversityWeifang 261000China Department of Surgery Air Force Medical CenterPLABeijing 100142China

Skin wounds are common in accidental injuries,and the intricacies of wound repair are closely linked to endogenous electric *** stimulation plays a pivotal role in the restorative processes of skin injuries,encompassing collagen deposition,angiogenesis,inflammation,and *** electrical stimulation therapy replicates and enhances the effects of endogenous wound electric fields by applying an external electric field to the wound site,thereby promoting skin wound *** this study,we developed a self-powered repetitive mechanical impacts-electrical stimulation(RMI-ES)system utilizing a BaTiO_(3)/polydimethylsiloxane(PDMS)piezoelectric composite *** to conventional electrical stimulation devices,the fabricated piezoelectric composite film efficiently harvests energy from the pressure applied by the stimulation device and the tensile force occurring during natural rat *** results demonstrated that piezoelectric stimulation generated by the composite membrane expedited the cell cycle,promoting fibroblast ***,piezoelectric stimulation induced favorable changes in fibroblast gene expression,including increased expression of transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF),collagen 1,collagen 3,vascular endothelial growth factor(VEGF),and alpha-smooth muscle actin(α-SMA),while reducing interleukin-6(IL-6)*** analysis revealed that piezoelectric stimulation may induce fibroblast migration,proliferation,and collagen expression by influencing PI3K/AKT serine/threonine kinase(AKT)*** confirmation through the addition of the PI3K inhibitor LY294002 validated that piezoelectric stimulation can regulate the repair process after skin injury through the ***,in vivo results demonstrated that the electric field at the wound site effectively promoted wound healing,reduced inflammation,and stimulated collagen deposition and ne

关键词： BaTiO3/polydimethylsiloxane(PDMS)nano-composite membrane piezoelectrical stimulation skin wound healing collagen deposition PI3K/AKT serine/threonine kinase(AKT)signaling pathway

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Cobalt-doped TiO_(2)@C hierarchical nanocomposites derived from Ti_(3)C_(2) MXene as cathodes for hybrid magnesium-lithium batteries

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Nano Research 2024年第1期17卷 253-261页

作者： Xiaohui li Yakun Tang Lang liu Yue Zhang Yang gao Mao Qian wenjie Ma State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830017China

TiO_(2)has been explored in hybrid magnesium-lithium batteries(HMLBs)due to the advantages of low self-discharge and small volume expansion during ion ***,how to improve the inherently low ionic and electrical conductivity of TiO_(2)is the problem that needs to be *** this work,a smart strategy is adopted to prepare cobalt-doped TiO_(2)@C(Co^(4+)-TiO_(2)@C)hierarchical nanocomposite derived from Co(II)(OH)n@*** with TiO_(2)@C(without cobalt doping),Co^(4+)-TiO_(2)@C shows the highest specific capacity(154.7 mAh·g^(-1)at 0.1 A·g^(-1)after 200 cycles)and extraordinary rate performance in *** excellent electrochemical performance of Co4+-TiO_(2)@C is ascribed to the synergistic effect of the hierarchical structure and *** experimental results and density functional theory(DFT)calculation reveal that the cobalt-doping has effectively improved the electronic conductivity and reduced the li+migration *** work provides a new insight to design TiO_(2)-based cathode materials with high-performance in HMLBs.

关键词： Ti_(3)C_(2)MXene TiO_(2) hybrid magnesium-lithium batteries hierarchical structure cobalt-doping

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Dynamic simulation analysis of molten salt reactor-coupled air-steam combined cycle power generation system

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Nuclear Science and Techniques 2024年第2期35卷 222-233页

作者： Jing-Lei Huang Guo-Bin Jia li-Feng Han wen-Qian liu li Huang Zheng-Han Yang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power *** model considers the impact of thermal properties of fluid variation on accuracy and has been validated with *** study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet ***,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also *** results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial *** simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.

关键词： Molten salt reactor Combined cycle Dynamic characteristic Control

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Sequential reactant water management by complementary multisite catalysts for surpassing platinum hydrogen evolution activity

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Nano Research 2024年第3期17卷 1232-1241页

作者： Yu lin Defang Ding Shicheng Zhu Qunlei wen Huangjingwei li Zhen li Youwen liu Yi Shen China Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan 430078China State Key Laboratory of Materials Processing and Die&Mould Technology and School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Alkaline hydrogen evolution reaction(HER)offers a near-zero-emission approach to advance hydrogen ***,the activity limited by the multiple reaction steps involving H_(2)O molecules transfer,absorption,and activation still unqualified the thresholds of economic ***,we proposed a multisite complementary strategy that incorporates hydrophilic Mo and electrophilic V into Ni-based catalysts to divide the distinct steps on atomically dispersive sites and thus realize sequential regulation of the HER *** Isotopic labeled in situ Raman spectroscopy describes 4-coordinated hydrogen bonded H_(2)O to be free H_(2)O passing the inner Helmholtz plane in the vicinity of the catalysts under the action of hydrophilic Mo ***,potential-dependent electrochemical impedance spectroscopy(EIS)reveals that electrophilic V sites with abundant 3d empty orbitals could activate the lone-pair electrons in the free H_(2)O molecules to produce more protic hydrogen,and dimerize into H_(2) at the Ni *** the sequential management of reactive H_(2)O molecules,NiMoV oxides multisite catalysts surpass Pt/C hydrogen evolution activity(49 mV@10 mA∙cm^(-2) over 140 h).Profoundly,this study provides a tangible model to deepen the comprehension of the catalyst–electrolyte interface and create efficient catalysts for diverse reactions.

关键词： hydrogen evolution activity complementary multisite catalysts sequential reactive water management interfacial water molecules

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Particle size characterization and sources of sediments in the Uzhumqin sand dunes

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Journal of Mountain Science 2024年第8期21卷 2631-2645页

作者： ZHANG Hao liu Yang DANG Xiaohong MENG Zhongju li Shuangli gao Yong Inner Mongolia Agricultural University Inner Mongolia 010018China Inner Mongolia Autonomous Region Water Resources Research Institute Hohhot 010020China

Sediment constitutes the fundamental basis for forming and evolving aeolian *** characteristics of sediment particle size offer insights into the development and evolution of sandy terrain,making their study critical to understanding aeolian geomorphology and sand *** this study,we combined high-density collection of surface sediments in the Uzhumqin sand dunes and GIS spatial analysis to analyze the particle size parameters and changes in the spatial distribution of surface sediments in this *** addition,we used an end-member analysis to identify the potential sources of the *** results showed that surface sediments in the Uzhumqin sand dunes had distinct spatial *** and coarse grain sands dominated the sediments in the dunes,and the mean grain size and the sorting coefficient generally increased along the prevailing wind direction,with high values in individual areas related to factors such as material sources and vegetation *** was strongly influenced by factors such as landform change and human activity,and spatial variability became more *** and the soil fractal dimension showed generally decreasing trends along the prevailing wind *** dune fixation,the contents of clay and powder particles in the soil increased;the mean particle size,the sorting coefficient,and the fractal dimension of the soil gradually increased,and the skewness and kurtosis gradually *** end-member analysis results indicated the existence of five end-members(EM)in the dune *** 1 was a mixed component of wind-deposited fine sands and nearby fluvial *** 2 was the main component of sediments in the study area and was the result of sorting lake sediments by wind action and by the local *** 3 may be a product of river flood *** 4 and EM 5 had coarser grain *** 4 was a lake-phase sediment product influenced by topographic and vegetation cover factors,and EM

关键词： Sediment Particle size Spatial differences End-member analysis Uzhumqin sand dunes

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Comparative analysis of the short and medium-term efficacy of the Da Vinci robot versus laparoscopic total mesangectomy for rectal cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1681-1690页

作者： Wei-Ge gao wen Shi Xu-Chen Gong Zhi-wen li Yiminjiang Tuoheti Department of Anorectal Surgery People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Anus and Intestine Surgery Cancer Hospital of Chinese Academy of Medical SciencesBeijing 100084China

BACKGROUND The Da Vinci robot-assisted surgery technique has been widely used in laparo-scopic mesangectomy for rectal ***,the short-term efficacy of these procedures compared to traditional laparoscopic surgery remains *** purpose of this study was to compare and analyze the short-and medium-term efficacy of Da Vinci robot and laparoscopic surgery in total mesangectomy(TME)for rectal cancer,so as to provide guidance and reference for clinical *** To investigate the safety and long-term efficacy of robotic and laparoscopic total mesorectal resection for the treatment of rectal *** The clinicopathologic data of 240 patients who underwent TME for rectal cancer in the Anorectal Department of People’s Hospital of Xinjiang Uygur Autonomous Region from August 2018 to March 2023 were retrospectively *** them,112 patients underwent laparoscopic TME(L-TME)group,and 128 patients underwent robotic TME(R-TME)*** intraoperative,postoperative,and follow-up conditions of the two groups were *** The conversion rate of the L-TME group was greater than that of the R-TME group(5.4%vs 0.8%,χ^(2)=4.417,P=0.036).The complication rate of the L-TME group was greater than that of the R-TME group(32.1%vs 17.2%,χ^(2)=7.290,P=0.007).The percentage of positive annular margins in the L-TME group was greater than that in the R-TME group(7.1%vs 1.6%,χ^(2)=4.658,P=0.031).The 3-year disease-free survival(DFS)rate and overall survival(OS)rate of the L-TME group were lower than those of the R-TME group(74.1%vs 85.2%,χ^(2)=4.962,P=0.026;81.3%vs 91.4%,χ^(2)=5.494,P=0.019);in patients with American Joint Committee on Cancer stage Ⅲ DFS rate and OS rate in the L-TME group were significantly lower than those in the R-TME group(52.5%vs 76.1%,χ^(2)=5.799,P=0.016;65.0%vs 84.8%,χ^(2)=4.787,P=0.029).CONCLUSION Compared with the L-TME group,the R-TME group had a better tumor prognosis and was more favorable for patients with rectal cancer

关键词： Rectal tumor Robots Laparoscopy Total mesangectomy Survival prognosis Retrospective analysis

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Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function

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National Science Review 2024年第2期11卷 145-154页

作者： Farong Ye Cheng li Feng-liang liu Xinliang liu Peng Xu Rong-Hua Luo wenping Song Yong-Tang Zheng Tianlei Ying biao Yu Ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–function relationships. Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice. Furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the N-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein

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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liu Xiao-rong li Shuo-fu MEI wen-ya liu Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(Plity,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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