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Microarray analysis of signalling interactions between inflammation and angiogenesis in subchondral bone in temporomandibular joint osteoarthritis

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Biomaterials Translational 2024年第2期5卷 175-184页

作者： Wenpin Qin Jialu gao jianfei Yan Xiaoxiao Han Weicheng Lu Zhangyu Ma Lina Niu Kai Jiao Department of Stomatology Tangdu Hospital&State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&National Clinical Research Centre for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi ProvinceChina

Inflammation and angiogenesis,the major pathological changes of osteoarthritis(OA),are closely associated with joint pain;however,pertinent signalling interactions within subchondral bone of osteoarthritic joints and potential contribution to the peripheral origin of OA pain remain to be *** we developed a unilateral anterior crossbite mouse model with osteoarthritic changes in the temporomandibular ***-based transcriptome analysis,besides quantitative real-time polymerase chain reaction,was performed to identify differentially expressed genes(DEGs).Overall,182 DEGs(fold change≥2,P<0.05)were identified between the control and unilateral anterior crossbite groups:168 were upregulated and 14 were *** subjecting significant DEGs to enrichment analyses,inflammation and angiogenesis were identified as the most ***-related DEGs were mainly enriched in T cell activation and differentiation and in the mammalian target of rapamycin/nuclear factor-κB/tumour necrosis factor ***,angiogenesis-related DEGs were mainly enriched in the Gene Ontology terms angiogenesis regulation and vasculature development and in the KEGG pathways of phosphoinositide 3-kinase-protein kinase B/vascular endothelial growth factor/hypoxia-inducible factor 1 ***-protein interaction analysis revealed a close interaction between inflammation-and angiogenesis-related DEGs,suggesting that phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta(Pi3kcd),cathelicidin antimicrobial peptide(Camp),C-X-C motif chemokine receptor 4(Cxcr4),and MYB proto-oncogene transcription factor(Myb)play a central role in their *** summarize,our findings reveal that in subchondral bone of osteoarthritic joints,signal interaction is interrelated between inflammation and angiogenesis and associated with the peripheral origin of OA pain;moreover,our data highlight potential targets for the inhibition of OA pain.

关键词： angiogenesis inflammation osteoarthritic pain osteoarthritis subchondral bone temporomandibular joint(TMJ)

喀斯特石漠化生态系统服务价值对生态治理的响应——以贵州花江峡谷石漠化治理示范区为例

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中国生态农业学报 2015年第6期23卷 775-784页

作者：高渐飞熊康宁贵州省山地资源研究所贵阳550001 国家喀斯特石漠化防治工程技术研究中心贵阳550001 贵州师范大学中国南方喀斯特研究院贵阳550001

为揭示喀斯特石漠化生态系统服务功能价值对生态治理的响应,以贵州花江峡谷为例,将提供产品、涵养水源、保持土壤、土壤肥力、固碳释氧5项功能作为服务价值评估指标,选择生态治理两个时段(前期2000—2005年、后期2005—2010年),基于实... 详细信息

为揭示喀斯特石漠化生态系统服务功能价值对生态治理的响应,以贵州花江峡谷为例,将提供产品、涵养水源、保持土壤、土壤肥力、固碳释氧5项功能作为服务价值评估指标,选择生态治理两个时段(前期2000—2005年、后期2005—2010年),基于实测与调查数据,采用物质量和价值量相结合的方法对生态系统服务价值进行了估算。研究区10 a的生态系统类型变化过程中,发生转变的面积14.29 hm2,占总面积的27.7%。其中林分、灌丛、其他生态系统面积有所增加,而耕地、裸岩荒地面积大幅度减少。2000—2005年研究区生态系统类型发生转变的面积11.83 hm2,占土地总面积的22.9%,主要变化区域集中在河岸两侧实施退耕还林区域。2005—2010年研究区生态系统类型发生转变的面积仅占总面积的4.8%,与上一阶段相比转变强度明显降低,变化区域较为分散。研究区生态治理后系统服务价值显著增加,2000—2010年共增加9.61×107元,其中前期增额占18.2%,后期占81.8%。前期年均增长3.49×106元,后期年均增长1.57×107元,后期生态服务价值增长更为显著。其中固定CO2、释放O2价值,产品供给价值和土壤肥力都是服务价值主要组成部分。功能价值的增加一方面源于服务价值低的生态系统向服务价值高的演变(10年间研究区耕地和裸岩荒地向经济生态系统转出868.60 hm2),另一方面归功于生态系统内部服务价值的增加,其贡献率大于80%,是驱动服务价值变化的主导因素。生态治理后生态系统类型间发生明显的空间转变,转变强度、场所与所实施生态治理工程的数量、区域密切相关。治理后生态系统类型间发生转变时间响应较快(前期转变面积占总转变面积的83.0%),但主要服务功能恢复期后才大幅度增加(后期增加功能价值占总增额的81.8%),相比较服务价值变化响应有一定滞后性。

关键词：生态服务价值生态系统类型生态治理喀斯特石漠化花江示范区

Clinical study of comparing LP and TP regimens in the treatment of advanced non-small cell lung cancer

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The Chinese-German Journal of Clinical Oncology 2010年第4期9卷 198-200页

作者： jianfei gao Sha Guan Wenjuan Deng Guochao Qiu Zhiguo Rao Bicheng Zhang Department of Oncology Wuhan General Hospital Guangzhou Command PLA Wuhan 430070 China

Objective:The aim of the study was to evaluate the responses and toxicities of liposome encapsulated paclitaxel (LEP) plus cisplatin (DDP) (LP regimen) and paclitaxel (TAX) plus DDP (TP regimen) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 cases with advanced NSCLC was randomized into two groups: the LP group (57 patients) and the TP group (32 patients). The responses, toxicities and survivals of the two groups were compared. Results: The response rates were 40.00% and 38.71% in the LP and TP groups respectively, but no significant difference was detected between them (P>0.05). The median times to progression (TTP), median remission times, median survival times and 1-year survival rates were 18 weeks, 20 weeks, 35 weeks and 35.09% in the LP group, and 17 weeks, 18 weeks, 31 weeks and 28.15% in the TP group, respectively, and no significant differences were detected between them (P>0.05). The incidence of grades I-II peripheral neuritis in the TP group (37.50%) was significantly higher than that in the LP group (19.29%) (P<0.05). The incidence of grades I-II allergic reaction in the TP group (12.50%) was significantly higher than that in the LP group (5.26%) (P<0.05). And the incidence of grades Ⅲ-IV nausea/vomiting in the TP group (15.63%) was significantly higher than that in the LP group (5.26%) (P<0.01), too. Conclusion: The effect of LP regimen is similar to that of TP regimen, but the incidences of peripheral neuritis, allergic reaction and nausea/vomiting in LP regimen are lower than those in TP regimen. In short, LP regimen may be the first-line chemotherapy regimen of advanced NSCLC.

关键词： non-small cell lung cancer (NSCLC) chemotherapy liposome encapsulated paclitaxel (LEP) paclitaxel (TAX) cisplatin (DDP)

Primary extraosseous Ewing's sarcoma of the lung in a 36-year-old female patient:clinical,imaging,and pathologic findings

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The Chinese-German Journal of Clinical Oncology 2013年第11期12卷 555-558页

作者： Yafei Zhang Junming Feng Zhiqiang Sun jianfei gao Bicheng Zhang Zhiguo Rao Department of Oncology Wuhan General Hospital of Guangzhou Command People’s Liberation Army Department of Pathology Wuhan General Hospital of Guangzhou Command People’s Liberation Army Department of Radiology Wuhan General Hospital of Guangzhou Command People’s Liberation Army

Primary extraosseous Ewing's sarcoma is a very rare clinical entity. In the report, we present the case of a 36year-old female patient who underwent resection of lung mass and was diagnosed as having Ewing's sarcoma b... 详细信息

关键词： Ewing's sarcoma extraosseous lung

基于广泛靶向代谢组学分析黑老虎不同部位成分差异

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热带亚热带植物学报 2023年第3期31卷 424-432页

作者：高渐飞周玮杨艳贵州科学院贵州省山地资源研究所贵阳550001 贵州工业职业技术学院贵阳550008 贵州省中国科学院天然产物化学重点实验室贵阳550014

为提高黑老虎(Kadsura coccinea)资源的综合利用率,采用广泛靶向代谢组学技术鉴定并分析了根、茎、叶代谢组分差异及高度富集成分。结果表明,在根、茎和叶中分别鉴定出642、650和619个代谢物,以酚酸、脂质、类黄酮和有机酸为主;叶与根... 详细信息

为提高黑老虎(Kadsura coccinea)资源的综合利用率,采用广泛靶向代谢组学技术鉴定并分析了根、茎、叶代谢组分差异及高度富集成分。结果表明,在根、茎和叶中分别鉴定出642、650和619个代谢物,以酚酸、脂质、类黄酮和有机酸为主;叶与根、茎与根的共有成分分别为566和650个,显著差异成分有442和393个,主要为酚酸、类黄酮和脂质,差异代谢物在苯丙烷生物合成、黄酮与黄酮醇生物合成通路中显著富集。代谢物总丰度和次生代谢物丰度均表现为叶>根>茎,叶中酚酸、类黄酮和脂质及茎中酚酸积累量显著高于根,而氨基酸及其衍生物、萜类、木脂素、香豆素、生物碱的丰度在根中显著上调。因此,黑老虎根、茎、叶有大量共有成分,叶和茎中酚酸、叶中类黄酮和脂质高度富集,含有新绿原酸、绿原酸、槲皮素等多个丰度较高且具有重要生物活性化合物,具有较高利用价值。

关键词：黑老虎代谢物酚类木脂素

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黑老虎植株不同部位木脂素和萜类成分分析

广西科学 2022年第6期29卷 1151-1159页

作者：高渐飞周玮杨艳贵州科学院贵州省山地资源研究所贵州贵阳550001 贵州工业职业技术学院贵州贵阳550008 贵州省中国科学院天然产物化学重点实验室贵州贵阳550014

黑老虎(Kadsura coccinea)为传统中药材,为深入了解木脂素类和萜类成分在植株不同部位的分布和积累状况,采用广泛靶向代谢组学技术鉴定其叶、茎、根中的代谢物,基于结构配置解析木脂素和萜类的多样性和丰度。结果显示:在黑老虎植株中共... 详细信息

黑老虎(Kadsura coccinea)为传统中药材,为深入了解木脂素类和萜类成分在植株不同部位的分布和积累状况,采用广泛靶向代谢组学技术鉴定其叶、茎、根中的代谢物,基于结构配置解析木脂素和萜类的多样性和丰度。结果显示:在黑老虎植株中共鉴定出39个木脂素类化合物,根(32个,特有13个)>茎和叶(同为24个),3个部位含17个相同的木脂素类化合物;同时,鉴定出41个萜类成分,根(39个)>茎和叶(同为36个),3个部位含34个相同的萜类化合物。黑老虎根部木脂素类化合物丰度(114.62×10^(6))远高于叶(23.37×10^(6))和茎(25.96×10^(6)),萜类化合物丰度为根(74.16×10^(6))>叶(37.06×10^(6))>茎(17.36×10^(6)),根部与叶、茎相同及特有的木脂素和萜类化合物丰度均较高。日本南五味子木脂素G、乙酰表戈米辛R、Kadcoccilactone F等在黑老虎根中高度富集,在叶、茎、根中都鉴定出Kadcoccilactone Q-R、Kadcoccilactone M等三萜类化合物,表明黑老虎具有较高的研究与利用价值。

关键词：黑老虎不同部位木脂素萜类多样性与丰度

黑老虎果实不同部位次生代谢成分及其富集差异

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食品工业科技 2022年第12期43卷 27-35页

作者：高渐飞周玮文锡梅杨艳贵州科学院贵州省山地资源研究所贵州贵阳550001 贵州工业职业技术学院贵州贵阳550008 贵州省中国科学院天然产物化学重点实验室贵州贵阳550014

为推进黑老虎果实开发利用,利用广泛靶向代谢组学技术鉴定其果皮、果肉、种子中代谢物,基于结构配置进行归类分析。结果显示:在黑老虎果实中共鉴定出307个次生代谢物,其中以酚酸(数量占38.8%)和黄酮(27.7%)占主导;果皮含272个、果肉286... 详细信息

为推进黑老虎果实开发利用,利用广泛靶向代谢组学技术鉴定其果皮、果肉、种子中代谢物,基于结构配置进行归类分析。结果显示:在黑老虎果实中共鉴定出307个次生代谢物,其中以酚酸(数量占38.8%)和黄酮(27.7%)占主导;果皮含272个、果肉286个、种子201个,3个部位共有180个;种子中酚酸、类黄酮和萜类化合物数量明显低于果肉和果皮,使其次生代谢物多样性也较低;果皮中次生代谢物丰度(81.62×10^(7))远高于果肉(25.61×10^(7))和种子(24.38×10^(7)),主要因黄酮类成分(花青素、黄酮醇、黄酮)的高度富集和生物碱上调;3个部位间显著差异代谢组分主要为酚酸和黄酮类化合物;黑老虎果皮富含类黄酮(槲皮素、儿茶素和矢车菊素类等),种子中木脂素丰度高,3个部位中都含鉴定出结构新颖的三萜化合物,表明其具有较高的利用和研究价值。

关键词：黑老虎果实不同部位广泛代谢组学类黄酮木脂素三萜

A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid

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Science China(Life Sciences) 2024年第10期67卷 2213-2223页

作者： Jingge Lian Liu Yang Hanbo Tan Shaoyi Su Leonor Serrano Lopes Fangxiao Cheng Junhao Yan Yu Fu Wanyi Fu Zhaoheng Xie jianfei Sun Jicong Zhang Zhiqian Tong Yajuan gao Hongbin Han Department of Radiology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Magnetic Resonance Imaging Technology Beijing 100191China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Department of Informatics Technical University of MunichGarching 80539Germany Department of Anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Neurology Peking University Third HospitalBeijing 100191China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China Key Laboratory of Alzheimer’s Disease of Zhejiang Province Institute of AgingSchool of Mental HealthWenzhou Medical UniversityWenzhou 325035China NMPA Key Laboratory for Evaluation of Medical Imaging Equipment and Technique Beijing 100191China

Ischemic stroke is a leading cause of death and disability *** response after stroke determines the outcome of ischemic injury.A recent study has reported an efficient method,epidural arterial implantation(EAI),for accelerating interstitial fluid(ISF)drainage,which provides a promising strategy to clear pro-inflammatory cytokines in the brain extracellular space(ECS).In this study,the method of EAI was modified(m-EAI)to control its function of accelerating the ISF drainage at different time points following ischemic *** neuroprotective effect of m-EAI on ischemic stroke was evaluated with the transient middle cerebral artery occlusion(tMCAO)rat *** results demonstrated the accumulation of IL-1β,IL-6,and TNF-αwas significantly decreased by activating m-EAI at 7 d before and immediately after ischemic attack in tMCAO rats,accompanied with decreased infarct volume and improved neurological *** study consolidates the hypothesis of exacerbated ischemic damage by inflammatory response and provides a new perspective to treat encephalopathy via brain *** research is essential to investigate whether m-EAI combined with neuroprotective drugs could enhance the therapeutic effect on ischemic stroke.

关键词： ischemic stroke brain extracellular space interstitial fluid modified epidural arterial implantation

基于广泛靶向代谢组学分析黑老虎种子中氨基酸和脂质组分

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中国油脂 2023年第1期48卷 87-93页

作者：高渐飞周玮刘妮杨艳贵州科学院/贵州省山地资源研究所贵阳550001 贵州工业职业技术学院贵阳550008 贵州省中国科学院天然产物化学重点实验室贵阳550014

为探究黑老虎种子作为新兴植物油料资源的潜力,利用广泛靶向代谢组学技术检测分析其氨基酸和脂质组分。结果表明:在基于鉴定出的代谢物结构配置分类下,黑老虎种子含脂质类、氨基酸及衍生物类化合物分别为121种和89种,前者数量和相对含量... 详细信息

为探究黑老虎种子作为新兴植物油料资源的潜力,利用广泛靶向代谢组学技术检测分析其氨基酸和脂质组分。结果表明:在基于鉴定出的代谢物结构配置分类下,黑老虎种子含脂质类、氨基酸及衍生物类化合物分别为121种和89种,前者数量和相对含量(30.7%)在11类成分中最高,后者数量居其次,相对含量(17.8%)位于第三;鉴定出20种基础氨基酸和8种人体必需氨基酸,其中L-脯氨酸、L-天冬氨酸、L-丝氨酸等7种药效氨基酸和L-亮氨酸、L-苏氨酸、L-异亮氨酸、L-苯丙氨酸和L-赖氨酸5种人体必需氨基酸含量较高;黑老虎种子中富含亚油酸、γ-亚麻酸、α-亚麻酸等脂肪酸和以溶血磷脂酰胆碱18∶2和18∶2(2n异构)为主的磷脂。黑老虎种子氨基酸类和脂质类组分丰富,多种高度富集成分具有突出的营养功能、活性作用和药用功效,在优质植物油脂开发等领域具有较高的价值。

关键词：黑老虎种子氨基酸及衍生物脂肪酸磷脂利用价值

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