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Science China(Lif. Sciences) 2009年第9期52卷 847-853页

作者： gao george f. Key Laboratory of.Pathogenic Microbiology and Immunology of.CAS (CASPMI) Institute of Microbiology Chinese Academy of Sciences (CAS) China-Japan Joint Laboratory of.Molecular Immunology and Molecular Microbiology Institute of Microbiology Chinese Academy of Sciences Graduate University of.Chinese Academy of.Sciences Beijing Institutes of.Lif. Science Chinese Academy of Sciences

Although worldwide concern has been raised since the large-scale outbreak of.highly pathogenic avian inf.uenza in wild birds at Qinghai Lake,China in 2005,the f.ctors responsible f.r the ability to kill waterf.wl remain unclear. The why and how questions of.the H5N1 virus species-jump into its reservoir host need to be answered. In this report we test the pathogenicity and adaptation of.Qinghai Lake (Clade 2.2) isolate to Muscovy ducks f.r f.rther understanding of.this virus. The isolate was highly pathogenic in ducks and retained its high pathogenicity even af.er 20 generations of.passage in ducks. During the process of.serial passages,only the NS gene developed non-synonymous substitutions,which caused two mutations in NS1 protein (Val23Ala and Leu207Pro) and one in NS2 (Phe55Leu). These mutations persisted immutably through all subsequent passages and the pathogenicity remained high,implying that highly pathogenic H5N1 virus remains stable in aquatic birds through oral transmission. Although the exact f.nctions of.these mutations are not known,our results provide an important f.undation f.r f.rther understanding the characteristics of.the Qinghai Lake isolates.

关键词： avian inf.uenza virus H5N1 mutation NS1/2 serial passages

The new emerging H7N9 inf.uenza virus indicates poultry as new mixing vessels

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Science China(Lif. Sciences) 2014年第7期57卷 731-732页

作者： LIU Di gao george f. Key Laboratory of.Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences Network Inf.rmation Center Institute of MicrobiologyChinese Academy of Sciences Beijing Institutes of.Lif. Science Chinese Academy of Sciences Of.ice of.Director-General Chinese Center for Disease Control and Prevention

Since 30 March 2013,the Chinese Center f.r Disease Control and Prevention(China CDC)has reported the f.rst laboratory-conf.rmed cases of.inf.uenza A H7N9 virus human *** new pathogen caused 144 human inf.ctions with 47 f.tal cases in year 2013,and continued to bring another wave in 2014,caused another 273 inf.ctions with 108deaths as of.27th *** H7N9 inf.uenza virus has again raised the global concerns of.the potential *** of.the origin and evolution of.this virus revealed that the novel H7N9 inf.uenza virus was reassorted f.om H7,N9and H9N2 subtypes of.inf.uenza viruses f.om domestic ducks,wild waterf.wls and poultry,respectively;and the processes of.genetic reassortments were sequential and dynamic[1?3].

关键词：甲型流感病毒中国疾病预防控制中心混合容器家禽 H9N2亚型人类感染全球性问题野生水禽

Ribavirin is ef.ective against drug-resistant H7N9 inf.uenza virus inf.ctions

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Protein & Cell 2016年第8期7卷 611-614页

作者： Bi, Yuhai Wong, Gary Liu, Yingxia Liu, Lei gao, george f. Shi, Yi Chinese Acad Sci Inst Microbiol CAS Key Lab Pathogen Microbiol & Immunol Beijing 100101 Peoples R China Shenzhen Third Peoples Hosp Shenzhen Key Lab Pathogen & Immun State Key Discipline Infect Dis Shenzhen 518112 Peoples R China Chinese Acad Sci Ctr Influenza Res & Early Warning CASCIRE Beijing 100101 Peoples R China Chinese Acad Sci Beijing Inst Life Sci RNIH Beijing 100101 Peoples R China Zhejiang Univ Collaborat Innovat Ctr Diag & Treatment Infect Di Hangzhou 310003 Zhejiang Peoples R China

Dear Editor, In f.bruary and March 2013, a novel inf.uenza A （H7N9） virus emerged in China, causing an acute respiratory distress syndrome and occasionally multiple organ f.ilure with high f.tality rates in humans （Li et al., 2014）. A total of.681 laboratory-conf.rmed cases and 275 deaths have been reported as of.November 13th,

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以T细胞受体为基础的免疫疗法研究进展

生物工程学报 2023年第10期39卷 4004-4028页

作者：陈缘高福谭曙光广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心广西南宁530021 中国科学院微生物研究所病原微生物与免疫学重点实验室北京100101 中国科学院大学存济医学院北京100049

T细胞是机体抗肿瘤免疫的核心,以T细胞功能调控为基础的免疫检查点疗法已经在多种肿瘤的临床治疗中取得了重大突破,以基因工程化T细胞为基础的过继性免疫细胞疗法在血液瘤治疗中取得了重要进展,免疫治疗已经对肿瘤的临床治疗产生了深刻... 详细信息

T细胞是机体抗肿瘤免疫的核心,以T细胞功能调控为基础的免疫检查点疗法已经在多种肿瘤的临床治疗中取得了重大突破,以基因工程化T细胞为基础的过继性免疫细胞疗法在血液瘤治疗中取得了重要进展,免疫治疗已经对肿瘤的临床治疗产生了深刻变革,成为肿瘤临床治疗策略的重要组成部分。T细胞受体(T cell receptor, TCR)赋予了T细胞识别肿瘤抗原的特异性,能够识别由主要组织相容性复合体(major histocompatibility complex, MHC)呈递的包括胞内抗原在内的广泛肿瘤抗原,具有高度的抗原敏感性,因而具有广泛的抗肿瘤应用前景。2022年第一款TCR药物的上市开启了TCR药物开发的新纪元,多项TCR药物临床研究表现出潜在的肿瘤治疗价值。本文综述了以TCR为基础的免疫治疗策略研究进展,包括T细胞受体工程化T细胞(Tcell receptor-engineered T cell, TCR-T)和TCR蛋白药物,以及基于TCR信号的其他免疫细胞疗法,以期为以TCR为基础的免疫治疗策略开发提供参考。

关键词： T细胞受体免疫治疗 T细胞受体工程化T细胞 T细胞衔接器

Diversif.ed anchoring f.atures the peptide presentation of.DLA-88*50801: f.rst structural insight into domestic dog MHC class I

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Diversified anchoring features the peptide presentation of D...

第十一届全国免疫学学术大会

作者： Xiao Jin Wang Ming Liu William J. gao george f. Key Laboratory of.Veterinary Bioproduction and Chemical Medicine of.the Ministry of.Agriculture Zhongmu Institutes of China Animal Husbandry Industry Co.Ltd National Institute f.r Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention

Background:Canines represent a crucial animal model f.r studying human diseases and organ transplantation,as well as the evolution of.domestic *** histocompatibility complexes(MHCs),with a central role in cellular immunity,are commonly used in the study of.dog population genetics and genome ***,the molecular basis f.r the peptide presentation of.dog MHC remains largely unknown.

关键词： domestic animal canine MHC I peptide

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H7N9亚型禽流感病毒的T细胞免疫研究

病毒学报 2018年第6期34卷 911-919页

作者：赵敏舒刘梅高福刘军中国科学院北京生命科学研究院北京100101 中国疾病预防控制中心病毒病预防控制所北京102206

2013年春季,我国首次出现人感染H7N9亚型禽流感疫情,随后H7N9禽流感病毒相继引发了五波流行,在病人中导致较多的重症感染,死亡率接近40%,成为近来的关注热点之一。本文对H7N9亚型禽流感病毒感染的T细胞免疫特征进行了系统综述,尤其是对H... 详细信息

2013年春季,我国首次出现人感染H7N9亚型禽流感疫情,随后H7N9禽流感病毒相继引发了五波流行,在病人中导致较多的重症感染,死亡率接近40%,成为近来的关注热点之一。本文对H7N9亚型禽流感病毒感染的T细胞免疫特征进行了系统综述,尤其是对H7N9禽流感患者在感染急性期及康复后的T细胞免疫特征、健康人群对H7N9的预存T细胞免疫、以及H7N9禽流感病毒与季节性流感病毒的交叉T细胞免疫特点等方面相关研究进展进行了总结。为了解禽流感病毒的T细胞免疫特征和研发新型流感疫苗提供科学参考。

关键词：流感病毒 H7N9 感染患者 T细胞免疫交叉免疫

The antibiotic resistome： gene f.ow in environments, animals and human beings

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f.ontiers of.Medicine 2017年第2期11卷 161-168页

作者： Yongf.i Hu george f. gao Baoli Zhu CAS Key Laboratory of.Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Beijing Key Laboratory of.Microbial Drug Resistance and Resistome Beijing 100101 China Collaborative Innovation Center f.r Diagnosis and Treatment of.Inf.ctious Diseases The First Affiliated Hospital Zhejiang University Hangzhou 310006 China Research Network of.lmmunity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences Beijing 100101 China Of.ice of.Director-General Chinese Center for Disease Control and Prevention (China CDC) Beijing 102206 China

The antibiotic resistance is natural in bacteria and predates the human use of.antibiotics. Numerous antibiotic resistance genes （ARGs） have been discovered to conf.r resistance to a wide range of.antibiotics. The ARGs in natural environments are highly integrated and tightly regulated in specif.c bacterial metabolic networks. However, the antibiotic selection pressure conf.rred by the use of.antibiotics in both human medicine and agriculture practice leads to a signif.cant increase of.antibiotic resistance and a steady accumulation of.ARGs in bacteria. In this review, we summarized, with an emphasis on an ecological point of.view, the important research progress regarding the collective ARGs （antibiotic resistome） in bacterial communities of.natural environments, human and animals, i.e., in the one health settings. We propose that the resistance gene f.ow in nature is ＂f.om the natural environments＂ and ＂to the natural environments＂; human and animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene ＂circulation.＂

关键词： antibiotic resistance resistome microbiome gene f.ow

Can Ebola virus become endemic in the human population？

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Protein & Cell 2016年第1期7卷 4-6页

作者： Gary Wong george f. gao Xiangguo Qiu Special Pathogens Program National Microbiology Laboratory Public Health Agency of Canada Winnipeg MB CanadaDepartment of Medical Microbiology University of Manitoba Winnipeg MB Canada Department of.Medical Microbiology University of Manitoba Winnipeg MB Canada CAS Key Laboratory of.Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of SciencesBeijing 100101 China National Institute f.r Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100052 China Of.iceof.Director-General Chinese Center for Disease Control and Prevention Beijing 102206 China

The 2014-15 Ebola virus reported during March 2014 Guinea. has shown itself.to （EBOV） outbreak, originally n the Western Af.ican nation of.be resistant to traditional con- tainment methods, with over 28,000 inf.ctions and 11,000 deaths over 18 months. Recently, news that a Scottish nurse had relapsed to EBOV disease with neurological symptoms at 10 months af.er recovery have astonished experts. The prolonged nature of.the outbreak has led to questions whether EBOV can become endemic in the human popula- tion, an undesirable outcome due to the large amount of.resources required to keep this virus under control. In this commentary, we discuss aspects EBOV disease with those caused by pathogens considered endemic in humans, as well as f.ctors which may contribute to sustained EBOV transmission in humans.

关键词： Can Ebola virus become endemic

Continuous edge chromatic numbers of.abelian group actions

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Science China Mathematics 2025年

作者： Su gao Ruijun Wang Tianhao Wang School of.Mathematical Sciences and Laboratory of.Pure Mathematics and Combinatorics Nankai University

We prove that f.r any generating set S of.Z~n, the continuous edge chromatic number χ′c（G） of.the Schreier graph of.the Bernoulli shif. action G = f.S, 2Z~n) is χ′（G） + 1 = |S| + 1. In particular, f.r the stan...

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HIV prevalence in suspected Ebola cases during the 2014-2016 Ebola epidemic in Sierra Leone

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Inf.ctious Diseases of.Poverty 2019年第2期8卷 87-90页

作者： William J.Liu Hai-Yang Hu Qiu-Dong Su Zhe Zhang Yang Liu Yu-Lan Sun Xian-Da Yang Da-Peng Sun Shao-Jian Cai Xiu-Xu Yang Idrissa Kamara Abdul Kamara Matt Lebby Brima Kargbo Patricia Ongpin Xiao-Ping Dong Yue-Long Shu Wen-Bo Xu Gui-Zhen Wu Michael Gboun george f.gao NHC Key Laboratory of.Biosaf.ty National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Jiangsu Provincial Center f.r Disease control and Prevention Nanjing 210009China Beijing Institute of.Biotechnology Beijing 100071China. Beijing Center f.r Disease Prevention and Control Beijing 100013China Jilin Provincial Center f.r Disease control and Prevention Changchun 130021China Shandong Provincial Center f.r Disease control and Prevention Jinan 250014China f.jian Provincial Center f.r Disease control and Prevention Fuzhou 350001China The Ministry of.Health and Sanitation FreetownSierra Leone UNAIDS FreetownSierra Leone Chinese Center f.r Disease Control and Prevention Beijing 102206China CAS Key Laboratory of.Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Sierra Leone-China f.iendship Biological Saf.ty Laboratory FreetownSierra Leone

Background:The 2014-2016 Ebola virus epidemic in West Af.ica was the largest outbreak of.Ebola virus disease(EVD)in *** the inf.uence of.other prevalent diseases such as human immunodef.ciency virus inf.ction and acquired immune def.ciency syndrome(HIV/AIDS)will help improve treatment and supportive care of.patients with *** presentation:We examined HIV and hepatitis C virus(HCV)antibody prevalence among suspected EVD cases f.om the Sierra Leone-China f.iendship Biological Saf.ty Laboratory during the epidemic in Sierra *** and HCV antibodies were tested in 678 EVD-negative samples by enzyme-linked immunosorbent assay.A high HIV prevalence(17.6%)and low HCV prevalence(0.22%)were observed among the suspected ***,we f.und decreased HIV positive rates among the suspected cases over the course of.the *** suggests a potentially benef.cial ef.ect of.an improved public health system af.er assistance f.om the World Health Organization and other international aid ***:This EVD epidemic had a considerable impact on the public health system and inf.uenced the prevalence of.HIV f.und among suspected cases in Sierra Leone,but also provided an opportunity to establish a better surveillance network f.r inf.ctious diseases.

关键词： HIV HCV Ebola Prevalence Sierra Leone