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Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

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Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： Xuan Sun Ming Yang Dapeng Sun Guangge Peng Yiming Deng Xingquan Zhao Liping Liu Ning Ma feng gao Dapeng Mo Wengui Yu Yongjun Wang Yilong Wang Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for *** Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with *** eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 14 days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial *** eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1:1 *** groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style *** participants will be followed up for *** outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 12 months of enrolment,is the primary *** BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating *** registration number NCT03703635;https://***.

关键词： balloon prospective centre

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Linkage of mineral inclusions and zoning of magnetite with fluid evolution of hydrothermal systems: A case study of the fenghuangshan Cu-Fe-Au skarn deposit， Eastern China

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Journal of Earth Science 2024年

作者： Xiao-Wen Huang Yiping Yang Mei-Fu Zhou Yu-Miao Meng Jian-feng gao Liang Qi State Key Laboratory of Ore Deposit Geochemistry， Institute of Geochemistry， Chinese Academy of Sciences CAS Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Materials， Guangzhou Institute of Geochemistry， Chinese Academy of Sciences

Magnetite from hydrothermal deposits may show compositional zoning with various mineral inclusions in response to the evolution of hydrothermal fluids. Magnetite from the fenghuangshan Cu-Fe-Au skarn deposit (Eastern China) is a common mineral formed in the earlier stage of skarnization. Magnetite grains have dark gray and light gray zones and contain diverse mineral inclusions. Dark gray zones have higher Si， Ca， Al， and Mg contents than light gray zones. The magnetite matrix from dark gray zones shows superstructure along the [0-11] zone axis in fast Fourier transform patterns， different from magnetite from light gray zones with normal structure. Three types of mineral inclusions are identified within magnetite: nano-， micron- and submicron-nanometer inclusions. Nanoinclusions hosted in dark gray zones are actinolite， diopside， and trace element-rich magnetite， and these are likely formed by growth entrapment during magnetite crystallization at the skarn stage. The chain-width order-disorder intergrowths of diopside nanoinclusion likely indicate fluctuating fluid compositions in a lattice scale. Submicron to nanometer inclusions at the boundary between dark gray and light gray zones are quartz， titanite， and Ti-rich magnetite， which were formed via a dissolution and reprecipitation process at the quartz-sulfide stage. Micron-inclusions randomly distributed in both dark and light gray zones include calcite， ankerite， quartz， and chlorite， and these were formed via penetration of fluids at the carbonate stage. Zoned magnetite was formed by fluid replacement， overgrowth， and fluid infilling. Our study highlights the importance of mineral inclusion assemblages， and textural and chemical zonation of magnetite in constraining fluid evolution.

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Fabricating bio-inspired high impact resistance carbon nanotube network films for multi-protection under an extreme environment

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Nano Research 2024年第9期17卷 7793-7802页

作者： Mingquan Zhu Kailu Xiao Wei Zhang Xudong Lei Yunxiang Bai Shijun Wang Peng Zhang feng gao Congying Wang Wenqiang Xu Huiyong Li Xianqian Wu Chao Wang Hui Zhang Luqi Liu Zhong Zhang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Department of Materials Science and Engineering Texas A&M UniversityCollege StationTexas 77840USA Institute of Mechanics Chinese Academy of SciencesBeijing 100190China School of Astronautics Harbin Institute of TechnologyHarbin150001China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China

The fabrication of light-weight,highly impact-resistant,and energy-absorbent materials is urgently demanded in many facets of the society from body armor to aerospace engineering,especially under an extreme *** nanotubes(CNTs),one of the strongest and toughest materials ever found,also have good conductivity,chemical stability,and thermal stability,etc,making them a competitive candidate as building blocks to help achieve the above *** this work,a kind of CNT network was prepared by using chlorosulfonic acid(CSA)to release the internal stress of super-aligned carbon nanotube films(SA-CNTF)and dendritic polyamide amine(PAMAM)to further introduce multiple hydrogen bonds and interlocking *** fabricated bioinspired carbon nanotube network films(PAMAM@C-CNTF)have a high toughness of 45.97 MJ/m3,showing an increase of 420%compared to neat *** importantly,the anti-impact performance of the films(e.g.,with a maximum specific energy absorption of 1.40 MJ/kg under 80-100 m/s projectile impact)is superior to that of conventional protective materials from steel and Kevlar fiber,and also exceeds that of any other reported carbon-based *** hierarchical energy dissipation mechanism was further revealed through experiment and *** functions including intelligent heating/anti-icing,ultraviolet protection,as well as electromagnetic interference shielding properties make these network films have great potential in practical multi-protection applications,especially under an extreme environment.

关键词： carbon nanotubes composites mechanical properties multi-function

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基于特征选择和iJaya-SVR的年度电力消费预测研究

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控制与决策 2024年第3期39卷 1039-1047页

作者：高锋邵雪焱北京大学工学院北京100871 中国科学院科技战略咨询研究院北京100190

准确的电力消费预测对能源规划和政策制定具有重要意义.鉴于已有研究忽略了特征冗余以及智能优化算法控制参数不确定对预测精度的影响,引入最大相关最小冗余(MRMR)算法筛选电力消费的关键影响因素作为预测指标,提出改进的Jaya算法(iJaya... 详细信息

准确的电力消费预测对能源规划和政策制定具有重要意义.鉴于已有研究忽略了特征冗余以及智能优化算法控制参数不确定对预测精度的影响,引入最大相关最小冗余(MRMR)算法筛选电力消费的关键影响因素作为预测指标,提出改进的Jaya算法(iJaya)用于优化支持向量回归(SVR)的超参数,进而构建MRMR-iJaya-SVR预测模型.以我国的年度电力消费数据为例,对MRMR-iJaya-SVR模型的预测效果进行验证,并利用北京市的年度电力消费数据测试其鲁棒性.结果表明:iJaya算法具有较强的全局搜索能力和较好的稳定性, MRMR-iJayaSVR模型在单步预测和多步预测中的表现均优于基准模型.此外,对于不同的数据集, MRMR-iJaya-SVR模型均具有良好的鲁棒性.

关键词：特征选择改进的Jaya算法最大相关最小冗余支持向量回归混合预测模型电力消费预测

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Luminescent metal-halide perovskites:fundamentals,synthesis,and light-emitting devices

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Science China Chemistry 2024年第6期67卷 1776-1838页

作者： Kang Wang Jeong Hui Kim Jie Yang Xiaoke Liu Yixuan Dou Yuxuan Li Weijian Tao Haiyun Dong Haiming Zhu Kaifeng Wu Li Na Quan feng gao Jianpu Wang Letian Dou Yong Sheng Zhao Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of PhotochemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN47907USA School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)&School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Physics Linköping UniversityLinköping58183Sweden Department of Chemistry Virginia TechBlacksburgVA24060USA State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Department of Chemistry Zhejiang UniversityHangzhou310058China Changzhou University Changzhou213164China Department of Chemistry Purdue UniversityWest LafayetteIN47907USA

Metal-halide perovskites have garnered considerable research attention as highly efficient light emitters in recent years due to their outstanding optoelectronic properties with remarkable tunability and excellent solution *** advancements have been achieved in the development of novel halide perovskites,and the exploitations of these materials in lightemitting *** review comprehensively outlines recent breakthroughs in metal-halide perovskites,encompassing the rational design of perovskite materials with tunable light emission properties,the controllable growth of single crystal for a deeper understanding of their structure-property relationships,as well as the fundamental insights into the photophysics and carrier dynamics in perovskite ***,it provides an overview of recent applications of perovskite materials in high-performance light-emitting diodes(LEDs)and lasers.

关键词： metal-halide perovskites perovskite luminescent materials perovskite synthesis excited-state processes perovskite light-emitting diodes perovskite lasers

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Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches

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Science China Life Sciences 2024年

作者： Yaohan Jiang Xiao Chen Chundi Wang Liping Lyu Saleh A.Al-Farraj Naomi A.Stover feng gao Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Marine College Shandong University Zoology Department College of Science King Saud University Department of Biology Bradley University Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all *** protists, which contain both germline and somatic genomes within a single cell, have evolved a special form of sexual reproduction called conjugation that involves mitosis, meiosis, fertilization, nuclear differentiation, genome rearrangement, and the development of unique cellular structures. The molecular basis and mechanisms of conjugation vary dramatically among ciliates, and many details of the process and its regulation are still largely unknown. In order to better comprehend these processes and mechanisms from an evolutionary perspective, this study provides the first comprehensive overview of the transcriptome and proteome profiles during the entire life cycle of the newly-established marine model ciliate Euplotes vannus. Transcriptome analyses from 14 life cycle stages(three vegetative stages and 11sexual stages) revealed over 26,000 genes that are specifically expressed at different stages, many of which are related to DNA replication,transcription, translation, mitosis, meiosis, nuclear differentiation, and/or genome rearrangement. Quantitative proteomic analyses identified 338 proteins with homologs associated with conjugation and/or somatic nuclear development in other ciliates, including dicer-like proteins, Hsp90 proteins, RNA polymerase II and transcription elongation factors, ribosomal-associated proteins, and ubiquitin-related proteins. Four of these homologs belong to the PIWI family, each with different expression patterns identified and confirmed by RT-qPCR,which may function in small RNA-mediated genome rearrangement. Proteins involved in the nonhomologous end-joining pathway are induced early during meiosis and accumulate in the developing new somatic nucleus, where more than 80% of the germline sequences are eliminated from the somatic genome. A number of new candidate genes and proteins likely t

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Research Progress in Traditional Chinese Medicine Treatment of Knee Osteoarthritis

Research and Inheritance of Traditional Chinese Medicine

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Research and Inheritance of Traditional Chinese Medicine 2024年第1期2卷 23-27页

作者： Miaomiao Yu feng gao Xuezhong Ren Jianghe Peng Guangzhou University of Chinese Medicine

Knee osteoarthritis(KOA)is a degenerative disease characterized by pathological changes in the cartilage and subchondral bone of the knee ***,knee joint pain is the main symptom,and in the later stages,deformities and mobility disorders may *** medicine lacks effective treatment methods for early and mid stage KOA,and has drawbacks such as significant side effects and high costs.A large number of stud‐ies have confirmed that traditional Chinese medicine has unique advantages in treating KOA,and has obvious advantages such as small trauma,low cost,and definite therapeu‐tic effect,which are gradually being accepted by a large number of KOA *** commonly used methods for preventing and treating KOA with traditional Chinese medicine in clinical practice include:oral administration of traditional Chinese medi‐cine,external application of traditional Chinese medicine,fumigation,acupuncture therapy,massage therapy for regulating tendons,and targeted penetration therapy of tra‐ditional Chinese *** to relevant literature,traditional Chinese medicine can significantly alleviate knee joint symptoms and improve knee joint function in patients with knee osteoarthritis,which is of great significance for the prevention and treatment of knee *** article provides a review of the research progress in the prevention and treatment of KOA using traditional Chinese medicine in recent years.

关键词： knee osteoarthritis Traditional Chinese Medicine research progress

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NOSES联合ERAS与常规腹腔镜手术治疗直肠癌的临床疗效对比

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解放军医学杂志 2024年第1期49卷 31-36页

作者：宋枫高峰徐明高健毛增喜解放军联勤保障部队第940医院结直肠肛门外科甘肃兰州730050 解放军联勤保障部队第944医院结直肠肛门外科甘肃酒泉753000

目的比较经自然腔道取标本手术(NOSES)联合快速康复外科(ERAS)与常规腹腔镜手术治疗直肠癌患者的临床疗效。方法选取2019年1月-2021年12月于解放军联勤保障部队第940医院结直肠肛门外科确诊的100例直肠癌患者为研究对象,其中49例行NOSE... 详细信息

目的比较经自然腔道取标本手术(NOSES)联合快速康复外科(ERAS)与常规腹腔镜手术治疗直肠癌患者的临床疗效。方法选取2019年1月-2021年12月于解放军联勤保障部队第940医院结直肠肛门外科确诊的100例直肠癌患者为研究对象,其中49例行NOSES联合ERAS治疗(设为观察组),51例行常规腹腔镜直肠癌根治术治疗(设为对照组)。比较两组术后C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、白细胞计数(WBC)、中性粒细胞百分比(NEUT)、K+浓度,术后肠蠕动恢复时间、首次离床活动时间、首次进流食时间、拔除尿管和引流管时间、住院时间,以及术中出血量、淋巴结检出数目、切缘阳性率、并发症发生率、疼痛评分等临床指标。结果观察组术后CRP、PCT、IL-6水平均明显低于对照组(P0.05)。观察组术后肠蠕动恢复时间、首次离床活动时间、首次进流食时间、拔除尿管及引流管时间、住院时间等均短于对照组,手术时间长于对照组,差异有统计学意义(P0.05)。两组并发症发生率比较差异无统计学意义(4.1%vs.7.8%,P>0.05);观察组术后第1、2、3天的疼痛评分均明显低于对照组(P<0.05)。结论NOSES联合ERAS治疗直肠癌,可缩小手术切口,减轻应激反应及术后疼痛,安全可行,有利于提高疗效,降低并发症发生率,值得推广应用。

关键词：直肠癌经自然腔道取标本手术快速康复外科腹腔镜外科手术

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The microbial community,nutrient supply and crop yields differ along a potassium fertilizer gradient under wheat-maize double-cropping systems

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Journal of Integrative Agriculture 2024年第10期23卷 3592-3609页

作者： Zeli Li Fuli Fang Liang Wu feng gao Mingyang Li Benhang Li Kaidi Wu Xiaomin Hu Shuo Wang Zhanbo Wei Qi Chen Min Zhang Zhiguang Liu Shandong Provincial Key Laboratory of Water and Soil Conservation and Environmental Protection College of Resources andEnvironmentLinyi UniversityLinyi 276000China National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources College of Resources and theEnvironmentShandong Agricultural UniversityTai’an 271018China Key Laboratory of Crop Specific Fertilizer Ministry of Agriculture and Rural Affairs/Xinyangfeng Agricultural Technology Co.Ltd.Jingmen 448001China Institute of Applied Ecology Chinese Academy of SciencesShenyang 110000China

Soil microorganisms play critical roles in ecosystem ***,the relative impact of the potassium(K)fertilizer gradient on the microbial community in wheat?maize double-cropping systems remains *** this long-term field experiment(2008-2019),we researched bacterial and fungal diversity,composition,and community assemblage in the soil along a K fertilizer gradient in the wheat season(K0,no K fertilizer;K1,45 kg ha^(-1) K_(2)O;K_(2),90 kg ha^(-1)K_(2)O;K3,135 kg ha^(-1)K2O)and in the maize season(K0,no K fertilizer;K_(1),150 kg ha^(-1) K_(2)O;K_(2),300 kg ha^(-1)K_(2)O;K_3,450 kg ha^(-1)K_(2)O)using bacterial 16S rRNA and fungal internally transcribed spacer(ITS)*** observed that environmental variables,such as mean annual soil temperature(MAT)and precipitation,available K,ammonium,nitrate,and organic matter,impacted the soil bacterial and fungal communities,and their impacts varied with fertilizer treatments and crop ***,the relative abundance of bacteria involved in soil nutrient transformation(phylum Actinobacteria and class Alphaproteobacteria)in the wheat season was significantly increased compared to the maize season,and the optimal K fertilizer dosage(K2 treatment)boosted the relative bacterial abundance of soil nutrient transformation(genus Lactobacillus)and soil denitrification(phylum Proteobacteria)bacteria in the wheat *** abundance of the soil bacterial community promoting root growth and nutrient absorption(genus Herbaspirillum)in the maize season was improved compared to the wheat season,and the K_(2)treatment enhanced the bacterial abundance of soil nutrient transformation(genus MND1)and soil nitrogen cycling(genus Nitrospira)genera in the maize *** results indicated that the bacterial and fungal communities in the double-cropping system exhibited variable sensitivities and assembly mechanisms along a K fertilizer gradient,and microhabitats explained the largest amount of the variation in crop yields,and

关键词： potassium fertilizer gradient microbial community wheat-maize double cropping climate change yield

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基于MC模型和Nelder-Mead单纯形算法的时域组织光谱学

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中国激光 2024年第3期51卷 138-147页

作者：张童刘东远高峰天津大学精密仪器与光电子工程学院天津300072 天津市生物医学检测技术与仪器重点实验室天津300072

生物组织光学参数的无创在体测量是近红外光谱学(NIRS)研究的基础课题之一。在已发展的NIRS方案中,时间分辨测量具备优良的同时反演吸收系数和散射系数的能力,而且近年来该技术的性价比显著提高,获得了更多关注,但其针对分层组织的参数... 详细信息

生物组织光学参数的无创在体测量是近红外光谱学(NIRS)研究的基础课题之一。在已发展的NIRS方案中,时间分辨测量具备优良的同时反演吸收系数和散射系数的能力,而且近年来该技术的性价比显著提高,获得了更多关注,但其针对分层组织的参数反演在准确性、稳定性和反演速度等方面尚存在一定的局限性。为此,本文提出了一种时域蒙特卡罗模型支持的Nelder-Mead单纯形算法,该算法利用双源探距下的时间分辨漫反射光信号,以循环迭代方式设置不同的基向量,经线性变换后无须求导便可启发式搜索目标函数的最优值,从而实现了高信效度的分层光学参数反演。模拟实验与仿体实验均表明:在组织光学参数反演方面,所提算法的精度优于传统算法,而且该算法具有良好的噪声鲁棒性和临床适应性,为生物组织光学参数的在体测量提供了新方法。

关键词：医用光学吸收系数约化散射系数蒙特卡罗模拟单纯形算法时域测量

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