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Multistimuli Responsive and Thermoregulated Capability of Coaxial Electrospun Membranes with Core-sheath Structure and Functional Polypyrrole Layer

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Chinese Journal of Polymer Science 2022年第11期40卷 1380-1388页

作者： Meng-Hang gao Wen Feng Xiao-Dong qi yong Wang Key Laboratory of Advanced Technologies of Materials(Ministry of Education) School of Materials Science&EngineeringSouthwest Jiaotong UniversityChengdu610031China

Developing thermal management fabrics with good energy storage and multistimuli responsive properties is important for regulating the body temperature in complex environment.Herein,the intelligent nonwoven membranes were fabricated via a coaxial electrospinning method,resulting in a core-sheath structure with poly(ethylene glycol)(PEG)as core and polyurethane(PU)as sheath.Additionally,polypyrrole(PPy)with good light absorption ability and electrical conductivity was deposited onto the surface of the PU@PEG electrospun fibers via electrochemical polymerization.The PPy layer enabled the membranes to respond quickly to sunlight and electrical stimuli.The membranes could heat up to 86°C under simulated sunlight within 200 s or produce remarkable electrothermal effect under a low voltage input of only 1V,exhibiting efficient energy conversion and storage performances.The photothermal and electrothermal conversion effect could be easily adjusted by controlling the polymerization time of PPy.Therefore,the multifunctional membranes with high latent heat,good mechanical properties as well as excellent photothermal/electrothermal conversion ability are promising in personal thermal management applications.

关键词： Phase change materials Polypyrrole Coaxial electrospinning Photothermal conversion Electrothermal conversion

Change in Sea Ice Cover is Responsible for Non-Uniform Variation in Winter Temperature over East Asia

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Atmospheric and Oceanic Science Letters 2015年第6期8卷 376-382页

作者： LI Fei WANG Hui-Jun GAO Yong-Qi Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Climate Change Research Center Chinese Academy of Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and Technology Nansen Environmental and Remote Sensing Center and Bjerknes Centre for Climate Research

Observed winter(December–February)surface air temperature over East Asia(0°–60°N,100–140°E)(TEA)shows non-uniform variation during 1979–2013,with cooling and weak warming north and south of40°N.To understand this,the authors perform statistical analysis(linear regression and composite)on the observed data.The results suggest that reduced(increased)autumn sea ice cover in the Barents-Kara Sea(BK-ASIC)lowers(warms)TEA over northern East Asia,which is consistent with previous studies.In comparison,increased(decreased)winter sea ice cover in the Sea of Okhotsk(O-WSIC),warms(cools)the air over southern East Asia.The mechanism can be described as follows:When the BK-ASIC decreases,the East Asian winter monsoon tends to be stronger with an intensified Siberian high,leading to cooling over northern East Asia.An O-WSIC increase is associated with cold anomalies north of 50°N,altering the meridional temperature gradient between the midlatitudes and tropics,and leading to a northward shift of the East Asian jet steam in the upper troposphere.In the low atmosphere,anomalous northeasterly winds prevail north of50°N and anomalous southerly winds control the southern coast of East Asia,contributing to the weak warming over southern East Asia.Version 3 of the Community Atmosphere Model also provides evidence for the impact of increased O-WSIC on the warm southern mode of TEA.

关键词： East Asia winter temperature Arctic sea ice cover

Nitrate signaling and use efficiency in crops

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Plant Communications 2022年第5期3卷 88-100页

作者： Yangyang gao Shengdong qi yong Wang State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai’anShandong 271018China

Nitrate(NO3–)is not only an essential nutrient but also an important signaling molecule for plant growth.Low nitrogen use efficiency(NUE)of crops is causing increasingly serious environmental and ecological problems.Understanding the molecular mechanisms of NO3–regulation in crops is crucial for NUE improvement in agriculture.During the last several years,significant progress has been made in understanding the regulation of NO3–signaling in crops,and some key NO3–signaling factors have been shown to play important roles in NO3–utilization.However,no detailed reviews have yet summarized these advances.Here,we focus mainly on recent advances in crop NO3–signaling,including short-term signaling,long-term signaling,and the impact of environmental factors.We also review the regulation of crop NUE by crucial genes involved in NO3–signaling.This review provides useful information for further research on NO3–signaling in crops and a theoretical basis for breeding new crop varieties with high NUE,which has great significance for sustainable agriculture.

关键词： nitrate signaling nitrogen use efficiency nitrate-regulatory gene nitrate regulation crop

Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling

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Chinese Journal of Integrative Medicine 2023年第4期29卷 316-324页

作者： XIAO Zhun JI qiang FU Ya-dong gao Si-qi HU yong-hong LIU Wei CHEN gao-feng MU yong-ping CHEN Jia-mei LIU Ping Institute of Liver Diseases Key Laboratory of Liver and Kidney Diseases(Ministry of Education)Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China E-Institute of Shanghai Municipal Education Commission Shanghai University of Traditional Chinese Medicine Shanghai 201203China Shanghai Key Laboratory of Traditional Chinese Medicine Shanghai 201203China

Objective:To observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model,and the underlying mechanisms were partly dissected in vivo and in vitro.Methods:Thirty-two male mice were randomly divided into 4 groups,including control,model,low-and high-dose amygdalin-treated groups,8 mice in each group.Except the control group,mice in the other groups were injected intraperitoneally with 10%carbon tetrachloride(CCl4)-olive oil solution 3 times a week for 6 weeks to induce liver fibrosis.At the first 3 weeks,amygdalin(1.35 and 2.7 mg/kg body weight)were administered by gavage once a day.Mice in the control group received equal quantities of subcutaneous olive oil and intragastric water from the fourth week.At the end of 6 weeks,liver tissue samples were harvested to detect the content of hydroxyproline(Hyp).Hematoxylin and eosin and Sirius red staining were used to observe the inflammation and fibrosis of liver tissue.The expressions of collagenⅠ(Col-Ⅰ),alpha-smooth muscle actin(α-SMA),CD31 and transforming growth factorβ(TGF-β)/Smad signaling pathway were detected by immunohistochemistry,quantitative real-time polymerase chain reaction and Western blot,respectively.The activation models of hepatic stellate cells,JS-1and LX-2 cells induced by TGF-β1 were used in vitro with or without different concentrations of amygdalin(0.1,1,10μmol/L).The effect of different concentrations of amygdalin on the expressions of liver sinusoidal endothelial cells(LSECs)dedifferentiation markers CD31 and CD44 were observed.Results:High-dose of amygdalin significantly reduced the Hyp content and percentage of collagen positive area,and decreased the mRNA and protein expressions of Col-Ι,α-SMA,CD31 and p-Smad2/3 in liver tissues of mice compared to the model group(P<0.01).Amygdalin down-regulated the expressions of Col-Ⅰandα-SMA in JS-1 and LX-2 cells,and TGFβR1,TGFβR2 and p-Smad2/3 in LX-2 cells compared to the model group(P<0.05 or P<0.01).Moreover,1 and 10μmol/L amygdalin inhibited the mRNA and protein expressions of

关键词： amygdalin liver fibrosis hepatic stellate cells liver sinusoidal endothelial cells TGF-β/Smad signalingpathway

Effect of Modified Xijiao Dihuang Decoction (加味犀角地黄汤) on Intestinal Flora and Th17/Treg in Rats with Radiation Enteritis

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Chinese Journal of Integrative Medicine 2021年第3期27卷 198-205页

作者： WANG Yu-guo gao Yue FENG Jian DOU yong-qi Medical School of Chinese People's Liberation Army The General Hospital of People's Liberation ArmyBeiing 100853China Beijing Institute of Radiation Medicine Beiing 100850China

Objective To observe the effect of Modified Xijiao Dihuang Decoction(加味犀角地黄汤,MXDD)on rats with radiation enteritis,and explore its action mechanism.Methods Thirty female Sprague Dawley rats were divided into the control,model,dexamethasone(DXM),golden bifid(GB)and MXDD groups using random number table,6 rats in each group.Except the control group,the other rats were developed into radiation enteritis model by exposing to a single 60Co-γray at a dose of 11 Gy.The rats in the DXM,GB and MXDD groups were treated with DXM(1.425 mg/kg),GB(0.8 g/kg)and MXDD(36.0 g/kg)for 3 days,respectively.Body weight and diarrhea condition of rats were evaluated daily.On day 3,the feces of rats were collected for intestinal flora detection and the small intestinal tissues were also collected.Bacterial species annotation,alpha and beta diversities as well as composition of intestinal flora were detected and compared.The protein and mRNA expressions of interleukin 17(IL-17),retinoid-related orphan nuclear receptor gamma t(ROR-γt)and forkhead/winged helix transcription factor p3(FoxP3)were determined by Western blot and polymerase chain reaction,respectively.The abundance and diversity of intestinal flora as well as the proportion at the phylum and genus levels were assayed by 16S rRNA metagenome sequencing.Correlation between intestinal flora and Th17/Treg was analyzed by heatmap method.Results On day 1 to 3 after radiation,compared with the control group,the body weight in model group was decreased(P<0.05 or P<0.01).Compared with the model group,MXDD could alleviate weight loss and diarrhea caused by irradiation.At the phylum level,MXDD cause a significant increase in Firmicutes,and a decrease in Proteobacteria(P<0.05 or P<0.01).At the genus level,MXDD reduced the proportion of Escherichia Shigella(P<0.01).In addition,IL-17 and FoxP3 mRNA and protein expression levels were down-regulated and ROR-γt was up-regulated by MXDD treatment(P<0.05).Besides,Firmicutes and Lactobacillus were positively correlated with FoxP3(r=0.73,0.79,respecti

关键词： Modified Xijiao Dihuang Decoction radiation enteritis intestinal flora Th17/Treg Chinese medicine

Microstructure and mechanical properties of Nb–Mo–ZrB_2 composites prepared by hot-pressing sintering

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International Journal of Minerals,Metallurgy and Materials 2018年第7期25卷 824-831页

作者： yuan gao zong-de liu qi wang yong-tian wang Key Laboratory of Condition Monitoring and Control for Power Plant Equipment of Ministry of Education North China Electric Power UniversityBeijing 102206China

Nb-Mo-ZrB2 composites （V（Nb）/V（Mo） = 1） with 15v01% or 30v01% of ZrB2 were fabricated by hot-pressing sintering at 2000~C The phases, microstxucture, and mechamcal properties were then investigated. The composites contain Nb-Mo solid solution （denoted as （Nb, Mo）ss hereafter）, ZrB, MoB, and NbB phases. Compressive strength test results suggest that the strength of Nb-Mo-ZrB2 composites increases with increasing ZrB2 content; Nb-Mo-30vol%ZrB2 had the highest compressive strength （1905.1 MPa）. The improvement in the compressive strength of the Nb-Mo-ZrB2 composites is mainly attributed to the secondary phase strengthening oftke stiffer ZrB phase, sol- id-solution strengthening oftke （Nb, Mo）ss matrix as well as fme-grain strengtkening. The fracture toughness decreases with increasing ZrB2 content. Finally, the fracture modes oftke Nb-Mo-ZrB2 composites axe also discussed in detail.

关键词： metal-matrix composites microstJ-ucture mechaNcal properties sintering

Development and validation of a nomogram for predicting survival in patients with acute pancreatitis

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世界急诊医学杂志(英文) 2023年第1期14卷 44-48页

作者： Xiao-guang Zhu Jia-mei Jiang yong-xia Li Jing gao Wei Wu qi-ming Feng Department of Emergency Medicine Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

BACKGROUND:Acute pancreatitis(AP)is a complex and heterogeneous disease.We aimed to design and validate a prognostic nomogram for improving the prediction of short-term survival in patients with AP.METHODS:The clinical data of 632 patients with AP were obtained from the Medical Information Mart for Intensive Care(MIMIC)-IV database.The nomogram for the prediction of 30-day,60-day and 90-day survival was developed by incorporating the risk factors identified by multivariate Cox analyses.RESULTS:Multivariate Cox proportional hazard model analysis showed that age(hazard ratio[HR]=1.06,95%confidence interval[95%CI]1.03-1.08,P<0.001),white blood cell count(HR=1.03,95%CI 1.00-1.06,P=0.046),systolic blood pressure(HR=0.99,95%CI 0.97-1.00,P=0.015),serum lactate level(HR=1.10,95%CI 1.01-1.20,P=0.023),and Simplified Acute Physiology Score II(HR=1.04,95%CI 1.02-1.06,P<0.001)were independent predictors of 90-day mortality in patients with AP.A prognostic nomogram model for 30-day,60-day,and 90-day survival based on these variables was built.Receiver operating characteristic(ROC)curve analysis demonstrated that the nomogram had good accuracy for predicting 30-day,60-day,and 90-day survival(area under the ROC curve:0.796,0.812,and 0.854,respectively;bootstrap-corrected C-index value:0.782,0.799,and 0.846,respectively).CONCLUSION:The nomogram-based prognostic model was able to accurately predict 30-day,60-day,and 90-day survival outcomes and thus may be of value for risk stratification and clinical decision-making for critically ill patients with AP.

关键词： Acute pancreatitis Risk factor Prognosis

Subpolar Gyre Index and the North Atlantic Meridional Overturning Circulation in a Coupled Climate Model

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Atmospheric and Oceanic Science Letters 2008年第1期1卷 29-32页

作者： GAO Yong-Qi YU Lei Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Nansen Environmental and Remote Sensing Center/Bjerknes Centre for Climate Research Bergen Norway

The subpolar gyre index (SPG), derived from the analysis of sea surface height (SSH), is proposed to be a potential indicator for the North Atlantic Meridional Overturning Circulation (AMOC) based on observation as well as the Ocean General Circulation Model (OGCM). We investigated the correspondence between the SPG and the AMOC in a coupled climate model. Our results confirm that the SPG can be used as an early indicator for the AMOC in the subtropical North Atlantic. Changes in the SPG are closely related to variations in the air-sea heat exchange in the Labrador Sea, and variations in deep water formation and southward dense water transport with the deep western boundary current (DWBC) in the North Atlantic.

关键词：亚极地环流北大西洋气候学海洋气候

Highly luminescent zero-dimensional lead-free manganese halides forβ-ray scintillation

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Nano Research 2022年第9期15卷 8486-8492页

作者： Linyuan Lian Wei qi Huaiyi Ding Hao Tian qi Ye yong-Biao Zhao Long Zhao Jianbo gao Daoli Zhang Jianbing Zhang School of Optical and Electronic Information Huazhong University of Science and Technology1037 Luoyu RoadWuhan 430074China Hubei Key Laboratory of Bioinorganic Chemistry&Materia Medica School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Yunnan Provincial Higher Education Institutions for Optoelectronics Device Engineering School of Physics and AstronomyYunnan UniversityKunming 650504China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China Department of Physics and Astronomy Ultrafast Photophysics of Quantum Devices LaboratoryClemson UniversityClemsonSC 29634USA Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Shenzhen Huazhong University of Science and Technology Research Institute Shenzhen 518057China

Because of their moderate penetration power,β-rays(high-energy electrons)are a useful signal for evaluating the surface contamination of nuclear radiation.However,the development ofβ-ray scintillators,which convert the absorbed high-energy electrons into visible photons,is hindered by the limitations of materials selection.Herein,we report two highly luminescent zerodimensional(0D)organic-inorganic lead-free metal halide hybrids,(C_(13)H_(30)N)_(2)MnBr_(4)and(C_(19)H_(34)N)_(2)MnBr_(4),as scintillators exhibiting efficientβ-ray scintillation.These hybrid scintillators combine the superior properties of organic and inorganic components.For example,organic components that contain light elements C,H,and N enhance the capturing efficiency ofβparticles;isolated inorganic[MnBr_(4)]2−tetrahedrons serve as highly localized emitting centers to emit intense radioluminescence(RL)underβ-ray excitation.Both hybrids show a narrow-band green emission peaked at 518 nm with photoluminescence quantum efficiencies(PLQEs)of 81.3%for(C_(13)H_(30)N)_(2)MnBr_(4)and 86.4%for(C_(19)H_(34)N)_(2)MnBr_(4),respectively.To enable the solution processing of this promising metal halide hybrid,we successfully synthesized(C_(13)H_(30)N)_(2)MnBr_(4)colloidal nanocrystals for the first time.Being excited byβ-rays,(C_(13)H_(30)N)_(2)MnBr_(4)scintillators show a linear response toβ-ray dose rate over a broad range from 400 to 2,800 Gy·s^(−1),and also display robust radiation resistance that 80%of the initial RL intensity can be maintained after an ultrahigh accumulated radiation dose of 240 kGy.This work will open up a new route for the development ofβ-ray scintillators.

关键词： zero-dimensional metal halide hybrids radiation sterilization β-ray scintillation nanocrystals