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Huoxue Jiedu Huayu recipe(活血解毒化瘀方) inhibits macrophage-secreted vascular endothelial growth factor-a on angiogenesis and alleviates renal fibrosis in the contralateral kidneys of unilateral ureteral obstruction rats

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Journal of Traditional Chinese Medicine 2024年第3期44卷 458-467页

作者： gao xiaomeng QIANG Panpan CHANG Jingyue FAN Lili YANG Fan XU Qingyou Graduate School Hebei University of Chinese Medicine Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns Hebei University of Chinese Medicine Institute of Integrative Medicine Hebei University of Chinese Medicine

OBJECTIVE: To elucidate the mechanism by which Huoxue Jiedu Huayu recipe( 活血解毒化瘀方, HJHR) regulates angiogenesis in the contralateral kidney of unilateral ureteral obstruction(UUO) rats and the mechanism by which it reduces of renal fibrosis. METHODS: Male Wistar rats were randomly divided into 4 groups: the sham group, UUO group(180 d of left ureter ligation), UUO plus eplerenone(EPL) group, and UUO plus HJHR group. After 180 d of oral drug administration, blood and contralateral kidneys were collected for analysis. Angiogenesis-and fibrosis-related indexes were detected. RESULTS: HJHR and EPL improved structural damage and renal interstitial fibrosis in the contralateral kidney and reduced the protein expression levels of α-smooth muscle actin(α-SMA), vimentin and collagen I. Moreover, these treatments could reduce the expression of vascular endothelial growth factor-A(VEGFA) by inhibiting the infiltration of macrophages. Furthermore, HJHR and EPL significantly reduced the expression of CD34 and CD105 by downregulating VEGFA production, which inhibited angiogenesis. Finally, the coexpressions of CD34, CD105 and α-SMA were decreased in the HJHR and EPL groups, indicating that endothelial-to-mesenchymal transition was inhibited. CONCLUSIONS: These findings confirm that HJHR alleviates contralateral renal fibrosis by inhibiting VEGFAinduced angiogenesis, encourage the use of HJHR against renal interstitial fibrosis and provide a theoretical basis for the clinical management of patients with CKD.

关键词： aldosterone epithelial-mesenchymal transition eplerenone Huoxue Jiedu Huayu recipe mineralocorticoid receptors unilateral ureteral obstruction

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郑州市防洪减灾问题分析与路径探索

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重庆建筑 2024年第2期23卷 27-29,37页

作者：高晓蒙兰州交通大学建筑与城市规划学院甘肃兰州730070

基于郑州市“720”暴雨事件中暴露出的城市防洪排涝建设方面的问题,从郑州市的自然地理格局入手,分析郑州市的地理与气候条件,对郑州市城市化建设、城市内涝情况、海绵城市建设等进行问题分析,提出郑州市防洪减灾的路径。结论得出:构建... 详细信息

基于郑州市“720”暴雨事件中暴露出的城市防洪排涝建设方面的问题,从郑州市的自然地理格局入手,分析郑州市的地理与气候条件,对郑州市城市化建设、城市内涝情况、海绵城市建设等进行问题分析,提出郑州市防洪减灾的路径。结论得出:构建城市生态安全格局、有效衔接城市体检与城市发展规划、建立常态化应急管理机制、完善救灾生命线系统等路径,有利于提高城市的防洪减灾能力,增强城市韧性,建设更加宜居的城市。

关键词：暴雨防洪减灾内涝海绵城市生态安全

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Huoxue Jiedu Huayu recipe(活血解毒化瘀方)alleviates contralateral renal fibrosis in unilateral ureteral obstruction rats by inhibiting the transformation of macrophages to myofibroblast

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Journal of Traditional Chinese Medicine 2023年第1期43卷 105-112页

作者： XIONG Yunzhao LIU Lingjin LIU Ziqian CHEN Gege HAO Juan gao xiaomeng QIANG Panpan WANG Zheng XU Qingyou Graduate School Hebei University of Chinese MedicineHebei Key Laboratory of Integrative Medicine on Liver-Kidney PatternsHebei University of Chinese MedicineHebei University of Chinese MedicineShijiazhuang 050091China Graduate School Hebei University of Chinese Medicine Hebei Key Laboratory of Integrative Medicine on Liver-Kidney PatternsHebei University of Chinese MedicineShijiazhuang 050091China Graduate School Hebei University of Chinese MedicineHebei Key Laboratory of Integrative Medicine on Liver-Kidney PatternsHebei University of Chinese MedicineDepartment of Internal MedicineHebei University of Chinese MedicineShijiazhuang 050091China

OBJECTIVE:To investigate the action and underlying mechanisms of Huoxue Jiedu Huayu recipe(活血解毒化瘀方,HJHR)against unilateral ureteral obstruction(UUO)-induced injury in the contralateral kidney.METHODS:Forty-eight male Sprague-Dawley rats weighing(200±10)g were used in this study and randomly assigned to 4 groups:a sham group,a UUO group,a UUO+eplerenone(EPL)group,and a UUO+HJHR group.The contralateral kidneys were harvested for further study 180 d after surgery.Histological analysis,immunohistochemistry and immunofluorescence were used to study the fibrosis of the contralateral kidneys obtained from UUO rats.Contralateral kidney damagerelated pathway proteins were detected by real-time polymerase chain reaction and Western blot analysis.RESULTS:HJHR significantly inhibited fibrosis of the contralateral kidney in UUO rats by attenuating the UUOinduced macrophage-to-myofibroblast transition(MMT)in the contralateral kidney.Moreover,HJHR attenuated fibrosis in the contralateral kidney of UUO rats by preventing MMT through the aldosterone/mineralocorticoid receptor/serum/glucocorticoid regulated kinase 1 pathway.CONCLUSIONS:Our findings suggest that HJHR may be a potential treatment for renal interstitial fibrosis of obstructive nephropathy.

关键词： ureteral obstruction renal fibrosis aldosterone receptors,mineralocorticoid macrophages myofibroblast Huoxue Jiedu Huayu recipe

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淡水养殖排污口全过程监测体系分析

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安徽农学通报 2024年第10期30卷 63-66页

作者：陈娟楼乔奇高小孟童悦浙江省生态环境科学设计研究院浙江杭州310007 湖州市生态环境局吴兴分局浙江湖州313002

随着水产养殖业的快速发展,水产养殖污染防治监测体系的重要性日益显现,特别是水产养殖排污口已正式纳入入河排污口监测范围,因而对水产养殖污染治理和尾水排放提出了更为严格的监测要求。本文以Z省淡水养殖为主要研究对象,分析该区域... 详细信息

随着水产养殖业的快速发展,水产养殖污染防治监测体系的重要性日益显现,特别是水产养殖排污口已正式纳入入河排污口监测范围,因而对水产养殖污染治理和尾水排放提出了更为严格的监测要求。本文以Z省淡水养殖为主要研究对象,分析该区域淡水养殖总体概况和尾水主要排污特征,针对水产养殖排污口监测体系存在的基础薄弱、尾水监测体系待进一步完善以及排污口规范化待进一步实施等短板,从水产养殖排污口全过程监测的角度提出加强源头管控、尾水监测、排污口规范化和长效管理等建议,为水产养殖主体持续完善污染防治设施和管理提供参考,有效促进水产养殖产业绿色可持续发展。

关键词：水产养殖养殖尾水养殖污染入河排污口

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腰髂部触发点内热针与冲击波治疗腰源性腹痛的效果

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临床医学研究与实践 2024年第20期9卷 30-33页

作者：郭强任建红高晓猛党彩艳西安市中心医院疼痛科陕西西安710003 乾县中医医院内一科陕西咸阳713300

目的观察腰髂部触发点内热针与冲击波治疗腰源性腹痛的效果。方法选取50例腰源性腹痛患者,随机将其分为观察组和对照组,各25例。观察组采用腰髂部触发点内热针治疗,对照组采用腰髂部触发点的冲击波治疗。比较两组的治疗效果。结果疗程... 详细信息

目的观察腰髂部触发点内热针与冲击波治疗腰源性腹痛的效果。方法选取50例腰源性腹痛患者,随机将其分为观察组和对照组,各25例。观察组采用腰髂部触发点内热针治疗,对照组采用腰髂部触发点的冲击波治疗。比较两组的治疗效果。结果疗程结束时及治疗后3、6个月,观察组的视觉模拟评分法(VAS)评分低于治疗前(P<0.05);疗程结束时,对照组的VAS评分低于治疗前(P<0.05);治疗后3、6个月,观察组的VAS评分低于对照组(P<0.05)。治疗后3个月,两组的简明健康状况调查表(SF-36)各维度评分均显著高于治疗前(P<0.05);治疗后3个月,观察组的躯体疼痛、精力及社会功能评分明显高于对照组(P<0.05)。观察组的治疗总有效率显著高于对照组(P<0.05)。两组患者治疗过程中均未发生不良反应,未服用镇痛药物。结论腰髂部触发点内热针与冲击波疗法短期内均能有效缓解疼痛,但前者较后者治疗腰源性腹痛的远期效果更好。

关键词：腰源性腹痛内热针触发点冲击波

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WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1225-1239页

作者： xiaomeng gao Jieqiong You Yanling Gong Meng Yuan Haiying Zhu Liang Fang Hong Zhu Meidan Ying Qiaojun He Bo Yang Ji Cao Institute of Pharmacology and Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China The Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 310058China Department of Biology Southern University of Science and TechnologyShenzhen 518055China Cancer Center of Zhejiang University Hangzhou 310058China

The dysregulation of transcription factors is widely associated with tumorigenesis.As the most well-defined transcription factor in multiple types of cancer,c-Myc can transform cells by transactivating various downstream genes.Given that there is no effective way to directly inhibit c-Myc,c-Myc targeting strategies hold great potential for cancer therapy.In this study,we found that WSB1,which has a highly positive correlation with c-Myc in 10 cancer cell lines and clinical samples,is a direct target gene of c-Myc,and can positively regulate c-Myc expression,which forms a feedforward circuit promoting cancer development.RNA sequencing results from Bel-7402 cells confirmed that WSB1 promoted cMyc expression through theβ-catenin pathway.Mechanistically,WSB1 affectedβ-catenin destruction complex-PPP2CA assembly and E3 ubiquitin ligase adaptorβ-TRCP recruitment,which inhibited the ubiquitination ofβ-catenin and transactivated c-Myc.Of interest,the effect of WSB1 on c-Myc was independent of its E3 ligase activity.Moreover,overexpressing WSB1 in the Bel-7402 xenograft model could further strengthen the tumor-driven effect of c-Myc overexpression.Thus,our findings revealed a novel mechanism involved in tumorigenesis in which the WSB1/c-Myc feedforward circuit played an essential role,highlighting a potential c-Myc intervention strategy in cancer treatment.

关键词： Transcription factors c-Myc WSB1 Ubiquitinationproteasome pathway β-Catenin destruction complex Feedback loop Tumorigenesis Cancer treatment

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Influence of soaking Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China

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Food Science and Human Wellness 2024年第3期13卷 1311-1321页

作者： Hui Nie Zhongyang gao Yanghe Luo Yajuan Wang Feiyang Wu Guangqing Mu xiaomeng Wu School of Food Science and Technology Dalian Polytechnic UniversityDalian 116034China Dalian Probiotic Function Research Key Laboratory Dalian Polytechnic UniversityDalian 116034China Guangxi Key Laboratory of Health Care Food Science and Technology Hezhou UniversityHezhou 542899China

To investigate the effects of drinking the soaking of Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China.It has been reported that longevity is closely related to metabolism and the gut microbiota.The 16S rRNA sequencing and liquid chromatography-mass spectrometry(LC-MS)were used to analysis fecal samples and explore the factors affecting longevity in the region.Interestingly,we discovered,that elderly individuals who had been drinking the soaking of M.domeri(Bois)Chev.leaves for a long time exhibited higher diversity of the gut microbiota than without drinking the soaking,notably.The proportions of Ruminococcaceae and Prevotella were decreased in those who did not drink this soaking.In addition,a total of 106 metabolites were characterized,and the people of long-lived people(>90 years old)and elderly people(<90 years old)who drinking soaking of M.domeri(Bois)Chev.leaves significantly altered the gut microbiota and upregulated levels of haplopine,farnesol,genipic acid,momordicinin,2-hydroxyestrone,hydroxyphenyllactic acid,caffeic acid,sophoraflavanone B,and soyasaponin I.We preliminarily determined that M.domeri(Bois)Chev.leaves consumption may be an important factor affecting longevity in this area.

关键词： Longevity Malus domeri(Bois)Chev.leaves Gut microbiota Metabolomics

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TaCHP encoding C1-domain protein stably enhances wheat yield in saline-alkaline fields

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Journal of Integrative Plant Biology 2024年第2期66卷 169-171页

作者： Guilian Xiao Minqin Wang xiaomeng Li Zhengning Jiang Hongjian Zhang Derong gao Boqiao Zhang Guangmin Xia Mengcheng Wang The Key Laboratory of Plant Development andEnvironment Adaptation Biology Ministry of Education School of Life ScienceShandong UniversityQingdao 266237China Key Laboratory of Wheat Biology and GeneticImprovement for Low&Middle Yangtze Valley Ministry ofAgriculture Lixiahe Agricultural Institute of Jiangsu ProvinceYangzhou 225007China

Salt and saline-alkaline stress seriously threaten crop production and food security worldwide(Yang and Guo,2018).Identifying genes that confer tolerance to these conditions without yield penalty would help mitigate this problem through molecular breeding(Liang et al.,2023;Sahu and Liu,2023).Although numerous stress-tolerance genes have been identified,their application potential in molecular breeding has rarely been confirmed through multi-year and multi-site field trials.

关键词： breeding fir alkaline

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Synergistic effects of carbon cycle metabolism and photosynthesis in Chinese cabbage under salt stress

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Horticultural Plant Journal 2024年第2期10卷 461-472页

作者： Hao Liang Qiling Shi Xing Li Peipei gao Daling Feng xiaomeng Zhang Yin Lu Jingsen Yan Shuxing Shen Jianjun Zhao Wei Ma State Key Laboratory of North China Crop Improvement and Regulation Key Laboratory of Vegetable Germplasm Innovation and Utilization of HebeiCollaborative Innovation Center of Vegetable Industry in HebeiCollege of HorticultureHebei Agricultural UniversityBaodingHebei 071000China

Chinese cabbage(Brassica rapa ssp. pekinensis) has a long cultivation history and is one of the vegetable crops with the largest cultivation area in China. However, salt stress severely damages photosynthesis and hormone metabolism, nutritional balances, and results in ion toxicity in plants. To better understand the mechanisms of salt-induced growth inhibition in Chinese cabbage, RNA-seq and physiological index determination were conducted to explore the impacts of salt stress on carbon cycle metabolism and photosynthesis in Chinese cabbage. Here, we found that the number of thylakoids and grana lamellae and the content of starch granules and chlorophyll in the leaves of Chinese cabbage under salt stress showed a time-dependent response, first increasing and then decreasing. Chinese cabbage increased the transcript levels of genes related to the photosynthetic apparatus and carbon metabolism under salt stress, probably in an attempt to alleviate damage to the photosynthetic system and enhance CO_(2) fixation and energy metabolism. The transcription of genes related to starch and sucrose synthesis and degradation were also enhanced;this might have been an attempt to maintain intracellular osmotic pressure by increasing soluble sugar concentrations. Soluble sugars could also be used as potential reactive oxygen species(ROS) scavengers, in concert with peroxidase(POD)enzymes, to eliminate ROS that accumulate during metabolic processes. Our study characterizes the synergistic response network of carbon metabolism and photosynthesis under salt stress.

关键词： Chinese cabbage Salt stress Carbon metabolism Photosynthesis Chloroplast

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Micro or nano:Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes

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Nano Research 2020年第2期13卷 511-526页

作者： Zhou Zhu Shaokang Jiang Yanhua Liu xiaomeng gao Shanshan Hu Xin Zhang Chao Huang Qianbing Wan Jian Wang Xibo Pei State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of ProsthodonticsWest China Hospital of StomatologSichuan UniversityChengdu 610041China College of Chemistry Sichuan UniversityChengdu 610064China

In recent years,various particulate materials have played important roles in medical applications.However,nano-and micron-sized particles of the same material could exhibit distinct properties due to different particle sizes.This finding provided a simple and effective way to improve the biological applications of particulate materials.Therefore,as a highly promising member,the effect of the particle size change of the magnesium metal organic framework-74(Mg-MOF74)was well worth evaluating.Here we firsth assessed the in vitro and in vivo toxicity of micron/nanoscale Mg-MOF74(m-Mg-MOF74/n-Mg-MOF74)in detail.Our in vitro study revealed that compared to micron-sized subjects,n-Mg-MOF74 provided a wider range of safe concentrations.Furthermore,both micron/nanoscale Mg-MOF74 showed good biocompatibility and allowed all the rats under the treatment to survive through the expected experimental periods,with n-Mg-MOF74 still showing lower cardiotoxicity.These advantages of nanoscale Mg-MOF74might benefit from its sustainable and balanced release of Ma^2+both inside and outside the cells.Based on the biosafety evaluation,advanced bio-functional assessments of m/n-Mg-MOF74 including early osteogenesis and angiogenesis were alsoperformed.Similarly,the suitable dose groups of n-Mg-MOF74 achieved optimal early osteogenic promotion and angiogenic stimulation effects.Overall,our combined data delineated the toxicity and biological behaviors of Ma-MOF74 of different scales,and sugqested nanoscale Mg-MOF74 as a better choice for future applications.This result revealed that particle size reductior might be a viable strategy to improve and expand medical applications of MOFs or other particulate materials.

关键词： magnesium metal organic framework-74 micron/nanoscale biological applications osteogenesis angiogenesis

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