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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei Duan Fei Hao wen Zhao Yudan gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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培养创新理念鼓励大胆探索——浅谈在信息技术课教学中开展创新教育的尝试

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毕节师范高等专科学校学报（综合版） 2002年第2期20卷 37-43页

作者：李廷扬高文献黄艳毕节师专中文系贵州毕节551700 大方一中贵州大方551600 大方教育局贵州大方551600

培养21世纪的信息技术人才和造就具有“创新精神和实践能力”的建设者,是当代教育的神圣使命。要完成这一使命,教师首先必须改革传统的教育现,要让学生从传统的被动接受知识的模式中解放出来,不做知识的奴隶,而是成为主动学习、积极摄取... 详细信息

培养21世纪的信息技术人才和造就具有“创新精神和实践能力”的建设者,是当代教育的神圣使命。要完成这一使命,教师首先必须改革传统的教育现,要让学生从传统的被动接受知识的模式中解放出来,不做知识的奴隶,而是成为主动学习、积极摄取,能驾驭自身学习活动的主人。基于“信息技术学科应该以任务驱动的方式,采取重自主、重环境、重实践、重创新为特点的教学模式进行教学”的认识,我们以培养学生创新精神和实践能力为目标,开展了“培养创新理念,鼓励大胆探索”的创新教育尝试。本文就:创新教育需要创设孕育创新精神的教学环境和人文环境;创新教育需要以具有创新观念和重实践运用的教学方法体系和教学模式来保障;创新教育需要以充分的实践作基础并通过实践实现创新等方面的问题,浅谈开展创新教育的做法和体会。

关键词：创新精神实践能力教学模式教学方法创新理念信息技术课教学创新教育

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基于COMSOL Multiphysics的PEMFC的数值模拟

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化学工业与工程 2008年第5期25卷 432-437页

作者：郝建新高现文高鹤明江苏大学能源与动力工程学院江苏镇江212013

由于燃料电池内的环境是高度反应性的,因此,很难在电池运行时进行许多详细的在线测量工作。为了更好地了解电池内复杂的流动结构、化学组分的传递过程、优化水、热管理以及缩短电池的设计和优化周期,这些信息常需要通过建立数学模型和... 详细信息

由于燃料电池内的环境是高度反应性的,因此,很难在电池运行时进行许多详细的在线测量工作。为了更好地了解电池内复杂的流动结构、化学组分的传递过程、优化水、热管理以及缩短电池的设计和优化周期,这些信息常需要通过建立数学模型和数值模拟工作来寻求。在建立了二维全电池模型的基础上,在COMSOL Multiphysics 3.3a环境下对全电池的内部电流密度、气体流速、气体压力和含水量等进行了数值模拟,并得出在模拟条件下,最大电流密度为9 027 A/m2、最大气体流速为0.7 m/s。

关键词： PEMFC 二维模型 COMSOL Multiphysics 数值模拟

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan gao Xia Li wen-Yuan gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Research on Coke Oven Gas-collector Pressure Decoupling Control

Research on Coke Oven Gas-collector Pressure Decoupling Cont...

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第24届中国控制与决策会议

作者： Wang Jie-sheng 1, 2 , gao xian-wen 1 , Liu Lin 2 1. College of Information Science and Engineering, Northeastern University, Shenyang 110014, China2. School of Electronic and Information Engineering, Liaoning University of Science & Technology, Anshan 114044, China

The gas-collector pressure control system of coke oven has the time-varied characteristic with strongly coupling, high non-linear, which is influenced by the process disturbances with high amplitudes. Based on the introduction about the coke oven gas collector coupling and its effect, all kinds of control method settling out the coupling of the gas collector pressure system are discussed in details, such as fuzzy controller, neural network controller, expert controller and hybrid intelligent controller. In the end, the existed problems and future research directions in the related field is concluded.

关键词： Coke Oven Gas-collector Pressure Control Decoupling Control

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专科学历小学教师培养目标与课程体系的建构

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昭通师范高等专科学校学报 2007年第2期29卷 56-60页

作者：沈雪松陶仁高显文昭通师范高等专科学校教育系云南昭通657000 昭通师范高等专科学校数学系云南昭通657000

复合型应用人才培养目标是现代教师教育发展的出发点和归宿,相应的课程模式构建就成了教师教育的核心问题.初等教育专业属师范教育类专业,在办学目标上,应培养具有丰富文化内涵和多元才能的小学教师;在课程设置上,应走综合创新的道路.... 详细信息

复合型应用人才培养目标是现代教师教育发展的出发点和归宿,相应的课程模式构建就成了教师教育的核心问题.初等教育专业属师范教育类专业,在办学目标上,应培养具有丰富文化内涵和多元才能的小学教师;在课程设置上,应走综合创新的道路.昭通师专教育系构建的“三主线一专长”文理大综合模式和在此基础上改造的“大文、大理”课程模式,经过多年的实践和研究,对专业化教师教育是一种新的尝试.

关键词：初等教育复合型应用人才培养目标课程模式

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试探非专业美术鉴赏教育中西方美术鉴赏的教法

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邢台职业技术学院学报 2008年第6期25卷 59-61页

作者：高献敏毛文青广西师范大学美术学院

非专业美术鉴赏教育,不能只停留在形象审美的表层水平和感性认知阶段,还应进行更深层的理性分析教学。在深层教学阶段,以文化为视点进行深入教学,不仅有利于学生理解和接受,还有助于打破学科界限,培养学生综合能力。本文对此教法深入探... 详细信息

非专业美术鉴赏教育,不能只停留在形象审美的表层水平和感性认知阶段,还应进行更深层的理性分析教学。在深层教学阶段,以文化为视点进行深入教学,不仅有利于学生理解和接受,还有助于打破学科界限,培养学生综合能力。本文对此教法深入探讨分析其应用价值和可行性,并对可能产生的负面问题提出了解决方法。

关键词：美术鉴赏教育形象审美文化审美文化视点

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医疗器械网上招标采购过程中供应商的信用管理

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医疗卫生装备 2007年第12期28卷 51-53页

作者：邢文荣陈峰周峰贾青宁高文娴兰州军区联勤部卫生部兰州市730000 兰州军区联勤部卫生部药品仪器检验所兰州市730050

结合军区医疗器械网上招标采购的工作实践,分析了在医疗器械网上招标采购过程中出现的各种供应商违规行为及其危害,剖析了导致这些行为的原因,提出了加强医疗器械网上招标采购供应商信用管理的建议。

关键词：医疗器械网上招标采购供应商信用管理

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Existence,Uniqueness and Asymptotic Behavior for the Vlasov–Poisson System with Radiation Damping

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Acta Mathematica Sinica,English Series 2017年第5期33卷 635-656页

作者： Jing CHEN xian wen ZHANG Ran gao College of Science Zhongyuan University of Technology School of Mathematics and Statistics Huazhong University of Science and Technology

We investigate the Cauchy problem for the Vlasov–Poisson system with radiation *** virtue of energy estimate and a refined velocity average lemma, we establish the global existence of nonnegative weak solution and asymptotic behavior under the condition that initial data have finite mass and energy. Furthermore, by building a Gronwall inequality about the distance between the Lagrangian flows associated to the weak solutions, we can prove the uniqueness of weak solution when the initial data have a higher order velocity moment.

关键词： Vlasov–Poisson system radiation damping velocity averages weak solution uniqueness

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