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A cyclic effect of cAMP and calcium signaling contributes to jujube growth and development

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Journal of Integrative Agriculture 2023年第7期22卷 2094-2110页

作者： WANG Li-xin WANG Lin-xia ZHANG Meng-ling QU Ying-yue YUAN Ye Ehsan SADEGHNEZHAD gao Meng-jiao ZHAO Ruo-yu QI Chao-feng GUO Xiao-xue ZHU wen-hui LI Rui-mei DAI Li LIU Meng-jun LIU Zhi-guo College of Horticulture Hebei Agricultural UniversityBaoding 071001P.R.China Research Center of Chinese Jujube Hebei Agricultural UniversityBaoding 071001P.R.China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education/College of Life SciencesNorthwest UniversityXi’an 710069P.R.China Department of Plant Biology Faculty of Biological SciencesTarbiat Modares UniversityTeheran 14115Iran

3´,5´-Cyclic adenosine monophosphate(cAMP)is an important metabolite that is specifically enriched in ***,the effect of cAMP on jujube cellular responses has not been comprehensively ***,we established jujube cell suspension cultures and investigated the calcium influx in response to cAMP treatment through protoplast isolation and fluorescence ***,cAMP treatment could promote jujube growth and increase the content of endogenous *** transcriptome analysis with transgenic Arabidopsis plants overexpressing adenylate cyclase(ZjAC)as a positive control,we identified 60 calcium-related differential expressed genes(DEGs)that contributed to the calcium signaling and inter-or intra-cellular *** treatments such as cAMP and the calcium ionophore A23187 could induce ZjAC expression,the accumulation of cAMP and calcium influx in jujube cells,while ethylene glycol tetraacetic acid(EGTA)or bithionol treatment inhibited these ***,the calcium channels and transporters in calcium influx,such as the ZjCNGC2 channel and the mitogen activated protein(MAP)kinase pathway,could be activated by cAMP *** summary,our findings demonstrated that cAMP biosynthesis is dependent on calcium influx and the amplifying effect between calcium and cAMP may be involved in intracellular signal induction,which might contribute to the growth and development of jujube.

关键词： cAMP calcium growth suspension cells protoplast signaling jujube

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中国共产党早期纪念马克思活动研究

红河学院学报 2024年第2期22卷 24-28页

作者：郭文倩高贤栋鲁东大学历史文化学院山东烟台264025

中国共产党对马克思的纪念始于中共建党前后,并作为中共的政治文化传统一直延续至今。中共在建党前后开始借助马克思的生辰、忌日开展马克思纪念活动,翻译马克思主义经典著作,介绍马克思生平,阐释马克思主义基本原理,揭示马克思主义对... 详细信息

中国共产党对马克思的纪念始于中共建党前后,并作为中共的政治文化传统一直延续至今。中共在建党前后开始借助马克思的生辰、忌日开展马克思纪念活动,翻译马克思主义经典著作,介绍马克思生平,阐释马克思主义基本原理,揭示马克思主义对中国的意义,为更多知识分子及民众了解和学习马克思主义提供了文本资料,为推动马克思主义中国化奠定了良好基础。

关键词：中国共产党马克思纪念活动

Synthesis and Antifungal Activity of Dehydroabietic Acid-Based Thiadiazole-Thiazolidinones

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Synthesis and Antifungal Activity of Dehydroabietic Acid-Bas...

中国化学会全国第十二届有机合成化学学术研讨会

作者： Chen,Nai-Yuan Duan,wen-Gui Ma,Yuan Yin,xian-Long Chen,Zhi-Cong School of Chemistry and Chemical Engineering Guangxi University

Dehydroabietic acid is a constituent of pine oleoresin and can be readily obtained from disproportionated *** has been reported to possess antimicrobial,antifungal,insecticidal,gastroprotective and antitumor *** to its broad bioactivities and unique characteristics,dehydroabietic acid has been used to synthesize novel bioactive compounds for many *** our previous works,various dehydroabietic acid-based compounds were synthesized and some of them were found to exhibit good biological activities.[1-6] In continuation of our study on the development and utilization of natural products-based bioactive compounds,a series of novel dehydroabietic acid-based thiadiazole-thiazolidinone compounds were designed and synthesized by integrating 1,3,4-thiadiazole and thiazolidinone heterocyclic moieties into the skeleton of dehydroabietic *** preliminary bioassay showed that the target compounds 3c（R= p-F）,3f（R= o-Br）,and 3n（R= m-OCH3） exhibited excellent inhibition rates of 91.3%（A-class activity level） against Gibberella zeae,which were equivalent to that of the commercial antifungal drug azoxystrobin served as the positive control in this study.

关键词： dehydroabietic acid thiadiazole thiazolidinone synthesis antifungal activity

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关于我国抗菌药研发影响因素的专家调查研究

中国新药杂志 2016年第15期25卷 1687-1692页

作者：高稳武志昂沈阳药科大学工商管理学院沈阳110016

目的:通过对抗菌药研发影响因素的梳理和评估,得出关键因素,进而提出相应的对策和建议,激励我国抗菌新药的研发,保障公众的健康。方法:通过文献研究,在创新扩散理论的基础上,初步梳理出抗菌药研发的影响因素,以专家意见法咨询专家意见,... 详细信息

目的:通过对抗菌药研发影响因素的梳理和评估,得出关键因素,进而提出相应的对策和建议,激励我国抗菌新药的研发,保障公众的健康。方法:通过文献研究,在创新扩散理论的基础上,初步梳理出抗菌药研发的影响因素,以专家意见法咨询专家意见,补充完善影响因素,运用层次分析法对其分析,得出关键因素。结果:创新属性和组织所在的环境对企业抗菌药研发意愿的影响很大,而组织特性的影响相对较小;注册审批制度、抗菌药使用受到管制、基础研发水平、临床需求、可替代性为影响程度较高的关键因素。结论:从政府和制药企业2个方面提出激励我国抗菌药研发的对策和建议。

关键词：抗菌药研发影响因素激励

Efficacy and safety of Kang’ai injection adjunct with TP chemotherapy for the treatment of non-small cell lung cancer: a systematic review and meta-analysis of randomized controlled trials

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TMR Cancer 2020年第5期3卷 199-210页

作者： Chen-Chen Zhao Chuan-Xin Liu xian-Bin Kong Jie Zhou wen-Tai Pang Tong Wu Ying-Jie Jia Department of Oncology First Teaching Hospital of Tianjin University of TCMTianjin 300381China Graduate School Tianjin University of TCMTianjin 301617China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Department of Oncology Second Affiliated Hospital of Tianjin University of TCMTianjin 300250China Evidence-based Medicine Center Tianjin University of TCMTianjin 301617China Department of Cardiology Second Affiliated Hospital of Tianjin University of TCMTianjin 300250China

Background:Combination therapy with traditional Chinese medicine and chemotherapy was proposed as a therapeutic strategy for non-small cell lung cancer ***,we performed a systematic review and metaanalysis of randomized controlled trials to assess effects of this combination therapy on non-small cell lung *** evaluate the efficacy and safety of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy in the treatment of non-small cell lung ***:A randomized controlled study of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy in the databases of China National Knowledge Infrastructure Database,WanFang Database,VIP Database,Sino-Med Database,PUBMED,EMBASE and Cochrane library was searched by *** literatures published from the database establishment to July 1,2020 were included in the search *** 2 evaluators independently evaluated and cross checked the quality of the study,Revman 5.3 was used to meta analyze the clinical effect of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy on patients with non-small cell lung ***:A total of 1,370 lung cancer patients were included in 20 *** results of meta-analysis showed that there were significant differences between the 2 groups in clinical efficacy(RR=1.32,95%CI(1.20,1.44)),quality of life(RR=1.44,95%CI(1.32,1.57)),immune function(MD=0.53,95%CI(0.23–0.83)),adverse reactions(RR=0.49,95%CI(0.41,0.58)).Conclusion:The Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy is effective and safe in the treatment of non-small cell lung cancer,and has great prospects for further ***,the quality of evidence was very *** the poor quality of evidence,we are not very confident in the *** look forward to more research and update results in the future and improve the evidence quality.

关键词： Kang’ai injection Non-small cell lung cancer Traditional Chinese medicine Chemotherapy Clinical research Meta analysis

EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

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Military Medical Research 2021年第1期8卷 25-36页

作者： Ji-Hang Zhang Yang Shen Chuan Liu Jie Yang Yuan-Qi Yang Chen Zhang Shi-Zhu Bian Jie Yu Xu-Bin gao Lai-Ping Zhang Jing-Bin Ke Fang-Zheng-Yuan Yuan wen-Xu Pan Zhi-Nian Guo Lan Huang Institute of Cardiovascular Diseases Department of CardiologyXinqiao HospitalArmy Medical UniversityChongqing 400037China

Background: More people ascend to high altitude(HA) for various activities, and some individuals are susceptible to HA illness after rapidly ascending from plains. Acute mountain sickness(AMS) is a general complaint that affects activities of daily living at HA. Although genomic association analyses suggest that single nucleotide polymorphisms(SNPs) are involved in the genesis of AMS, no major gene variants associated with AMS-related symptoms have been ***: In this cross-sectional study, 604 young, healthy Chinese Han men were recruited in June and July of 2012 in Chengdu, and rapidly taken to above 3700 m by plane. Basic demographic parameters were collected at sea level, and heart rate, pulse oxygen saturation(Sp O2), systolic and diastolic blood pressure and AMS-related symptoms were determined within 18–24 h after arriving in Lhasa. AMS patients were identified according to the latest Lake Louise scoring system(LLSS). Potential associations between variant genotypes and AMS/AMS-related symptoms were identified by logistic regression after adjusting for potential confounders(age, body mass index and smoking status).Results: In total, 320 subjects(53.0%) were diagnosed with AMS, with no cases of high-altitude pulmonary edema or high-altitude cerebral edema. Sp O2 was significantly lower in the AMS group than that in the non-AMS group(P=0.003). Four SNPs in hypoxia-inducible factor-related genes were found to be associated with AMS before multiple hypothesis testing correction. The rs6756667(EPAS1) was associated with mild gastrointestinal symptoms(P=0.013), while rs3025039(VEGFA) was related to mild headache(P=0.0007). The combination of rs6756667 GG and rs3025039 CT/TT further increased the risk of developing AMS(OR=2.70, P<0.001).Conclusions: Under the latest LLSS, we find that EPAS1 and VEGFA gene variants are related to AMS susceptibility through different AMS-related symptoms in the Chinese Han population;this tool might be useful for screenin

关键词： Acute mountain sickness Hypoxia Single nucleotide polymorphism Endothelial PAS domain protein 1 Vascular endothelial growth factor

利用遗传算法和模糊逻辑进行系统可靠性优化分配

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国防科技大学学报 2000年第1期22卷 56-59页

作者：王浩郁文贤庄钊文胡卫东国防科技大学电子科学与工程学院湖南长沙410073

提出一种使用遗传算法和模糊逻辑相结合进行系统可靠性优化分配的新方法。该方法使用模糊逻辑对系统研制初期可靠性设计中所存在的不精确限制条件和设计目标进行数学建模 ,然后利用遗传算法对数学模型进行求解。该方法充分利用了模糊逻... 详细信息

提出一种使用遗传算法和模糊逻辑相结合进行系统可靠性优化分配的新方法。该方法使用模糊逻辑对系统研制初期可靠性设计中所存在的不精确限制条件和设计目标进行数学建模 ,然后利用遗传算法对数学模型进行求解。该方法充分利用了模糊逻辑的建模效率和遗传算法的搜索效率 ,大大提高了系统可靠性分配的效率和精度。本文首先以两单元串联系统的可靠度优化为例进行说明 ,然后将算法扩展至多单元系统的可靠度及冗余度优化问题的求解。数值仿真实例显示了算法的性能和可行性。

关键词：遗传算法模糊逻辑可靠性分配系统可靠性

IEEE 802.11中上下行带宽公平分配机制

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北京邮电大学学报 2011年第2期34卷 126-130页

作者：张兵高泽华文柳高峰徐大雄信息光子学与光通信教育部重点实验室(北京邮电大学) 北京100876 泛网无线通信教育部重点实验室(北京邮电大学) 北京100876

为了提高网络整体性能,提出了一种基于Markov模型的概率发送机制——上下行带宽公平分配机制,不需要对现有客户端做任何改动,可通过调节接入点的最小竞争窗口和分组传输概率,实现上下行带宽的公平分配.推导了不同上下行数据流条件下保... 详细信息

为了提高网络整体性能,提出了一种基于Markov模型的概率发送机制——上下行带宽公平分配机制,不需要对现有客户端做任何改动,可通过调节接入点的最小竞争窗口和分组传输概率,实现上下行带宽的公平分配.推导了不同上下行数据流条件下保证带宽公平分配的接入点最优发送概率.仿真结果表明,该策略能在不降低系统总吞吐量的情况下提供精确的上下行带宽分配.

关键词： Markov模型公平性带宽分配策略

磁控管非平衡状态对Cr膜微观形貌及性能的影响

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材料热处理学报 2010年第10期31卷 100-105页

作者：文晓斌李显梁戈蒋百灵西安理工大学材料科学与工程学院陕西西安710048

采用直流磁控溅射方法于不同磁控管非平衡度状态下,通过单靶溅射模式在单晶Si衬底上制备了Cr膜。利用AFM、SEM、四探针测试仪及MTS Nano Indenter XP纳米压入测量仪分别对两种磁控管非平衡状态下所得Cr膜的微观形貌、电阻率、纳米硬度... 详细信息

采用直流磁控溅射方法于不同磁控管非平衡度状态下,通过单靶溅射模式在单晶Si衬底上制备了Cr膜。利用AFM、SEM、四探针测试仪及MTS Nano Indenter XP纳米压入测量仪分别对两种磁控管非平衡状态下所得Cr膜的微观形貌、电阻率、纳米硬度和抗磨损性进行了观察和分析,研究了不同磁控管非平衡状态下Cr膜微观结构与性能之间的关系。结果表明:磁控管非平衡状态显著影响着Cr膜的微观结构及性能。不同非平衡度状态下,镀层晶体均为沿Cr(110)择优生长的柱状晶组织。同一靶基距处,镀层晶粒尺寸及硬度与非平衡度大小成正比,而电阻率及抗磨损性能变化趋势却相反。靶基距亦为影响镀层微观结构和性能的重要因素之一。

关键词：磁控管非平衡度微观形貌纳米硬度抗磨损性