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Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 667-681页

作者： Yue Zhang Jingwen gao Na Li Peng Xu Shimeng Qu Jinqian Cheng Mingrui Wang Xueru Li Yaheng Song Fan Xiao Xinyu Yang Jihong Liu Hao Hong Ronghao Mu Xiaotian Li Youmei Wang Hui Xu Yuan Xie tianming gao Guangji Wang Jiye Aa Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesResearch Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical SciencesChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Monitoring and Control Drug Intelligence and Forensic CenterMinistry of Public SecurityBeijing 100193China School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Foreign Languages China Pharmaceutical UniversityNanjing 211198China Department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Pharmacology China Pharmaceutical UniversityNanjing 211198China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

Studies have suggested that the nucleus accumbens(NAc)is implicated in the pathophysiology of major depression;however,the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been ***,we identified a specific reduction of cyclic adenosine monophosphate(cAMP)in the subset of dopamine D1 receptor medium spiny neurons(D1-MSNs)in the NAc that promoted stress susceptibility,while the stimulation of cAMP production in NAc D1-MSNs efficiently rescued depression-like *** treatment enhanced cAMP both in D1-MSNs and dopamine D2 receptor medium spiny neurons(D2-MSNs)of depressed mice,however,the rapid antidepressant effect of ketamine solely depended on elevating cAMP in NAc *** discovered that a higher dose of crocin markedly increased cAMP in the NAc and consistently relieved depression 24 h after oral administration,but not a lower *** fast onset property of crocin was verified through multicenter ***,crocin specifically targeted at D1-MSN cAMP signaling in the NAc to relieve depression and had no effect on *** findings characterize a new strategy to achieve an exclusive and outstanding anti-depression benefit by elevating cAMP in D1-MSNs in the NAc,and provide a potential rapid antidepressant drug candidate,crocin.

关键词： CAMP Nucleus accumbens Depression D1-MSN D2-MSN

Prefrontal cortical circuits in anxiety and fear:an overview

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Frontiers of Medicine 2022年第4期16卷 518-539页

作者： Yihua Chen Nengyuan Hu Jianming Yang tianming gao State Key Laboratory of Organ Failure Research Key Laboratory of Mental Health of the Ministry of EducationGuangdong−Hong Kong−Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangdong Province Key Laboratory of Psychiatric DisordersDepartment of NeurobiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Pathological anxiety is among the most difficult neuropsychiatric diseases to treat pharmacologically,and it represents a major societal *** have implicated structural changes within the prefrontal cortex(PFC)and functional changes in the communication of the PFC with distal brain structures in anxiety *** that affect the activity of the PFC,including cognitive therapies and transcranial magnetic stimulation,reverse anxiety-and fear-associated circuit abnormalities through mechanisms that remain largely *** the subjective experience of a rodent cannot be precisely determined,rodent models hold great promise in dissecting well-conserved *** developed genetic and viral tools and optogenetic and chemogenetic techniques have revealed the intricacies of neural circuits underlying anxiety and fear by allowing direct examination of hypotheses drawn from existing psychological *** review focuses on studies that have used these circuit-based approaches to gain a more detailed,more comprehensive,and more integrated view on how the PFC governs anxiety and fear and orchestrates adaptive defensive behaviors to hopefully provide a roadmap for the future development of therapies for pathological anxiety.

关键词： prefrontal cortex anxiety fear neural circuits optogenetics DREADD

同期腹腔镜胆囊切除联合腹腔镜胆总管探查术或内镜括约肌切开取石术治疗胆囊结石合并胆总管结石的疗效比较

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中华普通外科杂志 2024年第2期39卷 105-109页

作者：田宏亮柏斗胜金圣杰周保换高添铭蒋国庆扬州大学临床医学院肝胆外科扬州225001 大连医科大学第一临床学院肝胆外科大连116027

目的探讨同期腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)联合腹腔镜胆总管探查术(laparoscopic common bile duct exploration,LCBDE)(LC+LCBDE)或同期LC联合术中内镜下十二指肠乳头括约肌切开术(intraoperative endoscopic sphincterotomy,IO-EST)(LC+IO-EST)治疗胆囊结石合并胆总管结石的疗效。方法回顾性分析2013年4月至2020年4月扬州大学临床医学院收治的903例胆囊结石合并胆总管结石患者的临床资料。结果根据手术方案不同,将其分为A组(LC+LCBDE)389例和B组(LC+IO-EST)514例。A组患者的胆总管结石复发率、再复发率显著低于B组患者(4.4%比8.4%,P=0.024;0.8%比3.1%,P=0.010)。通过逆概率加权后的逻辑回归分析显示,A组手术方案是胆总管结石复发和再复发的独立保护因素(OR=0.482,95%CI:0.365~0.637,P<0.001;OR=0.118,95%CI:0.080~0.173,P<0.001)。结论对于胆囊结石合并胆总管结石且胆总管直径≥8 mm的患者,LC+LCBDE相较于LC+IO-EST是更优选的治疗方案。

关键词：腹腔镜内窥镜胆总管探查术胆囊切除术胆总管结石

热驱动三元乙丙橡胶/二氧化硅复合材料的制备及性能研究

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橡胶工业 2024年第9期71卷 656-662页

作者：林勇邹永昆周小勤高天明余彪岭南师范学院化学化工学院广东湛江524048

以机械共混法制备三元乙丙橡胶(EPDM)/二氧化硅(SiO2)复合材料,采用机械训练工艺制备EPDM基人工肌肉材料,并研究其性能。结果表明:当机械训练的应变从50%增大至120%时,SiO2用量为40份、甲基丙烯酸锌用量为12份的EPDM复合材料(记作S40Z12... 详细信息

以机械共混法制备三元乙丙橡胶(EPDM)/二氧化硅(SiO2)复合材料,采用机械训练工艺制备EPDM基人工肌肉材料,并研究其性能。结果表明:当机械训练的应变从50%增大至120%时,SiO2用量为40份、甲基丙烯酸锌用量为12份的EPDM复合材料(记作S40Z12)的EPDM基人工肌肉材料的弹性模量从2.8 MPa增大至35.8 MPa,增大了12.8倍;机械训练后EPDM基人工肌肉材料的Kraus曲线斜率仍为负值且绝对值更大,表明EPDM基体与SiO2颗粒之间的界面作用增强;固定应力模式下,S40Z12@350%(机械训练应变为350%)的EPDM基人工肌肉材料的可逆驱动应变达到47%;EPDM基人工肌肉材料在受到热刺激响应作用下,能够驱动负载物体实现多次可逆切换上升与下降的重复动作,且驱动负载质量超过其自身质量的12600倍,驱动应变大于35%。

关键词：三元乙丙橡胶复合材料人工肌肉材料热驱动性能驱动负载

高分子材料与工程专业“校企联合”应用型高校人才培养模式探究

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热带农业工程 2024年第2期48卷 137-139页

作者：高天明谭德新何东宁余彪岭南师范学院化学化工学院广东湛江524048

应用型本科院校存在实践条件不足、学生实践能力偏弱、实践教学考核机制缺失等问题。针对岭南师范学院高分子材料与工程专业实践教学中存在的问题和不足,提出“校企联合”实践教学培养模式,共建实践教学基地,通过教学改革提升学生的工... 详细信息

应用型本科院校存在实践条件不足、学生实践能力偏弱、实践教学考核机制缺失等问题。针对岭南师范学院高分子材料与工程专业实践教学中存在的问题和不足,提出“校企联合”实践教学培养模式,共建实践教学基地,通过教学改革提升学生的工程实践能力,促进高质量应用型人才培养。

关键词：应用型高校高分子材料与工程 “校企联合”人才培养模式

荧光和羟基修饰聚天冬氨酸的制备与阻垢性能——推荐一个综合化学实验

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大学化学 2024年第1期39卷 294-304页

作者：高利军文日珍王赟郭妍蓓惠永海高天明张永飞岭南师范学院化学化工学院清洁能源材料化学广东普通高校重点实验室广东湛江524048

设计了荧光和羟基修饰聚天冬氨酸的制备、表征和阻垢性能的综合实验。首先合成了水溶性荧光物质和聚琥珀酰亚胺(PSI),然后用该荧光物质和乙醇胺修饰PSI并碱性水解,获得目标阻垢剂。用1H NMR、凝胶渗透色谱和荧光分光光度计表征该阻垢剂... 详细信息

设计了荧光和羟基修饰聚天冬氨酸的制备、表征和阻垢性能的综合实验。首先合成了水溶性荧光物质和聚琥珀酰亚胺(PSI),然后用该荧光物质和乙醇胺修饰PSI并碱性水解,获得目标阻垢剂。用1H NMR、凝胶渗透色谱和荧光分光光度计表征该阻垢剂,并通过静态阻垢试验测试该阻垢剂的阻垢性能。本实验融合了高分子化学、有机化学和分析化学内容,体现了“合成–表征–分析”的科学研究过程,强调了“物质–结构–性能”的科研思维模式,可以培养学生的实验素养和科研能力。

关键词：聚天冬氨酸荧光羟基阻垢综合化学实验

粗骨料特性对新拌自密实混凝土流动性能的影响

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混凝土 2024年第7期 169-173页

作者：葛智高天明王思琪盛丽艳陈萌萌孙柯万田涛袁化强山东大学齐鲁交通学院山东济南250002 山东黄河河务局滨州黄河河务局山东滨州256601 宁夏大学土木与水利工程学院宁夏银川750021

为探究粗骨料特性对自密实混凝土工作性和流变性的影响,首先采用骨料成像系统AIMS通过棱角、纹理、球度、棱角纹理等参数定量表征了4种粗骨料(碎石、鹅卵石、雨花石、玻璃珠)的颗粒形状及纹理特性;然后制备了4种不同粗骨料类型的自密实... 详细信息

为探究粗骨料特性对自密实混凝土工作性和流变性的影响,首先采用骨料成像系统AIMS通过棱角、纹理、球度、棱角纹理等参数定量表征了4种粗骨料(碎石、鹅卵石、雨花石、玻璃珠)的颗粒形状及纹理特性;然后制备了4种不同粗骨料类型的自密实混凝土并测试了扩展度、T500、屈服应力和塑性黏度;最后定量分析了新拌自密实混凝土工作性及流变参数与粗骨料特性之间的关系。结果表明:粗骨料特性对自密实混凝土工作性和流变性影响显著,制备的4种自密实混凝土的扩展度介于596~688 mm、T500介于5.8~9.1 s、屈服应力介于66~261 Pa、塑性黏度介于45~105 Pa·s;降低粗骨料的棱角和纹理,或者提高其球度,有利于提高自密实混凝土的流动性并降低其流变参数;CAAT综合量化了粗骨料的几何形状和表面纹理,与自密实混凝土扩展度、T500、静态屈服应力和塑性黏度均呈现良好的线性关系。

关键词：自密实混凝土工作性流变性粗骨料特性纹理

再生骨料对自密实混凝土工作性能与流变特性的影响

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市政技术 2024年第1期42卷 175-181页

作者：杨立君李烨刘彩虹凌一峰高天明葛智山东高速河南发展有限公司河南许昌461000 山东大学齐鲁交通学院山东济南250100

针对再生骨料对自密实混凝土(SCC)工作性能与流变特性的影响问题,使用再生砖粉、再生骨料取代SCC中的水泥、天然骨料,研究了再生砖粉不同取代率(1%、2.5%、5%)下SCC的工作性能与流变特性变化规律;分析了再生粗骨料取代率(15%、30%、50%... 详细信息

针对再生骨料对自密实混凝土(SCC)工作性能与流变特性的影响问题,使用再生砖粉、再生骨料取代SCC中的水泥、天然骨料,研究了再生砖粉不同取代率(1%、2.5%、5%)下SCC的工作性能与流变特性变化规律;分析了再生粗骨料取代率(15%、30%、50%)与预湿时间(0、2、24 h)对SCC工作性能与流变特性的影响;研究了再生细骨料的种类(混凝土再生细骨料、黏土砖再生细骨料以及混合型再生细骨料)、取代率(25%、50%、75%、100%)、预湿时间(0、2、24 h)对SCC工作性能与流变特性的影响规律。研究结果表明,黏土砖再生细骨料对SCC的工作性能影响最大,混凝土再生细骨料的影响相对较小,混合型再生细骨料介于二者之间;SCC的工作性能都随着这3种再生细骨料取代率的提高而降低,屈服应力与塑性黏度升高,即流变特性增强;相同取代率下,预湿时间越久,再生细骨料的工作性能就越低,再生粗骨料的工作性能在2 h时最优。该研究成果对于再生SCC的应用和推广有较好的理论与实际意义。

关键词： SCC 再生骨料工作性能流变特性

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Spatial differences of exergy use of cement manufacturing industry in China based on extended exergy accounting method

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Journal of Geographical Sciences 2015年第11期25卷 1393-1407页

作者： CHEN Fengnan SHEN Lei LIU Litao gao tianming Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Factory-level data from 23 provinces and some national statistical data in cement manufacturing industry and socio-economies in 2012 are used to analyze the spatial distribution of exergy use for China＇s cement manufacturing industry by the Extended Exergy Accounting method. This method takes full account of the inclusion of energy and raw material supply and other external factors （capital, labor and environment） into a comprehensive resource cost assessment. The extended exergy consumption and its intensity quantitatively at the provincial levels of cement production were calculated and then the agglomeration level of exergy use at the regional level was also evaluated. Based on this analysis, their spatial difference in size and efficiency of exergy use at the provincial level were identified. Moreover, their regional characteristics were revealed. Some important results could be drawn as follows. First, the invisible social cost accounted for 1/10 of the total exergy use in cement manufacturing industry, while the energy element shared about 9/10. Second, the gross distribution of exergy use in China＇s cement manufacturing industry was mainly concentrated in the eastern region like Anhui and Shandong provinces, and in the western region like Sichuan province. In terms of exergy use, the coal and electricity were the highest of energy costs in the eastern region, whereas the cost of capital, labor and external environmental factors highlighted the invisible social cost for cement production in the central and western regions to some extent. Third, the efficiency distribution of exergy use in China＇s cement manufacturing industry illustrated an incremental feature from west to east, especially for the energy, labor and capital efficiencies. An evaluation on the environmental efficiency indicated that provinces or regions like Tibet, Xinjiang, Inner Mongolia and Shanxi have undertaken much higher environmental costs. Fourth, the 23 provinces could be classified int

关键词： cement manufacturing industry spatial difference exergy use extended exergy accounting method