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Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro

Chinese Medical Journal 2009年第11期122卷 1260-1266页

作者： gao song yang xue-jun zhang wen-gao ji yan-wei pan qiang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China

Background Glioma is the most common primary brain tumor with poor prognosis. Temozolomide has been used with thalidomide to treat gliomas. We investigated the synergistic mechanism of these two drugs in vitro. Methods Human malignant glioma cells U251-MG were cultured and assigned to four groups with different treatments for 3 days： temozolomide group （100 μmol/L）, thalidomide group （100 μg/L）, temozolomide （100 μmol/L） plus thalidomide group （100 μg/L） and control group. MTT assay was applied to evaluate the cell viability. Cell cycle was analyzed by flow cytometry. The ultra-structural features of autophagosomes were observed with electron microscope. Acridine orange and monodansylcadaverine were adopted to label autophagosomes and flow cytometry was applied for quantification of autophagosomes. The expression of autophagy-associated protein was detected by Western blotting. Results Proliferation of tumor cell was obviously suppressed by temozolomide with thalidomide treatment than by either drug used alone （P=0.000 for each day）. The combination treatment induced cell cycle arrest at G0/G1 phase. Typical autophagic ultra-structural character was found after the combined treatment. Thalidomide promoted the autophagy induced by temozolomide. The autophagy-associated proteins - microtubule associated protein 1 light chain 3 （MAP1LC3） and Beclinl were more significantly up-regulated by the combined treatment than temozolomide used alone （MAP1LC3, P=0.000; Beclinl, P=0.004）. The expression level of phosphatase and tensin homolog deleted on chromosome ten （PTEN）, which promoted autophagy by suppressing PI3K/Akt/mTOR signaling pathway, was elevated by thalidomide （thalidomide group： P=0.000; combined group： P=0.002）. Conclusions Thalidomide enhances the cytotoxicity of temozolomide by promoting the autophagy induced by temozolomide. Contributing to the up-regulation of PTEN by thalidomide, the expression of autophagy associated protein-MAP1LC3 and Beclinl was enhanced,

关键词： glioma thalidomide temozolomide autophagy

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： wen-Tao zhang wen Huang Fu-jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao jiang Xiao-Ming Li xue-Fei Miao He Zhu Si Lan xue-Qian Wang Bao-Long Shen Zhe jia Feng-Qi zhang wei Wang Qi Liu yang Ren Xun-Li Wang Xiao-Ya Cui Xiao-yang Wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long gao jia-Ming Guo Zeng-Bao jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui Huang Ling-Kun zhang Yi-Ping Lu Xu-Bo Li Huai-jun Lin yan Ma wei-Ming yang Zhi-Hua Shen Hai-yan He Yong-Gang Sun Yong-jiang Huang De-Zhuang Wang Qing-Feng Liu Fei-yang Wang Hui Liu Hong-Hui Wu Li-qiang Wang yang Lu Nan Wang Tian-Li Wang wei-Bing Liao Yi-Han Wang Yuan Wu Yu-Zhen Yin jie pan Yi zhang Qing Wang jian-yang zhang Tao yang Yasir Sohail jin-Yu zhang Hua ji qiang Li wei-Di Liu Zhi-Gang Chen Xiong-jun Liu wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao jianshe Cao Antoine Chance xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen jinhui Chen ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jiNR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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人外周血内皮祖细胞转染自杀基因杀伤恶性胶质瘤细胞的体外研究

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中国现代神经疾病杂志 2008年第5期8卷 465-470页

作者：李罡杨学军纪延伟张文高潘强高松天津医科大学总医院神经外科

目的观察5-氟胞嘧啶诱导基因修饰型内皮祖细胞群发生自身死亡及其旁效应对共培养人脑胶质瘤细胞系U251的杀伤作用。方法采用密度梯度离心法分离经体外诱导培养的人外周血内皮祖细胞,经转染获得基因修饰型内皮祖细胞。RT-PCR法鉴定胞嘧... 详细信息

目的观察5-氟胞嘧啶诱导基因修饰型内皮祖细胞群发生自身死亡及其旁效应对共培养人脑胶质瘤细胞系U251的杀伤作用。方法采用密度梯度离心法分离经体外诱导培养的人外周血内皮祖细胞,经转染获得基因修饰型内皮祖细胞。RT-PCR法鉴定胞嘧啶脱氨酶(CD)基因在基因修饰型内皮祖细胞中的表达变化,观察野生型和基因修饰型内皮祖细胞在不同浓度5-氟胞嘧啶作用下的细胞存活率,以及基因修饰型内皮祖细胞所诱导的旁效应。结果真核细胞表达载体pCEA-CD-CAUP转染成功,CD基因在基因修饰型内皮祖细胞中表达阳性;在不同浓度5-氟胞嘧啶(0.01～1000.00μg/ml)作用下,基因修饰型内皮祖细胞存活率低于野生型内皮祖细胞,组间差异有统计学意义(均P80%。结论人外周血内皮祖细胞转染CD基因后,在5-氟胞嘧啶的作用下可发生自身死亡并触发旁效应而杀伤共培养的人脑胶质瘤细胞系U251细胞,为抗血管生成药物与自杀基因联合应用治疗恶性胶质瘤的体内实验及后续研究提供了依据。

关键词：干细胞内皮基因转染氟胞嘧啶神经胶质瘤

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沙利度胺联合替莫唑胺对胶质瘤细胞黏附、侵袭力及整合素表达的影响

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山东医药 2009年第30期49卷 1-3页

作者：纪延伟潘强张文高高松杨学军天津医科大学总医院天津300052

目的探讨沙利度胺(THD)联合替莫唑胺(TMZ)对人胶质母细胞瘤细胞株LN229黏附、侵袭能力的影响及其机制。方法LN229分别用加入DMSO(对照组)、THD(THD组)、TMZ(TMZ组)及THD+TMZ(联合组)的培养液培养,观察细胞的贴壁过程及形态变化。用流式... 详细信息

目的探讨沙利度胺(THD)联合替莫唑胺(TMZ)对人胶质母细胞瘤细胞株LN229黏附、侵袭能力的影响及其机制。方法LN229分别用加入DMSO(对照组)、THD(THD组)、TMZ(TMZ组)及THD+TMZ(联合组)的培养液培养,观察细胞的贴壁过程及形态变化。用流式细胞仪检测各组LN229中整合素αvβ3的表达。用黏附抑制实验与细胞侵袭实验测定细胞黏附及侵袭性。结果对照组和TMZ组LN229迅速形成伪足并与其他细胞接触形成单细胞层,整合素αvβ3均有较高表达。THD组和联合组LN229的伪足变短,形态有变圆倾向,整合素αvβ3表达减弱,其中贴壁细胞整合素αvβ3的阳性表达率分别为对照组的81.8%与77.9%,平均荧光强度(MFI)分别为对照组的66.8%、53.7%;悬浮细胞整合素αvβ3阳性表达率分别为对照组的63.7%、55.0%,MFI分别为对照组的49.8%、54.1%。THD组、TMZ组及联合组平均LN229黏附抑制率分别为25.23%、0.88%、26.83%。THD组及联合组平均每视野侵袭细胞数目较对照组和TMZ组减少(P均<0.05)。结论THD对LN229具有黏附抑制作用,对其黏附、迁移过程的抑制与细胞整合素αvβ3的表达有关。THD与TMZ间无协同作用。

关键词：沙利度胺替莫唑胺胶质瘤整合素

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替莫唑胺耐药人脑胶质瘤细胞系U251/TR建立及耐药机制

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医药导报 2014年第9期33卷 1121-1125页

作者：潘强杨学军高松纪延伟张文高山东省莱芜市人民医院泰山医学院附属莱芜医院神经外科莱芜271100 天津医科大学总医院神经外科天津300052 天津医科大学附属肿瘤医院胰腺肿瘤科天津300060 山东省交通医院神经外科济南250031 河北省沧州市中心医院神经外科沧州061001

目的建立替莫唑胺耐药人脑胶质瘤细胞系,探讨其耐药机制,以期为临床优化药物化疗方案提供参考。方法通过体外分步诱导方法使人U251胶质瘤细胞对替莫唑胺产生耐药,噻唑蓝比色法检测耐药指数及细胞存活率;采用Western-Blot、逆转录-聚合... 详细信息

目的建立替莫唑胺耐药人脑胶质瘤细胞系,探讨其耐药机制,以期为临床优化药物化疗方案提供参考。方法通过体外分步诱导方法使人U251胶质瘤细胞对替莫唑胺产生耐药,噻唑蓝比色法检测耐药指数及细胞存活率;采用Western-Blot、逆转录-聚合酶链免疫(RT-PCR)、免疫荧光、免疫组化法检测O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)表达变化,分析细胞耐药机制。结果历经8个月成功建立了对替莫唑胺耐药的胶质瘤细胞U251/TR,在替莫唑胺初始浓度为0.25μg·mL-1,终浓度为16.00μg·mL-1培养液中,U251/TR细胞半数抑制浓度(IC50)为未经诱导的U251胶质瘤细胞的7倍(P=0.00),其耐药指数约为7.00;U251/TR细胞MGMT表达水平较未经诱导的U251胶质瘤细胞明显增加(P=0.00)。结论通过分步诱导方法于体外成功建立1株对替莫唑胺耐药的U251/TR细胞系。MGMT表达水平升高是导致U251/TR细胞对替莫唑胺耐药的主要机制。

关键词：替莫唑胺神经胶质瘤 O6-甲基鸟嘌呤-DNA甲基转移酶抗药性

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胶质母细胞瘤MGMT基因启动子甲基化与蛋白表达

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中华神经外科杂志 2010年第6期26卷 527-530页

作者：潘强杨学军纪延伟孙健韩建国高松李罡张文高天津医科大学总医院神经外科 300052 中国人民解放军武装警察部队医学院附属医院脑系科

目的研究新发胶质母细胞瘤中肿瘤不同部位MGMT基因启动子甲基化及其蛋白表达关系及区域差异性.方法在30例新发胶质母细胞瘤肿瘤不同部位采取2～4块标本,其中5例在术中神经导航引导下采取.甲基化特异性PCR（MSP）法检测标本中MGMT基因... 详细信息

目的研究新发胶质母细胞瘤中肿瘤不同部位MGMT基因启动子甲基化及其蛋白表达关系及区域差异性.方法在30例新发胶质母细胞瘤肿瘤不同部位采取2～4块标本,其中5例在术中神经导航引导下采取.甲基化特异性PCR（MSP）法检测标本中MGMT基因启动子甲基化状况,免疫组化法（IHC）检测组织切片MGMT蛋白表达情况.结果 43.56%（44/101）检测肿瘤组织中出现MGMT基因启动子甲基化,免疫组化检测（阴性,细胞弱着色＜10%或细胞无着色;弱阳性,10%≤细胞着色≤50%;强阳性,细胞着色＞50%）发现MGMT蛋白表达情况分别为阴性（32.67%）,弱阳性（43.56%）,强阳性（23.76%）.MGMT基因启动子甲基化与其蛋白表达无明显相关性（x2=2.905,P=0.088）.在肿瘤不同取材部位组织之间57%的患者（17/30）MGMT蛋白表达水平与37%患者（11/30）启动子甲基化存在不均一性.结论 MGMT基因启动子甲基化可能不是MGMT蛋白表达的惟一调节因素.同一肿瘤不同取材部位组织MGMT蛋白表达与其基因启动子甲基化水平不均一性的结果质疑了单一取材标本的检测结果及其对临床治疗方案选择的指导意义.

关键词：神经胶质瘤胶质母细胞瘤 O6-甲基鸟嘌呤-DNA甲基转移酶 DNA甲基化免疫组化

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替莫唑胺改变人胶质瘤细胞系U251耐药机制的体外研究

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中国现代神经疾病杂志 2009年第6期9卷 583-588页

作者：潘强杨学军高松纪延伟张文高李瑜王维董雪涛王华民天津医科大学总医院神经外科 300052 天津医科大学附属肿瘤医院胰腺肿瘤科山东省交通医院神经外科河北省沧州市中心医院神经外科

目的建立替莫唑胺耐药人胶质瘤细胞系,探讨其耐药性变化规律及耐药机制,以期为临床优化药物化疗方案提供理论依据。方法采用分步诱导法使人胶质瘤细胞系U251对替莫唑胺耐药,磺酰罗丹明B比色法检测细胞耐药指数和存活率;Western blottin... 详细信息

目的建立替莫唑胺耐药人胶质瘤细胞系,探讨其耐药性变化规律及耐药机制,以期为临床优化药物化疗方案提供理论依据。方法采用分步诱导法使人胶质瘤细胞系U251对替莫唑胺耐药,磺酰罗丹明B比色法检测细胞耐药指数和存活率;Western blotting法检测O^6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)表达水平,以及倍增替莫唑胺终浓度后MGMT表达水平。结果成功建立替莫唑胺耐药U251/TR细胞,在替莫唑胺初始诱导剂量0.25μg/ml、终浓度16.00μg/ml培养液中,U251/TR细胞半数抑制浓度为(220.87±2.34)μmol/L,约为U251细胞[(33.12±1.52)μmol/L]的7倍(t=-116.542,P=0.000),其耐药指数约为7;U251/TR细胞MGMT表达水平为(1.47±0.30),较U251细胞(0.19±0.03)明显升高(t=-20.230,P=0.000)。与溶媒对照组比较,经倍增替莫唑胺终浓度诱导的U251/TR细胞仍呈现增殖抑制现象,以体外培养第3天时最为明显(P=0.000);MGMT表达水平相应降低(均P=0.000),呈现自身克服耐药现象。结论采用分步诱导法可于体外成功建立替莫唑胺耐药人胶质瘤细胞系。MGMT表达水平升高是导致U251/TR细胞对替莫唑胺耐药的主要机制,替莫唑胺可以通过自身消耗MGMT而改变U251/TR细胞的耐药特性,发挥抗耐药作用。

关键词：替莫唑胺脑肿瘤神经胶质瘤抗药性,肿瘤 O(6)-甲基鸟嘌呤-DNA甲基转移酶

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-wei Liu Yi-Peng jing Gang Wang Hao-Tong zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-jun Chen Kun-Xin Chen Li Chen xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng jian-Ning Fu Peng gao xue-Fei Gong Bo-Zhong Gu yan-Xin Guo Zhan-wen Han Bo-Liang He jin-Liang Hou Yong-Hui Hou wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu Zhi-Ying Huo Lei jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-wei Li Hai-Ning Li jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg ji-jun Ni Zhao-Xiang Qi Yong-jun Qi Shi-Yin Shen Huo-Ming Shi jing song Yi-Han song Ding-qiang Su Hong-jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang jian Wang jia-Ning Wang jian-Ling Wang jian-Ping Wang jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng wei Ming-Zhi wei Hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu yan Xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-Qin yang Ming yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng zhang Hua-wei zhang jian-Nan zhang Li-Pin zhang wei zhang Yong zhang yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao song Chen yan-Fen Chai Xiao-Hui Chen Yu-Guo Chen Shao-wen Cheng wen-wei Cheng Bang-Han Ding yang Deng jie Fu Bang-jiang Fang Mai-Ying Fan Li Gui Ping Gong wei Guo Shu-Bin Guo Liang Huang ji-Yuan Han Zhong ji Xian-Fei ji Xin-Cai ji Hong-Xu jin Xin-jun jiang Wang-Xiang jiang jia-Liang Liu Xiao-Ran Liu Zhi Liu Chuan-Zhu Lv Feng Lu Tan-Shi Li Xin Li Yong Li Shang-Lun Li Shuang-Ming Li Xiao-Gang Li Bao-jun Li Pei-Wu Li Chun-Sheng Li Zhi-jun Li Chang-Luo Li Xiang-Min Li Yin-Ping Li Zong-jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing Liao jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma Lin-Hao Ma jun-Qi Ma Shi-Nan Nie jie-Miao Ou-yang Peng Peng Qiao Pei Shu-Ming pan Guo-Zhong Qing Li-jie Qin Wu-Ying Qiao Fei Shao wei song Xing-Yue song Zhen-Ju song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang Tian Ying-Ping Tian jian-Guang Tian Chao-yang Tong Zi-Ren Tang Meng-Xiong Tang Guo-Ping Wu Zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang Xiao-Dan Wang Ling Wu wei wei Hua Xiang Feng Xu jun Xu jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu wen Yi Li-Shan yang Shi-jiao yan jin-jian Yao Shou-Chun yan xue-Zhong Yu Xian-Zhi Ye Xian-Liang yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou qiang Zhou jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu ji-Hong Zhu Hong zhang Mao zhang Hua zhang Na zhang Guo-qiang zhang Guo-Xiu zhang jin-song zhang wen-Wu zhang wen-Zhong zhang jian-Feng zhang Yi-Min Zhu jun Zeng Yuan Zheng Zhi-jie Zheng Shen Zhao yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-jing Zhao Hong-Ke Zeng Sheng-qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

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