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chinese Physics B 2013年第5期22卷 462-466页

作者：任胜东李斌成高丽峰王谦 Institute of Optics and Electronics Chinese Academy of Sciences University of the chinese academy of sciences

A combined frequency-swept and quasi-time-domain photocarrier radiometry （PCR） technique was developed to characterize thermally annealed silicon wafers with B＋, P＋, and As＋ ion implantation at doses ranging from 1 ×1011 cm-2 to 1 ×1016 cm-2. The implantation dose dependence of the PCR amplitude, the frequency dependencies of the PCR amplitude and phase, as well as the quasi-time-domain PCR waveforms were simultaneously employed to analyze all the ion-implanted silicon samples. The dependence of the effective lifetime on the implantation dose has been investigated and shown to be related to the trap density and the lifetime extracted from the transient PCR signals.

关键词： photocarrier radiometry ion implantation effective lifetime silicon

Spatial and temporal distribution of total ozone over china

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Journal of Environmental sciences 1999年第3期11卷 361-366页

作者： gao Qing xian, ren Zhen hai Institute of Atmospheric Physics, chinese academy of sciences, beijing 100012, china. E mail: gaoqx@*** Zhang Yun gang Center of Satellite Meteorology, beijing, china Zhang Cheng chang Beijin Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100012 China Center of Satellite Meteorology Beijing China beijing Institute of Meteorology Beijing China

In this paper the grid data of total ozone mapping spectrograph (TOMS) installed on Nimbus 7 satellite (1978 to 1994) was used and the spatial and temporal distribution of total ozone over china was analyzed. The research indicates that the Qinghai Tibet Plateau destroyed the latitudinal distribution of total ozone of china and the low value closed center emerged over Qinghai Tibet Plateau. Long time change trends of seasonal total ozone of Qinghai Tibet Plateau are provided. It shows that the most obvious decrease of total ozone occurs in winter (Jan.), then in summer (Jul.), the relevant slow change occurs in autumn (Oct.) and spring (Apr.).

关键词： total ozone TOMS Qinghai Tibet Plateau.

A draft sequence of the rice (Oryza sativa ssp. indica) genome

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chinese Science Bulletin 2001年第23期46卷 1937-1942页

作者： YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,ren Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, gao Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG Huanmingbeijing Genomics Institute/Center of Genomics & Bioinformatics, chinese academy of sciences, beijing 101300, china Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, china Institute of Genetics, chinese academy of sciences, beijing 100101, china National Hybrid Rice R & D Center, Changsha 410125, china Laboratory of Bioinformatics, Institute of Biophysics, chinese academy of sciences, beijing 100101, china College of Life sciences, Peking University, beijing 100871, china Institute of Theoretical Physics, chinese academy of sciences, beijing 1Q0080, china Digital china Ltd., beijing 100080, china Institute of Computing Technology, chinese academy of sciences, beijing 100080, china Medical College, Xi’an Jiaotong University, Xi’an 710061, chinaThese authors contributed equally to this work.Corresponding author.Corresponden beijing Genomics Institute/Center of Genomics & Bioinformatics Chinese Academy of Sciences Beijing China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province Hangzhou China College of Life sciences Peking University Beijing China Medical College Xi’an Jiaotong University Xi’an China Institute of Genetics Chinese Academy of Sciences Beijing China Laboratory of Bioinformatics Institute of Biophysics Chinese Academy of Sciences Beijing China National Hybrid Rice R & D Center Changsha China Institute of Theoretical Physics Chinese Academy of Sciences Beijing China Digital china Ltd. Beijing China Institute of Computing Technology Chinese Academy of Sciences Beijing China

The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a "whole genome shotgun" approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in china and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2.14.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package

关键词： rice genome draft sequences.

关于网格及其它分布计算技术的若干问题的讨论

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计算机科学 2003年第2期30卷 17-21,112页

作者：高全泉中国科学院数学研究所北京100080

Grid computing is a new field which distinguished from conventional distributed computing by its focus on large-scale virtual organizations resources sharing. Thispaper presents discussion of serval issues for Grid technologies and other contemporary distributed computing technologies. First, we introduce enterprise computing technologies in brief,including CORBA,DCOM, Java,Enterprise JavaBeans and J2EE ,and discuss how Grid technologies related to them. Next,we introduce an Internet-based parallel computing technology named Javelin. Other distrbuted computing technologies and how them related to Grid technologies are discussed. Finaly,we discuss the need of intergrid protocols to enable interoperability among different Grid systems,and serval other perspectives on Grids are also disscused.

关键词：网格分布计算资源共享数据共享计算机网络

Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1/GSDMD Pathway

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chinese Journal of Integrative Medicine 2024年第11期30卷 1027-1034页

作者： GUO Fan HAN Xiao YOU Yue XU Shu-juan ZHANG Ye-hao CHEN Yuan-yuan XIN gao-jie LIU Zi-xin ren Jun-guo CAO Ce LI Ling-mei FU Jian-hua Institute of Basic Medical sciences of Xiyuan Hospital China Academy of Chinese Medical Sciences beijing Key Laboratory of chinese Materia Pharmacology Department of Central Laboratory Kunshan Hospital of Chinese Medicine

Objective: To observe the protective effect and mechanism of hydroxyl safflower yellow A(HSYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs). Methods:HUVECs were treated with oxygen-glucose deprivation reperfusion(OGD/R) to simulate the ischemia reperfusion model, and cell counting kit-8 was used to detect the protective effect of different concentrations(1.25–160 μmol/L)of HSYA on HUVECs after OGD/R. HSYA 80 μmol/L was used for follow-up experiments. The contents of inflammatory cytokines interleukin(IL)-18, IL-1β, monocyte chemotactic protein 1(MCP-1), tumor necrosis factor α(TNF-α) and IL-6 before and after administration were measured by enzyme-linked immunosorbent assay. The protein expressions of toll-like receptor, NOD-like receptor containing pyrin domain 3(NLRP3), gasdermin D(GSDMD) and GSDMD-N-terminal domain(GSDMD-N) before and after administration were detected by Western blot. NLRP3 inflammasome inhibitor cytokine release inhibitory drug 3 sodium salt(CRID3 sodium salt, also known as MCC950) and agonist were added, and the changes of NLRP3, cysteine-aspartic acid protease 1(Caspase-1), GSDMD and GSDMD-N protein expressions were detected by Western blot. Results: HSYA inhibited OGD/R-induced inflammation and significantly decreased the contents of inflammatory cytokines IL-18,IL-1β, MCP-1, TNF-α and IL-6(P1 or P1/GSDMD pathway, HSYA can reduce the occurrence of pyroptosis after OGD/R and reduce the expression of NLRP3,Caspase-1, GSDMD and GSDMD-N proteins(P1). Conclusions: The protective effect of HSYA on HUVECs after OGD/R is related to down-regulating the expression of NLRP3 inflammasome and inhibiting pyroptosis.

关键词： chinese medicine NLRP3 inflammasome human umbilical vein endothelial cells hydroxysafflor yellow A myocardial reperfusion injury oxygen-glucose deprivation reperfusion pyroptosis

Efficient and selective removal of Pb(Ⅱ) from landfill leachate using L-serine-modified polyethylene/polypropylene nonwoven fabric synthesized via radiation grafting technique

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Nuclear Science and Techniques 2024年第4期35卷 144-155页

作者： Xin-Xin Feng Cheng Li Xuan-Zhi Mao Wan-Ning ren Yang gao Yu-Long He Zhe Xing Rong Li Guo-Zhong Wu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of chinese academy of sciences Beijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

In this study,to efficiently remove Pb(Ⅱ) from aqueous environments,a novel L-serine-modified polyethylene/polypropylene nonwoven fabric sorbent(NWF-serine)was fabricated through the radiation grafting of glycidyl methacrylate and subsequent L-serine *** effect of the absorbed dose was investigated in the range of 5–50 ***-serine was characterized by Fourier transform infrared spectroscopy,thermogravimetric analysis,and scanning electron *** adsorption tests were conducted to investigate the influences of pH,adsorption time,temperature,initial concentration,and sorbent dosage on the Pb(Ⅱ) adsorption performance of *** results indicated that Pb(Ⅱ) adsorption onto NWF-serine was an endothermic process,following the pseudo-second-order kinetic model and Langmuir isotherm *** saturated adsorption capacity was 198.1 mg/***-serine exhibited Pb(Ⅱ) removal rates of 99.8% for aqueous solutions with initial concentrations of 100 mg/L and 82.1% for landfill leachate containing competitive metal ions such as Cd,Cu,Ni,Mn,and ***,NWF-serine maintained 86% of its Pb(Ⅱ) uptake after five use *** coordination of the carboxyl and amino groups with Pb(Ⅱ) was confirmed using X-ray photoelectron spectroscopy and extended X-ray absorption fine structure analysis.

关键词： Landfill leachate Radiation grafting Polyethylene/polypropylene nonwoven fabric Pb(Ⅱ)removal

The system integration of image processing

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The system integration of image processing

Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity

2007亚洲光电子会议电子成像与多媒体技术分会场

作者： Chen Qi-xinga, b, Wu Qin-zhanga, gao Xiao-donga, ren Guo-qianga aThe Institute of Optics and Electronics, The chinese academy of sciences, Chengdu, china 610209 bGraduate School of the chinese academy of sciences, beijing, china 100039

An integration system was designed to apply to the remote communication of optics and electronics detection systems, which was integrated with programmable DSP and FPGA chirps in addition to a few Application Specific Integrated Circuits （ASICs）. It could achieve image binarization, image enhancement, data encryption, image compression encoding, channel encoding, data interleaving, etc., and the algorithms of these functions might be renewed or updated easily. The CCD color camera being a signal source, experiments had been done on the platform with a DSP chirp and a FPGA one. The FPGA chirp mainly realized the reconstruction of image’s brightness signal and the production of various timing signals, and the DSP chirp mainly accomplished the other functions. The algorithms to compress image data were based on discrete cosine transformation （DCT） and discrete wavelet transformation （DWT）, respectively. The experiment results showed that the developed platform was characterized by flexibility, programmability and re- configurability. The integration system is well suitable for the remote communication of optics and electronics detection systems.

关键词： System integration optics and electronics detection systems remote communication DWT DCT

来源： cnki会议评论

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Science china(Life sciences) 2024年第1期67卷 51-66页

作者： Yonghui Jiang Xueying gao Yue Liu Xueqi Yan Huangcong Shi Rusong Zhao Zi-Jiang Chen Fei gao Han Zhao Shigang Zhao Center for Reproductive Medicine Shandong UniversityJinan 250012China Research Unit of Gametogenesis and Health of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250012China Shandong Key Laboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250012China Shandong Provincial Clinical Research Center for Reproductive Health Jinan 250012China National Research Center of Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250012China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215000China Center for reproductive medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200127China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of ScienceBeijing 100101China

Obesity,which can arise from genetic or environmental factors,has been shown to cause serious damages to the reproductive *** ovary,as one of the primary regulators of female fertility,is a complex organ comprised of heterogeneous cell types that work together to maintain a normal ovarian microenvironment(OME).Despite its importance,the effect of obesity on the entire ovary remains poorly *** this study,we performed ovary single-cell and nanoscale spatial RNA sequencing to investigate how the OME changed under different kinds of obesity,including high-fat diet(HFD)induced obesity and Leptin ablation induced obesity(OB).Our results demonstrate that OB,but not HFD,dramatically altered the proportion of ovarian granulosa cells,theca-interstitial cells,luteal cells,and endothelial ***,based on the spatial dynamics of follicular development,we defined four subpopulations of granulosa cell and found that obesity drastically disrupted the differentiation of mural granulosa cells from small to large antral ***,HFD enhanced follicle-stimulating hormone(FSH)sensitivity and hormone conversion,while OB caused decreased sensitivity,inadequate steroid hormone conversion,and impaired follicular *** differences can be explained by the differential expression pattern of the transcription factor ***,our study provides a powerful and high-resolution resource for profiling obesity-induced OME and offers insights into the diverse effects of obesity on female reproductive disorders.

关键词： obesity ovarian microenvironment snRNA-seq Stereo-seq Foxo1

PRELIMINARY STUDY ON SEDIMENTARY ENVIRONMENT OF XIHU LAKE IN THE GREAT WALL STATION AREA, ANTARCTICA

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极地研究 1990年第1期 43-52页

作者： Xie Youyu(Institute of Geography, Academia Sinica, beijing 100012)Li Jiaying (Institute of Geology, chinese academy of Geology, beijing 100037)

The first author of this paper made a drilling through the water 3.5--4m deep in the Xihu Lake by using a gravity corer during 1985--1986 investigation in the Great wall Station area. The drill hole was 2.6 m deep and total 102 samples were collected. The author wishes to express her warmest thanks to gao Xinquan, ren Jiawen, Yang Yibi, Liu Xiaohan, Lin Yunfang and others who gave me energetic support during the sampling process.

关键词： Xihu Lake Great Wall Station Area Sedimentary environment.

Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-Yuan Zou Tian-Yi ren Jia-Qi Li Ting-Ying Jiao Meng-Yu Wang Lei-Jie Huang Shuang-Zhe Lin Yuan-Yang Wang Xiao-Zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of chinese academy of sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets