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hLife 2023年第2期1卷 63-70页

作者： George Fu gao Jules A Hoffmann Chris Walzer Jiahai lu Institute of Microbiology Chinese Academy of SciencesBeijingChina University of Strasbourg Institute for Advanced Study StrasbourgFrance Institute of Molecular and Cellular Biology CNRSInsect Models of Innate Immunity(M3IUPR9022)StrasbourgFrance Sino-French Hoffmann Institute School of Basic Medical ScienceGuangzhou Medical UniversityGuangdongChina Wildlife Conservation Society New YorkUSA University of Veterinary Medicine ViennaAustria Sun Yat-sen University GuangdongChina

Four heavyweight guests in the field of public health gathered together.No-bel Laureate Jules A Hoffmann,Academician George Fu gao,Professor Chris Walzer and Professor Jiahai lu discussed how to deal with global public health crises,such as the recent coronavirus disease 2019(COVID-19)pandemic,as well as the role of international organizations.The concept of“One Health”emerged as the latest approach to disease prevention and control.This concept emphasizes the intertwined health of humans,animals and the environment.The experts shared their thoughts and insights on how humanity can address emerging global public health crises through international cooperation.

关键词： Academician prevention Chris

The critical importance of epigenetics in autoimmune-related skin diseases

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Frontiers of Medicine 2023年第1期17卷 43-57页

作者： Lingyu gao Qianjin lu Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjing 210042China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases Chinese Academy of Medical SciencesNanjing 210042China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Nanjing 210042China qianlu5860@***

Autoimmune-related skin diseases are a group of disorders with diverse etiology and pathophysiology involved in autoimmunity.Genetics and environmental factors may contribute to the development of these autoimmune disorders.Although the etiology and pathogenesis of these disorders are poorly understood,environmental variables that induce aberrant epigenetic regulations may provide some insights.Epigenetics is the study of heritable mechanisms that regulate gene expression without changing DNA sequences.The most important epigenetic mechanisms are DNA methylation,histone modification,and noncoding RNAs.In this review,we discuss the most recent findings regarding the function of epigenetic mechanisms in autoimmune-related skin disorders,including systemic lupus erythematosus,bullous skin diseases,psoriasis,and systemic sclerosis.These findings will expand our understanding and highlight the possible clinical applications of precision epigenetics approaches.

关键词： epigenetics autoimmune-related skin diseases DNA methylation histone modifications noncoding RNAs

Controlling interstory drift ratio profiles via topology optimization strategies

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 165-178页

作者： Wenjun gao Xilin lu Department of Disaster Mitigation for Structures College of Civil EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Tongji UniversityShanghai 200092China

An approach to control the profiles of interstory drift ratios along the height of building structures via topology optimization is proposed herein.The theoretical foundation of the proposed approach involves solving a min-max optimization problem to suppress the maximum interstory drift ratio among all stories.Two formulations are suggested:one inherits the bound formulation and the other utilizes a p-norm function to aggregate all individual interstory drift ratios.The proposed methodology can shape the interstory drift ratio profiles into inverted triangular or quadratic patterns because it realizes profile control using a group of shape weight coefficients.The proposed formulations are validated via a series of numerical examples.The disparity between the two formulations is clear.The optimization results show the optimal structural features for controlling the interstory drift ratios under different requirements.

关键词： interstory drift ratio aggregation function bound formulation min-max problem topology optimization

Factors of Fetal Origin in the Regulation of Labor Initiation and Preterm Birth

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Maternal-Fetal Medicine 2023年第4期5卷 238-243页

作者： Longkun Ding lu gao Department of Physiology Naval Medical UniversityShanghai 200433China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200135China

Preterm birth is the leading cause of mortality and morbidity in newborns and children under 5 years-of-age.In order to improve the survival rate and quality of preterm infants,there is critical need to identify the specific mechanisms underlying the initiation of labor.Pregnancy represents a period of constant interactive dialog between mother and fetus.A disturbance in the pattern of maternal-fetal communication can induce physiological or pathological labor.Although a number of studies have investigated the contributions of maternal factors to the initiation of labor,the concept that fetal organ development and maternal adaptation are coordinated has emerged over recent years,thus emphasizing that factors of fetal origin may serve as hormonal signals for the initiation of labor.In this review,we summarize and discuss several specific mechanisms by which factors of fetal origin may influence parturition during term or preterm labor,including the specific regulation of fetal organs,including the lungs and accessory organs during pregnancy.Future research may focus on the specific pathways by which signals from the fetal lungs and other fetal organs interact with the maternal system to initiate eventual labor.

关键词： Premature birth Fetal origin factor Placenta Fetal membrane Parturition Term labor

N,S-codoped porous carbon nanosheets decorated with Fe_(3)C nanoparticles as high-performance anode materials for lithium ion hybrid supercapacitors

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Rare Metals 2022年第7期41卷 2517-2526页

作者： Lin gao lu-lu Zhang Xue-Lin Yang College of Electrical Engineering&New Energy Hubei Collaborative Innovation Center for Microgrid of New EnergyThree Gorges UniversityYichang 443002China

The practical applications of carbon anode for lithium-ion batteries(LIBs)are largely obstructed by their moderate rate capability and cyclic stability.Herein,we report a N,S-codoped porous carbon nanosheet(NSC)decorated with Fe_(3)C nanoparticles(Fe_(3)C/NSC)by a one-pot pyrolysis process.The high surface area and abundant defects of NSC can not only promote electrons and ions transfer,but also induce high pseudocapacitive contribution.More importantly,the synergistic catalysis effect of Fe-Nx and Fe_(3)C can catalyze the reversible conversion of some solid electrolyte interface(SEI)components to offer excess capacity during cycling.As expected,the Fe_(3)C-NSC anode delivers a discharge capacity of750 mAh·g^(-1)under a current density of 0.5 A·g^(-1)through 500 cycles and retains a dis-charge capacity of 366 mAh·g^(-1)at 4 A·g^(-1)after 1600 cycles,respectively.Most importantly,the lithium-ion capacitors based on Fe_(3)C/NSC anode demonstrate a high energy density of 249.5 Wh·kg^(-1)at 560 W·kg^(-1).

关键词： Fe_(3)C/NSC Lithium-ion batteries Pseudocapacitive behavior Lithium-ion capacitors

Review of technologies and their applications for the speciated detection of RO2 radicals

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Journal of Environmental Sciences 2023年第1期123卷 487-499页

作者： Yue gao Keding lu Yuanhang Zhang State Key Joint Laboratory of Environmental Simulation and Pollution Control State Environmental Protection Key Laboratory of Atmospheric Ozone Pollution ControlCollege of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China

Peroxy radicals(RO_(2)),which are formed during the oxidation of volatile organic compounds,play an important role in atmospheric oxidation reactions.Therefore,the measurement of RO_(2),especially distinct species of RO_(2)radicals,is important and greatly helps the exploration of atmospheric chemistry mechanisms.Although the speciated detection of RO_(2)radicals remains challenging,various methods have been developed to study them in detail.These methods can be divided into spectroscopy and mass spectrometry technologies.The spectroscopy methods contain laser-induced fluorescence(LIF),UV-absorption spectroscopy,cavity ring-down spectroscopy(CRDS)and matrix isolation and electron spin resonance(MIESR).The mass spectrometry methods contain chemical ionization atmospheric pressure interface time-of-flight mass spectrometry(CI-APi-TOF),chemical ionization mass spectrometry(CIMS),CI-Orbitrap-MS and the third-generation proton transfer reaction-time-of-flight mass spectrometer(PTR3).This article reviews technologies for the speciated detection of RO_(2)radicals and the applications of these methods.In addition,a comparison of these techniques and the reaction mechanisms of some key species are discussed.Finally,possible gaps are proposed that could be filled by future research into speciated RO_(2)radicals.

关键词： Speciated RO_(2)radicals Atmospheric chemistry Reaction mechanisms Mass spectrometry

3D face recognition:A comprehensive survey in 2022

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Computational Visual Media 2023年第4期9卷 657-685页

作者： Yaping Jing Xuequan lu Shang gao The School of Information Technology Deakin UniversityWaurn PondsVICAustrali

In the past ten years,research on face recognition has shifted to using 3D facial surfaces,as 3D geometric information provides more discriminative features.This comprehensive survey reviews 3D face recognition techniques developed in the past decade,both conventional methods and deep learning methods.These methods are evaluated with detailed descriptions of selected representative works.Their advantages and disadvantages are summarized in terms of accuracy,complexity,and robustness to facial variations(expression,pose,occlusion,etc.).A review of 3D face databases is also provided,and a discussion of future research challenges and directions of the topic.

关键词： 3D face recognition 3D face databases deep learning local features global feature

Astrocytes in Chronic Pain:Cellular and Molecular Mechanisms

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Neuroscience Bulletin 2023年第3期39卷 425-439页

作者： Huan-Jun lu Yong-Jing gao Institute of Pain Medicine and Special Environmental Medicine Co-innovation Center of NeuroregenerationNantong UniversityNantong 226019China

Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies.Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions,including chronic pain.Astrocytes regulate nociceptive synaptic transmission and network function via neuron–glia and glia–glia interactions to exaggerate pain signals under chronic pain conditions.It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain.Therefore,this review presents our current understanding of the roles of astrocytes in chronic pain,how they regulate nociceptive responses,and their cellular and molecular mechanisms of action.

关键词： Astrocyte Microglia Neuron-glia interaction Spinal cord Chronic pain

Numerical Simulation Investigation on Split Sleeve Cold Expansion of Ti-Al Stacked Structure

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1147-1154页

作者： gao Yue lu Shihong FU Jingyi College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Split sleeve cold expansion(SSCX)can efiectively enhance fatigue life of holes by improving the field of residual stress.Numerical simulations were conducted to investigate the parameter influence mechanism and obtain higher compressive residual stress(CRS).Expansion method,degree of cold expansion(DCE),friction coefficient between laminations and depth-diameter ratio were analyzed.For Ti-Al stacked joint holes,two expansion methods are proposed,namely aluminum alloy first followed titanium alloy(Al first)and titanium alloy first followed aluminum alloy(Ti first).The results show that expansion method and DCE have significant efiects on the field of circumferential residual stress,and the friction has a negligible influence.A higher value of CRS and a wider layer of plastic deformation are induced with Ti first.Optimal DCE of TiAl stacked structure is 5.2%-5.6%.As the depth-diameter ratio is in the range of 0.5-1.25,a positive linear correlation between the maximum compressive residual stress(CRS_(max))and depth-diameter ratio is shown.

关键词： Ti-Al stacked structure SSCX residual stress expansion method DCE

Preterm Labor,a Syndrome Attributed to the Combination of External and Internal Factors

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Maternal-Fetal Medicine 2022年第1期4卷 61-71页

作者： Yuanyuan Liu lu gao Department of Physiology Second Military Medical UniversityShanghai 200433China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200000China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200000China

Preterm labor(before 37 weeks’gestation)is the leading cause of neonatal mortality and morbidity,which can be divided into iatrogenic preterm labor,infectious preterm labor,and spontaneous preterm labor(sPTL).Up to now,there continue to be great difficulties in prediction and prevention of sPTL,owing to multiple risk factors,pathogenesis,and pathologic processes contributing to the event,which have not been fully clarified.Pregnancy maintenance and parturition is a complicated process with continuous maternal-fetal dialogue,in which both maternal and fetal factors participate and affect the outcome of pregnancy,including sPTL.Besides,external factors can also participate in sPTL,individually or through the interaction with internal factors.In this article,we summarize recent studies regarding sPTL from our and other groups,and discuss the risk factors and pathogenesis of preterm birth from both external and internal(maternal and fetal)aspects,so as to provide theoretical evidences for the diagnosis,prevention,and treatment of sPTL in the future.

关键词： Obstetric labor,premature Maternal factor Fetal factor Maternal-fetal crosstalk External factor