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微流控技术在生命分析化学中的应用进展

分析化学 2016年第12期44卷 1942-1949页

作者：张逢高丹梁琼麟清华大学深圳研究生院生命与健康学部清华大学化学系

微流控分析系统与宏观条件下的分析体系相比,具有样品和试剂消耗小、传质传热效率高、生物相容性较好、高通量并行分析、功能单元集成化、微型化及自动化控制等特点,在分析化学尤其是生命分析化学领域得到了广泛应用。本文以涉及细胞的... 详细信息

微流控分析系统与宏观条件下的分析体系相比,具有样品和试剂消耗小、传质传热效率高、生物相容性较好、高通量并行分析、功能单元集成化、微型化及自动化控制等特点,在分析化学尤其是生命分析化学领域得到了广泛应用。本文以涉及细胞的微流控技术为切入点,主要介绍了近五年来微流控芯片相关技术的发展,如芯片材料与制作技术、表面改性技术和液滴技术等,并简单总结微流控技术在药物筛选和细胞分析等生命分析化学领域的研究应用进展。

关键词：微流控技术药物筛选细胞分析综述

Superposed disturbance mechanism of sequential overlying strata collapse for gob-side entry retaining and corresponding control strategies

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Journal of Central South University 2018年第9期25卷 2258-2271页

作者： HAN Chang-liang ZHANG Nong RAN Zhi gao Rui YANG Hou-qiang School of Mines Key Laboratory of Deep Coal Resource MiningMinistry of EducationChina University of Mining and TechnologyXuzhou 221116China Xiaoqing Coal Mine Diaobingshan 112700China

Gob-area roof rupture movement is a key disturbance factor for gob-side entry *** characteristics of gob-area sequential roof collapse of overlying strata and superposed disturbance mechanism for gob-side entry retaining are obtained via physical simulation and theoretical analysis,in which the scope of disturbed strata is enlarged from main roof to fracture *** experiment reveals that as a working face advances,roof strata sequentially collapse from bottom to top and produce multiple disturbances to gob-side entry *** strata among the overlying strata control each *** roof subsidence is divided into three stages:flexure subsidence prior to rupture,rotational subsidence during rupture and compressive subsidence after *** amounts of deformation evident in each of the three stages are 15%,55%and 30%,*** the master stratum collapses,main roof subsidence approaches its maximum *** final span of the key stratum determines the moment and cycling of gob-side entry retaining *** roof subsidence influences the load on the filling *** sequential roof collapse of overlying strata results in fluctuations in the gob-side entry retaining *** formulae for the final span of the key stratum and the filling wall load are obtained via theoretical analysis.A control method for the stability of the gob-side entry retaining’s surrounding rock is proposed,which includes 3 measures:a“dual-layer”proactive anchorage support,roadside filling with dynamic strength matching and auxiliary support during ***,the gob-side entry retaining of the Xiaoqing mine E1403 working face is presented as an engineering case capable of verifying the validity of the research conclusions.

关键词： sequential roof collapse gob-side entry retaining superposed disturbance key stratum stability control

The RNA binding protein EHD6 recruits the m^(6)A reader YTH07 and sequesters OsCOL4 mRNA into phase-separated ribonucleoprotein condensates to promote rice flowering

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Molecular Plant 2024年第6期17卷 935-954页

作者： Song Cui Peizhe Song Chaolong Wang Saihua Chen Benyuan Hao Zhuang Xu liang Cai Xu Chen Shanshan Zhu Xiangchao Gan hui Dong Yuan Hu liang Zhou Haigang Hou Yunlu Tian Xi Liu liangming Chen Shijia Liu Ling Jiang Haiyang Wang Guifang Jia Shirong Zhou Jianmin Wan State Key Laboratory for Crop Genetics&Germplasm Enhancement and Utilization Zhongshan Biological Breeding LaboratoryNational Observation and Research Station of Rice Germplasm ResourcesNanjing Agricultural UniversityNanjing 210095China State Key Laboratory for Crop Gene Resources and Breeding Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking-Tsinghua Center for Life SciencesBeijing Advanced Center of RNA BiologyPeking UniversityBeijingChina Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding Agricultural College of Yangzhou UniversityYangzhou 225009China Max Planck Institute for Plant Breeding Research Carl-von-Linne´-Weg 1050829 KolnGermany

N6-Methyladenosine(m^(6)A)is one of the most abundant modifications of eukaryotic mRNA,but its comprehensive biological functionality remains further *** this study,we identified and characterized a new flowering-promoting gene,EARLY HEADING DATE6(EHD6),in ***6 encodes an RNA recognition motif(RRM)-containing RNA binding protein that is localized in the non-membranous cytoplasm ribonucleoprotein(RNP)granules and can bind both m^(6)A-modified RNA and unmodified RNA *** found that EHD6 can physically interact with YTH07,a YTH(YT521-B homology)domain-containing m^(6)A *** showed that their interaction enhances the binding of an m^(6)A-modified RNA and triggers relocation of a portion of YTH07 from the cytoplasm into RNP granules through phase-separated *** these condensates,the mRNA of a rice flowering repressor,CONSTANS-like 4(OsCOL4),becomes sequestered,leading to a reduction in its protein abundance and thus accelerated flowering through the Early heading date 1 *** together,these results not only shed new light on the molecular mechanism of efficient m^(6)A recognition by the collaboration between an RNA binding protein and YTH family m^(6)A reader,but also uncover the potential for m^(6)A-mediated translation regulation through phaseseparated ribonucleoprotein condensation in rice.

关键词： N6-methyladenosine m^(6)A EHD6 YTH domain-containing protein phase separation heading date

《功夫熊猫》“龙轴”与“大象无形”美学内涵辩异

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电影评介 2008年第19期 57-58页

作者：梁晖泉州师范学院

电影《功夫熊猫》中的龙轴采取"空白"方式呈现,明显借用了中国道家思想的外在形式,通过对中国传统文化的解读达到吸引中国观众的目的。但是《功夫熊猫》中的"空白"明显不同于中国传统文化对"空白"的认识,在中国传统文化中,"空白"被深刻... 详细信息

电影《功夫熊猫》中的龙轴采取"空白"方式呈现,明显借用了中国道家思想的外在形式,通过对中国传统文化的解读达到吸引中国观众的目的。但是《功夫熊猫》中的"空白"明显不同于中国传统文化对"空白"的认识,在中国传统文化中,"空白"被深刻的理解成"有"与"无"的关系,甚至提升至美学中极高审美境界——"大象无形"。

关键词：《功夫熊猫》龙之卷轴大象无形

Molecular phylogeny and morphological comparisons of the genus Hebius Thompson, 1913(Reptilia:Squamata: Colubridae) uncover a new taxon from Yunnan Province, China, and support revalidation of Hebius septemlineatus(Schmidt, 1925)

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Zoological Research 2021年第5期42卷 620-625页

作者： Shao-Bing Hou Zhi-Yong Yuan Ping-Fan Wei Gui-Gang Zhao gao-hui Liu Yun-He Wu Wen-Jing Shen Jin-Min Chen Peng Guo Jing Che State Key Laboratory of Genetic Resources and Evolution State Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of the Chinese Academy of SciencesKunmingYunnan 650204China Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunmingYunnan 650224China Chinese Research Academy of Environmental Sciences Beijing 100012China Faculty of Agriculture Forest and Food EngineeringYibin UniversityYibinSichuan 644007China

We describe a new species of the genus Hebius and provide evidence for the validity of *** ***..Morphological and molecular analyses of Hebius specimens collected in Yunnan Province,China,revealed three distinct lineages,namely the newly described Hebius weixiensis ***.,as well as ***(Boulenger,1904),and *** ***.(Schmidt 1925),which is removed from synonymy with *** on mitochondrial genealogy,Hebius weixiensis *** sister to *** ***.,while *** is sister to *** new species and *** comb.

关键词： removed Morphological sister

高负荷无氧运动训练对肥胖人群自由基代谢的影响

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科学技术与工程 2017年第21期17卷 217-221页

作者：梁辉平顶山学院平顶山467000

为研究高负荷无氧运动训练对肥胖人群自由基代谢的影响,按照肥胖标准选择某高职院校肥胖学生80名,随机将其划分成高负荷无氧运动训练组和对照组,对照组在实验期间不进行任何形式的运动,高负荷无氧运动训练组通过Monark功率自行车进行急... 详细信息

为研究高负荷无氧运动训练对肥胖人群自由基代谢的影响,按照肥胖标准选择某高职院校肥胖学生80名,随机将其划分成高负荷无氧运动训练组和对照组,对照组在实验期间不进行任何形式的运动,高负荷无氧运动训练组通过Monark功率自行车进行急性高负荷无氧运动训练。实验发现,高负荷无氧运动训练能够有效降低肥胖人群的体重等,帮助改善肥胖人群的身体形态,同时促使肥胖人群MDA含量增加,但无统计学意义,SOD、GSH-PX、T-AOC活力显著增加,由此说明肥胖人群在短暂缺氧的情况下能够增强清除自由基的能力和快速应激能力。

关键词：高负荷无氧运动训练肥胖人群自由基代谢

Kinetics and Mechanism of Hydration of Acrylic Acid over Ion-exchanged Resin:Experimental Exploration and DFT Calculation

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China Petroleum Processing & Petrochemical Technology 2024年第3期26卷 109-121页

作者： Yang Fengjing Luo Nianjun Chen Yuxiang Liu Chuanlei Wang Hao gao Weikang Guo Guanchu Jiang Hao Zhao Qiyue Zhou Yousheng Wang Yifan Li Peicheng Shen Benxian Sun hui State Key Laboratory of Green Chemical Engineering and Industrial Catalysis East China University of Science and TechnologyShanghai 200237China School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China International Joint Research Center of Green Energy Chemical Engineering East China University of Science and TechnologyShanghai 200237China

Liquid-phase acrylic acid hydration over solid-phase catalysts is a key reaction for the industrial productionof 3-hydroxypropionic acid. However, the relevant literature primarily focuses on the experimental aspects of catalystscreening and exploring reaction conditions, with few accurate descriptions of the reaction kinetics and determination ofthe reaction mechanism. Here, we combined kinetics experiments and theoretical calculations to elucidate the kinetics andmechanism of acrylic acid hydration on a resin catalyst. The pseudo-homogeneous model, and Langmuir-Hinshelwood-Haugen-Watson and Elie-Riedel (ER) heterogeneous models were used to explain the experimental kinetics data. TheER model can explain the experimental data very well, suggesting strong adsorption of acrylic acid on the surface of theresin catalyst. Furthermore, density functional theory calculations show that the hydration follows a stepwise, rather than aconcerted, reaction pathway. The present study provides theoretical insights into the reaction mechanism and kinetics, fillingthe gap in our understanding of the reaction on a fundamental level.

关键词： acrylic acid kinetics resin catalyst DFT method

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基于机器学习的图案分类研究进展

图学学报 2023年第3期44卷 415-426页

作者：边坤梁慧内蒙古科技大学艺术与设计学院内蒙古包头014010

回顾国内外结合机器学习进行图案分类的有关研究,从研究方法、文献数据分析、图案分类以及机器学习应用层面进行系统的梳理,了解目前国内外的研究现状以及研究进展,总结图案分类的方法以及不足之处,并对今后的发展进行展望,为更深入的... 详细信息

回顾国内外结合机器学习进行图案分类的有关研究,从研究方法、文献数据分析、图案分类以及机器学习应用层面进行系统的梳理,了解目前国内外的研究现状以及研究进展,总结图案分类的方法以及不足之处,并对今后的发展进行展望,为更深入的探索提供参考。以大量文献研究为基础,运用CiteSpace软件分析当前的研究热点及趋势,并详细对数据集构建、数据处理、特征提取和图案分类所使用的方法、经典模型以及机器学习在图案分类中的运用进行分析和总结。图案分类研究有从传统人工分类向机器分类转变的趋势;准确高效的获取目标图案特征可有效改善分类效果;图案分类研究存在数据库匮乏问题,不利于对图案分类的深入研究。通过智能化分类方法构建系统的图案数据库;并将分类技术运用于服务系统平台,实现图案活态化传承;在分类的基础上,结合各种组合算法进行图案的创新设计,推动图案的进一步发展。

关键词： CiteSpace 可视化分析研究热点与趋势图案分类机器学习

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Parental Presence Promoted Children Anesthesia Recovery: A Randomized Controlled Study

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Yangtze Medicine 2020年第1期4卷 54-61页

作者： Rong Hai Liu Zhang Xin liang Gaijing Wang Zumei gao Department of Medicine Yangtze University Jingzhou China Nursing Department of First Affiliated Hospital of Yangtze University Jingzhou China

Objective: There are few studies about restlessness and awakening of children during recovering from anesthesia accompanied by parents. Only one related study was retrieved in China. The purpose of this study is to investigate the effect of awakening, agitation and pain level in children after tonsillectomy accompanied by their parents. Methods: Children who met the inclusion criteria were randomly divided into experimental group and control group according to coin tossing method. There were 30 cases in the experimental group and 32 in the control group. The control group received routine nursing while the experimental group was given parental presence on the basis of routine nursing. Steward awakening score, Pediatric anesthesia emergence delirium (PAED), Scale and FLACC pain assessment scale were used to evaluate the children when they entered anesthesia recovery room and awaked respectively. Results: There was no significant difference in the scoring of three scales between the two groups when they entered anesthesia recovery room (P > 0.05). There was significant difference in Steward awakening score and PAED scale between the two groups when they came to recovery room (P P > 0.05). Conclusion: Parental presence can improve the recovery effect and reduce the restlessness of children after operation. Our study suggests that anesthetic children should be accompanied by their parents in the future.

关键词： Parental Presence Children Agitation Pain