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Numerical studies on four-engine rocket exhaust plume impinging on flame deflectors with afterburning

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Defence Technology（防务技术） 2021年第4期17卷 1207-1216页

作者： Zhi-tan Zhou Chang-fang Zhao Chen-yu Lu Gui-gao le School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China

This paper studies the four-engine liquid rocket flow field during the launching *** threedimensional compressible Navier-Stokes equations and two-equation realizable k-epsilon turbulence model,an impact model is established and flow fields of plume impinging on the two different shapes of flame deflectors,including wedge-shaped flame deflector and cone-shaped flame deflector,are *** finite-rate chemical kinetics is used to track chemical *** simulation results show that afterburning mainly occurs in the mixed *** the region of peak pressure occurs directly under the rocket nozzle,which is the result of the direct impact of exhaust *** with the wedgeshaped flame deflector,the cone-shaped flame deflector has great performance on guiding exhaust *** wedge-shaped and cone-shaped flame deflectors guide the supersonic exhaust plume away from the impingement point with two directions and circumferential direction,*** maximum pressure and temperature on the wedge-shaped flame deflector surface are 37.2%and 9.9%higher than those for the cone-shaped flame *** results provide engineering guidance and theoretical significance for design in flame deflector of the launch platforms.

关键词： Four-engine rocket Afterburning Impinging flow field Different deflectors Numerical simulations

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun Liu Kai gao Jingli Sun Yong Yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Anticancer effects of sweet potato protein on human colorectal cancer cells

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World Journal of Gastroenterology 2013年第21期19卷 3300-3308页

作者： Peng-gao Li Tai-Hua Mu le Deng Key Laboratory of Agro-products Processing Ministry of AgricultureInstitute of Agro-products Processing Science and TechnologyChinese Academy of Agricultural Sciences School of Public Health and Family Medicine Capital Medical University Beijing Municipal Key Laboratory of Clinical Epidemiology

AIM: To investigate the effects of proteins purified from sweet potato storage roots on human colorectal cancer cell lines. METHODS: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, Hoechst 33258 nuclear staining and Boyden transwell chamber methods were used to determine whether purified sweet potato protein (SPP) from fresh sweet potato roots affected proliferation, migration and invasion, respectively, of human colorectal cancer SW480 cells in vitro . The inhibitory effects of SPP on growth of human colorectal cancer HCT-8 cells intraperitoneally xenografted in nude mice and spontaneous lung metastasis of murine lewis lung carcinoma 3LL cells subcutaneously transplanted in C57 BL/6 mice were also investigated in vivo . RESULTS: SPP inhibited the proliferation of SW480 cells in a dose-dependent manner, with an IC 50 value of 38.732 μmol/L (r2 = 0.980, P = 0.003) in the MTT assay. Hoechst 33258 nuclear staining further revealed inhibition of cell viability and induction of apoptosis by SPP. The transwell assay disclosed significant reduction in migrated cells/field by 8 μmol/L SPP (8.4 ± 2.6 vs 23.3 ± 5.4, P = 0.031) and invaded cells/field through the ECMatrix by 0.8 μmol/L SPP, compared with the control (25.2 ± 5.2 vs 34.8 ± 6.1, P = 0.038). Both intraperitoneal (ip) and intragastric (ig) administration of SPP led to significant suppression of growth of intraperitoneally inoculated HCT-8 cells in nude mice to 58.0% ± 5.9% (P = 0.037) and 43.5% ± 7.1% (P = 0.004) of the controls, respectively, after 9 d treatment. Bloody ascites additionally disappeared after ip injection of trypsin inhibitor. Notably, ig and ip administration of SPP induced a significant decrease in spontaneous pulmonary metastatic nodule formation in C57 BL/6 mice (21.0 ± 12.3 and 27.3 ± 12.7 nodules/lung vs 42.5 ± 4.5 nodules/lung in controls, respectively, P les in the hind leg of mice decr

关键词： Sweet potato protein Colorectal cancer Cell proliferation Cell invasion Metastasis

Homotopy classification of maps between r-1 connected 2r dimensional manifolds

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Science China Mathematics 2007年第8期50卷 1093-1102页

作者： Xu-an ZHAO Hong-zhu gao Xiao-le SU School of Mathematical Sciences Beijing Normal UniversityBeijing 100875China

In this paper,we study the homotopy classification of continuous maps between two r-1 connected 2r dimensional topological manifolds M,*** we assume some knowledge on the homotopy groups of spheres,then the complete classification can be obtained from the homotopy invariants of M,*** design an algorithm and compose a program to give explicit computations.

关键词： r-1 connected 2r dimensional manifolds homotopy groups classification of maps

A fast boundary protection for an AC transmission line connected to an LCCHVDC inverter station

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Protection and Control of Modern Power Systems 2020年第1期5卷 328-339页

作者： Zhen Liu Houlei gao Sibei Luo le Zhao Yuyao Feng Key Laboratory of Power System Intelligent Dispatch and Control of Ministry of Education Shandong UniversityNo.17923Jingshi RoadJinan 250061China Electric Power Research Institute of State Grid Shanghai Electric Power Company No.171Handan RoadShanghaiChina

For AC transmission lines connected to an LCC-HVDC inverter station,commutation failure can lead to the wrong operation of traditional *** solve the problem,this paper proposes a fast protection scheme using transient information from one end of the AC *** boundary frequency characteristics of the AC line connected to LCC-HVDC inverter are analyzed *** reveals the existence of significant attenuation on both high frequency signals and some specific frequency *** on the boundary characteristics,a novel boundary protection principle utilizing a backward traveling wave is then proposed.A PSCAD/EMTDC simulation model of a±800 kV LCC-HVDC and 500 kV AC transmission system is established,and different fault cases are *** simulation results prove that the novel protection principle is immune to commutation failure,fault resistance and fault type.

关键词： LCC-HVDC Commutation failure Transient protection AC transmission line Inverter station Boundary characteristics

A Review on Swarm Intelligence and Evolutionary Algorithms for Solving Flexible Job Shop Scheduling Problems

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IEEE/CAA Journal of Automatica Sinica 2019年第4期6卷 904-916页

作者： Kaizhou gao Zhiguang Cao le Zhang Zhenghua Chen Yuyan Han Quanke Pan IEEE the Macao Institute of Systems Engineering at Macao University of Science and Technology 999078 China School of Computer at Liaocheng Univeristy Liaocheng252059China the Department of Industrial Systems Engineering and Management National University of SingaporeSingapore Centre for Maritime Studies National University of SingaporeSingapore the Institute for Infocomm Research(I2R) the Agency for ScienceTechnology and Research(A*STAR)Singapore the School of Computer at Liaocheng Univeristy Liaocheng 252059China School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200072China

Flexible job shop scheduling problems(FJSP)have received much attention from academia and industry for many *** to their exponential complexity,swarm intelligence(SI)and evolutionary algorithms(EA)are developed,employed and improved for solving *** than 60%of the publications are related to SI and *** paper intents to give a comprehensive literature review of SI and EA for solving ***,the mathematical model of FJSP is presented and the constraints in applications are ***,the encoding and decoding strategies for connecting the problem and algorithms are *** strategies for initializing algorithms?population and local search operators for improving convergence performance are ***,one classical hybrid genetic algorithm(GA)and one newest imperialist competitive algorithm(ICA)with variables neighborhood search(VNS)for solving FJSP are ***,we summarize,discus and analyze the status of SI and EA for solving FJSP and give insight into future research directions.

关键词： Evolutionary algorithm flexible job shop scheduling review swarm intelligence