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Web gis design and realization for groundwater {1.s in the Yellow River basin

Science china(Technological Sciences) 2004年第Z1期47卷 106-117页

作者： gao jianguo1,2, gong huili1,2, zhao wenji1,2, zhang xiaosong1 & yan ning2 1. resource, environment and gis.key laboratory of beijing, capital normal university, beijing 100037, china 2. 3 Dimension Information Extraction and Application key laboratory of Education Ministry, beijing 100037, china Correspondence should be addressed to gong huili Web gis design and realization for groundwa- ter resources in the Yellow River basin gao jianguo1,2, gong huili1,2, zhao wenji1,2, zhang xiaosong1 & yan ning2 1. resource, environment and gis.key laboratory of beijing, capital normal university, beijing 100037, china 2. 3 Dimension Information Extraction and Application key laboratory of Education Ministry, beijing 100037, china resource Environment and GIS Key Laboratory of Beijing Capital Normal University Beijing China 3 Dimension Information Extraction and Application key {1. of Education Ministry Beijing China

This article brings forward a design and realization scheme of Web gis in the Yellow River basin for the management of groundwater {1.s. The main goals are to manage and share data of massive-scale, to support the research of groundwater {1.s in the Yellow River basin. In this paper we point out the necessity and feasibility of building the distributed Web gis for geographical research objects on a large scale. We put forward some solutions for the construction of this kind of system including a holistic deployment strategy in the Internet, a scheme of distributed data storage and management, a design of application structure based on three tires architecture by each province and how they collaborate with each other. It also illuminates how the application server works, and sets forth the relations among databases which work together in this system.

关键词： the Yellow River basin, groundwater, Web gis.

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N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1.RAGE/NF-κB pathway in rats

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 228-238页

作者： Yu-Ze zhao Xue-{1. zhang Yi Yin Pei-Lun Xiao Meng gao Lu-Ming zhang Shuan-Hu Zhou Shu-Na Yu Xiao-Li Wang yan-Song zhao Department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina School of Medical Imaging Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Anatomy Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Departments of Orthopedic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

AIM:To observe the effects of N-acetylserotonin(NAS)administration on retinal ischemia-reperfusion(RIR)injury in rats and explore the underlying mechanisms involving the high mobility group box 1.HMGB1./receptor for advanced glycation end-products(RAGE)/nuclear factor-kappa B(NF-κB)signaling ***:A rat model of RIR was developed by increasing the pressure of the anterior chamber of the *** male Sprague Dawley were randomly divided into five groups:sham group(n=8),RIR group(n=28),RIR+NAS group(n=28),RIR+FPS-ZM1.group(n=8)and RIR+NAS+FPS-ZM1.group(n=8).The therapeutic effects of NAS were examined by hematoxylin-eosin(H&E)staining,and retinal ganglion cells(RGCs)*** expression of interleukin 1.beta(IL-1.),HMGB1.RAGE,and nod-like receptor 3(NLRP3)proteins and the phosphorylation of nuclear factorkappa B(p-NF-κB)were analyzed by immunohistochemistry staining and Western blot *** expression of HMGB1.protein was also detected by enzyme-linked immunosorbent assay(ELISA).RESULTS:H&E staining results showed that NAS significantly reduced retinal edema and increased the number of RGCs in RIR *** NAS therapy,the HMGB1.and RAGE expression decreased significantly,and the activation of the NF-κB/NLRP3 pathway was antagonized along with the inhibition of p-NF-κB and NLRP3 protein ***,NAS exhibited an anti-inflammatory effect by reducing IL-1.*** inhibitory of RAGE binding to HMGB1.by RAGE inhibitor FPS-ZM1.led to a significant decrease of p-NF-κB and NLRP3 expression,so as to the IL-1.expression and retinal edema,accompanied by an increase of RGCs in RIR ***:NAS may exhibit a neuroprotective effect against RIR via the HMGB1.RAGE/NF-κB signaling pathway,which may be a useful therapeutic target for retinal disease.

关键词： retinal diseases retinal ischemia—reperfusion injury N-acetylserotonin high mobility group box 1 receptor for advanced glycation end-products nuclear factor-κB rats

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Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao zhang Sen Luo Hai Li Shu-ning Sun Xian-Bo Wang Xin Zheng yan Huang Bei-Ling Li yan-Hang gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Jun-Ping Liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong yan Guo-Hong Deng Liang Qiao yan zhang Wen-Yi Gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun zhang yan Xiong Cong-Cong Zou Jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na gao Chun-yan Liu Wei Yuan Xue Mei Jing Li Tao Li Rong-Jiong Zheng Xin-Yi Zhou Jun zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State key {1. for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1.79(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(1..1.)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/1.0)for type-B ACLF,27.0%(58/21.)for type-A ACLF,9.0%(1.1.1.79)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu yanan Huo Qin Wan Yingfen Qin Ruying Hu Lixin Shi Qing Su Xuefeng Yu Li yan Guijun Qin Xulei Tang Gang Chen Min Xu Tiange Wang Zhiyun zhao Zhengnan gao Guixia Wang Feixia Shen Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei zhang Chao Liu Youmin Wang Tao yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing Wang Guang ning Yu Xu Yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong university Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 1.4538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1.h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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CT与MRI在胸椎占位的诊断价值

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标记免疫分析与临床 2024年第6期31卷 1038-1041页

作者：赵国梅王伟张宁傅岩高炳霞首都医科大学附属北京世纪坛医院干部综合科北京100038 首都医科大学附属北京康复医院康复放射科北京100144 首都医科大学附属北京世纪坛医院磁共振室北京100038 首都医科大学附属北京世纪坛医院CT室北京100038

目的分析计算机断层扫描(computerized tomography,CT)和磁共振成像(magnetic resonance imaging,MRI)对诊断胸椎占位的临床价值。方法回顾性分析201.年1.至2023年1.月在首都医科大学附属北京世纪坛医院住院的47例胸椎占位患者的临床... 详细信息

目的分析计算机断层扫描(computerized tomography,CT)和磁共振成像(magnetic resonance imaging,MRI)对诊断胸椎占位的临床价值。方法回顾性分析201.年1.至2023年1.月在首都医科大学附属北京世纪坛医院住院的47例胸椎占位患者的临床数据。入选患者均行手术治疗。且术前均行胸椎CT及胸椎MRI检查。将病理结果作为诊断的金标准。分析CT、MRI对胸椎占位的诊断与病理结果之间的差异。结果(1.47例胸椎占位的患者中,共22例确诊胸椎结核,1.例确诊胸椎肿瘤,9例为胸椎炎性病变。(2)CT诊断胸椎结核的灵敏度、特异性和准确度分别为81.82%、96.00%、89.36%。MRI诊断胸椎结核的灵敏度、特异性和准确度分别为1.0%、96.00%、97.87%。在胸椎结核诊断中,CT和MRI特异性和准确度方面差异无统计学意义(P>0.05),但MRI诊断胸椎结核的灵敏度显著高于CT(P2%。MRI诊断胸椎肿瘤的灵敏度、特异性和准确度分别为93.75%、96.77%、95.74%。在胸椎肿瘤诊断中,CT和MRI在灵敏度、特异性和准确度方面差异均无统计学意义(P>0.05)。结论CT和MRI在诊断胸椎占位方面均有良好的诊断价值,可较好地诊断胸椎结核及胸椎肿瘤。MRI在诊断胸椎结核方面的灵敏度更高。

关键词： CT MRI 胸椎结核胸椎肿瘤

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Probing dark matter particles from evaporating primordial black holes via electron scattering in the CDEX-1. experiment

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Science china(Physics,Mechanics & Astronomy) 2024年

作者： Zhenhua zhang Litao yang Qian Yue Kejun Kang Yuanjing Li Haipeng An Greeshma C. Jianping Chang Yunhua Chen Jianping Cheng Wenhan Dai Zhi Deng Changhao Fang Xinping Geng Hui gong Qiuju Guo Tao Guo Xuyuan Guo Li He Shengming He Jinwei Hu Hanxiong Huang Tuchen Huang Lin Jiang S.Karmakar Haubin Li Hanyu Li Jianmin Li Jin Li Qianyun Li Renmingjie Li Xueqian Li Yulan Li Yifan Liang Bin Liao FongKay Lin ShinTed Lin Jiaxuan Liu Shukui Liu yandong Liu Yu Liu Yuanyuan Liu Hao Ma Yucai Mao Qiyuan Nie Jinhua ning Hui Pan ningchun Qi Jie Ren Xichao Ruan Monoj Kumar Singh Tianxi Sun Changjian Tang yang Tian Guangfu Wang Junzheng Wang Li Wang Qing Wang Yufeng Wang Yunxiang Wang Henry Tsz-King Wong Shiyong Wu Yucheng Wu Haoyang Xing Rui Xu Yin Xu Tao Xue Yulu yan Nan Yi Chunxu Yu Haijun Yu Jianfeng Yue Ming Zeng Zhi Zeng Bingtao zhang Fengshou zhang Lei zhang Zhenyu zhang Jizhong zhao Kangkang zhao Minggang zhao Jifang Zhou Zuying Zhou Jingjun Zhu Sino-French Institute of Nuclear and Technology Sun Yet-sen University School of Physics Nankai University Department of Physics Banaras Hindu University Department of Physics Beijing Normal University key {1. of Particle and Radiation Imaging (Ministry of Education) and Department of Engineering Physics Tsinghua University Department of Physics Tsinghua University Institute of Physics Academia Sinica Taipei NUCTECH Company YaLong River Hydropower Development Company College of Nuclear Science and Technology Beijing Normal University College of Physics Sichuan University School of Physics Peking University Department of Nuclear Physics China Institute of Atomic Energy

Dark matter （DM） is a major constituent of the ***,no definite evidence of DM particles （denoted as“χ”） has been found in DM direct detection （DD） experiments to *** is a novel concept of detectingχfrom evaporating primordial black holes （PBHs）.We search forχemitted from PBHs by investigating their interaction with target *** examined PBH masses range from 1.1.1.to 7×1.1.g under the current limits of PBH abundance *** 205.4 kg·day data obtained from the CDEX-1. experiment conducted in the china Jinping Underground {1.,we exclude theχ-electron （χ-e）elastic-scattering cross sectionσχe～5×1.-29cm2forχwith a mass mχ0.1.ke V from our *** the higher radiation background but lower energy threshold （1.0 eV）,CDEX-1. fills a part of the gap in the previous *** (mχ,σχe) can be determined in the future,DD experiments are expected to impose strong constraints on fPBHfor large MPBHs.

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Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model

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Zoological Research 2023年第6期44卷 1003-1014页

作者： Zhongyun zhang ning zhang Xuancheng Lu Min Zhou Xiaoxiang yan Weiqiong Gu Jingru yang Qin zhang Cheng zhang Yuhuan gong Mingjun Jia Xiaoyu zhang Peng ning Mei Liu Xiaoyan Li Xiaomeng Shi Wenjun Liu George Fgao Guang ning Jiqiu Wang Yuhai Bi Department of Endocrinology and Metabolism Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineShanghai 200025China CAS key {1. of Pathogen Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China laboratory Animal Center Chinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Department of Respiratory and Critical Care Medicine Institute of Respiratory DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Cardiology Institute of Cardiovascular DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325000China university of Chinese Academy of Sciences Beijing 100049China

Severe acute respiratory syndrome coronavirus 2(SARSCo V-2)infection can result in more severe syndromes and poorer outcomes in patients with diabetes and ***,the precise mechanisms responsible for the combined impact of coronavirus disease 201.(COVID-1.)and diabetes have not yet been elucidated,and effective treatment options for SARS-Co V-2-infected diabetic patients remain *** investigate the disease pathogenesis,K1.-h ACE2 transgenic(h ACE2^(Tg))mice with a leptin receptor deficiency(h ACE2-Lepr^(-/-))and high-fat diet(h ACE2-HFD)background were *** two mouse models were intranasally infected with a 5×1.^(5) median tissue culture infectious dose(TCID_(50))of SARSCo V-2,with serum and lung tissue samples collected at 3days *** h ACE2-Lepr^(-/-)mice were then administered a combination of low-molecular-weight heparin(LMWH)(1.mg/kg or 5 mg/kg)and insulin via subcutaneous injection prior to intranasal infection with1.1.^(4) TCID_(50)of SARS-Co *** drug administration continued until the euthanasia of the *** of viral RNA loads,histopathological changes in lung tissue,and inflammation factors were *** demonstrated similar SARS-Co V-2 susceptibility in h ACE2^(Tg)mice under both lean(chow diet)and obese(HFD)***,compared to the h ACE2-Lepr^(+/+)mice,h ACE2-Lepr^(-/-)mice exhibited more severe lung injury,enhanced expression of inflammatory cytokines and hypoxia-inducible factor-1.(HIF-1.),and increased ***,combined LMWH and insulin treatment effectively reduced disease progression and severity,attenuated lung pathological changes,and mitigated inflammatory *** conclusion,preexisting diabetes can lead to more severe lung damage upon SARS-Co V-2 infection,and LMWH may be a valuable therapeutic approach for managing COVID-1.patients with diabetes.

关键词： SARS-CoV-2 Diabetes Mouse model Heparin Antiviral therapy

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牛煅烧骨的表征及其对成骨细胞的作用

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生物物理学报 2004年第6期20卷 483-488页

作者：高媛孔丽君王晨公衍道田杰谟赵南明张秀芳清华大学生物科学与技术系生物膜与膜生物工程国家重点实验室北京100084 清华大学核能技术研究院北京100084

以天然牛骨为原料,经过加工处理,分别在1.1.0和1.250℃烧结得到两组牛煅烧骨样品。测定了材料的物理性能,讨论了烧结温度对材料孔隙率及其结构等的影响。将两组煅烧骨样品分别与成骨前体细胞在体外复合培养,通过对细胞生长和分化情况的... 详细信息

以天然牛骨为原料,经过加工处理,分别在1.1.0和1.250℃烧结得到两组牛煅烧骨样品。测定了材料的物理性能,讨论了烧结温度对材料孔隙率及其结构等的影响。将两组煅烧骨样品分别与成骨前体细胞在体外复合培养,通过对细胞生长和分化情况的观察和测定,对两组多孔材料与成骨细胞的亲和性作出了评价。结果表明牛煅烧骨的主要成分为羟基磷灰石,保留了天然骨的网状孔隙结构,成骨细胞在两组材料上均能正常生长和分化,而且在1.1.0℃烧结的样品具有更好的成骨细胞亲和性,说明牛煅烧骨是一种有发展前途和应用前景的骨修复材料和骨组织工程支架材料。

关键词：羟基磷灰石骨结构特征生物相容性

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Detection and classification of breast lesions using multiple information on contrast-enhanced mammography by a multiprocess deep-learning system: A multicenter study

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中国癌症研究:英文版 2023年第4期35卷 408-423页

作者： Yuqian Chen Zhen Hua Fan Lin Tiantian Zheng Heng Zhou Shijie zhang Jing {1. Zhongyi Wang Huafei Shao Wenjuan Li Fengjie Liu Simin Wang yan zhang Feng zhao Hao Liu Haizhu Xie Heng Ma Haicheng zhang ning Mao School of Information and Electronic Engineering Shandong Technology and Business UniversityYantai 264005China Department of Radiology Yantai Yuhuangding HospitalAffiliated Hospital of Qingdao UniversityYantai 264000China School of Medical Imaging Binzhou Medical UniversityYantai 264003China Department of Radiology Fudan University Cancer CenterShanghai 200433China Department of Radiology Guangdong Maternal and Child Health HospitalGuangzhou 510010China School of Computer Science and Technology Shandong Technology and Business UniversityYantai 264005China Yizhun Medical AI Co.Ltd. Beijing 100080China Big Data and Artificial Intelligence laboratory Yantai Yuhuangding HospitalAffiliated Hospital of Qingdao UniversityYantai 264000China

Objective: Accurate detection and classification of breast lesions in early stage is crucial to timely formulate effective treatments for patients. We aim to develop a fully automatic system to detect and classify breast lesions using multiple contrast-enhanced mammography(CEM) ***: In this study, a total of 1.903 females who underwent CEM examination from three hospitals were enrolled as the training set, internal testing set, pooled external testing set and prospective testing set. Here we developed a CEM-based multiprocess detection and classification system(MDCS) to perform the task of detection and classification of breast lesions. In this system, we introduced an innovative auxiliary feature fusion(AFF)algorithm that could intelligently incorporates multiple types of information from CEM images. The average freeresponse receiver operating characteristic score(AFROC-Score) was presented to validate system’s detection performance, and the performance of classification was evaluated by area under the receiver operating characteristic curve(AUC). Furthermore, we assessed the diagnostic value of MDCS through visual analysis of disputed cases,comparing its performance and efficiency with that of radiolo{1.ts and exploring whether it could augment radiolo{1.ts’ ***: On the pooled external and prospective testing sets, MDCS always maintained a high standalone performance, with AFROC-Scores of 0.953 and 0.963 for detection task, and AUCs for classification were 0.909[95% confidence interval(95% CI): 0.822-0.996] and 0.91.(95% CI: 0.840-0.985), respectively. It also achieved higher sensitivity than all senior radiolo{1.ts and higher specificity than all junior radiolo{1.ts on pooled external and prospective testing sets. Moreover, MDCS performed superior diagnostic efficiency with an average reading time of 5 seconds, compared to the radiolo{1.ts’ average reading time of 3.2 min. The average performance of all radiolo{1.ts was also improved to

关键词： Deep learning contrast-enhanced mammography breast lesions detection classification

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STCF conceptual design report (Volume 1.: Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.gao Y.N.gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.gong T.gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui university Hefei 230039China Beihang university Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS key {1. of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central china {1. university Wuhan 430079China Central South university Changsha 410083China china {1. of Geosciences Wuhan 430074China china {1. of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan university Shanghai 200433China Goethe university Frankfurt D-60325 Frankfurt am MainGermany Guangxi normal {1. Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei normal {1. Shijiazhuang 050024China Hebei university Baoding 071002China Hefei university of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan normal {1. Xinxiang 453007China Henan university Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 1. Pokrovsky Bulvar Moscow 109028Russia Huangshan university Huangshan 245000China Hubei university of Automotive Technology Shiyan 442002China Hunan normal {1. Changsha 410081China Hunan university of Science and Technology Xiangtan 411201China Hunan university Changsha 410082China Indiana university BloomingtonIndiana 47405USA Inner Mongolia university Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin university Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×1.^(35) cm^(–2)·s^(–1. or *** STCF will produce a data sample about a factor of 1.0 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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