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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Life-Cycle Bearing Capacity for Pre-Stressed T-beams Based on Full-Scale Destructive Test

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Structural Durability & Health Monitoring 2025年第1期19卷 145-166页

作者： Yushan Ye Tao gao Liankun Wang Junjie Ma Yingchun Cai Heng Liu Xiaoge Liu China Construction Seventh Engineering Division Corp. Ltd.Zhengzhou450004China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou450001China

To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete *** on the measurement and ana-lysis of beam deﬂection,strain,and crack development under various loading levels during the research tests,combined with the veriﬁcation coefﬁcient indicators speciﬁed in the codes,the veriﬁcation coefﬁcients of bridges at different stages of damage can be *** results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test *** the complete linear elastic stage,both the deﬂection and bottom strain veriﬁcation coefﬁcients comply with the speciﬁcations,indicating a good structural load-bearing capacity no longer adheres to the code’s *** the non-linear stage,both coefﬁcients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing *** to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s speciﬁed *** strain veriﬁcation coefﬁcient sourced from the compression zone at the bottom of theﬂange is not recommended for assessing the bridge’s load-bearing capacity.

关键词： Pre-stressed T-beams whole process destructive test bearing capacity veriﬁcation coefﬁcient

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Weakly Supervised Object Localization with Background Suppression Erasing for Art Authentication and Copyright Protection

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Machine Intelligence Research 2024年第1期21卷 89-103页

作者： Chaojie Wu Mingyang Li Ying gao Xinyan Xie Wing W.Y.ng Ahmad Musyafa School of Computer Science and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The problem of art forgery and infringement is becoming increasingly prominent,since diverse self-media contents with all kinds of art pieces are released on the Internet every *** art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copyright ***,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level *** alleviate this,we propose a novel weakly supervised object localization(WSOL)with background su-perposition erasing(BSE),which recognizes objects with inexpensive image-level ***,integrated adversarial erasing(IAE)for vanilla convolutional neural network(CNN)dropouts the most discriminative region by leveraging high-level semantic ***,a background suppression module(BSM)limits the activation area of the IAE to the object region through a self-guidance ***,in the inference phase,we utilize the refined importance map(RIM)of middle features to obtain class-agnostic loc-alization *** experiments are conducted on paintings,CUB-200-2011 and ILSVRC to validate the effectiveness of our BSE.

关键词： Weakly supervised object localization erasing method deep learning computer vision art authentication and copyright protection

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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FeCo alloy@N-doped graphitized carbon as an efficient cocatalyst for enhanced photocatalytic H2 evolution by inducing accelerated charge transfer

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Journal of Energy Chemistry 2021年第1期30卷 92-101,I0004页

作者： Sibo Chen Yun Hau ng Jihai Liao Qiongzhi gao Siyuan Yang Feng Peng Xinhua Zhong Yueping Fang Shengsen Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643GuangdongChina Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510643GuangdongChina School of Energy and Environment City University of Hong KongHongkong 999077China Department of Physics South China University of TechnologyGuangzhou 510640GuangdongChina School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006GuangdongChina

Cocatalysts play important roles in improving the activity and stability of most *** is of great significance to develop economical,efficient and stable ***,using Na2CoFe(CN)6 complex as precursor,a novel noble-metal-free FeCo@ngC cocatalyst(nano-FeCo alloy@N-doped graphitized carbon) is fabricated by a simple pyrolysis *** with g-C3 N4, the optimal FeCo@ngC/g-C3N4 receives a boosted visible light driven photocatalytic H2 evolution rate of 42.2 μmol h-1, which is even higher than that of 1.0 wt% Pt modified g-C3N4 *** on the results of density functional theory(DFT) calculations and practical experiment measurements,such outstanding photocatalytic performance of FeCo@ngC/g-C3N4 is mainly attributed to two *** is the accelerated charge transfer behavior,induced by a photogene rated electrons secondary transfer performance on the surface of FeCo alloy *** other is related to the adjustment of H adsorption energy(approaching the standard hydrogen electrode potential) by the presence of external ngC thin *** factors play key roles in the H2 evolution *** outstanding performance highlights an enormous potential of developing noble-metal-free bimetallic nano-alloy as inexpensive and efficient cocatalysts for solar applications.

关键词： FeCo alloy nanoparticles Cocatalyst N-doped graphitized carbon g-C3N4 Visible light Hydrogen evolution

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Stability analysis of cut-fill and deep patch unsaturated slopes under steady infiltration conditions

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Science China Technological Sciences 2025年第1期 356-367页

作者： Fei ZHAng Shilin JIA Yufeng gao Key Laboratory of the Ministry of Education for Geomechanics and Embankment Engineering College of Civil and Transportation EngineeringHohai University

Cut-fill slopes, as an economical solution in mountainous road construction, are typically jeopardized by cracks and rainfall. Deep patch repair with geosynthetics is an effective technique to mitigate these issues. This paper proposes an upperbound analytical framework for evaluating the stability of cracked cut-fill slopes and deep patch slopes under one-dimensional steady infiltration. The proposed framework is employed to investigate suction-induced effects on slope stability and critical failure surface through a series of parametric analyses. The findings indicate that the suction-induced effect generally increases with air-entry pressure and approaches a constant value. The stability of a cracked cut-fill slope can be enhanced by deep patch repair with geosynthetics. Increasing the deep patch depth enhances local stability and reduces the required reinforcement strength. Generally, the depth of the deep patch should be greater than the crack depth to avoid local failures. Furthermore, a design method involving both local and global stability for deep patch slopes is presented, along with a design example for illustration.

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Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Li, Xufeng Chen, Chunyan Li, Zhenyang Yi, Peng Zou, Haihan Deng, gao Fang, Ming He, Junzhe Sun, Xin Yu, Ronghai Shui, Jianglan Pan, Caofeng Liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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骨科学领域组织透明化技术的应用与展望

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中国组织工程研究 2025年第15期29卷 3227-3234页

作者：高阳高原马炳江岳辉石永新牡丹江医学院黑龙江省牡丹江市157011 深圳大学附属华南医院广东省深圳市518111 深圳市光明区人民医院广东省深圳市518106

背景:骨组织作为高度矿化且结构复杂的结缔组织,在维持生物体形态和功能中扮演关键角色,传统的成像技术难以满足对其深入观察的需求。组织透明化技术的出现使得研究者能够更加清晰地观察到骨内的细微结构,如骨小梁、骨髓腔以及与骨组织... 详细信息

背景:骨组织作为高度矿化且结构复杂的结缔组织,在维持生物体形态和功能中扮演关键角色,传统的成像技术难以满足对其深入观察的需求。组织透明化技术的出现使得研究者能够更加清晰地观察到骨内的细微结构,如骨小梁、骨髓腔以及与骨组织相互作用的神经和血管网络,为骨科学的研究和临床应用开辟了新的视角。目的:旨在全面梳理组织透明化技术在骨科学领域的应用,并探讨其在骨组织结构与功能研究、疾病机制解析以及治疗策略创新中的潜力,同时对其创新点进行展望。方法:检索覆盖中国知网和PubMed数据库,英文检索词为“tissue clearing,tissue optical,bone”等,中文检索词为“组织透明化、骨、骨缺损”等,结合布尔逻辑以优化检索策略。纳入与组织透明化技术和骨科学研究直接相关的期刊论文和学位论文,排除关联性不强、重复或数据不完整的文献。最终纳入82篇文献进行分析,关注点包括透明化技术的效能、应用范围及对骨科学研究的贡献。结果与结论:①组织透明化技术在骨结构分析、骨代谢研究、骨肿瘤的病理学特征、骨折愈合过程、骨感染的机制研究以及骨移植和植入物材料的生物相容性评价等多个领域均展现出其独特的应用优势;②该技术的应用不仅加速了骨科学领域的基础研究进展,也为临床治疗提供了新的策略和方法,其在骨科学研究领域具有广阔的应用前景。

关键词：组织透明化技术骨科学三维成像骨组织生物医学成像

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失效的“压舱石”:经济安全化的现实转向

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国际安全研究 2025年第1期43卷 133-154,159页

作者：高程部彦君中国社会科学院拉丁美洲研究所中国社会科学院大学国际政治经济学院北京100007 同济大学政治与国际关系学院上海200092

经济安全化是国家通过安全叙述将非安全的经济议题转化为安全议题的过程。在国家认为经济合作的收益将损害其在权力竞争中的整体所得时,或者在国家间政治外交关系遇到巨大震荡或冲击时,国家安全逻辑会超越经济逻辑而生效。此时,安全与... 详细信息

经济安全化是国家通过安全叙述将非安全的经济议题转化为安全议题的过程。在国家认为经济合作的收益将损害其在权力竞争中的整体所得时,或者在国家间政治外交关系遇到巨大震荡或冲击时,国家安全逻辑会超越经济逻辑而生效。此时,安全与经济问题在刻意煽动下交织碰撞,国家间密切的经贸关系不仅难以成为管控两国矛盾与分歧的“压舱石”,反而会被国家视作现存的“安全威胁”,成为某些国家中断或破坏双边政治经济联系的借口与手段。国家间存在的经济相互依赖关系也会随之成为安全化操纵国维护与拓展权力、进行地缘政治竞争和打击、操纵他国的战略性工具。因此,文章以存在紧密经济相互依赖的中美与俄欧关系为案例,在比较中美、俄欧之间不同经济安全化动因的基础上,分析经济安全化转向背后的选择逻辑,为中国更好地应对经济安全化挑战、更有针对性地发挥“经济压舱石”作用提供一定思考。

关键词：经济安全化经济压舱石国家安全经济相互依赖

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基于知识图谱技术的计算机网络链路漏洞检测研究

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现代电子技术 2025年第1期48卷 97-101页

作者：辛瑞雯高云山西大学山西太原030006 山西大同大学计算机与网络工程学院山西大同037009

计算机网络链路的漏洞信息具有类型复杂、来源广及数量庞大等特点,导致此类漏洞的威胁判断尤为困难。知识图谱技术具有数据整合及统一表示特性,可以统一结构化整合呈现复杂特点的漏洞信息,为此,文中提出基于知识图谱技术的计算机网络链... 详细信息

计算机网络链路的漏洞信息具有类型复杂、来源广及数量庞大等特点,导致此类漏洞的威胁判断尤为困难。知识图谱技术具有数据整合及统一表示特性,可以统一结构化整合呈现复杂特点的漏洞信息,为此,文中提出基于知识图谱技术的计算机网络链路漏洞检测方法。收集计算机网络链路的各种数据源漏洞信息,抽取其中的漏洞实体知识与关系知识,构建网络链路漏洞知识图谱。运用卷积神经网络模型学习该知识图谱中的漏洞知识,通过训练后的模型实现网络链路漏洞检测。结果显示,该方法可针对包含不同类型、数量链路漏洞的工况,实现漏洞知识图谱的构建,并且漏洞威胁检测精度始终保持在90%以上。因此,说明所研究检测方法的检测结果精准可靠,可为计算机网络链路数据安全传输提供保障。

关键词：知识图谱计算机网络链路漏洞漏洞实体知识关系知识知识抽取网络安全

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