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Value-added anticancer reactivity of sub-5 nm Ag-drug nanoparticles derived from organosilver (Ⅰ) MOF

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Science China Chemistry 2019年第3期62卷 347-354页

作者： Chao-Yu Song Jia-Yuan Zhang Yuan Qiu Hai-Ping Jin Hui-Ming Zhang Shuang Liu Hong Liu Hong-Bin Qiu guang-gang gao School of Basic Medicine Jiamusi University School of Materials Science and Engineering University of Jinan School of Public Health Jiamusi University

A totally structure-determined organosilver(I) metal-oganic framework(MOF) of [{Ag_(18)(CF_3COO)_(18)(H_2O)_2}{Ag_4(erlotinib)_4}]_n·7nCH_3OH·3nH_2O(1) was first synthesized by the self-assembly of erlotinib drug ligand and silver salts in the study. 1 formed a NbO-like 3D network, which was built from Ag(I)-erlotinib induced chains and 18-core silver(I) nanoclusters. When 1 was dispersed in methanol solution, it formed derivative nanoparticles(1-NPs) with the average size of 3.81 nm. Silver(Ⅰ) ion is an efficient reactive oxygen species(ROS) evocator, whereas the erlotinib ligand possesses the targeting activity towards tumor cells. Therefore, IC_(50) values of 1-NPs for A549 and MRC-5 cells were respectively 0.97 and 7.28 μM, which were lower than IC_(50) value of erlotinib. It should be noted that the 7.5-fold higher inhibition effect on A549 cells allows 1-NPs to be a potential targeting anticancer drug for curing lung cancer. The study opens a new avenue to design anticancer drugs based on organosilver(I)MOF derivatives that can realize the value-added reactivity by combining clinical drugs with ROS-inductive silver(Ⅰ) ion.

关键词： erlotinib silver nanocluster targeting A549 cell supramolecular

Mesoporous nickel-iron binary oxide nanorods for efficient electrocatalytic water oxidation

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Nano Research 2017年第6期10卷 2096-2105页

作者： guang Liu Xusheng gao Kaifang Wang Dongying He Jinping Li Research Institute of Special Chemicals Taiyuan University of Technology Taiyuan 030024 China

The design and fabrication of low-cost, high-effidency, and stable oxygen-evolving catalysts are essential for promoting the overall efficiency of water electrolysis. In this study, mesoporous Ni1-xFexOy （0 〈 x 〈 1, 1 〈y 〈 1.5） nanorods were synthesized by the facile thermal decomposition of Ni-Fe-based coordination polymers. These polymers passed their nanorod-like morphology to oxides, which served as active catalysts for oxygen evolution reaction （OER）. Increasing the Fe-doping amount to 33 at.% decreased the particle size and charge-transfer resistance and increased the surface area, resulting in a reduced overpotential （-302 mV） at 10 mA/cm^2 and a reduced Tafel slope （-42 mV/dec）, which were accompanied by a far improved OER activity compared with those of commercial RuO2 and IrO2 electrocatalysts. At Fe-doping concentrations higher than 33 at.%, the trend of the electrocatalytic parameters started to reverse. The shift in the dopant concentration of Fe was further reflected in the structural transformation from a NiO （〈33 at.% Fe） rock-salt structure to a biphasic NiO/NiFe204 （33 at.% Fe） heterostructure, a NiFe204 （66 at.% Fe） spinel structure, and eventually to α-fe203 （100 at.% Fe）. The efficient water-oxidation activity is ascribed to the highly mesoporous one-dimensional nanostructure, large surface area, and optimal amounts of the dopant Fe. The merits of abundance in the Earth, scalable synthesis, and highly efficient electrocatalytic activity make mesoporous Ni-Fe binary oxides promising oxygen-evolving catalysts for water splitting.

关键词： water splitting oxygen evolving electrocatalytic Ni-Fe binary oxide nanorods

Modeling and analysis of passive dynamic bipedal walking with segmented feet and compliant joints

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Acta Mechanica Sinica 2012年第5期28卷 1457-1465页

作者： Yan Huang Qi-Ning Wang Yue gao guang-Ming Xie Intelligent Control Laboratory College of EngineeringPeking University

Passive dynamic walking has been developed as a possible explanation for the efficiency of the human gait. This paper presents a passive dynamic walking model with segmented feet, which makes the bipedal walking gait more close to natural human-like gait. The proposed model extends the simplest walking model with the addition of fiat feet and torsional spring based compliance on ankle joints and toe joints, to achieve stable walking on a slope driven by gravity. The push-off phase includes foot rotations around the toe joint and around the toe tip, which shows a great resemblance to human normal walking. This paper investigates the effects of the segmented foot structure on bipedal walking in simulations. The model achieves satisfactory walking results on even or uneven slopes.

关键词： Passive dynamic walking · Segmented feet·Compliant joints· Bipeds

Efficient and selective recovery of Ni, Cu, and Co from low-nickel matte via a hydrometallurgical process

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International Journal of Minerals,Metallurgy and Materials 2017年第3期24卷 249-256页

作者： guang-ju Chen Jian-ming gao Mei Zhang Min Guo School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China

Low-nickel matte was intensively characterized, and Ni, Cu, and Co were determined to exist mainly as (Fe,Ni)9S8and FeNi3, Cu5FeS4, and (Fe,Ni)9S8and Fe3O4(in isomorphic form), respectively. The efficient and selective extraction of Ni, Cu, and Co from the low-nickel matte in an (NH4)2S2O8/NH3·H2O solution system was studied. The effects of (NH4)2S2O8and NH3·H2O concentrations, leaching time, and leaching temperature on the metal extraction efficiency were systematically investigated. During the oxidative ammonia leaching process, the metal extraction efficiencies of Ni 81.07%, Cu 93.81%, and Co 71.74% were obtained under the optimal conditions. The relatively low leaching efficiency of Ni was mainly ascribed to NiFe alloy deactivation in ammonia solution. By introducing an acid pre-leaching process into the oxidative ammonia leaching process, we achieved the high extraction efficiencies of 98.03%, 99.13%, and 85.60% for the valuable metals Ni, Cu, and Co, respectively, from the low-nickel matte. © 2017, University of Science and Technology Beijing and Springer-Verlag Berlin Heidelberg.

关键词： Ammonia Cobalt Copper Efficiency Hydrometallurgy Leaching Nickel

Analysis of Direct and Inverse Cavity Scattering Problems

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Numerical Mathematics(Theory,Methods and Applications) 2011年第3期4卷 335-358页

作者： gang Bao Jinglu gao Peijun Li Department of Mathematics Zhejiang UniversityHangzhou 310027China. Department of Mathematics Michigan State UniversityEast LansingMI 48824USA. School of Mathematical Sciences Jilin UniversityChangchun 130023China. Department of Mathematics Purdue UniversityWest LafayetteIN 47907USA.

Consider the scattering of a time-harmonic electromagnetic plane wave by an arbitrarily shaped and filled cavity embedded in a perfect electrically conducting infinite ground plane.A method of symmetric coupling of finite element and boundary integral equations is presented for the solutions of electromagnetic scattering in both transverse electric and magnetic polarization *** the incident field,the direct problem is to determine the field distribution from the known shape of the cavity;while the inverse problem is to determine the shape of the cavity from the measurement of the field on an artificial boundary enclosing the *** this paper,both the direct and inverse scattering problems are discussed based on a symmetric coupling *** formulations for the direct scattering problem are presented,existence and uniqueness of weak solutions are studied,and the domain derivatives of the field with respect to the cavity shape are *** and local stability results are established in terms of the inverse problem.

关键词： Electromagnetic cavity direct problem inverse problem finite element methods boundary integral equations.

Geochemistry of borehole cutting shale and natural gas accumulation in the deepwater area of the Zhujiang River Mouth-Qiongdongnan Basin in the northern South China Sea

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Acta Oceanologica Sinica 2018年第2期37卷 44-53页

作者： gao gang ZHANG Gongcheng CHEN Guo gang Wenzhe SHEN Huailei ZHAO Ke State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum (Beijing) Beijing 102249 China Research Institute CNOOC Beijing 100020 China Geophysical Exploration Research Institute of Huabei Oilfield Company Renqiu 062552 China

The Qiongdongnan Basin and Zhujiang River（Pearl River） Mouth Basin, important petroliferous basins in the northern South China Sea, contain abundant oil and gas resource. In this study, on basis of discussing impact of oil-base mud on TOC content and Rock-Eval parameters of cutting shale samples, the authors did comprehensive analysis of source rock quality, thermal evolution and control effect of source rock in gas accumulation of the Qiongdongnan and the Zhujiang River Mouth Basins. The contrast analysis of TOC contents and Rock-Eval parameters before and after extraction for cutting shale samples indicates that except for a weaker impact on Rock-Eval parameter S2, oil-base mud has certain impact on Rock-Eval S1, Tmax and TOC contents. When concerning oil-base mud influence on source rock geochemistry parameters, the shales in the Yacheng/Enping,Lingshui/Zhuhai and Sanya/Zhuhai Formations have mainly Type Ⅱ and Ⅲ organic matter with better gas potential and oil potential. The thermal evolution analysis suggests that the depth interval of the oil window is between 3 000 m and 5 000 m. Source rocks in the deepwater area have generated abundant gas mainly due to the late stage of the oil window and the high-supper mature stage. Gas reservoir formation condition analysis made clear that the source rock is the primary factor and fault is a necessary condition for gas accumulation. Spatial coupling of source, fault and reservoir is essential for gas accumulation and the inside of hydrocarbon-generating sag is future potential gas exploration area.

关键词： cutting shale organic geochemistry gas accumulation deepwater area Qiongdongnan Basin Zhujiang River Mouth Basin

Nonsynchronized state estimation of uncertain discrete-time piecewise affine systems

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控制理论与应用（英文版） 2010年第3期8卷 286-292页

作者： Jianbin QIU gang FENG Huijun gao Space Control and Inertial Technology Research Center Harbin Institute of Technology Harbin Heilongjiang 150001 China Department of Manufacturing Engineering and Engineering Management City University of Hong Kong Hong Kong China

This paper investigates the problem of robust H-infinity state estimation for a class of uncertain discretetime piecewise affine systems where state space instead of measurable output space partitions are assumed so that the filter implementation may not be synchronized with plant state trajectory transitions. Based on a piecewise quadratic Lyapunov function combined with S-procedure and some matrix inequality convexifying techniques, two different approaches are developed to the robust filtering design for the underlying piecewise affine systems. It is shown that the filter gains can be obtained by solving a set of linear matrix inequalities （LMIs）. Finally, a simulation example is provided to illustrate the effectiveness of the proposed approaches.

关键词： Piecewise affine systems State estimation Linear fractional uncertainties Linear matrix inequality

Source identification of aluminum in surface sediments of the Yellow Sea off the Shandong Peninsula

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Acta Oceanologica Sinica 2015年第12期34卷 147-153页

作者： XU gang LIU Jian PEI Shaofeng KONG Xianghuai HU gang gao Maosheng Qingdao Institute of Marine Geology Ministry of Land and Natural Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and Technology Key Laboratory of Ministry of Land and Natural Resources for Marine Hydrocarbon Resources and Environment Geology Key Laboratory of China Geological Survey Bureau for Coastal Wetland Biogeosciences

Surface sediment samples in the near shore area of the north Shandong Peninsula are collected for grain size and element analyses. The results indicate that the surface sediments in the study area are primarily composed of the silt-sized components similar to the Huanghe River. The total concentration of aluminum varies from 5.57% to7.37%（average（6.33 ± 0.40）%）, and its spatial distribution is mainly controlled by the grain size. Correlations between the ratio of aluminum to titanium concentration and aluminum concentration, titanium concentration and the mean grain size indicate that aluminum in the near shore surface sediments is affected majorly by the terrigenous source, and partially by the anthropogenic source. The ratios of aluminum to titanium concentrations are larger than the background value of loess matter at some stations due to the existence of excess aluminum associated with human activities. Thus, the sources of aluminum should be identified firstly when aluminum is used as an index of terrigenous matter even in the near shore area dominated by terrigenous deposits.

关键词： aluminum source identification surface sediments Shandong Peninsula Yellow Sea

Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches

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Science China Life Sciences 2025年第1期 232-248页

作者： Yaohan Jiang Xiao Chen Chundi Wang Liping Lyu Saleh A.Al-Farraj Naomi A.Stover Feng gao Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Marine College Shandong University Zoology Department College of ScienceKing Saud University Department of Biology Bradley University Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology Center

Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all *** protists, which contain both germline and somatic genomes within a single cell, have evolved a special form of sexual reproduction called conjugation that involves mitosis, meiosis, fertilization, nuclear differentiation, genome rearrangement, and the development of unique cellular structures. The molecular basis and mechanisms of conjugation vary dramatically among ciliates, and many details of the process and its regulation are still largely unknown. In order to better comprehend these processes and mechanisms from an evolutionary perspective, this study provides the first comprehensive overview of the transcriptome and proteome profiles during the entire life cycle of the newly-established marine model ciliate Euplotes vannus. Transcriptome analyses from 14 life cycle stages(three vegetative stages and 11 sexual stages) revealed over 26,000 genes that are specifically expressed at different stages, many of which are related to DNA replication,transcription, translation, mitosis, meiosis, nuclear differentiation, and/or genome rearrangement. Quantitative proteomic analyses identified 338 proteins with homologs associated with conjugation and/or somatic nuclear development in other ciliates, including dicer-like proteins, Hsp90 proteins, RNA polymerase Ⅱ and transcription elongation factors, ribosomal-associated proteins, and ubiquitin-related proteins. Four of these homologs belong to the PIWI family, each with different expression patterns identified and confirmed by RT-qPCR,which may function in small RNA-mediated genome rearrangement. Proteins involved in the nonhomologous end-joining pathway are induced early during meiosis and accumulate in the developing new somatic nucleus, where more than 80% of the germline sequences are eliminated from the somatic genome. A number of new candidate genes and proteins likely t

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