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Prevalence of Acne Inversa(Hidradenitis Suppurativa)in China:A Nationwide Cross-Sectional Epidemiological Study

International Journal of Dermatology and Venereology 2022年第1期5卷 1-7页

作者： Zhong-Shuai Wang Jing Li qiang Ju Wei Lai Song-Mei Geng Xiao-Jing kang Xian Jiang hong-Zhong Jin hong-fu Xie Qing Sun Hang Li Shan-Shan Li Chen Yuan Li He hong Fang Gang Wang Juan Tao Xing-Hua gao Yan Wu You-Kun Lin Yu-Zhen Li Jun Gu Yan Yan Baoxi Wang Department of Dermatology Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China Department of Dermatology The Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdong 510630China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Peking University First HospitalBeijing 100034China Department of Dermatology the First Bethune Hospital of Jilin UniversityChangchunJilin 130021China Department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology Xijing HospitalAir Force Medical University of PLAXi’anShaanxi 710032China Department of Dermatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Dermatology the First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Dermatology the First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Department of Dermatology t

Objective:This study was performed to estimate the prevalence of hidradenitis suppurativa(HS)in China and describe the demographic and clinical features of HS in the Chinese ***:This multicenter clinic-based cross-sectional study was conducted in dermatology clinics within 19 hospitals located in 15 cities/provinces across China from September to October *** prevalence of HS was calculated as the percentage of patients with HS among all visitors at participating clinics during the 1-month study *** was independently diagnosed by two certified dermatologists at each *** visitors at participating clinics were screened,and all patients with HS were invited to participate in a questionnaire survey to elucidate the demographics and clinical features of HS in the Chinese ***:We identified 92 patients with HS among 274,742 visitors at participating *** prevalence rate was 0.03349%or 33.49 per 100,000 population(95%confidence interval,26.64–40.32),and the female:male ratio was 1.0:***:The overall prevalence of HS in China was lower than that in Western and other Asian countries with a predominance of male patients.

关键词： acne inversa/hidradenitis suppurativa epidemiology China

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Associations between serum uric acid and hepatobiliary-pancreatic cancer:A cohort study

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World Journal of Gastroenterology 2020年第44期26卷 7061-7075页

作者： Chong-Fei Huang Jun-Jun Huang Ning-Ning Mi Yan-Yan Lin qiang-Sheng He Ya-Wen Lu Ping Yue Bing Bai Jin-Duo Zhang Chao Zhang Teng Cai Wen-kang fu Long gao Xun Li Jin-Qiu Yuan Wen-Bo Meng The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Special Minimally Invasive Surgery Department The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Institute of Genetics School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina Gansu Province Institute of Hepatopancreatobiliary Lanzhou 730000Gansu ProvinceChina Gansu Province Key Laboratory Biotherapy and Regenerative Medicine Lanzhou 730000Gansu ProvinceChina Scientific Research and Planning Department The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Clinical Research Center and Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina The Fifth Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Uric acid is the end product of purine *** studies have found that serum uric acid(SUA)levels are associated with the total cancer ***,due to the dual effect of uric acid on cancer,the relationship between the SUA levels and most specific-site cancer remains *** To investigate the associations between the SUA levels and incidence of hepatobiliary-pancreatic *** In this prospective cohort study,444462 participants free of cancer from the UK Biobank were *** SUA levels were measured at baseline,and the incidence of hepatobiliary-pancreatic cancer was determined by contacting the cancer *** hazard ratios(HRs)and 95%confidence intervals(CIs)between the SUA levels and hepatobiliary-pancreatic cancer were investigated using multiple adjusted Cox regression models adjusted for potential *** In total,920 participants developed liver,gallbladder,biliary tract or pancreatic cancer during a median of 6.6 yrs of *** found that the HR of pancreatic cancer in the highest SUA group was 1.77(95%CI:1.29-2.42)compared with that in the lowest *** stratifying by gender,we further found that SUA was associated with an increased risk of pancreatic cancer only among the females(highest quartile vs lowest quartile HR 2.04,95%CI:1.35-3.08).Among the males,the SUA levels were positively associated with the gallbladder cancer risk(highest quartile vs lowest quartile HR 3.09,95%CI:1.28-7.46),but a U-shaped association with the liver cancer risk was observed(P-nonlinear=0.03).CONCLUSION SUA is likely to have gender-specific effects on hepatobiliary-pancreatic *** SUA levels are a risk factor for pancreatic cancer in females and gallbladder cancer in males.A U-shaped association with the liver cancer risk was identified.

关键词： Uric acid Liver neoplasms Pancreatic neoplasms Gallbladder neoplasms Biliary tract neoplasms Cohort studies

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Diagnosis and Treatment of Acne Inversa/Hidradenitis Suppurativa in China: An Expert Consensus Statement (2021 Version)

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International Journal of Dermatology and Venereology 2021年第2期4卷 100-108页

作者： hong Fang Xing-Hua gao Song-Mei Geng Heng Gu Jun Gu Li He Xian Jiang hong-Zhong Jin qiang Ju Xiao-Jing kang Wei Lai Cheng-Xin Li Hang Li Heng-Jin Li Shan-Shan Li Yu-Zhen Li Qing Sun Juan Tao Baoxi Wang Gang Wang Xin-Feng Wu Lei-hong Xiang hong-fu Xie Hao-Xiang Xu Jin-Hua Xu Yan Yan Zhi-Zhong Zheng Department of Dermatology The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang 310003China Department of Dermatology No.1 Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Dermatology Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200025China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of Dermatology and Venereology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Dermatology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Dermatology and Venerology Peking University First HospitalBeijing 100034China Department of Dermatology Hainan Hospital of PLA General HospitalSanyaHainan 572013China Department of Dermatology and Venereology The First Hospital of Jilin UniversityChangchunJilin 130021China Department of Dermatology Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Affiliated Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China De

Acne inversa/hidradenitis suppurativa is a chronic,recurrent,inflammatory skin disease that affects the pilosebaceous units,causinfollicular *** etiology and pathogenesis of acne inversa/hidradenitis suppurativa involves internal and external factors such as genetic susceptibility,inflammation and immunity,microorganisms,obesity,and *** inversa/hidradenitis suppurativa is difficult to treat,and the current aim of treatment is to control the frequency and duration of disease flares and improve the quality of *** protocols for acne inversa/hidradenitis suppurativa should be selected based on the disease severity *** treatments include antibiotics,retinoids,biologics,immunosuppressive agents,and antiandrogen *** treatments include surgery and laser/light *** consensus aims to further standardize the diagnosis and treatment procedures of acne inversa/hidradenitis suppurativa in China to facilitate its diagnosis and treatment.

关键词： acne inversa consensus diagnosis hidradenitis suppurativa therapy

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基于RGB的颜色辨识系统设计

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传感器与微系统 2012年第10期31卷 84-87页

作者：高富强李岭安康重庆大学自动化学院重庆400044 重庆大学光电技术及系统教育部重点实验室ICT研究中心重庆400044

传统颜色辨识系统需要白平衡调整,引入了人为误差,造成辨别精度较差。介绍了一种改进型颜色辨识方案,采用TCS3200D颜色传感器将颜色信号转换为数字信号后直接送至AT89C52单片机处理,硬件电路简单,在基本型软件算法的基础上设计了改进型... 详细信息

传统颜色辨识系统需要白平衡调整,引入了人为误差,造成辨别精度较差。介绍了一种改进型颜色辨识方案,采用TCS3200D颜色传感器将颜色信号转换为数字信号后直接送至AT89C52单片机处理,硬件电路简单,在基本型软件算法的基础上设计了改进型软件算法流程,避免了白平衡调整引入的人为误差,有效提高了辨识精度。实验结果表明:系统对不同颜色辨识速度快、精度高,可广泛应用于各种需要对颜色成分进行分析、辨识的行业。

关键词： RGB 颜色辨识 TCS3200D 改进型算法 AT89C52

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X射线工业CT中的数据采集

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核电子学与探测技术 2007年第4期27卷 688-691页

作者：高富强卢华曹鹏安康江仁清重庆大学ICT研究中心重庆大学自动化学院重庆400030

介绍了X射线工业CT中数据采集的一种方法。将X射线转换成与之成线性关系的微弱电流信号,通过检测电流信号测量出X射线的相对强度。这种采集方法可根据X射线的剂量强度,灵活的改变电流检测电路的参数,因此适用于不同能量级的X射线的采集... 详细信息

介绍了X射线工业CT中数据采集的一种方法。将X射线转换成与之成线性关系的微弱电流信号,通过检测电流信号测量出X射线的相对强度。这种采集方法可根据X射线的剂量强度,灵活的改变电流检测电路的参数,因此适用于不同能量级的X射线的采集。该X射线采集方法已经成功应用工业CT数据采集系统中。

关键词：数据采集弱电流检测 FPGA X射线

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工业CT数据采集系统

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核电子学与探测技术 2008年第3期28卷 556-559页

作者：高富强安康卢华曹鹏江仁清高福兵重庆大学ICT研究中心重庆400030 重庆大学自动化学院重庆400030 重庆通信学院重庆400035

工业CT机中需要对数百通道微弱光信号同时进行数据采集传输,本文介绍的系统是为满足这一要求而设计;系统采用FPGA+20位积分转化芯片模式构建探测部分,采用FPGA+AMCCS5335模式主控采集部分;运用多级缓存机制解决了实际应用中出现的数据... 详细信息

工业CT机中需要对数百通道微弱光信号同时进行数据采集传输,本文介绍的系统是为满足这一要求而设计;系统采用FPGA+20位积分转化芯片模式构建探测部分,采用FPGA+AMCCS5335模式主控采集部分;运用多级缓存机制解决了实际应用中出现的数据阻塞、丢失问题;该设计已应用于重庆大学ICT中心的多台工业CT机中,取得了良好的效果。

关键词：数百通道 FPGA PCI 数据采集传输多级缓存机制

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超大直径盾构隧道下穿黄河大堤沉降分析与控制研究

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现代隧道技术 2022年第3期59卷 211-219页

作者：朱牧原魏力峰方勇付强高腾达蒲松西南交通大学交通隧道工程教育部重点实验室成都610031 中铁十四局集团大盾构工程有限公司南京250032

为合理控制超大直径泥水平衡盾构下穿黄河大堤过程中产生的沉降,依托济泺路穿黄隧道工程,首先结合理论分析,提出了下穿大堤的盾构参数配置,并通过现场实测数据分析了盾构隧道穿堤过程中大堤段沉降的规律与特点,然后建立数值计算模型,精... 详细信息

为合理控制超大直径泥水平衡盾构下穿黄河大堤过程中产生的沉降,依托济泺路穿黄隧道工程,首先结合理论分析,提出了下穿大堤的盾构参数配置,并通过现场实测数据分析了盾构隧道穿堤过程中大堤段沉降的规律与特点,然后建立数值计算模型,精细化动态模拟盾构隧道掘进过程,围绕切口水压和注浆压力分析盾构参数对黄河大堤沉降的影响,最后对大堤变坡段的掘进参数过渡方案进行比选。结果表明:相较于普通平地段,大堤段在盾尾脱出阶段的沉降初期速率更大且更易受扰动影响,且大堤顶部对深层土体的扰动较为敏感;穿堤过程中提高盾构隧道掘进参数有利于沉降控制,但控制程度存在上限,提前进行掘进参数调整有利于进一步减小沉降,建议在穿堤过程中将切口水压从300~350 kPa逐渐增至500~550 kPa,并提前10~15环进行参数过渡。

关键词：穿黄隧道泥水平衡盾构黄河大堤沉降实测分析数值模拟

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高速多通道γ射线工业CT数据采集系统

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核电子学与探测技术 2011年第7期31卷 742-746页

作者：高富强陈晟飞戴正国安康重庆大学光电技术及系统教育部重点实验室ICT研究中心重庆大学自动化学院中国人民解放军63867部队

为满足γ射线工业CT的高速多通道数据采集要求,设计了针对性的高速数据采集系统实现数据的采集和处理。γ射线转换为放大的电流信号后,经信号处理电路进行放大、甄别、分频处理,然后信号经FPGA计数单元整理后传送到主控FPGA。主控FPGA... 详细信息

为满足γ射线工业CT的高速多通道数据采集要求,设计了针对性的高速数据采集系统实现数据的采集和处理。γ射线转换为放大的电流信号后,经信号处理电路进行放大、甄别、分频处理,然后信号经FPGA计数单元整理后传送到主控FPGA。主控FPGA作为控制核心,对配置为Slave FIFO工作模式的USB2.0内部的FIFO进行控制,数据通过块传输方式传输到上位机进行图像重建。为了现场采集的实际需求,系统的计数单元可以扩展,以实现更多通道的数据采集。实验结果表明:系统传输速度快,约为35 MB/s;并且最多可以扩展11片计数单元,采集1 024通道的数据。能够满足γ射线工业CT数据采集传输高速要求。

关键词： γ射线工业CT 数据采集 FPGA USB2.0 Slave FIFO

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一种X射线测厚校正方法的研究

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核电子学与探测技术 2013年第5期33卷 621-623,646页

作者：高富强陈赟飞安康周钦重庆大学自动化学院重庆400030 重庆大学光电技术及系统教育部重点实验室ICT研究中心重庆400030

针对工业CT系统中所使用的X射线是一种多能谱射线,进而导致厚度测量不准确的现象,介绍了X射线测厚原理,分析了X射线在对物体进行厚度测量时发生射束硬化现象对测量结果的影响,推导出一种用于测厚的校正数学模型,并通过CD-300BXR型工业C... 详细信息

针对工业CT系统中所使用的X射线是一种多能谱射线,进而导致厚度测量不准确的现象,介绍了X射线测厚原理,分析了X射线在对物体进行厚度测量时发生射束硬化现象对测量结果的影响,推导出一种用于测厚的校正数学模型,并通过CD-300BXR型工业CT研究平台对该数学模型进行了验证。实验结果表明,当被测钢板厚度范围为5～50 mm时,利用该校正模型进行测厚的相对误差在±0.5%以内,能满足实际测厚需求。

关键词：工业CT X射线测厚校正模型实验

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4,5-二(1H-四唑-5-基)-1H-咪唑的合成及热性能

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含能材料 2013年第4期21卷 443-448页

作者：毕福强李吉祯许诚樊学忠高红旭康冰葛忠学刘庆西安近代化学研究所陕西西安710065

以N,N-二甲基甲酰胺(DMF)为溶剂,优化了4,5-二(1H-四唑-5-基)-1H-咪唑(H3BT I)的合成工艺:4,5-二氰基咪唑、叠氮化钠和氯化铵的摩尔比为1:2.2:2.2,反应温度90℃,反应时间8 h,收率为94.6%。通过红外光谱、1HNMR、13C N M R和元素分析对H3... 详细信息

以N,N-二甲基甲酰胺(DMF)为溶剂,优化了4,5-二(1H-四唑-5-基)-1H-咪唑(H3BT I)的合成工艺:4,5-二氰基咪唑、叠氮化钠和氯化铵的摩尔比为1:2.2:2.2,反应温度90℃,反应时间8 h,收率为94.6%。通过红外光谱、1HNMR、13C N M R和元素分析对H3BTI的结构进行了表征,采用DSC和T G/DT G技术研究了H3BT I的热分解性能,用非等温DSC技术研究了热分解反应动力学。研究结果表明,H3BT I的活化能为197.62 kJ·mol-1,指前因子为16.16;H3BTI的临界爆炸温度为556.38 K,大于R DX的487.90 K,表明其热稳定性优于R DX;热分解反应的活化熵、活化焓和活化自由能分别为35.72 J·mol-1·K-1、193.66 kJ·mol-1和173.33 kJ·mol-1。

关键词：应用化学含能材料 4 5-二(1 H-四唑-5-基)-1 H-咪唑合成热性能

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