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Extracellular matrix gel is necessary for in vitro cultivation of insulin producing cells from human umbilical cord blood derived mesenchymal stem cells

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Chinese Medical Journal 2008年第9期121卷 811-818页

作者： gao feng wu de-quan hu yan-hua jin guang-xin department of General Surgery the Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China

Background Pancreatic islet cell transplantation is an effective approach to treat type 1 diabetes. However, this therapy is not widely used because of the severe shortage of transplantable donor islets. This study investigated whether mesenchymal stem cells （MSCs） derived from human umbilical cord blood （UCB） could be transdifferentiated into insulin producing cells in vitro and the role of extracellular matrix （ECM） gel in this procedure. Methods human UCB samples were collected and MSCs were isolated. MSCs specific marker proteins were analyzed by a flow cytometer, The capacities of osteoblast and adipocyte to differentiate were tested. Differentiation into islet like cell was induced by a 15-day protocol with or without ECM gel. Pancreatic characteristics were evaluated with immunofluorescence, reverse transcription polymerase chain reaction （RT-PCR） and flow cytometry. Insulin content and release in response to glucose stimulation were detected with chemiluminescent immunoassay system. Results Sixteen MSCs were isolated from 42 term human UCB units （38%）. human UCB-MSCs expressed MSCs specific markers and could be induced in vitro into osteoblast and adipocyte. Islet like cell clusters appeared about 9 days after pancreatic differentiation in the inducing system with ECM gel. The insulin positive cells accounted for （25.2~3.4）% of the induced cells. The induced cells expressed islet related genes and hormones, but were not very responsive to glucose challenge. When MSCs were induced without ECM gel, clusters formation and secretion of functional islet proteins could not be observed, Conclusions human UCB-MSCs can differentiate into islet like cells in vitro and ECM gel plays an important role in pancreatic endocrine cell maturation and formation of three dimensional structures.

关键词： umbilical cord blood mesenchymal stem cells induction insulin producing cells extracellular matrix

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A secretory function of human insulin-producing cells in vivo

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 255-260页

作者： hu, yan-hua wu, de-quan gao, feng Li, Guo-Dong Yao, Lei Zhang, xin-Chen Harbin Med Coll Dept Gen Surg Affiliated Hosp 2 Harbin 150086 Peoples R China

BACKGROUND: Mesenchymal stem cells derived from human umbilical cord blood (UCB-MSCs) have good research and application prospects in the treatment of diabetes. We once induced UCB-MSCs to differentiate into insulin-producing cells (IPCs) in vitro, but we did not know the functions of these cells in vivo. The aim of this study was to assess the functional effects of IPCs on insulin secretion and their role in the treatment of diabetes in vivo. METHODS: UCB-MSCs were induced to IPCs by an inducing protocol with extracellular matrix gel. BALB/C nude mice were made hyperglycemic by intraperitoneal injection of streptozotocin. The diabetic mice were transplanted with 1x10(7) IPCs under the renal capsule or with phosphate-buffered saline as a control. After transplantation, the grafts were analyzed by immunocytochemistry for the expression of human insulin; the serum human insulin levels were measured; and blood glucose and body weight status were monitored. RESULTS: Immunofluorescence showed that numerous IPCs under the kidney capsule were insulin-positive. On day 14 after transplantation, the serum human insulin level of the treatment group (n=9) averaged 0.44 +/- 0.12 mU/L, which was higher than that of the control group (n=9) that did not express insulin (t=10.842, Phuman insulin in diabetic mice, but more research is needed to make further use of them to regulate hyperglycemia and body weight in vivo. (Hepatobiliary Pancreat Dis Int 2009; 8: 255-260)

关键词： human umbilical cord blood mesenchymal stem cells insulin-producing cells diabetes cell transplantation

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Notch signaling： a novel regulating differentiation mechanism of human umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells in vitro

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Chinese Medical Journal 2010年第5期123卷 606-614页

作者： hu yan-hua wu de-quan gao feng LI Guo-dong ZHANG xin-chen department of General Surgery Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150086 China

Background human umbilical cord blood-derived mesenchymal stem cells （UCB-MSCs） could be induced to differentiate into insulin producing cells （IPCs） in vitro, which have good application potential in the cell replacement treatment of type-1 diabetes. However, the mechanisms regulating this differentiation have remained largely unknown. Notch signaling is critical in cell differentiation. This study investigated whether Notch signaling could regulate the IPCs differentiation of human UCB-MSCs. Methods Using an interfering Notch signaling protocol in vitro, we studied the role of Notch signaling in differentiation of human UCB-MSCs into IPCs. In a control group the induction took place without interfering Notch signaling. Results human UCB-MSCs expressed the genes of Notch receptors （Notch 1 and Notch 2） and ligands （Jagged 1 and deltalike 1）. human UCB-MSCs with over-expressing Notch signaling in differentiation resulted in the down-regulation of insulin gene level, proinsulin protein expression, and insulin-positive cells percentage compared with the control group. These results showed that over-expressing Notch signaling inhibited IPCs differentiation. Conversely, when Notch signaling was attenuated by receptor inhibitor, the induced cells increased on average by 3.06-fold （n=-4, P 〈0.001） in insulin gene level, 2.60-fold （n=-3, P 〈0.02） in proinsulin protein expression, and 1.62-fold （n=-6, P 〈0.001） in the rate of IPCs compared with the control group. Notch signaling inhibition significantly promoted IPCs differentiation with about 40% of human UCB-MSCs that converted to IPCs, but these IPCs were not responsive to glucose challenge very well both in vitro and in vivo. Hence, further research has to be carried out in the future. Conclusions Notch signaling may be an important mechanism regulating IPCs differentiation of human LICB-MSCs in vitro and Notch signaling inhibition may be an efficient way to increase the number of IPCs, which may resolve the shortage of

关键词： Notch signaling mesenchymal stem cells differentiation insulin producing cells diabetes

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Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes

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Nuclear Science and Techniques 2024年第4期35卷 208-220页

作者： Ao-yan Cheng Hao Cai Shi Chen Tian-Lu Chen Xiang Dong You-Liang feng Qi gao quan-Bu Gou Yi-Qing Guo Hong-Bo hu Ming-Ming Kang Hai-jin Li Chen Liu Mao-Yuan Liu Wei Liu Fang-Sheng Min Chu-Cheng Pan Bing-Qiang Qiao Xiang-Li Qian hui-Ying Sun Yu-Chang Sun Ao-Bo Wang Xu Wang Zhen Wang guang-guang xin Yu-hua Yao Qiang Yuan Yi Zhang School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650091China Ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China College of Physics Sichuan UniversityChengdu 610064China School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Aerospace Information Research Institute Suzhou 215123China College of Physics Chongqing UniversityNo.55 Daxuecheng South RoadHigh‑tech DistrictChongqing 401331China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China

The High Altitude detection of Astronomical Radiation(HADAR)experiment,which was constructed in Tibet,China,combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity advantages of focused Cherenkov *** objective is to observe transient sources such as gamma-ray bursts and the counterparts of gravitational *** study aims to utilize the latest AI technology to enhance the sensitivity of HADAR *** datasets and models with distinctive creativity were constructed by incorporating the relevant physical theories for various *** models can determine the type,energy,and direction of the incident particles after careful *** obtained a background identification accuracy of 98.6%,a relative energy reconstruction error of 10.0%,and an angular resolution of 0.22°in a test dataset at 10 *** findings demonstrate the significant potential for enhancing the precision and dependability of detector data analysis in astrophysical *** using deep learning techniques,the HADAR experiment’s observational sensitivity to the Crab Nebula has surpassed that of MAGIC and *** energies below 0.5 TeV and remains competitive with conventional narrow-field Cherenkov telescopes at higher *** addition,our experiment offers a new approach for dealing with strongly connected,scattered data.

关键词： VHE gamma-ray astronomy HADAR deep learning Convolutional neural networks

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Estimated prevalence and sociodemographic correlates of mental disorders in medical students of Hebei Province,China:A crosssectional study

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World Journal of Psychiatry 2023年第5期13卷 215-225页

作者： Wen-Ting Lu Pei-hua hu Na Li Lan Wang Ran Wang Zeng Wang Mei Song Tian-Yu Zhao Shi-Jie Guo Fan-Fan huang Bu-Fan Liu Ruo-Jia Ren Li yang quan Lin Yue-Hang Xu Na jin huan Chen Yuan-Yuan gao Zhi-feng wu guang-Yu Shi Da-Peng Liu Zhong-Qi Pan Chun-Chao Du Cui-Xia An Xue-Yi Wang Mental Health Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Technical Innovation Center Mental Health Assessment and InterventionShijiazhuang 050031Hebei ProvinceChina Hebei Clinical Research Center of Mental Disorders Institute of Mental HealthShijiazhuang 050031Hebei ProvinceChina Counseling and Mental Health Research Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Saitron Information Technology Co. LtdCangzhou 060000Hebei ProvinceChina

BACKGROUND In China,the identification rate and treatment rate of mental disorders are low,and there are few surveys on the prevalence of mental disorders among college students using diagnostic tools such as Mini-International Neuropsychiatric Interview(MINI),so the prevalence and treatment of mental disorders among college students are *** To estimate prevalence of mental disorders among medical students in Hebei Province,and provide guidance for improving their mental *** This was a cross-sectional study based on an Internet-based *** levels of medical students in Hebei Province were randomly selected(by cluster sampling)for *** the information network assessment system,the subjects scanned the 2D code with their mobile phones,clicked to sign the informed consent,and answered a scale.A self-designed general status questionnaire was used to collect information about age,gender,ethnicity,grade,and origin of *** MINI *** used to investigate mental *** analysis was performed with SPSS *** significant findings were determined using a two-tailed P value of *** A total of 7117 subjects completed the survey between October 11 and November 7,*** estimated prevalence of any mental disorders within 12 mo was 7.4%.Mood disorders were the most common category(4.3%),followed by anxiety disorders(3.9%);15.0%had been to psychological counseling,while only 5.7%had been to a psychiatric consultation,and only 10%had received drug therapy in the past 12 *** Although the estimated prevalence of mental disorders in medical students is lower than in the general population,the rate of adequate treatment is *** determined that improving the mental health of medical students is an urgent matter.

关键词： Hebei sectional college

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Disappearance of Superconductivity and a Concomitant Lifshitz Transition in Heavily Overdoped Bi_2Sr_2CuO_6 Superconductor Revealed by Angle-Resolved Photoemission Spectroscopy

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Chinese Physics Letters 2019年第1期36卷 60-64页

作者： Ying Ding Lin Zhao Hong-Tao yan Qiang gao jing Liu Cheng hu Jian-Wei huang Cong Li Yu Xu Yong-Qing Cai Hong-Wao Rong Ding-Song wu Chun-Yao Song hua-Xue Zhou Xiao-Li Dong Guo-Dong Liu Qing-yan Wang Shen-jin Zhang Zhi-Min Wang feng-feng Zhang feng yang Qin-JunPeng Zu-yan Xu Chuang-Tian Chen X.J.Zhou Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Technical Institute of Physics and Chemistry Chinese Academy of Sciences Collaborative Innovation Center of quantum Matter

By partially doping Pb to effectively suppress the superstructure in single-layered cuprate Bi_2Sr_2CuO_(6+δ)(Pb-Bi2201) and annealing them in vacuum or in high pressure oxygen atmosphere, a series of high quality Pb-Bi2201 single crystals are obtained with T_c covering from 17 K to non-superconducting in the overdoped region. High resolution angle resolved photoemission spectroscopy measurements are carried out on these samples to investigate the evolution of the Fermi surface topology with doping in the normal state. Clear and complete Fermi surfaces are observed and quantitatively analyzed in all of these overdoped Pb-Bi2201 samples. A Lifshitz transition from holelike Fermi surface to electron-like Fermi surface with increasing doping is observed at a doping level of ~0.35. This transition coincides with the change that the sample undergoes superconducting-to-non-superconducting *** results reveal the emergence of an electron-like Fermi surface and the existence of a Lifshitz transition in heavily overdoped Bi2201 samples. This provides important information in understanding the connection between the disappearance of superconductivity and the Lifshitz transition in the overdoped region.

关键词： Angular resolved light emission spectrometry Concomitant Lifshitz Transition Bi2Sr2CuO6

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冻存对人脐血间充质干细胞生物学特性的影响

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中国普外基础与临床杂志 2008年第1期15卷 36-40页

作者：吴德全胡彦华高峰金光鑫哈尔滨医科大学附属第二医院肝胆胰腹腔镜外科

目的观察冻存复苏对人脐血(human umbilical cord blood)间充质干细胞(mesenchymal stemcells,MSCs)生物学特性的影响。方法体外分离、培养人脐血MSCs,传代后,将第3代的MSCs加入含10%二甲基亚砜(DMSO)和90%胎牛血清的细胞冻存液中,-196... 详细信息

目的观察冻存复苏对人脐血(human umbilical cord blood)间充质干细胞(mesenchymal stemcells,MSCs)生物学特性的影响。方法体外分离、培养人脐血MSCs,传代后,将第3代的MSCs加入含10%二甲基亚砜(DMSO)和90%胎牛血清的细胞冻存液中,-196℃液氮保存4周,观察比较冻存前及冻存复苏后MSCs的形态、增殖及多向分化能力。结果冻存前及冻存复苏后,MSCs形态无明显差别,均呈典型的梭形,MSCs贴壁生长;MSCs生长曲线相似,冻存复苏后的细胞生长曲线略有下降,但差异无统计学意义(P>0.05);MSCs经脂肪诱导液诱导2周后,细胞浆中出现脂肪细胞所特有的脂肪滴,经0.5%油红O染色,脂肪滴染为红色,说明MSCs有向脂肪细胞分化的能力;MSCs经成骨诱导液诱导4周后,Von Kossa染色可见黑色的矿化结节沉积,钙结节的形成为成骨细胞特有,说明MSCs有向成骨细胞分化的能力。提示冻存复苏后MSCs经诱导仍然可以向脂肪细胞和成骨细胞分化,与冻存前无明显差异。结论人脐血MSCs经冻存复苏后,其生物学特性可获良好保持。

关键词：人脐血间充质干细胞冻存生物学特性

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-Li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping Li Yao-quan Chu Jian-Rong Shi Gang Wang Jian-Nan Zhang Zhong-Rui Bai Xiao-yan Chen feng-Fei Wang yan-xin Guo Jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi Li Yi-Han Song Yue wu yan-Xia Zhang xin-Lin Zhou Fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong Jian Li guang-Wei Li Shuang Li jing Song Yuan Tian Meng-xin Wang Yong-hui Hou Zhi-Ying huo Hong-Zhuan hu Ning-Sheng hu Zhong-Wen hu Lei Jia Fang-hua Jiang Xiang Jiang Zi-Bo Jiang Ge jin Ai-hua Li Qi Li Yin-Dun Mao Zheng-Hong Tang Qing-Sheng Tao Liang-Ping Tu Da-Qing Wang Dan Wang Jian-Ping Wang Lei Wang Shou-Guan Wang Shu-Qing Wang Ya-Nan Wang You Wang Yue-Fei Wang Ming-Zhi Wei Xiang-Xiang Xue Xiao-Zheng xing Ling-Zhe Xu xin-Qi Xu yan Xu de-hua yang Shi-Hai yang Zheng-Qiu Yao Yong Yu hui Yuan Chao Zhai En-Peng Zhang jing Zhang Li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai deng Xiao-Wei Liu Yi-Peng jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-quan Chu Guo-Ping Li Zhong-Rui Bai Yue wu yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-xin Chen Li Chen Xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei feng Jian-Ning Fu Peng gao Xue-Fei Gong Bo-Zhong Gu yan-xin Guo Zhan-Wen Han Bo-Liang He jin-Liang Hou Yong-hui Hou Wen Hou Hong-Zhuan hu Ning-Sheng hu Zhong-Wen hu Zhi-Ying huo Lei Jia Fang-hua Jiang Xiang Jiang Zhi-Bo Jiang Ge jin Xiao Kong Xu Kong Ya-Juan Lei Ai-hua Li Chang-hua Li guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li xin-Nan Li yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen huo-Ming Shi jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong wu Ke-Fei wu Xue-Bing wu Yu-Zhong wu Xiao-Zheng xing Ling-Zhe Xu xin-Qi Xu yan Xu Tai-Sheng yan de-hua yang Hai-feng yang hui-Qin yang Ming yang Zheng-Qiu Yao Yong Yu hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis

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Chinese Medical Journal 2019年第24期132卷 2899-2904页

作者： Chun Li yan Zhang hui Song Jie gao Dong-Bao Zhao Qi Zhu Dong-Yi He Li Wang Xiang-Pei Li Xu-Dong Liu Wei-Guo Xiao xin-Yu wu hua-Xiang wu Wei Tu Shao-Xian hu xin Wang Zhi-Jun Li Zhi-Min Lu Zhan-Yun Da Bo Liang Xiao-Min Liu jin-Wei Zhao Ling Li feng Han wu-Fang Qi Wei Wei Xu Ma Zhen-Bin Li Gui-Min Zheng feng-Xiao Zhang Yi Li You-Lian Wang guang-hui Ling jin-Wei Chen Xiao-Qiang Hou jing Zhang Qing-Ping Chen Chang-Lian Liu yan Zhang Jia-Shun Zeng Qing-hua Zou Yong-Fei Fang Yin Su Zhan-Guo Li department of Rheumatology and Immunology Peking University People's HospitalBeijing 100044China department of Rheumatology and Immunology Beijing Jishuitan HospitalBeijing 100035China department of Rheumatology and Immunology Changhai HospitalShanghai 200433China department of Rheumatology Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western MedicineShanghai 200052China department of Rheumatology and Immunology Anhui Provincial HospitalHefeiAnhui 230001China department of Rheumatology and Immunology The First Hospital of China Medical UniversityShenyangLiaoning 110001China department of Rheumatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China department of Rheumatology and Immunology Tongji HospitalWuhanHubei 430030China department of Rheumatology The First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233004China department of Rheumatology and Immunology Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China department of Rheumatology and Immunology The Hospital of Shunyi District BeijingBeijing 101300China department of Infection and Immunology Tianjin Union Medical CenterTianjin 300121China department of Rheumatology and Immunology Tianjin First Central HospitalTianjin 300192China department of Rheumatology and Immunology Tianjin Medical University General HospitalTianjin 300052China department of Rheumatology and Immunology Peace HospitalShijiazhuangHebei 050000China department of Rheumatology and Immunology Hebei General HospitalShijiazhuangHebei 050051China department of Rheumatology Jiangxi Provincial People's HospitalNanchangJiangxi 330006China Division of Rheumatology and Immunology The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China department of Rheumatology and Immunology The First College of Clinical Medical Science of China Three Gorges University&Yichang Central People's HospitalYichangHubei 443003China department of Rheu

Background:Clinical outcomes of undifferentiated arthritis(UA)are diverse,and only 40%of patients with UA develop rheumatoid arthritis(RA)after 3 *** predictive markers at disease onset for further intervention is ***,our objective was to analyze the clinical outcomes of UA and ascertain the predictors for RA ***:We performed a prospective,multi-center study from January 2013 to October 2016 among Chinese patients diagnosed with UA in 22 tertiary-care *** and serological parameters were obtained at ***-up was undertaken in all patients every 12 weeks for 2 *** factors of disease progression were identified using multivariate Cox proportional hazards ***:A total of 234 patients were recruited in this study,and 17(7.3%)patients failed to follow up during the *** the 217 patients who completed the study,83(38.2%)patients went into *** patients who developed RA had a higher rheumatoid factor(RF)-positivity(42.9%vs.16.8%,χ^2=8.228,P=0.008),anti-cyclic citrullinated peptide(CCP)antibodypositivity(66.7%vs.10.7%,χ^2=43.897,Pdependent predictor for RA development(hazard ratio 18.017,95%confidence interval:5.803–55.938;Pdependent predictor of RA,anti-CCP antibody should be tested at disease onset in all patients with UA.

关键词： Anti-cyclic citrullinated peptide antibody Arthritis,Rheumatoid Rheumatoid factor Undifferentiated arthritis

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