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Influence of weight management on the prognosis of steatohepatitis in chronic hepatitis B patients during antiviral treatment

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 416-425页

作者： Xiu-Juan Chang Yi-Wen Shi Jing wang hua-bao liu Yan chen xiao-Ning Zhu yong-ping chen Zu-jiang Yu Qing-hua Shang lin Tan Qin li li jiang Guang-Ming xiao liang chen wei Lu xiao-Yu Hu Qing-hua Long lin-Jing An Zi-yuan Zou Vincent Wai-Sun Wong yong-ping yang jian-gao Fan Department of liver Disease Chinese PLA General Hospitalthe Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Center for Fatty liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of liver Disease Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 610072China Department of liver Diseases Traditional Chinese Medicine Hospital of ChongqingChongqing 400038China Department of Infectious and liver Diseases Liver Research Centerthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Infectious Disease the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Center of Therapeutic liver Disease the 960th Hospital of Chinese PLATaian 271000China liver Disease Department Fuyang 2nd People's HospitalFuyang 236015China Department of liver Diseases Fuzhou Infectious Diseases HospitalFuzhou 350025China Department of Infectious Diseases Southwest HospitalArmy Military Medical UniversityChongqing 400038China Department of Infectious Diseases Guangzhou 8th People’s HospitalGuangzhou 510060China Department of Hepatic Diseases Shanghai Public Health Clinical CenterShanghai 201508China Department of liver Diseases Tianjin Second People’s HospitalTianjin Institute of HepatologyTianjin 300192China National Integrative Medicine Clinical Base for Infectious Diseases and Department of Infectious Diseases Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China Department of Infection and liver Disease Yichun People’s HospitalYichun 336028China Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina

Background:Although concomitant nonalcoholic steatohepatitis(NASH)is common in chronic hepatitis B(CHB),the impact of viral factors on NASH and the outcome of CHB patients concomitant with NASH remain *** aimed to investigate the outcomes of NASH in CHB patients receiving antiviral ***:In the post-hoc analysis of a multicenter trial,na?ve CHB patients receiving 72-week entecavir treatment were *** evaluated the biochemical,viral and histopathological responses of these *** histopathological features of NASH were also evaluated,using paired liver biopsies at baseline and week ***:A total of 1000 CHB patients were finally enrolled for analysis,with 18.2%of whom fulfilling the criteria of NASH.A total of 727 patients completed entecavir antiviral treatment and received the second *** HBe Ag loss,HBe Ag seroconversion and HBV-DNA undetectable rates were similar between patients with or without NASH(P>0.05).Among patients with NASH,the hepatic steatosis,ballooning,lobular inflammation scores and fibrosis stages all improved during follow-up(all Pline body mass index(BMI)≥23 kg/m2(Asian criteria)[odds ratio(OR):0.414;95%confidence interval(95%CI):0.190-0.899;P=0.012]and weight gain(OR:0.187;95%CI:0.050-0.693;P=0.026)were less likely to have NASH *** patients without NASH at baseline,22(3.7%)developed *** BMI≥23 kg/m2(OR:12.506;95%CI:2.813-55.606;P=0.001)and weight gain(OR:5.126;95%CI:1.674-15.694;P=0.005)were predictors of incident ***:Lower BMI and weight reduction but not virologic factors determine NASH resolution in *** value of weight management in CHB patients during antiviral treatment deserves further evaluation.

关键词： Nonalcoholic steatohepatitis Hepatitis B NASH resolution Antiviral treatment weight management

Association of Cytokines with Clinical Indicators in Patients with Drug-Induced liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO wei hua jianG Ting Ting SHEN Ge DENG Wen wang Shi Yu ZHANG Zi Yu li Xin Xin LU yao ZHANG Lu liu Ru Yu CHANG Min WU Shu ling gao yuan Jiao HAO Hong xiao chen xiao Xue HU Lei ping XU Meng Jiao YI wei XIE yao li Ming hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DIli)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DIli patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:Pliver damage in early stages of DIli,TNF-αand IL-6 may partake the inflammatory process of DIli.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Xue-Qian wang Feng-Qi Zhang xiao-Ya Cui Bing-Bing Fan Jia-Ming Guo Zhi-Min Guo Rui huang Wen huang Xu-Bo li Meng-Ru li Yan Ma Zhi-hua Shen yong-Gang Sun De-Zhuang wang Fei-yang wang li-Qiang wang Nan wang Tian-li wang wei wang xiao-yang wang Yi-Han wang Fu-Jie Yu Yu-Zhen Yin ling-Kun Zhang Yi Zhang jian-yang Zhang Qi Zhao Yu-ping Zhao Xin-Dong Zhu Yasir Sohail Ya-Nan chen Tao Feng Qi-Long gao Hai-Yan He yong-jiang huang Zeng-bao Jiao hua Ji yao jiang Qiang li xiao-Ming li wei-Bing liao huai-Jun lin hui liu Qi liu Qing-Feng liu wei-Di liu Xiong-Jun liu yang Lu Yi-ping Lu Wen Ma Xue-Fei Miao Jie Pan Qing wang Hong-hui Wu yuan Wu Tao yang wei-Ming yang Qian Yu Jin-Yu Zhang Zhi-Gang chen liang Mao yang Ren bao-Long Shen Xun-li wang Zhe Jia He Zhu Zhen-Duo Wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

Catheter ablation versus medical therapy for atrial fibrillation with prior stroke history:a prospective propensity score-matched cohort study

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Journal of Geriatric Cardiology 2023年第10期20卷 707-715,I0006页

作者： Wen-li DAI Zi-Xu ZHAO Chao jianG liu HE Ke-Xin yao Yu-Feng wang Ming-yang gao Yi-wei LAI Jing-Rui ZHANG Ming-xiao li Song ZUO Xue-yuan GUO Ri-Bo TANG Song-Nan li chen-Xi jianG Nian liu De-yong LONG Xin DU Cai-hua SANG jian-Zeng DONG Chang-Sheng MA Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Center for Cardiovascular DiseasesBeijingChina Heart Health Research Center BeijingChina Department of Cardiovascular Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

BACKGROUND Patients with atrial fibrillation(AF)and prior stroke history have a high risk of cardiovascular events despite anticoagulation *** is unclear whether catheter ablation(CA)has further benefits in these *** AF patients with a previous history of stroke or systemic embolism(SE)from the prospective Chinese Atrial Fibrillation Registry study between August 2011 and December 2020 were included in the *** were matched in a 1:1 ratio to CA or medical treatment(MT)based on propensity *** primary outcome was a composite of all-cause death or ischemic stroke(IS)/*** During a total of 4.1±2.3 years of follow-up,the primary outcome occurred in 111 patients in the CA group(3.3 per 100 person-years)and in 229 patients in the MT group(5.7 per 100 person-years).The CA group had a lower risk of the primary outcome compared to the MT group[hazard ratio(HR)=0.59,95%CI:0.47–0.74,Plity(HR=0.43,95%CI:0.31–0.61,Plity(HR=0.32,95%CI:0.19–0.54,Plinical trials are warranted to confirm the benefits of CA in these patients.

关键词： prospective fibrillation matched

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang li li‑Jiao wang Xiang‑Biao Qiu Jing‑Wen li wei Xu Tao li Ze‑Bin lin Chang‑Jun Ning yong‑Hao chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai jiang‑Bo Bai Jie bao ping Cao Qi‑ping chen Zhen chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He yong‑cheng He yang Hong Yi‑wei Hu Han‑Xiong huang wei‑hua Jia Hao‑Yu jiang wei jiang Zhi‑Jie jiang Zheng‑yao Jin ling Kang Bo li Chao li Gong li Jia‑Wen li xiao li yang li Jie liu rong liu Shu‑Bin liu Guang‑yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑cheng wang Zhao‑hui wang Zhong‑wei Wen xiao‑Guang Wu Xuan Wu li‑Kun Xie Yi‑wei yang Han Yi yong‑Ji Yu Guo‑hui Zhang lin‑Hao Zhang Mo‑Han Zhang Qi‑wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑yong Zhang Mao‑yuan Zhao Lu‑ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao Dong li Shao-lin Xiong Yan-Qiu Zhang yang Su wei chen Yi Zhao xiao-Bo li Jia-Cong liu Wen-Xi Peng Rui Qiao Xin-Qiao li Xiang-yang Wen li-Ming Song Shi-Jie Zheng Xin-Ying Song xiao-Yun Zhao Yue huang Shuang-Nan Zhang Shuo xiao Ce Cai Zheng-hua An Can chen Gang chen wei chen Yan-Qi Du Min gao Ke Gong Dong-Ya Guo Zhi-wei Guo jian-jian He Bin li Chao li Chao-yang li Gang li jian-hui li Lu li Qing-Xin li Yan-Guo li Jing liang xiao-hua liang Jin-yuan liao xiao-Jing liu Ya-Qing liu Qi Luo Xiang Ma Bin Meng Ge Ou Dong-li Shi Jing-Yan Shi Gong-Xing Sun Xi-Lei Sun You-li Tuo chen-wei wang hui wang Jin wang Jin-Zhou wang ping wang Wen-Shuai wang Hong Wu Sheng-Lun Xie Yan-Bing Xu Yu-Peng Xu wang-chen Xue Sheng yang Min yao jian-Ying Ye Qi-Bin Yi Chao-Yue Zhang Da-li Zhang Fan Zhang Fei Zhang Hong-Mei Zhang Kai Zhang Peng Zhang xiao-Lu Zhang Zhen Zhang Guo-Ying Zhao Shi-Yi Zhao Chao Zheng Xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo yong-Heng Zhao Gang Zhao li-Cai Deng xiao-wei liu Yi-Peng Jing Gang wang Hao-Tong Zhang jian-rong Shi Xiang-Qun Cui yao-Quan Chu Guo-ping li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-yuan chen jian-Jun chen Kun-Xin chen li chen Xue-Lei chen xiao-Yan chen Ying chen Norbert Christlieb Jia-Ru Chu chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng jian-Ning Fu Peng gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-liang He Jin-liang Hou yong-hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-hua jiang Xiang jiang Zhi-Bo jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-hua li Chang-hua li Guang-wei li Hai-Ning li jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-ping li yuan liang Chien-cheng lin Chao liu Gen-rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang Hong-Chi wang jian wang Jia-Ning wang jian-ling wang jian-ping wang Jun-Xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-Qing wang Xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng wei Ming-Zhi wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-hua yang Hai-Feng yang hui-Qin yang Ming yang Zheng-Qiu yao yong Yu hui yuan Hai-Bo yuan Hai-Long yuan wei-Min yuan Chao Zhai En-Peng Zhang hua-wei Zhang jian-Nan Zhang li-Pin Zhang wei Zhang yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-liang li Ming-Sheng huang wei-Zhu yang Guo-Wen Yin Bin-Yan Zhong Jun-hui Sun Zhi-cheng Jin jian-jian chen Nai-jian Ge Wen-Bin Ding Wen-hui li Jin-hua huang wei Mu Shan-Zhi Gu Jia-ping li hui Zhao Shu-wei Wen Yan-Ming Lei Yu-Sheng Song Chun-wang yuan wei-Dong wang Ming huang wei Zhao jian-Bing Wu Song wang Xu Zhu jian-Jun Han wei-Xin Ren Zai-Ming Lu Wen-Ge Xing yong Fan Hai-Lan lin Zi-Shu Zhang Guo-hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng yong chen Xu-Ya Zhao Zhu-Ting Fang Qi wang Jin-wei Zhao Ai-Bing Xu jian Xu Qing-hua Wu huan-Zhang Niu jian wang Feng Dai Dui-ping Feng Qing-Dong li rong-Shu Shi Jia-Rui li Guang yang Hai-Bin Shi jian-Song Ji Yu-E liu Zheng Cai Po yang yang Zhao xiao-li Zhu li-Gong Lu gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang yong-Hao chen Jing-Yu Tang Rui-Rui Fan Qiang li Gong li Dong liu Zheng-yao Jin Xing-Zhu Cui Tian-Xiang chen Yi-wei yang rong liu Han Yi yang li Zhen yang Qi An Hao-Fan Bai jiang-Bo Bai Jie bao ping Cao Qi-ping chen Zhen chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He yong-cheng He yang Hong Yi-wei Hu Han-Xiong huang wei-hua Jia Hao-yu jiang wei jiang Zhi-jie jiang ling Kang Bo li Chao li Jia-Wen li xiao li Jie liu Shu-Bin liu Guang-yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-hui Song Kang Sun Zhi-Xin Tan li-Jiao wang Peng-cheng wang Zhao-hui wang Zhong-wei Wen xiao-Guang Wu Xuan Wu li-Kun Xie yong-Ji Yu Guo-hui Zhang lin-Hao Zhang Mo-Han Zhang Qi-wei Zhang Xian-Peng Zhang Yu-liang Zhang Yue Zhang Zhi-yong Zhang Mao-yuan Zhao Lu-ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method