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Control of fine particulate nitrate during severe winter haze in“2+26”cities

Journal of Environmental Sciences 2024年第2期136卷 261-269页

作者： Chuang Qin Xiao Fu Tao Wang jian gao Jiaqi Wang Institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Department of Civil and Environmental Engineering Hong Kong Polytechnic UniversityHong Kong 99907China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 10084China

The“2+26”cities,suffering the most severe winter haze pollution,have been the key region for air quality improvement in *** prominent nitrate pollution is one of the most challenging environmental issues in this region,necessitating development of an effective control ***,we use observations,and state-of-the-art model simulations with scenario analysis and process analysis to quantify the effectiveness of the future SO_(2)-NO_(X)-VOC-NH_(3) emission control on nitrate pollution mitigation in“2+26”*** on a serious winter haze episode,we find that limited NO_(X)emission reduction alone in the short-term period is a less effective choice than VOC or NH_3emission reduction alone to decrease nitrate concentrations,due to the accelerated NO_(X)-HNO_(3)conversion by atmospheric oxidants and the enhanced HNO_(3)to NO_(3)^(-)partition by ammonia,although deep NO_(X)emission reduction is essential in the long-term *** synergistic NH_(3) and VOC emission control is strongly recommended,which can counteract the adverse effects of nonlinear photochemistry and aerosol chemical feedback to decrease nitrate *** extra benefits will be reduced if the synergistic NH_(3) and VOC reduction is delayed,and thus reducing emission of multiple precursors is urgently required for the effective control of increasingly severe winter nitrate pollution in“2+26”cities.

关键词： Nitrate Winter haze pollution Emission reduction “2+26”cities

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Recent progress on transition metal oxides and carbon-supported transition metal oxides as catalysts for thermal decomposition of ammonium perchlorate

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Defence Technology（防务技术） 2021年第4期17卷 1471-1485页

作者： Teng Chen Yi-wen Hu Cai Zhang Zhao-jian gao School of Material and Chemical Engineering Xuzhou University of TechnologyXuzhouJiangsuPR China Xi’an Modern Chemistry Research Institute Xi’anShaanxiPR China Xuzhou University of Technology XuzhouJiangsuPR China

As a main oxidizer in solid composite propellants,ammonium perchlorate(AP)plays an important role because its thermal decomposition behavior has a direct influence on the characteristic of solid composite *** improve the performance of solid composite propellant,it is necessary to take measures to modify the thermal decomposition behavior of *** recent years,transition metal oxides and carbon-supported transition metal oxides have drawn considerable attention due to their extraordinary catalytic *** this review,we highlight strategies to enhance the thermal decomposition of AP by tuning morphology,varying the types of metal ion,and coupling with carbon *** enhanced catalytic performance can be ascribed to synergistic effect,increased surface area,more exposed active sites,and accelerated electron transportation and so *** mechanism of AP decomposition mixed with catalyst has also been briefly ***,a conclusive outlook and possible research directions are suggested to address challenges such as lacking practical application in actual formulation of solid composite propellant and batch manufacturing.

关键词： Transition metal oxides Carbon-supported transition metal oxides Catalyst Ammonium perchlorate Thermal decomposition

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Application of immune checkpoint inhibitors and microsatellite instability in gastric cancer

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World Journal of Gastroenterology 2024年第21期30卷 2734-2739页

作者： Shi-Yan Yan jian-gao Fan Department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China

In this editorial we comment on the article by Li published in the recent issue of the World Journal of *** focus specifically on the application of immune checkpoint inhibitors(ICIs)and microsatellite instability(MSI)in gastric cancer(GC).The four pillars of GC management have long been considered,including surgery,chemotherapy,radiotherapy and targeted ***,immunotherapy has recently emerged as a“fifth pillar”,and its use is rapidly *** are four principal strategies for tumor immunotherapy:ICIs,tumor vaccines,adoptive immunotherapy and nonspecific *** them,ICIs are the most advanced and widespread type of cancer immunotherapy for *** breakthrough results for ICIs have paved the way to a new era of cancer *** particular,inhibition of the PD-1/PD-L1 axis with ICIs,including nivolumab and pembrolizumab,has emerged as a novel treatment strategy for advanced ***,these therapies are sometimes associated with often subtle,potentially fatal immune-related adverse events(irAEs),including dermatitis,diarrhea,colitis,endocrinopathy,hepatotoxicity,neuropathy and *** must be aware of these irAEs and improve the detection of these processes to prevent inappropriate discharges,emergency department revisits,and downstream *** studies have revealed that MSI-high or mismatch-repair-deficient tumors,regardless of their primary site,have a promising response to ***,it is important to detect MSI before applying ICIs for treatment of GC.

关键词： Gastric cancer Immune checkpoint inhibitors Microsatellite instability Immunotherapy Immune-related adverse events

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Integrin antagonists are effective and safe for Crohn's disease:a meta-analysis

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World Journal of Gastroenterology 2015年第15期21卷 4744-4749页

作者： Wen-Song Ge jian-gao Fan Department of Gastroenterology Shanghai Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

AIM: To evaluate the efficacy and safety of integrin antagonists, including natalizumab and vedolizumab, in Crohn's disease(CD).METHODS: We carried out a literature search in Pub Med, MEDLINE, EMBASE and the Cochrane Library to screen for citations from January 1990 to August2014. Data analysis was performed using Review Manager version ***: A total of 1340 patients from five studies were involved in this meta-analysis. During 6-12 wk treatment, integrin antagonists increased the rate of clinical response and remission with OR = 1.69, 95%CI: 1.37-2.09 and 1.84, 95%CI: 1.44-2.34, respectively. No significant difference was found between integrin antagonists and placebo treatments regarding their adverse reactions(OR = 1.07, 95%CI: 0.83-1.38) and serious adverse reactions(OR = 0.81, 95%CI: 0.57-1.15).CONCLUSION: The results prove the efficacy and safety of integrin antagonists for CD treatment, although the treatment strategies varied.

关键词： Crohn's disease Drug efficacy Integrinantagonist Meta-analysis Drug safety

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Synthesis and Characterization of Soluble Reactive Copoly (aryl ether ketone ketone)

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Chinese Chemical Letters 2001年第4期12卷 325-326页

作者： Yan gao Xi gao jian Zhi Yong XU Yue gao Qian jiang Lü Department of Polymer Science&Materials Dalian University of TechnologyDalian 116012

Soluble reacitve copoly (aryl ether ketone ketone) was synthesized from the condensation of 2.2 ' .3.3 ' .6.6 ' -hexaphenyl-4.4 ' -diphenol. 2.2-p-hydroxyphenl 1-tso-propane. and 1-methyl-cyclohex-1-ene-4.5-diyl-bis) ... 详细信息

关键词： Poly(aryl ether ketone ketone) synthesis solubility.

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MTC: A Multi-Task Model for Encrypted Network Traffic Classification Based on Transformer and 1D-CNN

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Intelligent Automation & Soft Computing 2023年第7期37卷 619-638页

作者： Kaiyue Wang jian gao Xinyan Lei Department of Information Network Security People’s Public Security University of ChinaBeijing102600China Safety Precaution Laboratory of Ministry of Public Security Beijing102600China

Traffic characterization(e.g.,chat,video)and application identifi-cation(e.g.,FTP,Facebook)are two of the more crucial jobs in encrypted network traffic *** two activities are typically carried out separately by existing systems using separate models,significantly adding to the difficulty of network *** Neural Network(CNN)and Transformer are deep learning-based approaches for network traf-fic *** is good at extracting local features while ignoring long-distance information from the network traffic sequence,and Transformer can capture long-distance feature dependencies while ignoring local *** on these characteristics,a multi-task learning model that combines Transformer and 1D-CNN for encrypted traffic classification is proposed(MTC).In order to make up for the Transformer’s lack of local detail feature extraction capability and the 1D-CNN’s shortcoming of ignoring long-distance correlation information when processing traffic sequences,the model uses a parallel structure to fuse the features generated by the Transformer block and the 1D-CNN block with each other using a feature fusion *** structure improved the representation of traffic features by both blocks and allows the model to perform well with both long and short length *** model simultaneously handles multiple tasks,which lowers the cost of *** reveal that on the ISCX VPN-nonVPN dataset,the model achieves an average F1 score of 98.25%and an average recall of 98.30%for the task of identifying applications,and an average F1 score of 97.94%,and an average recall of 97.54%for the task of traffic *** advanced models on the same dataset are chosen for comparison,the model produces the best *** prove the generalization,we applied MTC to CICIDS2017 dataset,and our model also achieved good results.

关键词： Encrypted traffic classification multi-task learning feature fusion transformer 1D-CNN

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Metabolic syndrome and non-alcoholic fatty liver disease:Asian definitions and Asian studies

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Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 572-578页

作者： Fan, jian-gao Peng, Yong-De Jiao Tong Univ Shanghai Peoples Hosp 1 Ctr Fatty Liver Dis Shanghai 200080 Peoples R China Jiao Tong Univ Shanghai Peoples Hosp 1 Dept Endocrinol Shanghai 200080 Peoples R China

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), as conventionally recognized, is a metabolic disorder largely confined to residents of affluent industrialized Western countries. However, obesity and insulin resistance are not restricted to the West, as witnessed by their increasingly universal distribution. In particular, there has been an upsurge in metabolic syndrome in the Asia-Pacific region, although there are critical differences in the extent of adiposity between Eastern and Western populations. DATA SOURCES: An English-language literature search using PubMed (1999-2007) on obesity, metabolic syndrome and NAFLD, focusing on Asian definitions and Asian studies. RESULTS: NAFLD appears to be of long-standing insulin resistance and likely represents the hepatic manifestation of the metabolic syndrome. With insulin resistance as a common factor, the disease is associated with atherosclerosis and cardiovascular risk. All features of the metabolic syndrome and related events are assessed for practical management of NAFLD, although the criteria for the diagnosis of obesity and central obesity differ across racial groups. CONCLUSIONS: The increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension and ultimately metabolic syndrome, puts a very large population at risk of developing NAFLD in the coming decades. The simultaneous identification and appropriate treatment of the components of metabolic syndrome are crucial to reduce hepatic as well as cardiovascular morbidity and mortality.

关键词： metabolic syndrome non-alcoholic fatty liver disease obesity diabetes mellitus insulin resistance

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Parameter Identification and Application of Slippage Kinematics for Tracked Mobile Robots

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Journal of Beijing Institute of Technology 2019年第4期28卷 687-695页

作者： Hongyang Liu jianzhong Wang jian gao School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China Great Wall Motor Co. Ltd.Baoding 071000HebeiChina

A new parameter identification method is proposed to solve the slippage problem when tracked mobile robots execute turning *** motion is divided into two states in this paper:pivot turning and coupled turning between angular velocity and linear *** the processing of pivot turning,the slippage parameters could be obtained by measuring the end point in a square *** the process of coupled turning,the slippage parameters could be calculated by measuring the perimeter of a circular path and the linear distance between the start and end *** identification results showed that slippage parameters were affected by ***,a fuzzy rule base was established with the basis on the identification data,and a fuzzy controller was applied to motion control and dead *** method effectively compensated for errors resulting in unequal tension between the left and right tracks,structural dimensions and *** results demonstrated that the accuracy of robot positioning and control could be substantially improved on a rigid floor.

关键词： tracked mobile robot tracked vehicle kinematics model slippage parameters fuzzy controller

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Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease:a multicenter clinical trial

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 375-380页

作者： jian-gao Fan Department of Gastroenterology Shanghai First People's Hospital Shanghai Jiaotong University Shanghai 200080 China. fanjg@***

BACKGROUND:Currently, the management of non-alcoholic fatty liver disease (NAFLD) is less than certain. Some choleretic might be of potential benefit and deserve further evaluation. This multicenter clinical trial was designed to evaluate the efficacy and safety of Chinese herbal medicine Danning Pian (composed of rhubarb, grant knotweed, dried green orange peel and dried old orange peel) in the short-term treatment of patients with NAFLD.METHODS:The efficacy and safety of Danning Pian in the short-term treatment of NAFLD were investigated in 232 patients by a multicenter clinical trial during the period of July 1999 to February 2000. The patients consisting of 189 males and 43 females with an average age of 46.1+/-8.7 years were given 3-5 tablets of Danning Pian orally thrice daily for 3 months in addition to the other comprehensive therapy. The effects of Danning Pian on NAFLD were evaluated by the improvement of clinical symptoms, blood lipids, hepatic enzymes and liver ultrasonographic features. The drug safety was monitored by physical examinations, vital signs, and laboratory tests in addition to the assessment of the adverse events.RESULTS:All the enrolled patients completed the study except one whose serum ALT level was moderately increased during the therapy with Danning Pian. The effective rate of Danning Pian for the improvement of clinical symptoms, serum ALT levels, blood lipid and fatty liver was 85.8%, 78.2%, 39.6% and 34.0% respectively after the therapy for 3 months. However, the reduction of excessive body weight and waistline did not reach the significant level on the whole after the therapy. The general mild adverse events included diarrhea, skin rash and mild to moderate elevation of serum ALT level. The incidence of adverse reaction was 15.1%.CONCLUSION:The data of this trial indicate that Danning Pian is effective and safe, generally well-tolerated without severe adverse events, in the treatment of patients with NAFLD over a 3-month period.

关键词： Chinese herbal medicine Danning Pian fatty liver non-alcoholic therapy

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Synthesis of New Soluble Polyarylates Containing Phthalazinone Moiety

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Chinese Chemical Letters 2006年第1期17卷 140-142页

作者： Yu Rong gao Jin Yan WANG Cheng LIU Xi gao jian Department of Polymer Science and Materials Dalian University of Technology Dalian 116012

A novel diacid chloride, 2-（4-chlorocarboxyphenyl）-4-[3,5-dimethyl-4-（4-chlorocarbo-xylphenoxy）phenyl]-2,3-phthalazin-l-one 2, was synthesized and used for the preparation of polyarylates with inherent viscosities of 0.25-0.37 dL·g^-1. The glass transition temperatures of polyarylates were in the range of 217-272℃. The temperatures at 10% weight loss of polyarylates were found to be in the range of 434-464℃ in nitrogen atmosphere and their structure was confirmed by FTIR and IH NMR. The amorphous polyarylates exhibited excellent solubility in a variety of solvents such as NMP, DMAc, DMF and chloroform.

关键词： Polyarylates phthalazinone solubility thermal behavior.

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