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Science China Life Sciences 2024年

作者： Jie Li Xing-Chun Li Hui-Yun gan Yue Zhang Zi-Xuan guo Yu-Xuan Liu Yong-Qing Lin Liang-Dong guo State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences

Plant diversity significantly impacts ecosystem processes and functions, yet its influence on the community assembly of leaf fungi remains poorly understood. In this study, we investigated leaf epiphytic and endophytic fungal communities in a Chinese subtropical tree species richness experiment, ranging from 1 to 16 species, using amplicon sequencing to target the internal transcribed spacer 1 region of the rDNA. We found that the community assembly of epiphytic and endophytic fungi was predominantly governed by stochastic processes, with a higher contribution of dispersal limitation on epiphytic than on endophytic fungal communities but a higher contribution of selection on endophytic than on epiphytic fungal communities. The plant-epiphytic fungus interaction network was more complex(e.g., more highly connected and strongly nested but less specialized and modularized) than the plant-endophytic fungus interaction network. Additionally,tree species richness was positively correlated with the network complexity and diversity of epiphytic(α-, β-and γ-diversity) and endophytic(β-and γ-diversity) fungi, but was not associated with the contribution of the stochastic and deterministic processes on the community assembly of epiphytic and endophytic fungi. This study highlights that tree species diversity enhances the diversity and network complexity,rather than alters the ecological processes in community assembly of leaf-associated fungi.

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Clinical characteristics and risk factors of post-operative intestinal flora disorder following laparoscopic colonic surgery:A propensityscore-matching analysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1259-1270页

作者： gan-Bin Li Chen-Tong Wang Xiao Zhang Xiao-Yuan Qiu Wei-Jie Chen Jun-Yang Lu Lai Xu Bin Wu YiXiao guo-Le Lin Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China

BACKGROUND Intestinal flora disorder(IFD)poses a significant challenge after laparoscopic colonic surgery,and no standard criteria exists for its diagnosis and *** To analyze the clinical features and risk factors of *** Patients with colon cancer receiving laparoscopic surgery were included using propensity-score-matching(PSM)*** on the occurrence of IFD,patients were categorized into IFD and non-IFD *** clinical characteristics and treatment approaches for patients with IFD were *** regression analysis was performed to identify the risk factors of *** The IFD incidence after laparoscopic surgery was 9.0%(97 of 1073 patients).After PSM,97 and 194 patients were identified in the IFD and non-IFD groups,*** most common symptoms of IFD were diarrhea and abdominal,typically occurring on post-operative days 3 and *** patients were managed conservatively,including modulation of the intestinal flora(90.7%),oral/intravenous application of vancomycin(74.2%),and insertion of a gastric/ileus tube for decompression(23.7%).Multivariate regression analysis identified that preoperative intestinal obstruction[odds ratio(OR)=2.79,95%CI:1.04–7.47,P=0.041]and post-operative antibiotics(OR=8.57,95%CI:3.31–23.49,P<0.001)were independent risk factors for IFD,whereas pre-operative parenteral nutrition(OR=0.12,95%CI:0.06–0.26,P<0.001)emerged as a protective *** A stepwise approach of probiotics,vancomycin,and decompression could be an alternative treatment for *** attention is warranted post-operatively for patients with pre-operative obstruction or early use of antibiotics.

关键词： Colon cancer,Laparoscopy Intestinal flora disorder Clinical characteristics Risk factors

Epidemiological Characteristics of Fracture Among Children Aged 6-17 Years-China,2019-2021

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China CDC weekly 2024年第32期6卷 799-803,I0001页

作者： Lu Cui Qian gan Juan Xu Peipei Xu Titi Yang Wei Cao Hongliang Wang Haoyan guo Ruihe Luo Jianfen Zhang Hui Pan Wenhua Zhao Zhenyu Yang Yuxiang Yan Qian Zhang Department of Epidemiology and Biostatistics School of Public HealthCapital Medical UniversityBeijingChina National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijingChina Key Laboratory of Public Nutrition and Health National Health Commission of the People’s Republic of ChinaBeijingChina

Summary What is already known about this topic?Fractures are a common and serious injury among *** many studies have utilized clinical data,there is a lack of large-scale community-based research in *** is added by this report?This cross-sectional study provides national and regionally representative data on the prevalence of fractures among Chinese children aged 6–17 years(6.93%),with higher rates observed in males than in females(8.13%vs.5.71%)and in rural areas compared to urban areas(7.22%vs.6.62%).The most common site of fracture was the upper limbs(4.24%,accounting for 63.0%of fractures).What are the implications for public health practice?The need to enhance awareness of fracture prevention is critical,particularly for children in rural areas and males in middle *** recommend that local authorities increase investments in educational programs and child safety ***,promoting balanced diets for children,training in proper exercise techniques,and reinforcing participation in outdoor sports are essential.

关键词： prevention utilized children

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超重核充气谱仪装置

原子能科学技术 2011年第10期45卷 1262-1265页

作者：张志远甘再国黄明辉黄天衡马龙马飞郑勇周小红徐瑚珊詹文龙中国科学院近代物理研究所甘肃兰州730000 中国科学院研究生院北京100049

介绍在兰州重离子研究装置(HIRFL)上新建的一台用于超重核实验研究的充气谱仪装置,描述该装置的基本结构及设计参数。利用已知截面的反应175 Lu(40 Ar,4～5n)211,210 Ac测试谱仪的性能,得到余核在不同He气气压下的电荷态分布,其平衡电... 详细信息

介绍在兰州重离子研究装置(HIRFL)上新建的一台用于超重核实验研究的充气谱仪装置,描述该装置的基本结构及设计参数。利用已知截面的反应175 Lu(40 Ar,4～5n)211,210 Ac测试谱仪的性能,得到余核在不同He气气压下的电荷态分布,其平衡电荷态测量值与经验公式计算值符合较好。对于该反应,此实验条件下充气谱仪对余核的传输效率下限为14%。

关键词：超重核充气谱仪平衡电荷态传输效率

Z=105质量数为259的新同位素的合成和鉴别(英文)

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高能物理与核物理 2001年第6期25卷 602-606页

作者：范红梅甘再国秦芝雷祥国徐岩冰何建军刘洪业吴晓蕾郭俊盛周小红袁双贵靳根明中国科学院近代物理研究所兰州730000

利用 1 2 0MeV的2 2 Ne离子束轰击2 41　Am靶 ,通过2 41　Am(2 2 Ne ,4n) 2 5 9　Db反应合成了一个Z =1 0 5,质量数为 2 59的新同位素 .反应产物是用氦喷嘴技术和转动轮装置传输收集的 .借助一系列金硅面垒探测器探测到了反应产物及其... 详细信息

利用 1 2 0MeV的2 2 Ne离子束轰击2 41　Am靶 ,通过2 41　Am(2 2 Ne ,4n) 2 5 9　Db反应合成了一个Z =1 0 5,质量数为 2 59的新同位素 .反应产物是用氦喷嘴技术和转动轮装置传输收集的 .借助一系列金硅面垒探测器探测到了反应产物及其子核的α衰变 .新同位素的原子序数Z和质量数A是借助该同位素和已知的2 5 5 　Lr核之间的遗传关系得到了确定的鉴别 .新同位素2 5 9　Db的测量半衰期为 (0 51± 0 1 6)s;它的α粒子能量为 9 4 7MeV .由本实验导出的2 5 9　Db的Qα

关键词：新同位素 a衰变母-子核遗传关系半衰期测量

Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang Shi-Xuan Chen Yuan Xiong guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative *** contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative *** paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future *** highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ***,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE ***,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

Hsa-miR-483-5p/mRNA network that regulates chemotherapy resistance in locally advanced rectal cancer identified through plasma exosome transcriptomics

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World Journal of Clinical Oncology 2024年第8期15卷 1061-1077页

作者： gan-Bin Li Wei-Kun Shi Xiao Zhang Xiao-Yuan Qiu guo-Le Lin Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China

BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal ***,the underlying mechanisms remain *** To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of *** In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA *** Exosome hsa-miR-483-5p was up-regulated in good responders *** analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling *** analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor *** addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 ***,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was *** This study provides insights into the mechanism of chemoresistance in terms of exosomal ***,further research is required within the framework of our established miRNA-mRNA network.

关键词： Locally advanced rectal cancer Neoadjuvant chemoradiotherapy Poor-responders Good responders Exosome miRNA

Blowing up of Solutions to the Cauchy Problem for the Generalized Zakharov System with Combined Power-Type Nonlinearities

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1917-1936页

作者： zai Hui gan Bo Ling guo Chun Xiao guo College of Mathematics and Software Science Sichuan Normal University Institute of Applied Physics and Computational Mathematics Department of Mathematics China University of Mining and Technology Beijing

This paper deals with blowing up of solutions to the Cauchy problem for a class of general- ized Zakharov system with combined power-type nonlinearities in two and three space dimensions. On the one hand, for co = ＋oo we obtain two finite time blow-up results of solutions to the aforementioned 4 ≤ p 〈 N＋2/N-2 4 system. One is obtained under the condition a ≥ 0 and 1 ＋ 4/N or a 〈 0 and 1 〈 p 〈 1 ＋（N = 2,3）; the other is established under the condition N = 3, 1 〈 p 〈 N=2/N-2 and α（p - 3）〉 0. On the other hand, for co 〈＋∞ and α（p - 3）〉 0, we prove a blow-up result for solutions with negative energy to the Zakharov system under study.

关键词： Generalized Zakharov system blowing up combined power-type nonlinearities Lyapunov function in time

Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast

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Journal of Integrative Plant Biology 2024年第8期66卷 1703-1717页

作者： Qishuang Li Xiang Jiao Xinyi Li Wenlong Shi Ying Ma Xiangmei Tan Jingyi gan Jimei Liu Jian Yang Jian Wang Baolong Jin Tong Chen Ping Su Yujun Zhao Yifeng Zhang Jinfu Tang Guanghong Cui Yun Chen Juan guo Luqi Huang School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Life Sciences Chalmers University of TechnologyGothenburg SE-41296Sweden State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaThe Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Aporphine alkaloids have diverse pharmacological activities;however,our understanding of their biosynthesis is relatively *** studies have classified aporphine alkaloids into two categories based on the configuration and number of substituents of the D-ring and have proposed preliminary biosynthetic pathways for each *** this study,we identified two specific cytochrome P450 enzymes(CYP80G6 and CYP80Q5)with distinct activities toward(S)-configured and(R)-configured substrates from the herbaceous perennial vine Stephania tetrandra,shedding light on the biosynthetic mechanisms and stereochemical features of these two aporphine alkaloid ***,we characterized two CYP719C enzymes(CYP719C3 and CYP719C4)that catalyzed the formation of the methylenedioxy bridge,an essential pharmacophoric group,on the A-and D-rings,respectively,of aporphine *** the functional characterization of these crucial cytochrome P450 enzymes,we reconstructed the biosynthetic pathways for the two types of aporphine alkaloids in budding yeast(Saccharomyces cerevisiae)for the de novo production of compounds such as(R)-glaziovine,(S)-glaziovine,and *** study provides key insight into the biosynthesis of aporphine alkaloids and lays a foundation for producing these valuable compounds through synthetic biology.

关键词： aporphine alkaloids biosynthesis CYP719C CYP80 engineered yeast

Sharp Threshold of Global Existence for the Klein-Gordon Equations with Critical Nonlinearity

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Acta Mathematicae Applicatae Sinica 2009年第2期25卷 273-282页

作者： zai-hui gan Bo-ling guo Jian Zhang College of Mathematics and Software Science Sichuan Normal University Chengdu 610068 China Institute of Applied Physics and Computational Mathematics PO Box 8009 Beijing 100088 China

In this paper, we present a cross-constrained variational method to study the Cauchy problem of the nonlinear Klein-Gordon equations with critical nonlinearity in two space dimensions. By constructing a type of cross-constrained variational problem and establishing so-called cross-invariant manifolds of the evolution flow, we establish a sharp threshold of global existence and blowup of it. Furthermore, we answer the question： How small are the initial data if the solution exists globally.

关键词： Sharp threshold Klein-Gordon equation cross-constrained variational problem global existence blowup