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原发性肺动脉肉瘤的诊断和治疗

中国呼吸与危重监护杂志 2010年第6期9卷 635-638页

作者：高元明刘双陈东甘辉立首都医科大学附属北京安贞医院呼吸科北京100029

目的提高对原发性肺动脉肉瘤(PAS)的认识和早期诊治水平。方法结合北京安贞医院2001年10月至2010年5月手术病理确诊的4例PAS患者的临床资料和国外有关文献,对原发性肺动脉肉瘤的临床特点进行总结分析。结果原发性肺动脉肉瘤患者主要表... 详细信息

目的提高对原发性肺动脉肉瘤(PAS)的认识和早期诊治水平。方法结合北京安贞医院2001年10月至2010年5月手术病理确诊的4例PAS患者的临床资料和国外有关文献,对原发性肺动脉肉瘤的临床特点进行总结分析。结果原发性肺动脉肉瘤患者主要表现为活动性呼吸困难、气短和胸闷,休息可缓解,和肺血栓栓塞症相似,但前者无下肢深静脉血栓形成,胸部增强CT肺动脉造影多显示肺动脉扩张,主肺动脉及左、右肺动脉内大块充盈缺损,管腔外浸润阴影,溶栓、抗凝治疗无效等,确诊需手术。手术成功治疗后症状多明显缓解,术后辅以放疗和/或化疗可提高疗效。结论原发性肺动脉肉瘤临床上罕见,临床表现和肺血栓栓塞症相似,易误诊为肺血栓栓塞症而给予溶栓抗凝治疗。胸部增强CT肺动脉造影及手术病理有助明确诊断,手术切除是主要治疗方法。

关键词：肺动脉肉瘤诊断治疗

东北典型盐碱湿地碳排放的水深临界阈值及其温度依赖性

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湖泊科学 2025年第1期37卷 159-170,I0015-I0017页

作者：李姝臻刘强甘罗扬武海涛王波北京师范大学环境学院水环境模拟国家重点实验室北京100875 北京师范大学环境学院教育部水沙科学重点实验室北京100875 中国科学院长春分院长春130022 吉林莫莫格国家级自然保护区白城137316

作为全球重要的碳库,湿地在缓解气候变化方面发挥了重要作用。然而在全球变暖背景下,湿地的碳排放(尤其是甲烷(CH_(4))排放)存在高度变异性和不确定性,极大地削弱了湿地碳库功能的发挥。为了探究不同水深梯度下东北盐碱湿地碳排放通量... 详细信息

作为全球重要的碳库,湿地在缓解气候变化方面发挥了重要作用。然而在全球变暖背景下,湿地的碳排放(尤其是甲烷(CH_(4))排放)存在高度变异性和不确定性,极大地削弱了湿地碳库功能的发挥。为了探究不同水深梯度下东北盐碱湿地碳排放通量的特征,本研究以莫莫格湿地为主要研究区,选取5种代表性植被(芦苇(Phragmites australis)、扁秆藨草(Bolboschoenus planiculmis)、三江藨草(Schoenoplectus nipponicus)、香蒲(Typha orientalis ***)和碱蓬(Suaeda glauca)),布设Marsh Organ中型实验生态系统模拟不同水深生境,揭示CH_(4)和二氧化碳(CO_(2))排放通量变化及其环境影响因子。结果表明,莫莫格湿地-10~50 cm水深范围内5种代表性植被生长季CH_(4)排放通量范围为0.07~86.74 mg/(m^(2)·h),平均值为8.89 mg/(m^(2)·h),其主要环境影响因素为水深、气温和表层10 cm土壤含水量;在研究水深范围内,代表性植被生长季CO_(2)排放通量范围为10.59~1891.08 mg/(m^(2)·h),平均值为450.12 mg/(m^(2)·h),其主要环境影响因素为水深、气温和表层10 cm土壤含水量。不同植被对碳排放的贡献量有所差异,具体来说,芦苇和香蒲的CH_(4)排放通量最高,而藨草的CO_(2)排放通量最高。碳排放随水深变化呈现分段规律,CH_(4)排放随水深变化呈现先增加后减少的趋势,而CO_(2)则呈现相反规律,随水深变化先减小后增加,其水深临界阈值均出现在22 cm处。在不同水深范围内,CO_(2)排放对于水深的敏感性均大于CH_(4),且当水深大于22 cm时,CH_(4)和CO_(2)均呈现出更高的水深敏感性。碳排放在不同水深范围对温度的敏感程度不同,当水深小于22 cm时,CH_(4)和CO_(2)均呈现出更高的温度敏感性,然而当水深大于22 cm时,二者对温度均不敏感。结果表明升温背景下,东北典型盐碱湿地水陆过渡区关键生态系统在不同水深范围内呈现出不对称的响应模式,频繁的水位波动会极大地改变湿地碳排放格局,从而影响到湿地碳功能的稳定发挥。

关键词：碳排放水深温度依赖性莫莫格湿地阈值

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心血管疾病危险人群健康教育的实践与思考

西北医学教育 2009年第2期17卷 311-314页

作者：甘辉立佟秋红张健群首都医科大学附属北京安贞医院/北京市心肺血管疾病研究所心外科北京100029 首都医科大学附属北京安贞医院/北京市心肺血管疾病研究所教育处北京100029

心血管疾病健康科普教育实践,可有效地降低心血管疾病的发病率,提高心血管内、外科介入及手术治疗效果。建立院前、院中、院后三级科普健康教育体系;医务人员全员参与、多形式综合应用的健康教育实践;医学科普健康教育以"预防"为重点的... 详细信息

心血管疾病健康科普教育实践,可有效地降低心血管疾病的发病率,提高心血管内、外科介入及手术治疗效果。建立院前、院中、院后三级科普健康教育体系;医务人员全员参与、多形式综合应用的健康教育实践;医学科普健康教育以"预防"为重点的导向;构建患者社区医院专业医院金三角关系等经验在心血管疾病健康教育实践中证明为积极有效的措施。但心血管疾病健康教育应把受众人群进一步扩大到青少年和农村人群,同时注意对心血管患者的心理健康教育和减少危险因子的教育。

关键词：心血管疾病危险人群健康教育

应用ROSS手术治疗儿童主动脉瓣病变的研究

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中华小儿外科杂志 2007年第8期28卷 397-400页

作者：甘辉立张健群李继勇穆军升李温斌伯平孔睛宇曹向荣毛斌首都医科大学附属北京安贞医院心外科 100029

目的评价应用Ross手术治疗儿童主动脉瓣病变的效果。方法回顾性分析1994年1月～2005年1月Ross手术治疗儿童主动脉瓣病变26例,其中男18例,女8例,平均年龄(12.4±5.3)岁。主动脉瓣赘生物7例,主动脉瓣二瓣叶畸形9例,主动脉瓣叶脱垂6例,瓣... 详细信息

目的评价应用Ross手术治疗儿童主动脉瓣病变的效果。方法回顾性分析1994年1月～2005年1月Ross手术治疗儿童主动脉瓣病变26例,其中男18例,女8例,平均年龄(12.4±5.3)岁。主动脉瓣赘生物7例,主动脉瓣二瓣叶畸形9例,主动脉瓣叶脱垂6例,瓣叶发育不良3例,主动脉瓣成形术后再发主动脉瓣关闭不全1例。所有患儿均采用自体带瓣肺动脉行主动脉根部替换,均应用同种肺动脉带瓣管道重建右室流出道。结果本组26例无手术死亡,1例术后大出血而2次开胸止血。在2例12年、24例(24.5±3.8)个月的随访期间,1例术后1年同种肺动脉瓣感染致感染性心内膜炎再次手术时死亡。25例血流动力学优良,23例无主动脉瓣反流,2例仅存在轻微主动脉瓣反流;4例有同种异体肺动脉瓣轻度反流,1年后左室舒张末径从术前的(65.24±12.7)mm显著缩小到(49±8.23)mm(P<0.05)。结论应用Ross手术治疗儿童主动脉瓣病变可取得较好的围术期及近中期效果。

关键词：主动脉瓣肺动脉瓣心脏外科手术

东方肉座菌GH10家族木聚糖酶基因的克隆及异源表达

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生物学杂志 2015年第5期32卷 1-6,10页

作者：吴金连薛勇黎海龙刘健甘礼惠龙敏南厦门大学能源学院厦门361102

木聚糖酶是降解半纤维素最主要的酶,对于开发可再生生物能源具有重要的应用价值。分别以东方肉座菌(Hypocrea orientalis)EU7-22的基因组DNA和c DNA为模板,利用染色体步移和PCR技术首次克隆获得该菌GH10家族木聚糖酶Ⅲ的基因(xynⅢ),并... 详细信息

木聚糖酶是降解半纤维素最主要的酶,对于开发可再生生物能源具有重要的应用价值。分别以东方肉座菌(Hypocrea orientalis)EU7-22的基因组DNA和c DNA为模板,利用染色体步移和PCR技术首次克隆获得该菌GH10家族木聚糖酶Ⅲ的基因(xynⅢ),并对其进行生物信息学分析。结果表明:该基因全长1283 bp(gxynⅢ),含有3个内含子;CDS序列为1044 bp(cxynⅢ),编码347个氨基酸,N端含有一个16 aa的信号肽序列;XYNⅢ氨基酸序列与Trichoderma pseudokoningii的endoxylanase具有较高的同源性。经生物信息学分析,XYNⅢ成熟蛋白可能含有18个N-糖基化位点,其理论等电点(p I)为6.14,蛋白质分子质量为36.55 ku,属于亲水性蛋白;SWISS-Model建模预测,XYNⅢ成熟蛋白中含有11个α螺旋,其核心结构为8个β折叠片围成一个柱状结构。同时将编码成熟蛋白的基因片段mxynⅢ与p PIC9K质粒连接构建表达载体后转化毕赤酵母,对重组子表达产物进行酶活检测显示该基因能在毕赤酵母中表达有生物活性的XYNⅢ并分泌到胞外,发酵液中的木聚糖酶活在诱导培养168 h后可达到127.5 IU/m L。

关键词：东方肉座菌木聚糖酶Ⅲ 基因克隆生物信息学分析异源表达

半纤维素侧链降解酶——α-葡萄糖醛酸酶的研究进展

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新能源进展 2014年第5期2卷 327-333页

作者：吴金连薛勇黎海龙甘礼惠刘健龙敏南厦门大学能源学院厦门361102

半纤维素是自然界中最丰富的可再生资源之一,将半纤维素降解为单糖并转化为燃料或化学品一直是科学界研究的热点。半纤维素是由木糖基主链以及α-葡萄糖醛酸等侧链共同组成的异质多聚体。α-葡萄糖醛酸酶是半纤维素完全降解过程中的关... 详细信息

半纤维素是自然界中最丰富的可再生资源之一,将半纤维素降解为单糖并转化为燃料或化学品一直是科学界研究的热点。半纤维素是由木糖基主链以及α-葡萄糖醛酸等侧链共同组成的异质多聚体。α-葡萄糖醛酸酶是半纤维素完全降解过程中的关键酶之一,能够水解4-O-甲基葡萄糖醛酸与木糖之间的α-1,2-糖苷键。本文综述了α-葡萄糖醛酸酶的分类、催化机制及晶体结构、酶学性质和基因克隆表达等方面的研究进展,同时对该研究进行了展望。

关键词：半纤维素 α-葡萄糖醛酸酶结构催化机理酶学特性

Rare case of lupus enteritis presenting as colorectum involvement:A case report and review of literature

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World Journal of Clinical Cases 2023年第34期11卷 8176-8183页

作者： hui gan Fei Wang Yuan gan li Wen Department of Radiology The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China Department of Radiology Luzhou People’s HospitalLuzhou 646000Sichuan ProvinceChina Department of Barracks Section The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China

BACKGROUND Systemic lupus erythematosus(SLE)is a multisystem autoimmune disease that can affect the gastrointestinal *** cases of lupus enteritis(LE)involve the small intestine,while the involvement of the whole colon and rectum without the small intestine being affected is extremely *** SUMMARY A 35-year-old woman was diagnosed with colorectal LE after initially presenting with intermittent abdominal pain and vomiting for two *** had a regular medication history for five years following the diagnosis of SLE but had been irregular in taking medications,which may have contributed to the onset of LE and led to her current hospital *** to the 2019 Classification criteria for SLE of the European League Against Rheumatism/American College of Rheumatology,this case scored ***,abdominal computed tomography revealed significant wall edema of the colon and rectum,ischemia and hyperemia of the ascending colon intestinal wall,mesenteric vessel engorgement,increased mesangial fat attenuation,ascites,and bilateral ureter-hydronephrosis,all indicative of colon and rectum *** tests also showed lower levels of complement C3 and C4,with an antinuclear antibody titer of 1:***,it was clear that this case involved the colon and rectum without affecting the small intestine,representing a rare manifestation of *** patient received treatment with 10 mg of methylprednisolone sodium succinate,100 mL of 0.9%sodium chloride,hydroxychloroquine(100 mg),and nutrition *** one week of methylprednisolone and hydroxychloroquine therapy,her SLE symptoms and disease activity improved *** Although colorectal LE without small intestine involvement is very rare,early diagnosis and excellent management with corticosteroids prevented the need for surgical *** should be aware of colorectal LE without small intestine involvement as a manifestation of lupus flare.

关键词： Lupus enteritis Systemic lupus erythematosus Colon and rectum Target sign Comb sign Methylprednisolone and hydroxychloroquine Case report

Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

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Science China life Sciences 2025年

作者： Lu gan Yi Yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend lity to T2D. Mediation analyses of the inverse association between T

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Graphene surface plasmon polaritons transport on curved substrates

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Photonics Research 2015年第6期3卷 300-307页

作者： Ting-hui Xiao lin gan Zhi-Yuan li Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences

We theoretically investigate the transport property of graphene surface plasmon polaritons(GSPPs) on curved graphene substrates. The dispersion relationship, propagation length, and field confinement are calculated by an analytical method and compared with those on planar substrates. Based on our theory, the bend of graphene nearly does not affect the property of GSPPs except for an extremely small shift to the lower frequency for the same effective mode index. The field distributions and the eigenfrequencies of GSPPs on planar and cylindrical substrates are calculated by the finite element method, which validates our theoretical analysis. Moreover, three types of graphene-guided optical interconnections of GSPPs, namely, planar to curved graphene film, curved to planar graphene film, and curved to curved graphene film, are proposed and examined in detail. The theoretical results show that the GSPPs propagation on curved graphene substrates and interconnections will not induce any additional losses if the phase-matching condition is satisfied. Additionally, the extreme tiny size of curved graphene for interconnection at a certain spectra range is predicted by our theory and validated by the simulation of 90° turning of GSPPs. The bending effect on the property of GSPPs is systematically analyzed and identified. Our studies would be helpful to instruct design of plasmonic devices involving curved GSPPs, such as nanophotoniccircuits, flexible plasmonic, and biocompatible devices.

关键词： Graphene surface plasmon polaritons transport on curved substrates