检索结果-南通市图书馆

Mitophagy and cGAS-STING crosstalk in neuroinflammation

Acta Pharmaceutica Sinica B 2024年第8期14卷 3327-3361页

作者： Xiaogang Zhou Jing Wang Lu Yu gan Qiao Dalian Qin Betty Yuen-Kwan Law Fang Ren Jianming Wu Anguo Wu Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou 646000China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao SAR 999078China Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chongqing Traditional Chinese Medicine HospitalChongqing 400021China

Mitophagy,essential for mitochondrial health,selectively degrades damaged *** is intricately linked to the cGAS-STING pathway,which is crucial for innate *** pathway responds to mitochondrial DNA and is associated with cellular stress *** review explores the molecular details and regulatory mechanisms of mitophagy and the cGAS-STING *** critically evaluate the literature demonstrating how dysfunctional mitophagy leads to neuroinflammatory conditions,primarily through the accumulation of damaged mitochondria,which activates the cGAS-STING *** activation prompts the production of pro-inflammatory cytokines,exacerbating *** review emphasizes the interaction between mitophagy and the cGAS-STING *** mitophagy may suppress the cGAS-STING pathway,offering protection against ***,impaired mitophagy may activate the cGAS-STING pathway,leading to chronic ***,we explored how this interaction influences neurodegenerative disorders,suggesting a common mechanism underlying these *** conclusion,there is a need for additional targeted research to unravel the complexities of mitophagy-cGAS-STING interactions and their role in *** review highlights potential therapies targeting these pathways,potentially leading to new treatments for neuroinflammatory and neurodegenerative *** synthesis enhances our understanding of the cellular and molecular foundations of neuroinflammation and opens new therapeutic avenues for neurodegenerative disease research.

关键词： Neuroinflammation Mitophagy cGAS-STING Innate immunity Mitochondrial DNA Crosstalk Therapeutic avenues Neurodegenerative diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synergistic effect between Co single atoms and Pt nanoparticles for efficient alkaline hydrogen evolution

引用

Materials Futures 2024年第3期3卷 111-120页

作者： Chengyong Shu Jingwen Cao Zhuofan gan Peixi Qiu Zhixu Chen Lian Guanwu Zhongxin Chen Chengwei Deng Wei Tang School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China School of Science and Engineering The Chinese University of Hong KongShenzhenGuangdong 518172People’s Republic of China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power SourcesShanghai 200245People’s Republic of China

In the pursuit of sustainable energy solutions,the efficiency of the hydrogen evolution reaction(HER)in alkaline conditions has been a significant challenge,primarily due to the sluggish dissociation of water molecules on platinum(Pt)*** this critical issue,our study introduces an innovative Pt-Co@NCS *** catalyst synergistically combines Pt nanoparticles with Co single atoms on a nitrogen-doped carbon scaffold,overcoming the traditional bottleneck of slow water *** unique porous concave structure and nitrogen-enriched surface not only provide abundant anchoring sites for Co atoms but also create a conducive hydrophilic environment around the Pt *** design leads to a drastic improvement in the water dissociation process,as demonstrated by CO stripping and deuterium labeling *** an outstanding current density of 162.8 mA cm^(−2) at−0.1 V versus RHE,a Tafel slope of 26.2 mV dec^(−1),and a superior nominal mass activity of 15.75 mAμgPt^(−1),the Pt-Co@NCS catalyst represents a significant step forward in enhancing alkaline HER efficiency,indicating promising advancements in the field.

关键词： synergistic catalysis single atom catalysts alkaline water splitting flow electrolyser hydrogen evolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The“depict”strategy for discovering new compounds in complex matrices:Lycibarbarspermidines as a case

引用

Journal of Pharmaceutical Analysis 2024年第3期14卷 416-426页

作者： Chen Han Zhixin Zhang Zhiyang Feng Chuanjia Zhai Xuejiao Li Yulian Shi Xiang Li Miao Li Ying Wang gan Luo Xiaoyan Gao Department of Chinese Medicine Analysis School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China

The comprehensive detection and identification of active ingredients in complex matrices is a crucial *** chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex ***,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 *** are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low *** comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this ***,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine ***,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target ***,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of ***,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly *** on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally *** integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.

关键词： Mass spectrometric detection Weak response signals Complex matrices Novel lycibarbarspermidines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inflation Transmission Diagnostics via a Bayesian Graph Vector Autoregressive Model with Markov Switching

引用

Journal of Systems Science & Complexity 2024年

作者： FU Jiali CAI Fengjing WU Jinran ZHAO Shangrui WANG You-gan College of Mathematics and Physics Wenzhou University Institute for Positive Psychology and Education Australian Catholic University School of Science Wuhan University of Technology School of Mathematics and Physics The University of Queensland

The transmission of inflation is a widespread occurrence, and managing inflationary pressures is a crucial macroeconomic challenge. Although inflation is a typical macroeconomic variable,its contemporaneous and lagged causal relationships have not been thoroughly investigated, which could result in missing important policy insights. The Bayesian graph vector autoregression(BGVAR)model can identify contemporaneous and lagged causal relationships among economic variables, but it lacks practical research on inflationary inflation. To account for the structural transformation in the inflation transmission process, the authors propose a Bayesian graph vector autoregressive model with Markov switching(MS-BGVAR), which considers both regime switching and contemporaneous causality among macroeconomic variables. The proposed study focuses on analyzing the dynamics of inflation transmission relationships among G7 countries under different regimes, as these countries represent developed nations. The authors use inflation data from 1971–2019, which shows two distinct inflation regimes within the sample period. The authors conduct simulation experiments to generate moderately dimensional simulated data for both regimes and indicators, demonstrating the theoretical reliability of the proposed model in accurately identifying graph structures. Finally, the authors apply the proposed model to identify structural breaks and causal transmission relationships in the inflation transmission process of G7 economies, demonstrating that the proposed model has significant economic significance and good explanatory power in the selected target countries.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Single-atom catalysts: controlled synthesis and dynamic mechanism in electrochemical oxygen evolution substitution reactions

引用

Rare Metals 2024年第10期43卷 4903-4920页

作者： Qin Zhao Rong gan Yi-Ling Ran Quan-Lei Ma Wen-Wen Chen Yue-Xin Guo Yan Zhang Ding-Sheng Wang School of Chemistry Southwest Jiaotong University School of Life Science and Engineering Southwest Jiaotong University Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua University

Single-atom catalysts(SACs) have attracted much attention in the field of electrocatalysis due to their100% atomic utilization efficiency, clear active center and adjustable support. The application of SACs to anodic oxygen evolution substitution reactions with high conversion efficiency and selectivity is undoubtedly ***, a full understanding of the interactions between metal single-atom active sites and supports, and an in-depth understanding of the active centers and catalytic mechanisms of SACs in the electro-oxidation of small molecules are the keys to the development of high-performance catalysts. This review focuses on the synthesis of different support SACs and the interactions between single atoms and supports at the inter-face, and introduces the reaction mechanism of SACs in the electro-oxidation of different small-molecule substrates, such as ethanol, urea and hydrazine, with the aim of providing insights and ideas for the design of more efficient and ideal catalysts. Finally, we discuss the current challenges and future opportunities in the field.

关键词： Synthesis (chemical)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

SmEGY3 mediates H_(2)O_(2) production to enhance high-temperature stress tolerance by activating the expression of SmCSD1 in eggplant

引用

Horticultural Plant Journal 2024年第5期10卷 1247-1251页

作者： Renjian Liu Bingwei Yu Bingbing Shu Yuyuan Wang Yuwei gan Yonggui Liang Zhengkun Qiu Shuangshuang Yan Bihao Cao Key Laboratory of Horticultural Crop Biology and Germplasm Innovation in South China Ministry of AgricultureCollege of HorticultureSouth China Agricultural UniversityGuangzhouGuangdong 510642China Guangdong Vegetable Engineering and Technology Research Center South China Agricultural UniversityGuangzhouGuangdong 510642China

High temperature(HT)has major effects on the growth and production of vegetable crops,including eggplant(Solanum melongena L.).Eggplant seedlings,flower organs,and fruits are affected by high temperature stress(HTS).Nonetheless,key HT response factors are rare in *** this study,we found that SmEGY3 was localized in chloroplasts and nuclei,and the expression was induced by *** confirmed that SmEGY3 played a positive role in regulating heat tolerance of plants by virus-induced gene silencing(VIGS)and overexpression *** to the control plants,the SmEGY3-silenced plants showed significantly decrease in the H_(2)O_(2) content and H_(2)O_(2)-mediated retrograde signalling genes expression while the SmEGY3-overexpressing plants displayed significantly increase.

关键词： crops fir organs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bismuth clusters pinned on TiO_(2) porous nanowires boosting charge transfer for CO_(2) photoreduction to CH_(4)

引用

Nano Research 2024年第3期17卷 1190-1198页

作者： Jiazhi Meng Kaiwen Wang Yang Wang Jiangping Ma Chaogang Ban Yajie Feng Bin Zhang Kai Zhou Liyong gan Guang Han Danmei Yu Xiaoyuan Zhou College of Physics and Institute of Advanced Interdisciplinary Studies Chongqing UniversityChongqing 401331China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Beijing Key Lab of Microstructure and Properties of Advanced Materials Beijing University of TechnologyBeijing 100124China Analytical and Testing Center Chongqing UniversityChongqing 401331China

Artificial photosynthesis in carbon dioxide(CO_(2))conversion into value-added chemicals attracts considerable attention but suffers from the low activity induced by sluggish separation of photogenerated carriers and the kinetic bottleneck-induced unsatisfied ***,we prepare a new-style Bi/TiO_(2) catalyst formed by pinning bismuth clusters on TiO_(2) nanowires through being confined by pores,which exhibits high activity and selectivity towards photocatalytic production of CH_(4) from CO_(2).Boosted charge transfer from TiO_(2) through Bi to the reactants is revealed via in situ X-ray photon spectroscopy and time-resolved photoluminescence(PL).Further,in situ Fourier transform infrared results confirm that Bi/TiO_(2) not only overcomes the multi-electron kinetics challenge of CO_(2) to CH_(4) via boosting charge transfer,but also facilitates proton production and transfer as well as the intermediates*CHO and*CH_(3)O generation,ultimately achieving the tandem catalysis towards *** calculation also underlies that the more favorable reaction step from*CO to*CHO on Bi/TiO_(2) results in CH_(4) production with higher *** work brings new insights into rational design of photocatalysts with high performance and the formation mechanism of CO_(2) to CH_(4) for solar energy storage in future.

关键词： carbon dioxide(CO_(2))photoreduction charge transfer tandem catalysis methanation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Room-temperature ferromagnetism and piezoelectricity in metalfree 2D semiconductor crystalline carbon nitride

引用

Nano Research 2024年第6期17卷 5670-5679页

作者： Yong Wang Dingyi Yang Wei Xu Yongjie Xu Yu Zhang Zixuan Cheng Yizhang Wu Xuetao gan Wei Zhong Yan Liu Genquan Han Yue Hao Wide Bandgap Semiconductor Technology Disciplines State Key Laboratory School of MicroelectronicsAcademy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710071China Emerging Device and Chip Laboratory Hangzhou Institute of TechnologyXidian UniversityHangzhou 311200China INRS Centre for Energy Materials and Telecommunications1650 Boul.Lionel BouletVarennesQC J3X 1P7Canada National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures and Jiangsu Provincial Key Laboratory for NanotechnologyNanjing UniversityNanjing 210093China School of Education Jiangsu Open UniversityNanjing 210036China Department of Physics Shaanxi University of Science and TechnologyXi’an 710021China Department of Applied Physical Sciences The University of North Carolina at Chapel HillChapel HillNC 27514USA Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi'an 710129 China

Two-dimensional(2D)materials that combine ferromagnetic,semiconductor,and piezoelectric properties hold significant potential for both fundamental research and spin electronic ***,the majority of reported 2D ferromagnetic-semiconductor-piezoelectric materials rely on d-electron systems,which limits their practical applications due to a Curie temperature lower than room temperature(RT).Here,we report a high-crystallinity carbon nitride(CCN)material based on sp-electrons using a chemical vapor deposition *** exhibits a band gap of 1.8 eV and has been confirmed to possess substantial in-plane and out-of-plane ***,we acquired clear evidences of ferromagnetic behavior at room *** structural characterizations combined with theoretical calculations reveal that incorporating structural oxygen into the highly ordered heptazine structure causes partial substitution of nitrogen sites,which is primarily responsible for generating room-temperature ferromagnetism and *** a result,the strain in wrinkles can effectively modulate the domain behavior and piezoelectric potential at room *** addition of RT ferromagnetic-semiconductor-piezoelectric material based on sp-electrons to the family of two-dimensional materials opens up numerous possibilities for novel applications in fundamental research and spin electronic devices.

关键词： crystallinity carbon nitride room-temperature ferromagnetism piezoelectricity magnetic force microscopy density functional theory(DFT)calculations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biodegradable,strong,and clear wood package for plastic alternative

引用

Nano Research 2024年第9期17卷 8531-8541页

作者： Jianfu Tang Xueqin Fan Haozhou Huang Xiaofei Dong Xueqi Li Peiru Wang Ran Yin Yanjun Xie Jian Li gang Tan Zhenqian Pang Wentao gan Key Laboratory of Bio-based Material Science&Technology(Ministry of Education) Northeast Forestry UniversityHarbin 150040China Department of Architecture College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou 310027China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100China Heilongjiang Key Laboratory of Complex Traits and Protein Machines in Organisms Northeast Forestry UniversityHarbin 150040China

Using biodegradable material derived from renewable resources as petroleum-based plastics replacement is a promising way towards sustainable ***,the insufficient mechanical properties and complex manufacturing process of bioplastics still need to be improved for high-quality food ***,we report a top-down strategy to transform natural wood into a clear wood packaging film through scalable delignification and polyvinyl alcohol(PVA)*** wood packaging film demonstrates a laminated structure with completely collapsed cell walls and PVA intertwined together after energy-saving air drying,resulting in high light transmittance with low haze,good mechanical performance,and high barrier performance for oxygen and water *** dynamics simulations reveal the underlying fracture mechanism between cellulose and PVA,which effectively enhances the Young’s modulus and strength of the wood packaging *** findings contribute to the development of biodegradable and strong packaging materials,as well as other food-related applications,using sustainable wood.

关键词： wood food package mechanical enhancement plastic replacement biodegradability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolution of the Mangrove Wetland since the Holocene:Current Progress and Future Perspectives

引用

Journal of Earth Science 2024年第5期35卷 1669-1678页

作者： Xueyan Yan Xianzhong Ke Qinghua Li Yiqun gan Xianjun Xie Yamin Deng Geological Survey China University of GeosciencesWuhan 430074China Wuhan Center China Geological Survey(Central South China Innovation Center for Geosciences)Wuhan 430205China School of Environmental Studies China University of GeosciencesWuhan 430074China

Mangrove wetlands are among the four most productive tropical and subtropical *** are also a core component of the coastal blue carbon ecosystem,which is of great ecological significance to human beings,plants,animals,and the global carbon *** has been a global decrease in the distribution of mangrove forests,and their ecological function has gradually degenerated since the *** from coastal mangrove wetlands can provide records of climate change and human activities,and multiple proxies including palynology,leaf fossil,biomarkers,DNA,phytolith and stable isotopes,can be used to reconstruct the evolutionary stages of paleo-mangroves and to identify the effect of natural processes and human activities on the distribution and evolution of *** information can provide theoretical support for mangrove protection and for improving carbon sequestration *** paper summarizes and compares the multiple proxies for mangrove reconstruction,reviews progress in the study of natural succession of global mangroves since the Holocene,expands on the influence mechanisms of human activities on mangrove growth and development and uses past information to lay a foundation for a model to predict future mangrove development.

关键词： mangrove Holocene multiproxy sedimentary environment climate change environ-mental geology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：