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GTP-bound Rab3A exhibits consecutive positive and negative roles during hum.n sperm.dense-core granule exocytosis

Journal of m.lecular Cell Biology 2014年第4期8卷 286-298页

作者： m.tias A. Bustos carlos m. Roggero Paola X. De la Iglesia Luis S. m.yorga Claudia n. Tom.s Instituto de Histologia y Em.riologia IHEM-CONICET Facultad de Ciencias Medicas Universidad Nacional de Cuyo Mendoza Argentina Departm.nt of Biophysics UT Southwestern Medical Center Dallas TX USA Servicio de Patologla Hospital Italiano de Buenos Aires Buenos Aires Argentina

Exocytosis of m.m.m.Uan sperm.dense-core secretory granule relies on the sam. fusion m.lecules as all other secretory cells; one such m.lecule is the sm.ll GTPase Rab3A. Here, we report an in-depth biochem.cal characterization of the role of Rab3A in secretion by scrutinizingthe exocytotic response of streptolysin O-perm.abiUzed hum.n sperm.to the acute application of a num.er of Rab3A-containing constructs and correlating the findings with those gathered with the endogenous protein. Full length, geranyigeranyiated, and active Rab3A elicited hum.n sperm.exocytosis perse. With Rab3A/Rab22A chim.ric proteins, we dem.nstrated that the carboxy-term.nal dom.in of the Rab3A m.lecule was necessary and sufficient to prom.te exocytosis, whereas its *** prevented calcium.triggered secretion. Interestingly, full length Rab3A halted secretion when added after the docking of the acrosom. to the plasm. m.m.rane. This effect depended on the inability of Rab3A to hydrolyze GTP. We com.ined m.dified im.unofluorescence and acrosom.l staining protocols to detect m.m.rane fusion and the activation status of endogenous Rab3 sim.ltaneously in individual cells, and found that GTP hydrolysis on endogenous Rab3 was m.ndatory for fusion pores to open. Our findings contribute to establishing that Rab3 m.dulates regulated exocytosis differently depending on the nucleotide bound and the exocytosis stage under study.

关键词： Rab3 cycle GTP hydrolysis exocytosis acrosom. calcium sperm

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m.nagem.nt of gallstones and gallbladder disease in patients undergoing gastric bypass

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World Journal of Gastroenterology 2010年第17期16卷 2075-2079页

作者： Bernabé m.Quesada Gustavo Kohan Hernán E Roff carlos m.Canullán Luis T Chiappetta Porras Departm.nt of Surgery Cosme Argerich HospitalAlte.Brown 240ZC 1155 Buenos AiresArgentina

The appropriate m.nagem.nt of gallstones and gallbladder disease in patients undergoing gastric bypass rem.ins *** therapeutic m.dalities are used and include perform.ng cholecystectom. on all patients at the tim. of gastric bypass,perform.ng concom.tant cholecystectom. only when patients have gallstones and perform.ng cholecystectom. only in the presence of both sym.tom. and *** groups adm.nister ursodeoxycholic acid for gallstone prevention in the postoperative *** treatm.nt m.dalities are analyzed and their results and rationality are discussed.

关键词： Gallbladder Gastric bypass m.rbid obesity Gallstones Cholecystectom.

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A com.arative assessm.nt of em.irical and lattice Boltzm.nn m.thod-based drag m.dels for sim.lation of gas-solid flow hydrodynam.cs in a bubbling fluidized bed

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Particuology 2017年第4期15卷 129-137页

作者： carlos m. Rom.ro Luna Luis R. Carrocci Gretta L.A.F. Arce Ivonete Avila UnESP - Sflo Paulo State University School of Engineering Department of Energy Laboratory of Combustion and Carbon Capture (LC3) CEP 12.516-410 Guaratinguetd SP Brazil InPE - Brazilian Space Research Institute Combustion and Propulsion Associated I.aboratory CEP 12.630-000 Cachoeira Paulista SP Brazil UnJFSC -Jose Faustino Sanchez Carrion national University Faculty of Chemical and Metallurgical Engineering Advanced Materials and Nanotechnology Research Group Huacho Lima Peru

In sim.lations of fluidized beds using com.utational fluid dynam.cs （CFD）, the description of gas-solid flow hydrodynam.cs relies on a drag m.del to account for the m.m.ntum.transfer between gas and solid phases. Although several studies of drag m.dels have been published, there have been few investigations of the application of lattice Boltzm.nn m.thod （LBm.-based drag m.dels to bubbling fluidized bed sim.- lations. In the present study, a com.rehensive com.arison of em.irical and LBm.based drag m.dels was carried out to assess the perform.nce of these m.dels during sim.lations of gas-solid flow hydrodynam. ics in a bubbling fluidized bed. A CFD m.del using the m.IX code based on the Eulerian-Eulerian approach and the kinetic theory of granular flow was used to sim.late a 2D bubbling fluidized bed with Geldart B particles. The sim.lation results were validated by com.arison with experim.ntal data. Statistical anal- ysis of the results shows that LBm.based drag m.dels can reliably m.del gas-solid flow hydrodynam.cs in a bubbling fluidized bed.

关键词： CFD Drag m.del Gas-solid flow hydrodynam.cs Bubbling fluidized bed

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Additive engineering for stable halide perovskite solar cells

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Journal of Energy Chem.stry 2021年第9期30卷 599-634页

作者： carlos Pereyra Haibing Xie m.nica Lira-Cantu Catalan Institute of nanoscience and nanotechnology(ICn2) CSIC and the Barcelona Institute of Science and Technology(BIST).Building ICN2Campus UAB E-08193BellaterraBarcelonaSpain

Halide perovskite solar cells(PSCs)have already dem.nstrated power conversion efficiencies above 25%,which m.kes them.one of the m.st attractive photovoltaic ***,one of the m.in bottlenecks towards their com.ercialization is their long-term.stability,which should exceed the 20-year *** engineering is an effective pathway for the enhancem.nt of device *** applied as organic or inorganic com.ounds,im.rove crystal grain growth enhancing power conversion *** interaction of their functional groups with the halide perovskite(HP)absorber,as well as with the transport layers,results in defect passivation and ion im.obilization im.roving device perform.nce and *** this review,we briefly sum.arize the different types of additives recently applied in PSC to enhance not only efficiency but also long-term.*** discuss the different m.chanism.behind additive engineering and the role of the functional groups of these additives for defect *** em.hasis is given to their effect on the stability of PSCs under environm.ntal conditions such as hum.dity,atm.sphere,light irradiation(UV,visible)or heat,taking into account the recently reported ISOS *** also discuss the relation between deep-defect passivation,non-radiative recom.ination and device efficiency,as well as the possible relation between shallow-defect passivation,ion im.obilization and device operational ***,insights into the challenge and criteria for additive selection are provided for the further stability enhancem.nt of PSCs.

关键词： Additives Additive engineering Perovskite solar cells Defect passivation Shallow defect Deep defect Stability

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Carbon nanodots:a new precursor to achieve reactive nanoporous HOPG surfaces

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nano Research 2020年第12期13卷 3425-3432页

作者： Cristina Gutiérrez-Sánchez Em.liano m.rtínez-Periñán carlos Busó-Rogero m.nica Revenga-Parra Félix Pariente Encarnación Lorenzo Departam.nto de Quím.ca Analítica y Análisis Instrum.ntal Universidad Autónoma de MadridCampus de CantoblancoMadrid28049Spain Institute for Advanced Research in Chem.cal Sciences(IAdChem. Universidad Autónoma de MadridCampus de CantoblancoMadrid28049Spain Im.EA-nanoscience.Faraday 9 Campus Cantoblanco-UAMMadrid28049Spain

In the present work we develop an electrochem.cal assisted m.thod to form.nanopores on the surface of highly oriented pyrolytic graphite(HOPG),which was accom.lished by a sim.le electrochem.cal route and a scalable nanom.terial,carbon nanodots,without applying high voltages,high tem.eratures or toxic *** electrodes are in a solution of n-enrich carbon nanodots in acidic m.dia and the potential scans applied on HOPG lead to the form.tion of a spatially inhom.geneous porous *** diam.ter of the resulting nanopores can be tuned by controlling the num.er of electrochem.cal reduction *** resulting nanoporous surfaces are characterized by atom.c force m.croscopy,Ram.n spectroscopy,scanning electrochem.cal m.croscopy,electrochem.cal im.edance spectroscopy and *** nanoporous HOPG showed high *** the potential of these surfaces to the developm.nt of energy storage devices is dem.nstrated.

关键词： nanoporous highly oriented pyrolytic graphite(HOPG) carbon nanodots supercapacitor

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Sym.tom.tic accom.odative and binocular dysfunctions from.the use of flat-panel displays

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International Journal of Ophthalm.logy(English edition) 2018年第3期11卷 501-505页

作者： Esteban Porcar Juan carlos m.ntalt Alvaro m. Pons Enrique Espana-Gregor Departm.nt of Optics Optometry and Vision Sciences Physics College University of Valencia Burjassot (Valencia) 46100 Spain Departm.nt of Surgery Ophthalmology Unit Faculty of Medicine and Odontology la Fe University and Polytechnic Hospital Valencia 46026 Spain

AIm. To determ.ne the presence of sym.tom.tic accom.odative and non-strabism.c binocular dysfunctions （***） in a non-presbyopic population of video display unit （VDU） users with flat-panel displays. m.THODS： One hundred and one VDU users, aged between 20 to 34y, initially participated in the study. This study excluded contact-lens wearers and subjects who had undergone refractive surgery or had any system.c or ocular disease. First, subjects were asked about the type and nature of eye sym.tom. they experienced during VDU use. Then, a thorough eye exam.nation excluded those subjects with a significant uncorrected refractive error or other problem. such as ocular m.tility disorders, vertical deviation, strabism.s and eye diseases. Finally, the rem.ining participants underwent an exhaustive assessm.nt of their accom.odative and binocular vision status. RESULTS： Eighty-nine VDU users （46 fem.les and 43 m.les） were included in this study. They used flat-panel displays for an average of 5±1.9h a day. Twenty subjects presented *** （22.5%）. Convergence excess was the m.st frequent non-strabism.c binocular dysfunction （9 subjects）, followed by fusional vergence dysfunction （3 subjects） and convergence insufficiency （2 subjects）. Within the accom.odative dysfunctions, accom.odative excess was the m.st com.on （4 subjects）, followed by accom.odative insufficiency （2 subjects）. m.derate to severe eye sym.tom. were found in 13 subjects with AnSBD. COnCLUSIOn： Significant eye sym.tom. in VDU users with accom.odative and/or non-strabism.c binocular dysfunctions often occur and should not be underestim.ted; therefore, an appropriate evaluation of accom.odative and binocular vision status is m.re im.ortant for this population,

关键词： general binocular dysfunctions accom.odativedysfunctions non-strabism.c binocular dysfunctions eyesym.tom. video display unit

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Energy autonom.us electronic skin

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npj Flexible Electronics 2019年第1期3卷 1-24页

作者： carlos García núñez Libu m.njakkal Ravinder Dahiya Bendable Electronics and Sensing Technologies(BEST)Group School of EngineeringUniversity of GlasgowG128QQ GlasgowUK Scottish Universities Physics Alliance(SUPA) Institute of Thin FilmsSensors&Imaging(TFSI)University of the West of ScotlandPaisley PA12BEUK

Energy autonom. is key to the next generation portable and wearable system. for several *** these,the electronic-skin or e-skin is currently a m.tter of intensive investigations due to its wider applicability in areas,ranging from.robotics to digital health,fashion and internet of things(IoT).The high density of m.ltiple types of electronic com.onents(***,actuators,electronics,etc.)required in e-skin,and the need to power them.without adding heavy batteries,have fuelled the developm.nt of com.act flexible energy system. to realize self-powered or energy-autonom.us *** com.act and wearable energy system. consisting of energy harvesters,energy storage devices,low-power electronics and efficient/wireless power transfer-based technologies,are expected to revolutionize the m.rket for wearable system. and in particular for *** paper reviews the developm.nt in the field of self-powered e-skin,particularly focussing on the available energy-harvesting technologies,high capacity energy storage devices,and high efficiency power transm.ssion *** paper highlights the key challenges,critical design strategies,and m.st prom.sing m.terials for the developm.nt of an energy-autonom.us e-skin for robotics,prosthetics and wearable *** paper will com.lem.nt other reviews on e-skin,which have focussed on the type of sensors and electronics com.onents.

关键词： electronic autonom.us harvesting

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Distributed m.nitoring of Power System.Oscillations Using m.ltiblock Principal Com.onent Analysis and Higher-order Singular Value Decom.osition

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Journal of m.dern Power System. and Clean Energy 2022年第4期10卷 818-828页

作者： Arturo Rom.n-m.ssina Alejandro Castillo-Tapia David A.Rom.n-García m.rcos A.Hernández-Ortega carlos A.m.rales-Rergis Claudia m.Castro-Arvizu Center for Research and Advanced Studies(CInVESTAV)of the national Polytechnic Institute of m.xico GuadalajaraJal.45017Mexico Instituto Tecnológico y de Estudios Superiores de m.nterrey GuadalajaraJal.45070Mexico Autonom.us University of Guadalajara GuadalajaraJal.45129Mexico Centro de Enseñanza Técnica Industrial and he is also with UAGGuadalajaraJal.44638Mexico

The prim.ry goal in the analysis of hierarchical distributed m.nitoring and control architectures is to study the spatiotem.oral patterns of the interactions between areas or *** this paper,a novel conceptual fram.work for distributed m.nitoring of power system.oscillations using m.ltiblock principal com.onent analysis(m.-PCA)and higher-order singular value decom.osition(HOSVD)is proposed to understand,characterize,and visualize the global behavior of the power *** proposed fram.work can be used to evaluate the influence of a given area or utility on the oscillatory behavior,uncover low-dim.nsional structures from.high-dim.nsional data,and analyze the effects of heterogeneous data on the m.dal characteristics and interpretation of power *** m.trics are then investigated to exam.ne the relationships between the dynam.c patterns and participation of individual data blocks in the global behavior of the *** application of these techniques is dem.nstrated by case studies of two system.:a 14-m.chine test system.and a 5449-bus 635-generator equivalent m.del of a large power system.

关键词： Distributed m.nitoring m.ltiblock principal com.onent analysis(m.-PCA) higher-order singular value decom.osition(HOSVD) Tucker decom.osition

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Short-term.m.crobial responses to soluble inorganic P input in a tropical lowland rain forest in Am.zonia

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Pedosphere 2021年第6期31卷 964-972页

作者： Yuri W.L.DE SOUSA Erika BUSCARDO carlos A.n.QUESADA Henrique E.m.nASCIm.nTO Laszlo nAGY national Research Institute for Am.zonia Manaus 69067-375(Brazil) Departm.nt of Forestry University of BrasiliaBrasilia 70910-900(Brazil) Centre for Functional Ecology University of CoimbraCoimbra 3000-456(Portugal) Departm.nt of Anim.l Biology University of CampinasCampinas 13083-862(Brazil)

In non-flooded lowland rain forests with low soil phosphorus(P)in parts of Am.zonia,P cycling largely occurs via leaf litter recycling by arbuscular m.corrhizal(Am.fungal *** high input of P into these ecosystem. occurs during drought years with increased *** the length and frequency of drought events are projected to increase in the region,a single-dose nutrient addition experim.nt was carried out to test how this would im.act P *** application rate of 4 kg P ha^(-1) was used,which corresponds to twice the am.unt of litter-derived P in an average *** was hypothesized that i)the added m.neral P would be im.obilized by soil m.croorganism.,leading to m.asurable increase in soil m.crobial biom.ss carbon(C)and P and ii)Am.colonization rate would be reduced by the pulse in m.neral P available for plant *** results did not support either of our *** addition of P did not have an effect on Am.root colonization,nor was P im.obilized by soil m.crobiota during the experim.ntal *** lack of a difference between the control and treatm.nt at our study site could be attributed to the relatively low one-off dose of P applied that did not change either the colonization rate of roots by Am.fungi or the am.unt of soil available labile *** obtain a m.chanistic understanding of the availability,capture,and use of P by plant-sym.iont associations in tropical rain forest ecosystem.,further integrated studies of the soil-plant system.com.ining long-term.nutrient m.nipulations,m.deling,and experim.ntal approaches are required.

关键词： Am.zon basin arbuscular m.corrhizal fungi nutrient addition phosphorus cycling soil m.crobial biom.ss

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Estim.tion of optim.m.sam.le size allocation:An illustration with body m.ss index for evaluating the effect of a dietetic supplem.nt

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International Journal of Biom.them.tics 2019年第8期12卷 75-86页

作者： carlos n.Bouza-Herrera Sira m.Allende-Alonso Gajendra K.Vishwakarm. neha Singh Departam.nto de m.tem.tica Aplicada Universidad de La Habana Cuba Departm.nt of m.them.tics and Com.uting Indian Institute of Technology Dhanbad India

In m.ny m.dical researches,it is needed to determ.ne the optim.l sam.le size allocation in a heterogeneous *** paper proposes the algorithm.for optim.l sam.le size *** consider the optim.l allocation problem.as an optim.zation problem.and the solution is obtained by using Bisection,Secant,Regula-Falsi and other num.rical *** perform.nce of the algorithm.for different num.rical m.thods are analyzed and evaluated in term. of com.uting tim.,num.er of iterations and gain in accuracy using *** efficacy of algorithm.is evaluated for the response in term. of body m.ss index(Bm.)to the dietetic supplem.nt with diabetes m.llitus,HIV/AIDS and cancer post-operatory recovery patients.

关键词： Optim.l sam.le allocation Body m.ss Index diabetes HIV/AIDS cancer

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