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Predictive value of preoperative albumin-bilirubin score and other risk factors for short-term outcomes after open pancreatoduodenectomy

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世界临床病例杂志 2023年第26期11卷 6051-6065页

作者： Hana Zavrtanik Davide Cosola David Badovinac Benjamin Hadžialjević gašper Horvat Danaja Plevel Selene Bogoni Paola Tarchi Nicolòde Manzini AlešTomažič department of Abdominal Surgery University Medical Centre LjubljanaLjubljana 1000Slovenia Clinica Chirurgica Azienda Sanitaria Universitaria Giuliano IsontinaCattinara HospitalTrieste 34149Italy department of Medical Surgical and Health SciencesUniversity of TriesteTrieste 34149Italy Faculty of Medicine University of LjubljanaLjubljana 1000Slovenia

BACKGROUND Pancreatoduodenectomy represents a complex procedure involving extensive organ resection and multiple alimentary *** is still associated with high morbidity,even in high-volume *** tools including preoperative patient-related factors to preoperatively identify patients at high risk for postoperative complications could enable tailored perioperative management and improve patient *** To evaluate the clinical significance of preoperative albumin-bilirubin score and other risk factors in relation to short-term postoperative outcomes in patients after open *** This retrospective study included all patients who underwent open pancreatic head resection(pylorus-preserving pancreatoduodenectomy or Whipple resection)for various pathologies during a five-year period(2017-2021)in a tertiary care setting at University Medical Centre Ljubljana,Slovenia and Cattinara Hospital,Trieste,***-term postoperative outcomes,namely,postoperative complications,postoperative pancreatic fistula,reoperation,and mortality,were evaluated in association with albumin-bilirubin score and other risk *** logistic regression models were built to identify risk factors associated with these short-term postoperative *** Data from 347 patients were *** complications,major postoperative complications,postoperative pancreatic fistula,reoperation,and mortality were observed in 52.7%,22.2%,23.9%,21.3%,and 5.2%of patients,*** was no statistically significant association between the albumin-bilirubin score and any of these short-term postoperative complications based on univariate *** controlling for other predictor variables in a logistic regression model,soft pancreatic texture was statistically significantly associated with postoperative complications[odds ratio(OR):2.09;95%confidence interval(95%CI):1.19-3.67];male gender(OR:2.12;95%CI:1.15-3.93),soft pan

关键词： Pancreatoduodenectomy Albumin Bilirubin Postoperative complications Pancreatic fistula Perioperative care

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Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in Korea:A nationwide retrospective cohort

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Journal of Integrative Medicine 2023年第2期21卷 176-183页

作者： Hyejin Jung Tiana Won ga-Yeon Kim Jowon Jang Sujung Yeo Sabina Lim department of Meridian&Acupoint College of Korean MedicineKyung Hee UniversitySeoul02447Republic of Korea WHO Collaborating Center for Traditional Medicine East-West Medical Research InstituteKyung Hee UniversitySeoul02447Republic of Korea department of Meridian and Acupoint College of Korean MedicineSang Ji UniversityWonju26339Republic of Korea

Objective The main aim of this study is to investigate whether acupuncture could be an effective complementary treatment for reducing the risk of macrovascular complications in diabetic patients currently taking antidiabetic medications using a nationwide population-based *** We conducted a retrospective cohort study to assess the efficacy of acupuncture on cardiovascular complications in diabetic patients using data from patients between 40 and 79 years of age,newly diagnosed with diabetes between 2003 and 2006,found in the National Health Insurance Service-National Sample Cohort(NHIS-NSC)in *** the data,we identified 21,232 diabetic patients who were taking antidiabetic medication between 2003 and *** selected patients were divided into two groups-those who received acupuncture at least three times and those who received no acupuncture(non-acupuncture)in the year following their diagnosis of *** 1:1 propensity score matching(PSM),each group had 3350 patients,and the observation ceased at the occurrence of a major adverse cardiovascular event(MACE),which was defined as either myocardial infarction,stroke,or death due to cardiovascular *** After PSM,the acupuncture group had a lower incidence of MACE(hazard ratio[HR]:0.87;95%confidence interval[CI]:0.81-0.94;P=0.0003)and all-cause mortality(HR:0.77;95%CI:0.70-0.84;P<0.0001)than the non-acupuncture group;the HRs for stroke-related mortality(HR:0.75;95%CI:0.56-1.00;P=0.0485),ischemic heart disease mortality(HR:0.53;95%CI:0.34-0.84;P=0.006)and circulatory system disease mortality(HR:0.67;95%CI:0.55-0.82;P<0.0001)were lower in the acupuncture group than in the non-acupuncture group in the secondary *** Our results indicate that diabetic patients receiving acupuncture treatment might have a lower risk of MACE,all-cause mortality and cardiovascular *** population-based retrospective study suggests beneficial effects of acupuncture in preventing macro

关键词： Acupuncture Diabetes Major adverse cardiovascular event Myocardial infarction Stroke Macrovascular complication

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The expanding Asgard archaea and their elusive relationships with Eukarya

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mLife 2022年第1期1卷 3-12页

作者： Violette Da Cunha Morgan gaïa Patrick Forterre CEA CNRSInstitute for Integrative Biology of the Cell(I2BC)UniversitéParis-SaclayGif-sur-YvetteFrance Génomique Métabolique GénoscopeInstitut François JacobCEACNRSUniv.EvryUniversitéParis-SaclayEvryFrance Département de Microbiologie Institut PasteurParisFrance

The discovery of Asgard archaea and the exploration of their diversity over the last 6 years have deeply impacted the scientific community working on eukaryogenesis,rejuvenating an intense debate on the topology of the universal tree of life(uTol).Here,we discuss how this debate is impacted by two recent publications that expand the number of Asgard lineages and eukaryotic signature proteins(ESPs).We discuss some of the main difficulties that can impair the phylogenetic reconstructions of the uTol and suggest that the debate about its topology is not *** notably hypothesize the existence of horizontal gene transfers between ancestral Asgards and proto-eukaryotes that could result in the observed abnormal behaviors of some Asgard ESPs and universal marker *** hypothesis is relevant regardless of the scenario considered regarding *** implies that the Asgards were already diversified before the last eukaryotic common ancestor and shared the same biotopes with *** suggest that some Asgards might be still living in symbiosis today with modern Eukarya.

关键词： Asgard horizontal gene transfer molecular phylogeny tree of life

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不同海拔高度芜菁营养成分分析

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新疆农业科学 2024年第3期61卷 652-664页

作者：李晓娟赵文菊尕桑邓昌蓉赵孟良任延靖青海大学西宁810016 青海大学农林科学院青藏高原种质资源研究与利用实验室西宁810016 玉树藏族自治州农牧业综合服务中心青海玉树815000 青海大学三江源生态和高原农牧业国家重点实验室西宁810016

【目的】研究不同海拔高度对芜菁营养成分的影响,分析芜菁在青海省的适生区范围,为芜菁种植选择最佳适生区以及提高资源利用率提供重要的依据。【方法】选取不同来源的13份芜菁为材料,比较分析芜菁在青海省西宁市(海拔2261 m,A处理)、... 详细信息

【目的】研究不同海拔高度对芜菁营养成分的影响,分析芜菁在青海省的适生区范围,为芜菁种植选择最佳适生区以及提高资源利用率提供重要的依据。【方法】选取不同来源的13份芜菁为材料,比较分析芜菁在青海省西宁市(海拔2261 m,A处理)、青海省海南藏族自治州贵南县(海拔3100 m,B处理)和青海省玉树藏族自治州玉树市小苏莽乡(海拔3750 m,C处理)3个不同海拔的地区种植对其营养成分的影响。【结果】随着海拔高度的增加,芜菁的可溶性双缩脲蛋白质含量增加、总糖含量增加、亚硝酸盐含量增加、硝态氮含量降低、含水量降低,而海拔高度对芜菁抗坏血酸含量、总抗氧化能力和粗纤维含量没有显著影响,表现为在B处理下,抗坏血酸含量高于其他两个地区,总抗氧化能力更强,粗纤维含量比较高。海拔高度与总糖、亚硝酸盐含量呈极显著正相关,与可溶性糖、硝态氮含量呈极显著负相关;土壤理化性质与可溶性蛋白、可溶性糖、总糖、硝态氮和亚硝酸盐含量具有相关性。【结论】在不同海拔地区芜菁含有的营养成分间存在显著差异,4份材料(1402、W_(30)、昌都和玉树芫根)在海拔2261和3100 m的地区各营养成分含量表现更优,1份材料(W 22)在海拔为3750 m的地区营养含量表现更佳。9个营养指标中有4个与海拔高度达到显著性相关;土壤理化性质与营养成分含量具有相关性。

关键词：芜菁海拔营养成分相关性

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水润滑轴承用聚合物复合材料的摩擦学研究进展

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材料保护 2024年第1期57卷 111-122,162页

作者：田颖车清论贺仁张嘎郑少梅青岛理工大学机械与汽车工程学院山东青岛266033 中国科学院兰州化学物理研究所固体润滑国家重点实验室甘肃兰州730000

聚合物复合材料因其优异的自润滑、高化学稳定性和减振降噪等特性而备受关注。以水作为工作介质的水润滑轴承具有环境友好、维护成本低及结构设计简单等特点,已被广泛应用于船舶、水电和化工等领域。首先总结了水润滑轴承用聚合物复合... 详细信息

聚合物复合材料因其优异的自润滑、高化学稳定性和减振降噪等特性而备受关注。以水作为工作介质的水润滑轴承具有环境友好、维护成本低及结构设计简单等特点,已被广泛应用于船舶、水电和化工等领域。首先总结了水润滑轴承用聚合物复合材料特性,归纳了聚合物复合材料在水润滑条件下的摩擦学性能及磨损机制,介绍了提高聚合物复合材料摩擦学性能的常规方法,并进一步探讨了材料内部结构、摩擦界面微观结构与材料宏观摩擦学特性的内在关联。指出促进水润滑聚合物-金属配副摩擦界面原位生长固体润滑特性转移膜,可弥补水膜润滑能力不足、显著提高配副的摩擦学性能,深入研究水润滑状态下复合材料的微观摩擦磨损机制,对于理解水润滑配副的摩擦学机理有重要的意义。

关键词：水润滑轴承聚合物复合材料转移膜摩擦学机理

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少数民族地方高校《兽医微生物学》实验教学改革探讨——西藏农牧学院为例

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现代畜牧科技 2024年第7期 180-182页

作者：贡嘎益西措姆罗润波索朗斯珠西藏农牧学院动物科学学院西藏林芝860000

《兽医微生物学》作为一门实践操作性很强的动物医学专业基础课,同时需要学生具备一定的学习能力和思考能力。在本课程中,学生除了系统掌握微生物学基本理论,还应具有较强的实际操作能力,其掌握实验室诊断技术,为动物疫病诊断、治疗以... 详细信息

《兽医微生物学》作为一门实践操作性很强的动物医学专业基础课,同时需要学生具备一定的学习能力和思考能力。在本课程中,学生除了系统掌握微生物学基本理论,还应具有较强的实际操作能力,其掌握实验室诊断技术,为动物疫病诊断、治疗以及防控等具有重要的实践意义。该文主要以西藏农牧学院动物医学专业学生为例,通过学生学习能力、动手能力特点,结合实践教学工作经验,对《兽医微生物学》实验教学改革进行初步探讨,以供参考借鉴。

关键词：兽医微生物学实验教学教学改革

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基于Levy-AVOA优化模糊PID的动力定位船舶循迹控制研究

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舰船科学技术 2024年第6期46卷 73-80页

作者：赵勇丁锐张静李吉德国网山东省电力公司山东济南250001 国网烟台供电公司山东烟台264000

为了提高动力定位(DP)铺缆船在铺设海底电缆时的路径循迹能力,设计非洲秃鹫算法优化模糊PID的船舶控制器(AVOA-Fuzzy-PID)。船舶运动数学模型采用三自由度,加入风、浪、流作用力模拟海况,以船舶的位置和姿态矢量与实际值的差值作为控制... 详细信息

为了提高动力定位(DP)铺缆船在铺设海底电缆时的路径循迹能力,设计非洲秃鹫算法优化模糊PID的船舶控制器(AVOA-Fuzzy-PID)。船舶运动数学模型采用三自由度,加入风、浪、流作用力模拟海况,以船舶的位置和姿态矢量与实际值的差值作为控制器输入。在传统PID控制器基础上加入模糊控制,根据模糊控制规则寻求K_(p)、K_(i)、K_(d)的调整变化量ΔK_(p)、ΔK_(i)、ΔK_(d)与e和de间的关系,自动调节参数,加强控制器稳定性,使船舶沿规划路径向目标位置航行。采用非洲秃鹫算法结合Levy飞行策略计算船舶模型,通过确定每组最优秃鹫、秃鹫饥饿率、探索和开发4个阶段,并在开发阶段引入Levy飞行策略,增强全局搜索能力,确定秃鹫食物源最优位置,防止结果陷入局部最优,提高计算结果精确性。仿真结果表明,结合AVOA算法的模糊PID控制器能够提高船舶路径跟踪效率,使其跟踪过程较为平顺。通过对比PSO、ga和SSA算法优化Fuzzy-PID控制器参数可以看出,AVOA对K_(p)、K_(i)、K_(d)参数整定收敛速度较快,控制器适应度值较低,寻优精度较高,能够使船舶沿规划路径航行。

关键词： DP铺缆船路径循迹模糊控制 Levy飞行策略非洲秃鹫算法

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A bibliometric analysis and visualization of research on heart failure complicated with malnutrition

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Frontiers of Nursing 2023年第4期10卷 413-426页

作者： Wu-ga Jishi Jin-Bo Fang Jie Li West China School of Nursing/department of West China Hospital Sichuan UniversityChengduSichuan 610065China

Objective:This study aimed to have a good knowledge of heart failure complicated with malnutrition research status,hotspots,and forecast research trends using bibliometric analysis and visualization of studies of hear t failure complicated with malnutrition in the past 10 ***:Ar ticles related to malnutrition-induced hear t failure were obtained from the Web of Science Core Collection(Wo SCC)series from January 2012 to January *** software(Java Cite Space 5.8R3 and Microsoft Excel 2019)were used to perform bibliometric and knowledge-map analysis,including analyzing the annual publication and trend of ar ticles,authors and co-cited authors,institutions/countries,co-cited journals,co-occurrence,clusters,and burst of keywords,co-cited references,and reference ***:A total of 672 articles appeared in 180 scientific journals by 4249 authors from 1453 institutions in 71 *** the past 10 years,the number of related studies released has shown an upward trend,and the range of increases has been larger over the past 5 *** Kasai released the most papers,while Anker S D had the most ***,active cooperation existed in complicated hear t failure with researchers on ***,Journal of The American College of Cardiology,and Clinical Nutrition were the top 3 co-cited *** USA,Japan,and China were the most productive countries,while Johns Hopkins University was the most active *** addition,the reference published by Ponikowski P had the most co-citations,relating to as a knowledge *** latest hotspots of hear t failure complicated with malnutrition mainly included research on:(1)assessment of nutrition status,the impact/risk factor of nutrition,and the prevalence and outcome of the patients;(2)hear t failure complicated with malnutrition when complicated with other diseases,for example,chronic kidney disease and diabetes mellitus;(3)the nutrition of child patients with heart fail

关键词： bibliometric CiteSpace heart failure malnutrition visualization

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Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma

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International Journal of Oral Science 2023年第1期15卷 76-86页

作者： Libo Liang Yi Li Binwu Ying Xinyan Huang Shenling Liao Jiajin Yang ga Liao General Practice Medical Center West China HospitalSichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina department of Laboratory Medicine West China HospitalSichuan UniversityChengduChina West China School/Hospital of Stomatology Sichuan UniversityChengduChina department of Information Management Department of Stomatology InformaticsWest China Hospital of StomatologySichuan UniversityChengduChina

Tongue squamous cell carcinoma is highly malignant and has a poor *** this study,we aimed to combine whole-genome sequencing,whole-genome methylation,and whole-transcriptome analyses to understand the molecular mechanisms of tongue squamous cell carcinoma *** tongue squamous cell carcinoma and adjacent normal tissues from five patients with tongue squamous cell carcinoma were included as five paired *** multi-omics sequencing,differentially methylated intervals,methylated loop sites,methylated promoters,and transcripts were screened for variation in all paired *** were analyzed to determine biological processes in tongue squamous cell *** found five mutated methylation promoters that were significantly associated with mRNA and lncRNA expression *** annotation of these transcripts revealed their involvement in triggering the mitogen-activated protein kinase cascade,which is associated with cancer progression and the development of drug resistance during *** prognostic signature models constructed based on WDR81 and HNRNPH1 and combined clinical phenotype-gene prognostic signature models showed high predictive efficacy and can be applied to predict patient prognostic risk in clinical *** identified biological processes in tongue squamous cell carcinoma that are initiated by mutations in the methylation promoter and are associated with the expression levels of specific mRNAs and ***,changes in transcript levels affect the prognosis of tongue squamous cell carcinoma patients.

关键词： squamous involvement signature

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基于数据挖掘的藏医泻治方配伍规律及用药特点分析

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中南民族大学学报（自然科学版） 2024年第2期43卷 194-200页

作者：扎西卓玛才旦拉毛嘎登尼玛贡保东知嘎务西藏藏医药大学拉萨850000 青海民族大学西宁810000 西藏自治区藏医院拉萨850004 甘肃中医药大学兰州730000

为藏医泻治方临床合理用药及新药研发提供理论依据,搜集《藏医经典文献集成》中关于历代藏医泻治方的古籍文献;共收集到92本有关藏医泻治方的古籍文献及356首藏医泻治方,应用SPPS Modeler 18软件分析法等方法,对其进行整理及分析,结果发... 详细信息

为藏医泻治方临床合理用药及新药研发提供理论依据,搜集《藏医经典文献集成》中关于历代藏医泻治方的古籍文献;共收集到92本有关藏医泻治方的古籍文献及356首藏医泻治方,应用SPPS Modeler 18软件分析法等方法,对其进行整理及分析,结果发现356首藏医泻治方中使用频次最高的前10的药物依次为白狼毒、长蝝诃子、巴豆、大果大戟、硇砂、大黄、漆树脂、荜拔、斑蝥、甘青大戟.其次,应用Apriori算法的关联规则分析法,将支持度设置为5%,置信度15%条件下发现94条藏医泻治方常用药对;其中白狼毒-长蝝诃子、白狼毒-巴豆、长蝝诃子-巴豆、白狼毒-大果大戟等是藏医泻治方2399条药对中最为常用的药物组合.356首藏医泻治方剂中使用频次最高的药物及组方关联最强的核心药对都以白狼毒、长蝝诃子、巴豆、大果大戟、硇砂等毒性较强的药物为主,而藏医临床上针对这些毒性药物具有非常严格的入药条件,必须经过专业的藏医炮制工艺技术,才能入药服用;同时,提高自身临床经验,确保泻治药物质量,搞清泻治药物炮制原理,掌握泻治疗法的具体操作方法是藏医泻治疗法临床合理应用的前提和所需条件.

关键词：藏医藏药泻治方数据挖掘配伍规律

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