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New Epigenetic Modifications in Human Diseases

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New Epigenetic Modifications in Human Diseases

Novel Pro-oncogene Pathway in Lung Cancer

遗传学为人类造福——全球华人遗传学大会

作者： Peng Jin Department of Human Genetics Emory University School of Medicine Atlanta ga 30322 USA.

＜正＞5-Methylcytosine（5-mC） is an important DNA modification found in eukaryotes that impacts gene regulation and disease ***,5-hydroxymethylcytosine（5-hmC）,another form of DNA modification,has been *** has been shown that 5-hmC is significantly enriched in the central nervous system relative to many other tissues and cell *** elucidate

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中国肺癌杂志 2009年第6期 17-18页

作者： Shouwei HAN Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, ga, USA 30322

Lung cancer is one of the most common malignant tumors in the world, and is the leading cause of cancer death in men and women in the world. Despite recent advances in understanding the molecular biology of lung

关键词： NSCLC Novel Pro-oncogene Pathway in Lung Cancer PPAR Pro

NONLINEAR OPTICS IN QUANTUM WIRES

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中国科学院大学学报 1995年第1期 17-20页

作者： Chen Rei-min(Department of Physics and Astronomy, State University of New York at Buffalo Buffalo, New York 14260-1500, USA and Department of Physics, Emory University, Atlanta, ga 30322, USA)Lin Duo-liang (Department of Physics, Hong Kong University of S

ＮＯＮＬＩＮＥＡＲＯＰＴＩＣＳＩＮＱＵＡＮＴＵＭＷＩＲＥＳ￥ＣｈｅｎＲｅｉ－ｍｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＰｈｙｓｉｃｓａｎｄＡｓｔｒｏｎｏｍｙ，ＳｔａｔｅＵｎｉｖｅｒｓｉｔｙｏｆＮｅｗＹｏｒｋａｔＢｕｆｆａｌｏＢ... 详细信息

ＮＯＮＬＩＮＥＡＲＯＰＴＩＣＳＩＮＱＵＡＮＴＵＭＷＩＲＥＳ￥ＣｈｅｎＲｅｉ－ｍｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＰｈｙｓｉｃｓａｎｄＡｓｔｒｏｎｏｍｙ，ＳｔａｔｅＵｎｉｖｅｒｓｉｔｙｏｆＮｅｗＹｏｒｋａｔＢｕｆｆａｌｏＢｕｆｆａｌｏ，ＮｅｗＹｏｒｋ１４２...

关键词： optical nonlinearity nonlinear optical susceptibility silicon quantum wires

Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake

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Genes & Diseases 2024年第1期11卷 23-25页

作者： Andrew Fesler ga-Ram Hwang Jingfang Ju Department of Pathology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA The Northport Veteran's Administration Medical Center NorthportNY 11768USA Curamir Therapeutics Inc. WoburnMA 01801USA

One of the major obstacles for nucleic acid-based medicine is cellular uptake due to the concern of efficiencyand potential toxicity of the *** this work,we developed a novel approach to eliminate the need for a vehicle to allow for the cellular uptake of siRNA-based therapy with a unique modification strategy that also further enhances therapeutic *** discovery may be of great importance for the development of siRNA-based therapeutics as cellular uptake remains a critical *** this study,we have tested the potential of this modification strategy for siRNA using a siRNA that targets B-cell lymphoma-2(BCL-2).

关键词： eliminate uptake modified

Role of CDK5 on ATM phosphorylation in neuronal death induced by DNA damage

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Role of CDK5 on ATM phosphorylation in neuronal death induce...

The first record of a Konservat-Lagerstätten in which early post-settlement stages of fossil archaeobalanids(Cirripedia:Balanomorpha)are preserved

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Bo TIAN~(1,2),Zi-Xu MAO~(1,*) 1 Department of Pharmacology and Neurology,Emory University School of Medicine,Atlanta,ga 30322 2 Department of Neurology,Tongji Medical college of Huazhong University of Science and Technology,Wuhan,400030, China

＜正＞Objective The phosphatidylinositol-3-kinase-like kinase ATM（Ataxia - telangiectasia mutated） plays a central role in coordinating the DNA damage responses including cell cycle checkpoint control,DNA repair,and apoptosis. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer ***,the mechanism by which DNA damage activates ATM is poorly *** Different analysis by protein determination,kinase assays,real-time PCR,infection with adenoviruses or Antiviruses and survival assays among others,were used to demonstrate that Cdk5 mediates DNA damage signaling through ATM *** We show that Cdk5（cyclin-dependent kinase 5）,activated by DNA damage,directly phosphorylates ATM at serine 794 in postmitotic *** at serine 794 precedes and is required for ATM autophosphorylation at serine 1981, and activates ATM kinase ***5-ATM signal regulates phosphorylation and function of ATM targets p53 and *** of Cdk5-ATM pathway attenuates DNA damage-induced neuronal cell cycle reentry and expression of p53 targets PUMA and Bax,protecting neurons from DNA damage-induced *** This study reveals the role of Cdk5 on ATM phosphorylation after DNA *** of Cdk5 by DNA damage serves as a critical signal to initiate ATM response and regulate ATM-dependent cellular processes.

关键词： CDK5 ATM DNA damage neuronal death phosphorylation

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Integrative Zoology 2024年第2期19卷 200-223页

作者： Tomáš KOCÍ Rok gaŠPARIC John BUCKERIDGE Martina KOCOVÁ VESELSKÁ Aleš ŠOSTER Ivancická581 PragueCzech Republic Palaeontological Department Natural History MuseumNational MuseumPragueCzech Republic Oertijdmuseum Bosscheweg 80Boxtel5293 WBThe Netherlands Institute for Palaeobiology and Evolution Novi TrgKamnikSlovenia Earth and Oceanic Systems Group RMIT UniversityMelbourneAustralia Museums Victoria CarltonVictoriaAustralia Department of Paleobiology and Paleoecology Institute of Geology of the Czech Academy of SciencesPragueCzech Republic Institute of Geology and Palaeontology Charles UniversityPragueCzech Republic Faculty of Natural Sciences and Engineering University of LjubljanaLjubljanaSlovenia

A diverse sessile barnacle fauna from a Miocene shallow-water deposit at Dolnja Stara vas in Slovenia is *** includes the first descriptions of early post settlement juveniles of Actinobalanus sloveniensis attached to mangrove *** represent three distinct growth phases,the earliest being interpreted as being less than 24 h post settlement,the others being 1 to 2 days post *** assessment of their taphonomy is *** adult balanomorphs are attached to a variety of organic substrates,including mangrove leaves and branches,fragments of the conifers?Taxodioxylon,Carapoxylon,pine cones,molluscs,and cetacean *** barnacles include ***,Amphibalanus venustus,and Perforatus perforatus—many with opercula retained within the *** retains some of the original shell *** is the second record of barnacle–plant associations from the Central Paratethys from Kamnik and *** paleoecology and paleogeography of the site are discussed.

关键词： acorn barnacles barnacle metamorphosis epibiont paleoecology taxonomy

HN3 Reaction with the C(100)-2×1 Surface:A DFT Study

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HN3 Reaction with the C(100)-2×1 Surface:A DFT Study

Interactions of the Tetraspanin Web with Different Signaling Pathways Underlie the Function of KAI1 Metastasis Suppressor

2001年纳米和表面科学与技术全国会议

作者： Xin Lu, gang Fu, Nanqin Wang, Qianer Zhang, and M.C. Lin State Key Laboratory for Physical Chemistry of Solid Surfaces & Department of Chemistry, Xiamen University, Xiamen 361005, PR China h Cherry L. Emerson Center for Scientific Computation & Department of Chemistry, Emory University, Atlanta, ga 30322, USA

Carbon nitride has some superlative properties, such as a large bandgap and a hardness superior than diamond. It is thus of interest to study nitridation of diamond surface. The gas-surface reaction of HN3 with the C(100)-2×1 surface has been investigated recently in our laboratory by means of density functional cluster model calculations. The calculations revealed the following two reaction pathways:

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中国肺癌杂志 2009年第6期 41-41页

作者： Jintang DONG Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, ga 30322, USA

The KAI1 (kang ai 1) metastasis suppressor gene, also known as CD82, is a member of the tetraspanin superfamily that form a complex protein network on cellular membrane to regulate multiple biological processes

关键词： Interactions of the Tetraspanin Web with Different Signaling Pathways Underlie the Function of KAI1 Metastasis Suppressor

Targeting Mnk/eIF4E Signaling for Cancer Therapy

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中国肺癌杂志 2009年第6期 19-19页

作者： Shiyong SUN Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, ga 30322, USA

The synthesis of many oncognic proteins such as c-Myc, VEGF, ODC, cyclin D1, HIF-1 and Mcl-1 are regulated by cap-dependent translational mechanism because the mRNAs of these genes possess long and highly

关键词： Targeting Mnk/eIF4E Signaling for Cancer Therapy CGP ODC