检索结果-南通市图书馆

早产儿小脑损伤的超声与MRI检出率及影像学表现

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2009年第5期32卷 489-489页

作者： S.J.Steggerda L.M.Leijser F.T.Wiggers-de Brune J.van der grond F.J.Walther g.van wezel-meijler 秦乃姗 Department of Pediatrics Division of NeonatologyLeiden University Medical Center

目的以MR影像为参考标准．探讨一组过早产儿经前囟（AF）常规头颅超声（US）并补充经乳突囟（MF）和后囟（PF）的超声检查小脑损伤的检出率及其影像学特征。材料与方法此前瞻性研究经学术委员会批准并获得知情同意通知。一组77例早产儿... 详细信息

目的以MR影像为参考标准．探讨一组过早产儿经前囟（AF）常规头颅超声（US）并补充经乳突囟（MF）和后囟（PF）的超声检查小脑损伤的检出率及其影像学特征。材料与方法此前瞻性研究经学术委员会批准并获得知情同意通知。一组77例早产儿（小于32周）在新生儿期行多次超声检查，分别采用经AF、PF和MF声窗影像。其中59例在同等月龄段行MRI检查。

关键词：影像学表现 MRI检查超声检查小脑损伤早产儿检出率影像学特征学术委员会

A model for real-time computation of fuselage-rotor interference

在线全文

学校读者我要写书评

暂无评论

International Journal of Modeling, Simulation, and Scientific Computing 2017年第4期8卷 10-24页

作者： Berend g.van der Wall Jianping Yin Institute of Flight Systems DLR Lilienthalplatz 738108 BraunschweigGermany Institute of Aerodynamics and Flow Technology DLR Lilienthalplatz 738108 BraunschweigGermany

A simple analytical real-time capable model to account for fuselage-induced velocities at rotor blade elements is described at the example of the Bo105 *** of the fuselage-induced flow fields in the volume of rotor operation above the fuselage are first computed by a panel method in the range of angle of attack and sideslip of±90°.The model parameters are then estimated based on these *** usefulness of the model in combinations of angle of attack and sideslip is demonstrated.

关键词： Helicopter aerodynamics fuselage-rotor interference real-time simulation

Computationally predicted energies and properties of defects in gaN

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2017年第1期3卷 374-383页

作者： John L.Lyons Chris g.van de Walle Center for Computational Materials Science Naval Research LaboratoryWashingtonDC 20375USA Materials Department University of CaliforniaSanta BarbaraCA 93106-5050USA

Recent developments in theoretical techniques have significantly improved the predictive power of density-functional-based *** this review,we discuss how such advancements have enabled improved understanding of native point defects in *** review the methodologies for the calculation of point defects,and discuss how techniques for overcoming the band-gap problem of density functional theory affect native defect *** particular,we examine to what extent calculations performed with semilocal functionals(such as the generalized gradient approximation),combined with correction schemes,can produce accurate *** properties of vacancy,interstitial,and antisite defects in gaN are described,as well as their interaction with common *** also connect the first-principles results to experimental observations,and discuss how native defects and their complexes impact the performance of nitride ***,we find that lower-cost functionals,such as the generalized gradient approximation,combined with band-edge correction schemes can produce results that are qualitatively ***,important physics may be missed in some important cases,particularly for optical transitions and when carrier localization occurs.

关键词： correction approximation properties

What makes(hydroxy)chloroquine ineffective against COVID-19:insights from cell biology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2021年第3期13卷 175-184页

作者： Dania Altulea Sjors Maassen Maksim V.Baranov g.van den Bogaart Department of Molecular Immunology and Microbiology Groningen Biomolecular Sciences and Biotechnology InstituteUniversity of GroningenGroningenthe Netherlands Department of Tumor Immunology Radboud Institute for Molecular Life SciencesRadboud University Medical CenterNijmegenthe Netherlands

Since chloroquine(CQ)and hydroxychloroquine(HCQ)can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in cultured cells,the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease(COVID-19).However,despite promising preliminary findings,many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against ***,we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.

关键词： coronavirus COVID-19 SARS-CoV-2 chloroquine hydroxychloroquine

Influence of core stiffness on the behavior of tall timber buildings subjected to wind loads

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2021年第1期15卷 213-226页

作者： Zhouyan XIA Jan-Willem g.van DE KUILEN Andrea POLASTRI Ario CECCOTTI Minjuan HE Wood Research Munich Technical University of MunichMunich 80797Germany Tree and Timber Institute(IVALSA)of the Italian National Research Council San Michele all’Adige 38010Italy College of Civil Engineering Tongji UniversityShanghai 100029China

This study analyzes the feasibility of the use of cross-laminated timber(CLT)as a load-bearing structural element in a 40-story building based on Chinese design *** proposed design of the high-rise concrete-CLT building utilizes the core-outrigger *** is used for the central core and outriggers,and CLT is used for the rest of the structure of the *** element models with different types of connections were developed using SAP2000 to analyze the lateral behavior of the building under wind *** finite element models with rigid connections deduce the wind load distributions on individual structural elements,which determine the total number and the stiffness of fasteners of the CLT ***,spring links with equivalent stiffness that simulate the mechanical fasteners were employed in *** results indicate that CLT increases the lateral flexibility of the building.A closed concrete core was substituted by two half cores to measure the requirement of the maximum lateral ***,the acceleration at the building top still exceeded the limitation prescribed in Chinese Code JgJ 3-2010 owing to the lightweight of CLT and decreased stiffness of the hybrid *** restrict this top acceleration within the limit,further approaches to increase the stiffness in the weak direction of the building are *** such as the modification of the floor layout,increase in the thickness of walls,and addition of extra damping capacity should be considered and verified in the future.

关键词： cross-laminated timber tall timber buildings finite element analysis horizontal deflection top acceleration

global and Regional Surface Nitrogen Balances in Intensive Agricultural Production Systems for the Period 1970-2030

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2005年第2期15卷 137-155页

作者： A. F. BOUWMAN g.van DRECHT K. W. van der HOEK Netherlands Environmental Assessment Agency Netherlands Environmental Assessment AgencyLaboratory for Environmental Monitoring National Institute for Public Health and the EnvironmentP .O. Box 13720 BA Bilthoven (The Netherlands)National Institute for Public Health and the EnvironmentP .O. Box 13720 BA Bilthoven (The Netherlands)National Institute for Public Health and the EnvironmentP. O. Box 13720 BA Bilthoven (The Netherlands)

global nitrogen (N) budgets for intensive agricultural systems were compiled for a 0.5 by 0.5 degree resolution. These budgets include N inputs (N fertilizer, animal manure, biological N fixation and atmospheric N deposition) and outputs (N removal from the field in harvested crops and grass and grass consumption by grazing animals, ammonia volatilization,denitrification and leaching). Data for the historical years 1970 and 1995 and a projection for 2030 were used to study changes in the recovery of N and the different loss terms for intensive agricultural systems. The results indicate that the overall system N recovery and fertilizer use efficiency slowly increased in the industrialized countries between 1970 and 1995, the values for developing countries have decreased in the same period. For the coming three decades our results indicate a rapid increase in both the industrialized and developing countries. High values of ＞ 80% for fertilizer use efficiency may be related to surface N balance deficits, implying a depletion of soil N and loss of soil fertility. The projected intensification in most developing countries will cause a gradual shift from deficits to surpluses in the coming *** projected fast growth of crop and livestock production, and intensification and associated increase in fertilizer inputs will cause a major increase in the surface N balance surplus in the coming three decades. This implies increasing losses of N compounds to air (ammonia, nitrous oxide and nitric oxide), and groundwater and surface water (nitrate).

关键词： animal manure fertilizer intensive agriculture nitrogen surface balance

Surface N balances and reactive N loss to the environment from global intensive agricultural production systems for the period 1970-2030

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2005年第z2期48卷 767-779页

作者： A.F.Bouwman g.van Drecht K.W.van der Hoek Netherlands Environmental Assessment Agency National Institute for Public Health and the Environment P.O.Box 13720 BA BilthovenThe Netherlands Laboratory for Environmental Monitoring National Institute for Public Health and the Environment P.O.Box 13720 BA BilthovenThe Netherlands

Data for the historical years 1970 and 1995 and the FAO-Agriculture Towards 2030 projection are used to calculate N inputs (N fertilizer, animal manure, biological N fixation and atmospheric deposition) and the N export from the field in harvested crops and grass and grass consumption by grazing animals. In most industrialized countries we see a gradual increase of the overall N recovery of the intensive agricultural production systems over the whole 1970-2030 period. In contrast, low N input systems in many developing countries sustained low crop yields for many years but at the cost of soil fertility by depleting soil nutrient pools. In most developing countries the N recovery will increase in the coming decades by increasing efficiencies of N use in both crop and livestock production systems. The surface balance surplus of N is lost from the agricultural system via different pathways, including NH3 volatilization, denitrification, N2O and NO emissions, and nitrate leaching from the root zone. global NH3-N emissions from fertilizer and animal manure application and stored manure increased from 18 to 34 Tg·yr-1 between 1970 and 1995, and will further increase to 44 Tg·yr-1 in 2030. Similar developments are seen for N2O-N (2.0 Tg·yr-1 in 1970, 2.7 Tg·yr-1 in 1995 and 3.5 Tg·yr-1 in 2030) and NO-N emissions (1.1 Tg·yr-1 in 1970, 1.5Tg·yr-1 in 1995 and 2.0 Tg·yr-1 in 2030).

关键词： surface N balances reactive N loss global intensive agricultural system.

Insights from an academic endeavor into central nervous system drug discovery

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An M.Voets Tim vanmierlo Rudy Schreiber BIOMED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University MS Center(UMSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013).

关键词： academic approval consequences

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation