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Applied Mathematics and Mechanics(English Edition) 2012年第8期33卷 1001-1014页

作者： B.J.gIREEsHA g.s.roopa C.s.BAgEWADI Department of studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451KarnatakaIndia

This paper investigates the problem of hydrodynamic boundary layer flow and heat transfer of a dusty fluid over an unsteady stretching surface. The study considers the effects of frictional heating （viscous dissipation） and internal heat generation or ab- sorption. The basic equations governing the flow and heat transfer are reduced to a set of non-linear ordinary differential equations by applying suitable similarity transformations. The transformed equations are numerically solved by the Runge-Kutta-Fehlberg-45 order method. An analysis is carried out for two different cases of heating processes, namely, variable wall temperature （VWT） and variable heat flux （VHF）. The effects of various physical parameters such as the magnetic parameter, the fluid-particle interaction pa- rameter, the unsteady parameter, the Prandtl number, the Eckert number, the number density of dust particles, and the heat source/sink parameter on velocity and temperature profiles are shown in several plots. The effects of the wall temperature gradient function and the wall temperature function are tabulated and discussed.

关键词： heat transfer boundary layer flow stretching surface dusty fluid viscousdissipation non-uniform heat source numerical solution

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Navier’s slip condition on time dependent Darcy-Forchheimer nanofluid using spectral relaxation method

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Journal of Central south University 2019年第7期26卷 2000-2010页

作者： Younghae DO g. K. RAMEsH g. s. roopa M. sANKAR Department of Mathematics KNU-Center for Nonlinear Dynamics Kyungpook National University Daegu 41566 Korea Department of Mathematics K.L.E. Society’s J.T. College Gadag-582102 Karnataka India Department of Mathematics Malnad College of Engineering Hassan-573202 Karnataka India Department of Mathematics School of Engineering Presidency University Bengaluru-560064 Karnataka India

In industrial applications involving metal and polymer sheets, the flow situation is strongly unsteady and the sheet temperature is a mixture of prescribed surface temperature and heat flux. Further, a proper choice of cooling liquid is also an important component of the analysis to achieve better outputs. In this paper, we numerically investigate Darcy-Forchheimer nanoliquid flows past an unsteady stretching surface by incorporating various effects, such as the Brownian and thermophoresis effects, Navier’s slip condition and convective thermal boundary conditions. To solve the governing equations, using suitable similarity transformations, the nonlinear ordinary differential equations are derived and the resulting coupled momentum and energy equations are numerically solved using the spectral relaxation method. Through the systematically numerical investigation, the important physical parameters of the present model are analyzed. We find that the presence of unsteadiness parameter has significant effects on velocity, temperature, concentration fields, the associated heat and mass transport rates. Also, an increase in inertia coefficient and porosity parameter causes an increase in the velocity at the boundary.

关键词： Darcy-Forchheimer flow nanoliquid Navier’s slip convective condition numerical solution

BE-RPL:Balanced-load and Energy-efficient RPL

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Computer systems science & Engineering 2023年第4期45卷 785-801页

作者： s.Jagir Hussain M.roopa Department of Electronics and Communication Engineering SRM Institute of Science and TechnologyRamapuramChennaiIndia

Internet of Things(IoT)empowers imaginative applications and permits new services when mobile nodes are *** IoT-enabled low-power and lossy networks(LLN),the Routing Protocol for Low-power and Lossy Networks(RPL)has become an established standard routing *** under standard RPL remains a difficult issue as it causes continuous path disturbance,energy loss,and increases the end-to-end delay in the *** this unique circumstance,a Balanced-load and Energy-efficient RPL(BE-RPL)is *** is a routing technique that is both energy-efficient and *** responds quicker to link breakage through received signal strength-based mobility monitoring and selecting a new preferred parent *** proposed system also implements load balancing among stationary nodes for leaf node *** nodes with more leaf nodes are restricted from participating in the election for a new preferred *** performance of BE-RPL is assessed using the COOJA *** improves the energy use,network control overhead,frame acknowledgment ratio,and packet delivery ratio of the network.

关键词： COOJA simulator energy handover internet of things BE-RPL load balancing low-power and lossy network mobility routing protocols RPL

Efficient Energy-Aware Resource Management Model(EEARMM)Based Dynamic VM Migration

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Computer systems science & Engineering 2022年第11期43卷 657-669页

作者： V.roopa K.Malarvizhi s.Karthik Department of Information Technology Sri Krishna College of TechnologyCoimbatore641042India Department of Electrical&Electronics Engineering Kumaraguru College of TechnologyCoimbatore641049India Department of Computer science&Engineering SNS College of TechnologyCoimbatore641035TamilnaduIndia

In cloud environment,an efficient resource management establishes the allocation of computational resources of cloud service providers to the requests of users for meeting the user’s *** proficient resource management and work allocation determines the accomplishment of the cloud ***,it is very difficult to persuade the objectives of the Cloud service Providers(CsPs)and end users in an impulsive cloud domain with random changes of workloads,huge resource availability and complicated service policies to handle them,With that note,this paper attempts to present an Efficient Energy-Aware Resource Management Model(EEARMM)that works in a decentralized ***,the model involves in reducing the number of migrations by definite workload management for efficient resource *** is,it makes an effort to reduce the amount of physical devices utilized for load balancing with certain resource and energy consumption management of every *** Estimation Model Algorithm(EMA)is given for determining the virtual machine ***,VM-selection Algorithm(sA)is also provided for choosing the appropriate VM to migrate for resource *** the incorporation of these algorithms,overloading of VM instances can be avoided and energy efficiency can be improved *** performance evaluation and comparative analysis,based on the dynamic workloads in different factors provides evidence to the efficiency,feasibility and scalability of the proposed model in cloud domain with high rate of resources and workload management.

关键词： Resource management model energy efficient cloud computing VM migration workload management

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： giulia Comini Eilís Dowd Pharmacology&Therapeutics and galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain gabriele Univ.grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage