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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong ge dai li Rongrong Zhong Qiang liu Fanglian Chen Ping lei Department of geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor lY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

基于背景噪声研究东滩矿区地下介质波速变化特征

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大地测量与地球动力学 2025年第1期45卷 55-59页

作者：戴宗辉曲均浩山东省地震局济南市250014

基于地震背景噪声互相关方法,利用东滩煤矿CCH和BDS台2022-02-0802:00-2023-03-0807:00连续波形数据计算地下介质波速变化,并分析其与63上06工作面回采作业和矿震活动的相关性。研究结果表明,63上06工作面回采作业对地下介质波速影响明... 详细信息

基于地震背景噪声互相关方法,利用东滩煤矿CCH和BDS台2022-02-0802:00-2023-03-0807:00连续波形数据计算地下介质波速变化,并分析其与63上06工作面回采作业和矿震活动的相关性。研究结果表明,63上06工作面回采作业对地下介质波速影响明显;波速转折变化与矿震发生也具有较为明显的相关性,反映出地下应力水平变化与矿震发生的关系;矿震对地下应力的释放也可导致波速出现小幅度波动变化。

关键词：背景噪声波速变化东滩煤矿矿震

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang liang Bei Hu longlong Ren Yanjuan liu Yuhu Zhang Chengbo dai Hejun Wu Weifeng li Xin li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Spectroscopic Properties of Sr 5p_(1/2)ns Autoionizing States

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Chinese Physics letters 1996年第8期13卷 579-582页

作者： dai Chang-jian lÜJun Department of Physics Zhejiang UniversityHangzhou 310027

The resonance profile of the Sr 5p_(1/2)ns states and angular dependence of ejected electrons have been studied by using three-step excitation *** levels and widths of the 5p_(1/2)ns states with n ranging from 7 to 10 are *** electrons originated from the decays to different ionic states are resolved with the time-of-flight detector.

关键词： scheme states

Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

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Science China life Sciences 2025年第1期 303-305页

作者： Ziqian Xu lianpan dai Jun liu National Key laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention CAS Key laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences

Vector-borne viruses, transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al., 2022).Among them, dengue virus-induced epidemics, have dramatically increased worldwide in recent decades. The report released by the World Health Organization(WHO) at the end of 2023 showed that dengue epidemic globally surged in2023, with the number of reported cases nearing a historical peak.

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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

MANY-SERVER QUEUES WITH CUSTOMER ABANDONMENT:A SURVEY OF DIFFUSION AND FlUID APPROXIMATIONS

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Journal of Systems Science and Systems Engineering 2012年第1期21卷 1-36页

作者： J. g. dai Shuangchi HE H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta GA 30332 USA. Department of Industrial and Systems Engineering National University of Singapore Singapore 11757

The performance of a call center is sensitive to customer abandonment. In this survey paper, we focus on g/gI/n ＋ gI parallel-server queues that serve as a building block to model call center operations. Such a queue has a general arrival process （the g ）, independent and identically distributed （iid） service times with a general distribution （the first g1 ）, and iid patience times with a general distribution （the ＋gI）. Following the square-root safety staffing rule, this queue can be operated in the quality- and efficiency-driven （QED） regime, which is characterized by large customer volume, the waiting times being a fraction of the service times, only a small fraction of customers abandoning the system, and high server utilization. Operational efficiency is the central target in a system whose staffing costs dominate other expenses. If a moderate fraction of customer abandonment is allowed, such a system should be operated in an overloaded regime known as the efficiency-driven （ED） regime. We survey recent results on the many-server queues that are operated in the QED and ED regimes. These results include the performance insensitivity to patience time distributions and diffusion and fluid approximate models as practical tools for performance analysis.

关键词： Heavy traffic square-root safety staffing quality- and efficiency-driven regime efficiency-driven regime piecewise OU process

Three-dimensional dynamics of supported pipes conveying fluid

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Acta Mechanica Sinica 2017年第6期33卷 1065-1074页

作者： l.Wang T.l.Jiang H.l.dai Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074 China

This paper deals with the three-dimensional dynamics and postbuckling behavior of flexible supported pipes conveying fluid, considering flow velocities lower and higher than the critical value at which the buckling instability occurs. In the case of low flow velocity, the pipe is stable with a straight equilibrium position and the dynamics of the system can be examined using linear theory. When the flow velocity is beyond the critical value, any motions of the pipe could be around the postbuckling configuration(non-zero equilibrium position) rather than the straight equilibrium position, so nonlinear theory is required. The nonlinear equations of perturbed motions around the postbuckling configuration are derived and solved with the aid of galerkin discretization. It is found, for a given flow velocity,that the first-mode frequency for in-plane motions is quite different from that for out-of-plane motions. However, the second-or third-mode frequencies for in-plane motions are approximately equal to their counterparts for out-of-plane motions, keeping almost constant values with increasing flow velocity. Moreover, the orientation angle of the postbuckling configuration plane for a buckled pipe can be significantly affected by initial conditions, displaying new features which have not been observed in the same pipe system factitiously supposed to deform in a single plane.

关键词： Pipe conveying fluid Three-dimensional dynamics Instability Natural frequency Postbuckling configuration

Silica-coating-assisted nitridation of TiO_(2) nanoparticles and their photothermal property

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Nano Research 2021年第9期14卷 3228-3233页

作者： Qilin Wei Danielle l.Kuhn Zachary Zander Brendan g.Delacy Hai-lung dai Yugang Sun Department of Chemistry Temple University1901 North 13th StreetPhiladelphiaPennsylvania 19122USA U.S.Army Edgewood Chemical Biological Center Research&Technology DirectorateAberdeen Proving GroundMaryland 21010USA

Nanoparticles of refractory compounds represent a class of stable materials showing a great promise to support localized surface plasmon resonances(lSPRs)in both visible and near infrared(NIR)spectral *** is still challenging to rationally tune the lSPR band because of the difficulty to control the density of charge carriers in individual refractory nanoparticles and maintain the dispersity of nanoparticles in the processes of synthesis and *** this work,controlled chemical transformation of titanium dioxide(TiO_(2))nanoparticles encapsulated with mesoporous silica(SiO_(2))shells to titanium nitride(TiN)via nitridation reaction at elevated temperatures is developed to tune the density of free electrons in the resulting titanium-oxide-nitride(TiO_(x)N_(y))*** tunability enables a flexibility to support lSPR-based optical absorption in the synthesized TiO_(x)N_(y)@SiO_(2) core-shell nanoparticles across both the visible and NIR *** silica shells play a crucial role in preventing the sintering of TiO_(x)N_(y) nanoparticles in the nitridation reaction and maintaining the stability of TiOxNy nanoparticles in *** lSPR-based broadband absorption of light in the TiO_(x)N_(y)@SiO_(2) nanoparticles exhibits strong photothermal effect with photo-to-thermal conversion efficiency as high as〜76%.

关键词： titanium-oxide-nitride nanoparticles mesoporous silica coating nitridation reaction structural transformation plasmonic absorption photothermal effect