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四川纺织科技 2000年第2期 19-33页

作者： g.e evans J Shore C.V Stead 蒲宗耀陈松

efficacy of nonsolvent flower pollen extracts in healthy women with urinary incontinence:A randomized,double-blind,placebo-controlled,parallel study

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Current Urology 2024年第3期18卷 203-211页

作者： Marc Moulin erin D.Lewis David C.Crowley Colleen e.May Malkanthi evans KgK Science Inc. LondonOntarioCanada graminex L.L.C.SaginawMIUSA

Background Urinary incontinence(UI)is a debilitating and common condition that adversely affects quality of *** and surgical approaches for managing UI symptoms may result in undesirable risks and *** randomized,double-blind,placebo-controlled,parallel study investigated the efficacy of 2 nonsolvent flower pollen extracts on UI in healthy *** and methods One-hundred and fourteen women aged 40–75 years who scored≥5 on the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-SF)were randomized to receive either graminex®RCT Fem™UI,graminex®PollenBerry®,or placebo for 24 *** primary outcome was the change in the ICIQ-SF score between the trial and placebo groups after 24 weeks of *** secondary outcomes included changes in the frequency of nocturia(recorded in 3-day void diaries)and 24-hour leakage volume(assessed via pad weight)after 6,12,18,and 24 weeks of supplementation and changes in stress-induced urinary leakage volume(after completion of a provocative maneuver challenge)after 24 weeks of *** All the groups demonstrated improvement in ICIQ-SF scores at week 24(pe RCT Fem™UI group had the g.eatest improvement in ICIQ-SF scores(−4.07±3.4),followed by the PollenBerry®group(−3.34±2.87)and placebo group(−2.61±3.52).The RCT Fem™UI group had corresponding improvements in 24-hour leakage volume(−17.68±39.84 g)and frequency of nocturia(−0.52±1.26)(p≤0.05).PollenBerry®supplementation significantly improved stress-induced urinary leakage volume(−7.12±15.64 g)at week *** study products demonstrated safe hematological and chemical *** RCT Fem™UI supplementation resulted in significant and clinically meaningful reductions in UI severity,with corresponding improvements in daily urinary leakage volume and frequency of ***®significantly improved stress-induced urinary leakage volume,sug.esting that it may be eff

关键词： Urinary incontinence Pollen extract Healthy women Dietary supplement ICIQ-SF Urinary leakage

enantioselective iridium-catalyzed allylic substitution with a Reformatsky reagent: direct construction of β-stereogenic homoallylic esters

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Science China Chemistry 2024年

作者： Debasis Pal Kirana D.Veeranna Yuk Fai Wong P.Andrew evans Department of Chemistry Queen's University(Canada) Xiangya School of Pharmaceutical Sciences Central South University

The Reformatsky reagent derived from ethyl bromoacetate circumvents the challenge associated with the direct regio-and enantioselective iridium-catalyzed allylic alkylation with an unstabilized aliphatic ester enolate. Notably, this work represents the first example of using a Reformatsky reagent in a metal-allyl reaction, which permits the direct construction of enantioenriched β-stereogenic homoallylic esters without preactivation of the pronucleophile or post-reaction modification of the product(e.g., thermal decarboxylation of a 1,3-dicarbonyl). Moreover, the process allows the coupling of a broad range of sterically and electronically diverse electrophiles bearing aryl, heteroaryl and alkenyl derivatives, including the significantly more challenging alkyl-substituted allylic carbonates. The versatility of the ester product is exemplified by a series of functional group manipulations and the development of a concise and efficient enantioselective total synthesis of the natural product,(+)-descurainolide A. Finally, mechanistic studies indicate that the zinc enolate behaves as a soft nucleophile that underg.es outer-sphere alkylation.

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Broad Hormonal Responses Induced by Aluminum in Roots of Dwarf Transgenics of Solanum lycopersicum L. cv “Micro-Tom”

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American Journal of Plant Sciences 2024年第5期15卷 349-358页

作者： Arthur B. Rates Daniela Boanares Daniele S. g. Pianetti Felipe Della-Torre Joni e. Lima Marcel g. C. França Department of Botany and Plant Physiology Laboratory Federal University of Minas Gerais Belo Horizonte Brazil

The spatial pattern distribution of plant hormones in response to aluminum (Al) toxicity in roots remains to be shown. This study was performed to assess the root hormonal accumulation and gene expression in response to Al toxicity in five transgenic miniature dwarf tomatoes cv. Micro-Tom (MT). MT and MT transgenics to acid indole acetic, cytokinin, gibberellin, abscisic acid and ethylene were cultivated in nutrient solutions containing different Al concentrations. Root growth elongation was measured and cellular damage was visualized by staining evans’s blue. The gUS reporter gene staining technique was used to visualize hormonal changes in MT apex root tissues. Data indicated that the MT is sensitive to Al that induced significant growth inhibition and cellular damage. Al concentration of 27 μM was significantly toxic, inducing root apex darkening and inhibition of root development. The qualitative evaluation of gUS reporter gene expression showed intense crosstalk among all hormones studied, underscoring the complexity of signaling induced by Al in apex roots. Results point out to a major understanding of the hormonal signaling in response to Al toxicity, which may induce a change of root growth and architecture with growth inhibition and cell constraints modulated by all different hormones evaluated.

关键词： gene Reporter Metal Plant Hormones Root Staining

Ultrasound-assisted microfeeding of fine powders

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Particuology 2008年第1期6卷 2-8页

作者： Xuesong Lu Shoufeng Yang Julian R.g. evans Department of Materials Queen Mary University of London Mile End Road London E1 4NS UK

Ultrasonic microfeeding of powders is a new and promising method for use in solid freeforming and pharmaceutical dosing. In this work, computer-controlled microfeeding systems using ultrasonic vibration of a capillary were built. A wide range of controlled, stable rates of flow and switching control were achieved in the acoustic vibration system and uniform powder doses were obtained in the ultrasonic system. experimental results show that nozzle diameter, transmission fluid depth, waveform, voltage amplitude, frequency and oscillation duration all influence the dose mass. Among these factors, nozzle diameter, voltage amplitude and oscillation duration can be best used to control the dose mass. An artificial neural network （ANN） technique was applied to predict the dose mass. Based on these research results, four types of microfeeding were proposed.

关键词： Microfeeding Ultrasound Fine powders

extrusion Freeforming of Millimeter-Wave electromag.etic Bandgap (eBg) Photonic Crystals

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Tsinghua Science and Technology 2009年第S1期14卷 168-174页

作者：吕雪松 Lee Yoonjae evans Julian R g PARINI Clive g Department of Chemistry University College London 20 Gordon Street London WC1H 0AJ UK Department of electronic engineering Queen Mary University of London Mile End Road London E1 4NS UK

extrusion freeforming can be used for the rapid prototyping of millimeter-wave electromag.etic bandgap (eBg) structures. In this work, an alumina-polymer paste with a relatively high volatility solvent (propanol) was used and the characteristics of the ceramic paste, particularly the rheological features are described. The advantage of high volatility solvent is that the viscosity and elastic modulus of the paste are increased sharply as the solvent evaporates. Thus, the rigidity of the extruded filament is quickly increased as a small amount of solvent evaporates. Finally, by employing this procedure, different eBg structures such as 2-D, 3-D woodpile and aperiodic structures were fabricated and their bandgaps were measured. The experimental results show that extrusion freeforming is a relatively simple and easy method to fabricate these woodpile structures with a bandgap in the 90-110 gHz region.

关键词： extrusion freeforming paste rheology electromag.etic bandgap (eBg) crystal

electrophysiological assessment of primary cortical neurons genetically engineered using iron oxide nanoparticles

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Nano Research 2017年第8期10卷 2881-2890页

作者： Michael g. evans Arwa Al-Shakli Stuart I. Jenkins Divya M. Chari School of Life Sciences Keele University Keele Staffordshire ST5 5BG UK Institute for Science and Technology in Medicine Keele University Keele Staffordshire ST5 5BG UK

The development of safe technolog.es to genetically modify neurons is of g.eat interest in regenerative neurology, for both translational and basic science applications. Such approaches have conventionally been heavily reliant on viral transduction methods, which have safety and production limitations. Mag.etofection （mag.et-assisted gene transfer using iron oxide nanoparticles as vectors） has emerged as a highly promising non-viral alternative for safe and reproducible genetic modification of neurons. Despite the high potential of this technology, there is an important gap in our knowledge of the safety of this approach, namely, whether it alters neuronal function in adverse ways, such as by altering neuronal excitability and signaling. We have investigated the effects of mag.etofection in primary cortical neurons by examining neuronal excitability using the whole cell patch clamp technique. We found no evidence that mag.etofection alters the voltage-dependent sodium and potassium ionic currents that underpin excitability. Our study provides important new data supporting mag.etofection as a safe technology for bioengineering of neuronal cell populations.

关键词： transfection mag.etic nanoparticle g.een fluorescent protein (gFP) whole-cell patch clamp fluorescence microscopy

Taxonomic revision of lizards from the Paleocene deposits of the Qianshan Basin, Anhui, China

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古脊椎动物学报 2016年第3期54卷 243-268页

作者： DONg Li-Ping Susan e. evans WANg Yuan Key Laboratory of Vertebrate evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and Paleoanthropology Chinese Aeademy ofScienees Beijing 100044 China Department of Cell and Developmental Biology University College Lonclon London WC1E6BT.UK)

Although the Late Cretaceous lizard fauna of China and Mongolia is relatively well-known, information on Paleocene lizards from the same region is currently limited. Several species of lizards have been reported from the Paleocene Wanghudun and Doumu formations of Qianshan Basin on the basis of frag.entary specimens, namely Agama sinensis Hou, 1974, Anhuisaurus huainanensis Hou, 1974, Anqingosanrus brevicephalus Hou, 1976, Changjiangosaurus huananensis Hou, 1976, Qianshanosaurus huangpuensis Hou, 1974, and Tinosaurus doumuensis Hou, 1974. In this paper, we review all the reported material of these taxa with the aid of new technology, including CT scanning, and according to current views of squamate relationships and classification. Revised descriptions and classifications are given for each taxon, leading to changes in our understanding of faunal composition. This, in turn, reveals g.eater morphological and ecological diversity among the Paleocene lizards of the Qianshan Basin, including the occurrence of a varaniform (IVPP V 22767), and the reinterpretation of Anqingosaurus as a possible burrower. Further work on the Paleocene Qianshan lizards is ongoing and the discovery of new specimens may help to solve the puzzles these strange lizards have posed.

关键词： Qianshan Basin Anhui Paleocene lizards phylogeny taxonomic revision CT-scan

Relativistic domain-wall dynamics in van der Waals antiferromag.et MnPS_(3)

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npj Computational Materials 2022年第1期8卷 27-35页

作者： Ignacio M.Alliati Richard F.L.evans Kostya S.Novoselov elton J.g.Santos School of Mathematics and Physics Queen’s University BelfastBelfastBT71NNUK Department of Physics The University of YorkYorkYO105DDUK Institute for Functional Intelligent Materials National University of SingaporeSingapore117544Singapore Institute for Condensed Matter Physics and Complex Systems School of Physics and AstronomyThe University of EdinburghEdinburghEH93FDUK Higgs Centre for Theoretical Physics The University of EdinburghEdinburghEH93FDUK

The discovery of two-dimensional(2D)mag.etic van der Waals(vdW)materials has flourished an endeavor for fundamental problems as well as potential applications in computing,sensing and storage *** particular interest are antiferromag.ets,which due to their intrinsic exchange coupling show several advantages in relation to ferromag.ets such as robustness against external mag.etic *** we show that,despite of this cornerstone,the mag.etic domains of recently discovered 2D vdW MnPS_(3)antiferromag.et can be controlled via mag.etic fields and electric *** achieve ultrafast domain-wall dynamics with velocities up to~3000 m s^(−1)within a relativistic *** contraction and emission of spin-waves in the terahertz gap are observed with dependence on the edge termination of the *** results indicate that the implementation of 2D antiferromag.ets in real applications can be further controlled through edge engineering which sets functional characteristics for ultrathin device platforms with relativistic features.

关键词： relativistic dynamics antiferromag.et

Searching for a route to synthesize in situ epitaxial Pr_(2)Ir_(2)O_(7) thin films with thermodynamic methods

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npj Computational Materials 2021年第1期7卷 1320-1325页

作者： Lu guo Shun-Li Shang Neil Campbell Paul g.evans Mark Rzchowski Zi-Kui Liu Chang-Beom eom Department of Materials Science and engineering University of Wisconsin-MadisonMadisonWisconsinUSA Department of Materials Science and engineering The Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA Department of Physics University of Wisconsin-MadisonMadisonWisconsinUSA

In situ growth of pyrochlore iridate thin films has been a long-standing challenge due to the low reactivity of Ir at low temperatures and the vaporization of volatile gas species such as IrO_(3)(g)and IrO_(2)(g)at high temperatures and high PO_(2).To address this challenge,we combine thermodynamic analysis of the Pr-Ir-O_(2)system with experimental results from the conventional physical vapor deposition(PVD)technique of *** results indicate that only high growth temperatures yield films with crystallinity sufficient for utilizing and tailoring the desired topological electronic properties and the in situ synthesis of Pr_(2)Ir_(2)O_(7)thin films is fettered by the inability to grow with PO_(2)on the order of 10 Torr at high temperatures,a limitation inherent to the PVD ***,we sug.est techniques capable of supplying high partial pressure of key species during deposition,in particular chemical vapor deposition(CVD),as a route to synthesis of Pr_(2)Ir_(2)O_(7).

关键词： process thermodynamic synthesis