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Managements of recurrent hepatocellular carcinoma after liver transplantation: A systematic review

World Journal of gastroenterology 2015年第39期21卷 11185-11198页

作者： Nicola de'angelis Filippo Landi Maria Clotilde Carra Daniel Azoulay Unit of Digestive Hepato-Pancreato-Biliary Surgery and Liver Transplantation Henri-Mondor Hospital Inserm Unité 4394-MACBEth 94010 Créteil France department of Advanced Biomedical Sciences University Federico Ⅱ of Naples University Paris 7 Denis Diderot Rothschild Hospital Inserm Unité 955-IMRB 94010 Créteil France

AIM: To investigate the efficacy(survival) and safety of treatments for recurrent hepatocellular carcinoma(HCC) in liver transplantation(LT) ***: Literature search was performed on available online databases without a time limit until January 2015. Clinical studies describing survival after HCC recurrence in LT patients were retrieved for a fulltext evaluation. A total of 61 studies were selected: 13 case reports, 41 retrospective case series, and 7 retrospective comparative ***: Based on all included studies, the mean HCC recurrence rate was 16% of all LTs for HCC. A total of 1021 LT patients experienced HCC recurrence. The median time from LT to HCC recurrence was 13 mo(range 2-132 mo). The majority of patients(67%) presented with HCC extra-hepatic recurrences, involving lung, bone, adrenal gland, peritoneal lymph nodes, and rarely the brain. Overall survival after HCC recurrence was 12.97 mo. Surgical resection of localized HCC recurrence and Sorafenib for controlling systemic spread of HCC recurrence were associated with the higher survival rates(42 and 18 mo, res-pectively). However, Sorafenib, especially when combined with m TOR, was frequently associated with severe side effects that required dose reduction or discontinuation CONCLUSION: Management of recurrent HCC in LT patients is challenging and associated with poor prognosis independently of the type of treatment.

关键词： Recurrent hepatocellular carcinoma Liver transplan

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Synthesis and Photophysical Properties of 9,10-Disubstituted Anthracenes

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Materials Sciences and Applications 2015年第11期6卷 943-952页

作者： Roberto Pizzoferrato Pietro Tagliatesta Carlo Schillaci Paolo Prosposito Roberta de angelis Dipartimento di Ingegneria Industriale Universit&agrave di Roma Tor Vergata Roma Italy Dipartimento di Ingegneria Industriale Università di Roma Tor Vergata Roma Italy Dipartimento di Scienze e Tecnologie Chimiche Universit&agrave di Roma Tor Vergata Roma Italy Dipartimento di Scienze e Tecnologie Chimiche Università di Roma Tor Vergata Roma Italy

We report the synthesis and photophysical characterization of four 9,10-disubstituted dipheny-lanthracenes with specific modifications of the model backbone which involve both the 9,10 para substituents at the phenyl rings and the substitution with carbon-carbon triple bonds. The effects of such modifications on the photoluminescence and electroluminescence properties have been investigated on the basis of the diphenylanthracene molecular characteristics and in view of application to light-emitting.devices. We have found that the substitution with the carbon-carbon triple bonds at the two 9,10-phenyls noticeably alters the electronic states of the reference molecule, also introducing a certain degree of sensitivity to the phenyl substituents, which improves the tunability of the optical emission. Differently, the 9,10 para substituents produce minor changes in the single-molecule properties, due to the lack of electronic conjugation across the 9,10-phenyls. However, even a single nitro substituent in the phenyl para position produces the formation of excimers, which appreciably reduces the optical quantum efficiency. These properties are maintained in solid-state blends and simple spin-coated bilayer electroluminescent devices have been fabricated.

关键词： Blue Material Electroluminescence PVK 9 10-Diphenylanthracene Organic Light-Emitting devices

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Which method of distal pancreatectomy is cost-effective among open,laparoscopic,or robotic surgery?

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Hepatobiliary Surgery and Nutrition 2018年第5期7卷 345-352页

作者： Maylis Rodriguez Riccardo Memeo Piera Leon Fabrizio Panaro Stylianos Tzedakis Ornella Perotto Sharmini Varatharajah Nicola de’angelis Pietro Riva Didier Mutter Francis Navarro Jacques Marescaux Patrick Pessaux general Digestiveand Endocrine SurgeryNouvel Hopital CivilStrasbourgFrance Institut de Recherche Contre les Cancers de l’Appareil Digestif(IRCAD)/Research Institute against Digestive Cancer StrasbourgFrance Institut Hospitalo-Universitaire(IHU) Institute for Minimally Invasive Hybrid Image-Guided SurgeryUniversite de StrasbourgStrasbourgFrance department of Digestive Surgery Hopital Saint-EloiMontpellierFrance

Background: The aim of this study was to analyze the clinical and economic impact of robotic distal pancreatectomy, laparoscopic distal pancreatectomy, and open distal pancreatectomy. Methods: All consecutive patients who underwent distal pancreatic resection for benign and malignant diseases between January 2012 and december 2015 were prospectively included. Cost analysis was performed;all charges from patient admission to discharge were considered. Results: There were 21 robotic (RDP), 25 laparoscopic (LDP), and 43 open (ODP) procedures. Operative time was longer in the RDP group (RDP =345 minutes, LDP =306 min, ODP =251 min, P=0.01). Blood loss was higher in the ODP group (RDP =192 mL, LDP =356 mL, ODP =573 mL, P=0.0002). Spleen preservation was more frequent in the RDP group (RDP =66.6%, LDP =61.9%, ODP =9.3%, P=0.001). The rate of patients with Clavien-Dindo > grade III was higher in the ODP group (RDP =0%, LDP =12%, ODP =23%, P=0.01), especially for non-surgical complications, which were more frequent in the ODP group (RDP =9.5%, LDP =24%, ODP =41.8%, P=0.02). Length of hospital stay was increased in the ODP group (ODP =19 days, LDP =13 days, RDP =11 days, P=0.007). The total cost of the procedure, including the surgical procedure and postoperative course was higher in the ODP group (ODP =30,929 Euros, LDP=22,150 Euros, RDP =21,219 Euros, P=0.02). Conclusions: Cost-effective results of RDP seem to be similar to LDP with some better short-term outcomes.

关键词： Robotic distal pancreatectomy cost-effective laparoscopic

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Octreotide treatment for neonatal chylothorax

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World Journal of Pediatrics 2018年第6期14卷 623-623页

作者： Carlo Bellini Laura Costanza de angelis Tommaso Bellini Neonatal Intensive Care Unit Neonatal Emergency Transport ServiceDepartment of Intensive CareIRCCS GasliniLargo G.Gaslini 516147 GenoaItaly

We have read the interesting paper by Costa and Saxenaentitled ‘‘Surgical chylothorax in neonates: management andoutcomes”, recently published in the World Journal of Pediatrics[ 1 ]. There are few points of the article that we wouldlike to discuss. We recently published a systematic reviewfocusing on the use of octreotide for congenital and acquiredchylothorax in newborns [ 2 ]. Our review concluded thatoctreotide was safe and eff ective in the treatment of chylothoraxin newborns, especially for the congenital forms, andthat octreotide therapy should be considered as an adjunctivetreatment in term and preterm neonates aff ected by congenitaland acquired chylothorax.

关键词： chylothorax treatment Octreotide

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Time-dependent measurement of high-power laser light reflection by low-Z foam plasma

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High Power Laser Science and Engineering 2021年第3期9卷 40-53页

作者： M.Cipriani S.Yu.gus’kov F.Consoli R.de angelis A.A.Rupasov P.Andreoli g.Cristofari g.Di giorgio M.Salvadori ENEA Fusion and Technologies for Nuclear Safety DepartmentC.R.FrascatiFrascati(Rome)Italy Lebedev Physical Institute MoscowRussia Universita di Roma La Sapienza RomaItaly INRS-EMT VarennesQuebecCanada

Porous materials have many applications for laser–matter interaction experiments related to inertial confinement *** new knowledge about the properties of the laser-produced plasma of porous media is a challenging *** this work,we report,for the first time to the best of our knowledge,the time-dependent measurement of the reflected light of a terawatt laser pulse from the laser-produced plasma of low-Z foam material of overcritical *** experiments have been performed with the ABC laser,with targets constituted by foam of overcritical density and by solid media of the same chemical *** implemented in the MULTI-FM code a model for the light reflection to reproduce and interpret the experimental *** the simulations together with the experimental results,we indicate a criterion for estimating the homogenization time of the laser-produced plasma,whose measurement is challenging with direct diagnostic techniques and still not achieved.

关键词： porous materials foams high-power lasers numerical simulations inertial confinement fusion

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Infrared upconversion imaging in nonlinear metasurfaces

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Advanced Photonics 2021年第3期3卷 83-92页

作者： Rocio Camacho-Morales Davide Rocco Lei Xu Valerio Flavio gili Nikolay Dimitrov Lyubomir Stoyanov Zhonghua Ma Andrei Komar Mykhaylo Lysevych Fouad Karouta Alexander Dreischuh Hark Hoe Tan giuseppe Leo Costantino de angelis Chennupati Jagadish Andrey E.Miroshnichenko Mohsen Rahmani Dragomir N.Neshev The Australian National University Research School of PhysicsARC Centre of Excellence for Transformative Meta-Optical SystemsDepartment of Electronic Materials EngineeringCanberraACTAustralia University of Brescia Department of Information EngineeringBresciaItaly University of New South Wales School of Engineering and Information TechnologyCanberraACTAustralia Nottingham Trent University School of Science and TechnologyAdvanced Optics and Photonics LaboratoryDepartment of EngineeringNottinghamUnited Kingdom UniversitéParis Diderot Matériaux et Phénomènes QuantiquesParisFrance Friedrich Schiller University Jena Institute of Applied PhysicsAbbe Center of PhotonicsJenaGermany Sofia University Department of Quantum ElectronicsFaculty of PhysicsSofiaBulgaria

Infrared imaging is a crucial technique in a multitude of applications,including night vision,autonomous vehicle navigation,optical tomography,and food quality *** infrared imaging technologies,however,require the use of materials such as narrow bandgap semiconductors,which are sensitive to thermal noise and often require cryogenic *** demonstrate a compact all-optical alternative to perform infrared imaging in a metasurface composed of gaAs semiconductor nanoantennas,using a nonlinear wave-mixing *** experimentally show the upconversion of short-wave infrared wavelengths via the coherent parametric process of sum-frequency *** this process,an infrared image of a target is mixed inside the metasurface with a strong pump beam,translating the image from the infrared to the visible in a nanoscale ultrathin imaging *** results open up new opportunities for the development of compact infrared imaging.devices with applications in infrared vision and life sciences.

关键词： metasurfaces nonlinear optical processes infrared photonics imaging.

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Nonlinear frequency conversion in optical nanoantennas and metasurfaces:materials evolution and fabrication

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Opto-Electronic Advances 2018年第10期1卷 1-12页

作者： Mohsen Rahmani giuseppe Leo Igal Brener Anatoly V. Zayats Stefan A. Maier Costantino de angelis Hoe Tan Valerio Flavio gili Fouad Karouta Rupert Oulton Kaushal Vora Mykhaylo Lysevych Isabelle Staude Lei Xu Andrey E. Miroshnichenko Chennupati Jagadish Dragomir N. Neshev Research School of Physics and Engineering The Australian National University Canberra ACT 2601 Australia Matériaux et Phénomènes Quantiques Université Paris Diderot-Sorbonne Paris Cité 10 rue A. Domon et L. Duquet 75013 Paris France Center for Integrated Nanotechnologies Sandia National Laboratories Albuquerque New Mexico 87185 United States department of Physics King’s College London Strand London WC2R 2LS United Kingdom The Blackett Laboratory Department of Physics Imperial College London London SW7 2AZ United Kingdom Chair in Hybrid Nanosystems Nano Institute Munich Fakultat für Physik Ludwig-Maximilians-Universitat München München Germany deptartment of Information Engineering Universitàdegli Studi di Brescia and INO-CNR Via Branze 38 25123 Brescia Italy Institute of Applied Physics Abbe Center of Photonics Friedrich Schiller University Jena 07745 Jena Germany School of Engineering and Information Technology University of New South Wales Canberra ACT 2600 Australia

Nonlinear frequency conversion is one of the most fundamental processes in nonlinear *** has a wide range of applications in our daily lives,including novel light sources,sensing,and information *** is usually assumed that nonlinear frequency conversion requires large crystals that gradually accumulate a strong ***,the large size of nonlinear crystals is not compatible with the miniaturisation of modern photonic and optoelectronic ***,shrinking the nonlinear structures down to the nanoscale,while keeping favourable conversion efficiencies,is of great importance for future photonics *** the last decade,researchers have studied the strategies for enhancing the nonlinear efficiencies at the nanoscale,*** employing different nonlinear materials,resonant couplings and hybridization *** this paper,we provide a compact review of the nanomaterials-based efforts,ranging from metal to dielectric and semiconductor nanostructures,including their relevant nanofabrication techniques.

关键词： nonlinear nanophotonics metallic nanoantennas dielectric nanoantennas III-V semiconductor nanoantenna nanofabrication

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Current trends and perspectives in interventional radiology for gastrointestinal cancers

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World Journal of Radiology 2021年第10期13卷 314-326页

作者： Elisa Reitano Nicola de'angelis giorgio Bianchi Letizia Laera Stavros Spiliopoulos Roberto Calbi Riccardo Memeo Riccardo Inchingolo Division of general Surgery Department of Translational MedicineUniversity of Eastern PiedmontNovara 28100Italy Unit of Minimally Invasive and Robotic Digestive Surgery "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70021Italy department of Oncology "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70021Italy 2^(nd) department of Radiology School of MedicineNational and Kapodistrian University of AthensAthens 12461Greece department of Radiology "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70124Italy Unit of Hepato-Pancreatic-Biliary Surgery "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70021Italy Interventional Radiology Unit "F.Miulli"General Regional HospitalAcquaviva delle Fonti 70021Italy

gastrointestinal(gI)cancers often require a multidisciplinary approach involving surgeons,endoscopists,oncologists,and interventional radiologists to diagnose and treat primitive cancers,metastases,and related *** this context,interventional radiology(IR)represents a useful minimally-invasive tool allowing to reach lesions that are not easily approachable with other *** the last years,through the development of new devices,IR has become increasingly relevant in the context of a more comprehensive management of the oncologic *** embolization,ablative techniques,and gene therapy represent useful and innovative IR tools in gI cancer ***,IR can be useful for the management of gI cancer-related complications,such as bleeding,abscesses,gI obstructions,and neurological *** aim of this study is to show the principal IR techniques for the diagnosis and treatment of gI cancers and related complications,as well as to describe the future perspectives of IR in this oncologic field.

关键词： Interventional radiology Radiology Colorectal cancer gastric cancer Malignancy Embolization

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Chemical Sensitivity of Luminescent Epitaxial Surface InP Quantum Dots

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Journal of Sensor Technology 2013年第1期3卷 1-5页

作者： Roberta de angelis Mauro Casalboni Ivan Colantoni Liliana D’Amico Fabio de Matteis Fariba Hatami William T. Masselink Paolo Prosposito department of Physics Humboldt University Berlin Germany INSTM Research Unit of the University of Roma “Tor Vergata” Rome Italy Physics department University of Rome “Tor Vergata” Rome Ital Physics department University of Rome “Tor Vergata” Rome Italy

Surface InP quantum dots grown by gas source molecular beam epitaxy on In0.48ga0.52P buffer layer lattice matched to gaAs substrate shows a broad-band near-infrared photoluminescence ranging from 750 to 865 nm dependent on their dimensions. A reversible luminescence intensity enhancement has been observed when the quantum dots were exposed to vapours of different chemical solvents with the highest sensitivity for alcohol (methanol and ethanol) vapours. The luminescent behaviour is dependent on the solvent type and concentration. The peak energy and band shape of the luminescence are not affected by the solvent vapour.

关键词： Vapour Sensitivity Quantum Dot Photoluminescence InP Organic Solvent

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超声内镜在胰腺癌中的应用现状与展望

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中国普通外科杂志 2014年第3期23卷 269-277页

作者： Claudio de angelis Rosario Francesco Brizzi Rinaldo Pellicano 冯铁成李新营意大利都灵大学圣.乔瓦尼巴蒂斯塔医院内镜与超声内镜中心胃肠与肝病科

胰腺疾病的诊治在临床上一直是一个难点。在过去的几年中我们见证了放射学和核医学成像的技术进步。考虑到这一点,我们尝试描述超声内镜(EUS)在胰腺癌(PC)诊断及分期的过程中新的角色。到目前为止对于PC最准确的成像技术是对比增强计算... 详细信息

胰腺疾病的诊治在临床上一直是一个难点。在过去的几年中我们见证了放射学和核医学成像的技术进步。考虑到这一点,我们尝试描述超声内镜(EUS)在胰腺癌(PC)诊断及分期的过程中新的角色。到目前为止对于PC最准确的成像技术是对比增强计算机断层扫描(CT)和EUS。后者在检测微小病灶及评估肿瘤大小和淋巴结情况时具有最高的精度,但对于一个可疑的胰腺病变的患者而言,螺旋CT或最新的磁共振成像(MRI)仍是首要的选择。如在CT、MRI扫描为阴性结果而临床上高度怀疑PC,或是CT/MRI扫描后可疑病变需细胞组织学确认时,可应用EUS。相信在不久的将来用于诊断和治疗胰腺疾病的EUS将有更大的发展空间,并且病理结果将为其提供最好的应用证据。

关键词：胰腺肿瘤超声检查腔内超声检查

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