检索结果-南通市图书馆

Radioisotope production using lasers:From basic science to applications

Matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： M.R.d.Rodrigues A.Bonasera M.Scisciò J.A.Pérez-Hernández M.Ehret F.Filippi P.L.Andreoli M.Huault H.Larreur d.Singappuli d.Molloy d.Raffestin M.Alonzo g.g.Rapisarda d.Lattuada g.L.guardo C.Verona Fe.Consoli g.Petringa A.McNamee M.La Cognata S.Palmerini T.Carriere M.Cipriani g.d. giorgio g.Cristofari R.de angelis g.A.P.Cirrone d.Margarone L.giuffrida d.Batani P.Nicolai K.Batani R.Lera L.Volpe d.giulietti S.Agarwal M.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of Mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom dipartimento di Fisica e Astronomia“E.Majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly dipartimento di Fisica e geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Solar-driven CO_(2) conversion to methane and methanol using.d.fferent nanostructured Cu_(2)O-based catalysts modified with Au nanoparticles

引用

Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian d.Moura Torquato Juliana Fde Brito gustavo A.Andolpho Mateus A.gonçalves Leonardo d.de angelis Lucas d.germano Susana I.Córdoba de Torresi Teodorico C.Ramalho Maria V.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Modelling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil department of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)modified with Cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of CO_(2)to produce value-added compounds.A thin layer of polydopamine was used as both an adherent agent and an electron transfer mediator,due to itsπ-conjugated electron *** highest production yield was achieved using a TNT@PdA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μM cm^(-2))and 27.8%(50.4μM cm^(-2))for methanol and methane,*** performance of the photoelectrodes was shown to be Cu_(2)O facet-dependent,with cubic structures leading to greater conversion of CO_(2)to methanol(43%)and methane(27%),compared to the octahedral morphology,while a higher percentage of metallic gold on the nanostructured Cu_(2)O surface was mainly important for *** functional theory(dFT)calculations supported these findings,attributing the superior photoelectrocatalytic performance of the TNT@PdA/Nc/Au40%electrode for CH4generation to the formation of an OCH3intermediate bonded to Au *** using isotope-labeling and analysis by gas chromatograph-mass(gC-MS)demonstrated that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and13CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polydopamine CO_(2) photoelectroreduction dFT calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Further investigation on the fusion of ^(6)Li with ^(209)Bi target at near-barrier energies

引用

Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 d.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 J.J.Valiente-dobón d.Testov M.Mazzocco A.gozzelino C.Parascandolo d.Pierroutsakou M.La Commara A.goasduff d.Bazzacco d.R.Napoli F.galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin g.d. angelis M.Siciliano R.Menegazzo S.M.Lenzi J.L.Ferreira J.Rangel Serkan Akkoyun L.F.Canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced Study in Nuclear Energy&Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly dipartimento di fisica Astronomia dell'Universita di padova PadovaItaly State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly dipartimento di Farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics division Argonne National LaboratoryLemont-ILUSA departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete and incomplete fusion cross sections for ^(6)Li+^(209)Bi were measured using the in-beamγ-ray method around the Coulomb *** cross sections of(deuteron captured)incomplete fusion(ICF)products were re-quantified experimentally for this reaction *** results reveal that the ICF cross section is equivalent to that of complete fusion(CF)above the Coulomb barrier and dominant near or below the Coulomb barrier.A theoretical calculation based on the continuum discretized coupled channel(CdCC)method was performed for the aforementioned CF and ICF cross sections;the result is consistent with the *** universal fusion function(UFF)was also compared with the measured CF cross section for different barrier parameters,demonstrating that the CF suppression factor is significantly influenced by the choice of potential,which can reflect both dynamic and static effects of breakup on the fusion process.

关键词： cross section incomplete fusion suppression factor weakly bound nuclei

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

引用

Nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： gao-Long Zhang Zhen-Wei Jiao guang-Xin Zhang E.N.Cardozo B.Paes Shi-Peng Hu Jian-Qiang Qian daniele Mengoni Wei-Wei Qu Cong-Bo Li Yun Zheng Huan-Qiao Zhang Hui-Bin Sun Nan Wang Chun-Lei Zhang J.J.Valiente-dobón d.Testov M.Mazzocco A.gozzelino C.Parascandolo d.Pierroutsakou M.La Commara A.goasduff d.Bazzacco d.R.Napoli F.galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin gde angelis M.Siciliano R.Menegazzo S.M.Lenzi S.Akkoyun L.F.Canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil Laboratorio TANdAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced Study in Nuclear Energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPaduaItaly dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Laboratori Nazionali di Legnaro INFN35020 LegnaroItaly INFN Sezione di Napoli80126 NaplesItaly dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics division Argonne National LaboratoryLemontILUSA department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 MeV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei Cross section

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adaptive nanopores:A bioinspired label-free approach for protein sequencing and identification

引用

Nano Research 2021年第1期14卷 328-333页

作者： Andrea Spitaleri denis garoli Moritz Schutte Hans Lehrach Walter Rocchia Francesco de angelis CONCEPT Lab Istituto Italiano di TecnologiaVia Morego 30Genova1-16163Italy Center for Omics Sciences IRCCS San Raffaele Scientific InstituteMilanVia Olgettina 58Milano1-20132Italy Plasmon Nanotechnology Unit Istituto Italiano di TecnologiaVia Morego 30Genova1-16163Italy AB ANALITICA s.r.l Via Svizzera 161-35127 PadovaItaly Alacris Theranostics gmbH Max-Planck-Strasse 3D-12489 BerlinGermany Max Planck Institute for Molecular genetics Ihnestrasse 63-73D-14195 BerlinGermany

Single molecule protein sequencing would tremendously impact in proteomics and human biology and it would promote the development of novel diagnostic and therapeutic ***,its technological realization can only be envisioned,and huge challenges need to be *** difficulties are inherent to the structure of proteins,which are composed by several different *** long standing efforts,only few complex techniques,such as Edman degradation,liquid chromatography and mass spectroscopy,make protein sequencing ***,these techniques present significant limitations in terms of amount of sample required and dynamic range of *** is known that proteins can distinguish closely similar ***,several proteins can work as biological nanopores in order to perform single molecule detection and ***,while dNA sequencing by means of nanopores is demonstrated,very few examples of nanopores able to perform reliable protein-sequencing have been reported ***,we investigate,by means of molecular dynamics simulations,how a re-engineered protein,acting as biological nanopore,can be used to recognize the sequence of a translocating peptide by sensing the MshapeH of individual *** our simulations we demonstrate that it is possible to discriminate with high fidelity,9 different amino-acids in a short peptide translocating through the engineered *** method,here shown for fluorescence-based sequencing.d.es not require any labelling of the peptidic *** results can pave the way for a new and highly sensitive method of sequencing.

关键词： nanopores single molecule sequencing protein sequencing luorescence resonance energy transfer(FRET) amino-acids fluorescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel Phialophora species from leaf-cutting ants (tribe Attini)

引用

Fungal diversity 2014年第2期65卷 65-75页

作者： d.Attili-angelis A.P.M.duarte F.C.Pagnocca N.S.Nagamoto M.de Vries J.B.Stielow g.S.de Hoog Center for the Study of Social Insects UNESP-São Paulo State UniversitySão PauloSPBrazil division of Microbial Resources CPQBAUniversity of CampinasCampinasSPBrazil department of Plant Protection UNESP-São Paulo State UniversityBotucatuSPBrazil Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and Ecosystem dynamics University of AmsterdamAmsterdamThe Netherlands Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina Research Center for Medical Mycology Peking University Health Science CenterBeijingChina Shanghai Institute of Medical Mycology Changzheng HospitalSecond Military Medical UniversityShanghaiChina Basic Pathology department Federal University of ParanáStateCuritibaParanáBrazil King Abdulaziz University JeddahSaudi Arabia

Ants in the tribe Attini(Hymenoptera,Formicidae)maintain a 50 million-year-old lifestyle of co-evolution with symbiotic basidiomycetous fungi which they cultivate as essential source of ***,other microorganisms have been reported from ant habitats indicating a higher diversity of consistently associated species than established to ***,black yeast-like fungi have been reported as a possible symbiont,like a competitor of the actinomycete bacteria that grow in the integument of the *** the mating season,gynes of Atta capiguara and *** were collected from nests located in Botucatu,SP,Brazil and sampled using flotation *** analysis based on ITS,partial 28S(LSU)andβ-tubulin sequences revealed the occurrence of two novel species of Phialophora among the melanized fungi isolated.

关键词： Black yeasts Chaetothyriales gynes Phialophora Cyphellophora Atta Ant cuticle Neotropical fungal ecology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Short-term clinical outcomes of laparoscopic vs open rectal excision for rectal cancer: A systematic review and metaanalysis

引用

World Journal of gastroenterology 2017年第44期23卷 7906-7916页

作者： Aleix Martínez-Pérez Maria Clotilde Carra Francesco Brunetti Nicola de'angelis department of digestive Hepatobiliary Surgery and Liver Transplantation Henri Mondor University Hospital AP-HP Université Paris Est - UPEC department of general and digestive Surgery Hospital Universitario Doctor Peset Rothschild Hospital AP-HP Université Paris VII

AIM To review evidence on the short-term clinical outcomes of laparoscopic(LRR) vs open rectal resection(ORR) for rectal *** A systematic literature search was performed using Cochrane Central Register, MEdLINE, EMBASE, Scopus, Open grey and Clinical *** register for randomized clinical trials(RCTs) comparing LRR vs ORR for rectal cancer and reporting short-term clinical outcomes. Articles published in English from January 1, 1995 to June, 30 2016 that met the selection criteria were retrieved and reviewed. The Preferred Reporting Items for Systematic reviews and Meta-Analysis(PRISMA) statements checklist for reporting a systematic review was followed. Random-effect models were used to estimate mean differences and risk ratios. The robustness and heterogeneity of the results were explored by performing sensitivity analyses. The pooledeffect was considered significant when P ded. No differences were found in postoperative mortality(P = 0.19) and morbidity(P = 0.75) rates. The mean operative time was 36.67 min longer(95%CI: 27.22-46.11, P d blood loss was 88.80 ml lower(95%CI:-117.25 to-60.34, P d the mean incision length was 11.17 cm smaller(95%CI:-13.88 to-8.47, P d by sensitivity analyses that focused on the four major RCTs. The mean length of hospital stay was 1.71 d shorter(95%CI:-2.84 to-0.58, P day of the first bowel movement) was 0.68 d shorter(95%CI:-1.00 to-0.36, P did not confirm a significant difference between LRR and ORR for these latter two parameters. The overall quality of the evidence was rated as high. CONCLUSION LRR is associated with lesser blood loss, smaller incision length, and longer operative times compared to ORR. No differences are observed for postoperative morbidity and mortality.

关键词： Laparoscopic rectal resection Open rectal resection Laparoscopy Rectal cancer Postoperative morbidity Short-term outcomes Systematic review Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Navigated liver surgery:State of the art and future perspectives

引用

Hepatobiliary & Pancreatic diseases International 2022年第3期21卷 226-233页

作者： Paschalis gavriilidis Bjørn Edwin Eg.d.jus Pelanis Ernest Hidalgo Nicola de’angelis Riccardo Memeo Luca Aldrighetti Robert P Sutcliffe department of Hepato-Pancreato-Biliary and Liver Transplant Surgery Queen Elizabeth University Hospitals Birmingham NHS Foundation TrustB152THUK The Intervention Centre and department of HPB Surgery Oslo University Hospital and Faculty of MedicineUniversity of OsloOsloNorway department of Hepato-Pancreatico-Biliary Surgery and Transplantation Hospital Universitari Vall d’HebronBarcelonaSpain department of digestive Surgery University Hospital Henri Mondor(AP-HP)94010 Creteil and University of Paris EstCreteilFrance department of Hepatobiliary and Pancreatic Surgery Miulli HospitalAcquaviva delle FontiBari 70021Italy division of Hepatobiliary Surgery San Raffaele HospitalVia Olgettina 60Milan 20132Italy

Background:In recent years,the development of digital imaging technology has had a significant influence in liver *** ability to obtain a 3-dimensional(3d)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3d computer models,3d printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICg)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital *** combination of both has transformed the abstract thinking until now based on 2d imaging into a 3d preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).data sources:A literature search was performed from inception until January 2021 in MEdLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CdSR),google Scholar,and National Institute for Health and Clinical Excellence(NICE)***:Fifty-one pertinent articles were retrieved and *** different types of digital imaging technologies and the real-time navigated liver surgery were estimated and ***:ICg fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of ***,3d models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor *** liver transplantation and especially in living.d.nor liver transplantation(LdLT),3d printed models of the donor’s live

关键词： Navigated Hepatic surgery 3d Computer assistance Image guidance Image guided surgery Indocyanine green 3d print Visual simulation Virtual reality Augmented reality Real-time navigated liver surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of seed amplification assay and surface-enhanced Raman spectroscopy combined approach on the clinical diagnosis of Alzheimer’s disease

引用

Translational Neurodegeneration 2023年第1期12卷 416-427页

作者： Cristiano d’Andrea Federico Angelo Cazzaniga Edoardo Bistaffa Andrea Barucci Marella de angelis Martina Banchelli Edoardo Farnesi Panagis Polykretis Chiara Marzi Antonio Indaco Pietro Tiraboschi giorgio giaccone Paolo Matteini Fabio Moda Institute of Applied Physics“Nello Carrara” National Research Council50019 Sesto FiorentinoItaly division of Neurology 5 and Neuropathology Fondazione IRCCS Istituto Neurologico Carlo Besta20133 MilanItaly Institute of Physical Chemistry(IPC)and Abbe Center of Photonics(ACP) Friedrich Schiller University Jena07743 JenaGermany Leibniz Institute of Photonic Technology 07745 JenaGermany

Background The current diagnosis of Alzheimer’s disease(Ad)is based on a series of analyses which involve clinical,instrumental and laboratory ***,signs,symptoms and biomarker alterations observed in Ad might overlap with other dementias,resulting in *** Here we describe a new diagnostic approach for Ad which takes advantage of the boosted sensitivity in biomolecular detection,as allowed by seed amplification assay(SAA),combined with the unique specificity in biomolecular recognition,as provided by surface-enhanced Raman spectroscopy(SERS).Results The SAA-SERS approach supported by machine learning.d.ta analysis allowed efficient identification of pathological Aβoligomers in the cerebrospinal fluid of patients with a clinical diagnosis of Ad or mild cognitive impairment due to *** Such analytical approach can be used to recognize disease features,thus allowing early stratification and selection of patients,which is fundamental in clinical treatments and pharmacological trials.

关键词： Alzheimer’s disease Amyloid-βprotein Seed amplification assay Surface-enhanced Raman spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy

引用

World Journal of gastroenterology 2008年第29期14卷 4643-4651页

作者： Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata d'Incà Salvatore Cucchiara gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando gian Luigi de angelis giuseppe Corritore Fabrizio Bossa Vito Annese U.U. O.O. di gastroenterologia ed Endoscopia Ospedale IRCCS-CSSSan Giovanni Rotondo (Fg) 71013 Italy Cattedra di gastroenterologia Università di PadovaPadova 35122 Italy Clinica Pediatrica Università "La Sapienza" Roma 00185 Italy Cattedra di gastroenterologia Università di NapoliNapoli 80131 Italy Clinica Pediatrica Università di Napoli Napoli 80131 Italy Unità di gastroenterologia Ospedale "Sacco" Milano 20157 Italy Clinica Pediatrica Università di Palermo Palermo 90128 Italy Clinica Pediatrica Università di Parma Parma 43100 Italy

AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBd) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBd genes. METHOdS: Total of 763 patients with Crohn's disease (Cd, 189 diagnosed at age diagnosed d 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATg16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARd15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of g allele of ATg16L1 SNP (Ala197Thr) was increased in patients with Cd compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and g (minor) alleles of Arg381gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in Cd (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P d with controls (6% and 38%, respectively). The A allele (but not g) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARd15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBd, and ATg16L1 with Cd, in both adult- and pediatric-onset subsets in our study population.

关键词： Inflammatory bowel disease Crohn'sdisease Ulcerative colitis genetic predisposition Autophagy-related 16-like 1 Interleukin 23 receptor genome-wide association study Pediatric inflammatorybowel disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：