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162Er核的能级结构

162Er核的能级结构

A complete compilation of matrix metalloproteinase expression in human malignant gliomas

第九届全国核物理大会

作者：温书贤 H.Ryed A.brockstedt g.b.hagemann 中国原子能科学研究院核物理所 Lunf university Sweden The Niels bohr Institude University of Copenhagen

在意大利的 gASP(Legnaro)实验装置上,通过Nb(O,6n)熔合蒸发反应研究了Er 核的能级结构。入射束的能量为85MeV,共积累了近300× 10个γ-γ符合事件．根据初步数据分析的结果建立了一个新的能级纲图共观察到了13条能带,其中六条已为 ***...

在意大利的 gASP(Legnaro)实验装置上,通过Nb(O,6n)熔合蒸发反应研究了Er 核的能级结构。入射束的能量为85MeV,共积累了近300× 10个γ-γ符合事件．根据初步数据分析的结果建立了一个新的能级纲图共观察到了13条能带,其中六条已为 *** 等人报告过,另外的七条是在这次实验中观察到的。新能级宇称和自旋的确认主要是在已有工作的基础上及系统学的分析,特别是与同中子数核比较而得出的．Er 核的能级结构与Yb 非常相似,包括各带的带头能量,能级能量, 以及回弯频率都非常接近。更为有趣的是Er 的能级纲图上有一个强耦合带,它衰变到基带的6和8能级。同样的耦合带在Er 和Er 中也观察到了。初步确认为由7/2[523]和7/2[404]质子组态耦合成为7的能带, 但此带在 Yb 的同位素中未发现。在系统学分析的基础上确认了Er 各个带的组态．能级纲图如图1。

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World Journal of Clinical Oncology 2012年第5期3卷 67-79页

作者： Carsten hagemann Jelena Anacker Ralf-Ingo Ernestus giles H Vince Department of Neurosurgery Tumorbiology Laboratory University of Würzburg Josef-Schneider-Str. 11 D-97080 Würzburg Germany Department of Obstetrics and gynaecology University of Würzburg Josef-Schneider-Str. 4 D-97080 Würzburg Germany

glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(gbM) cell-lines, as well as in gbM biopsies as compared with low-grade astrocytoma(LgA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LgA and 15 gbM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy.

关键词： Astrocytic tumor Expression pattern glioblastoma cell-lines glioblastoma multiforme Matrix metalloproteinase

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^(125)Cs的能级结构

原子核物理评论 2004年第4期21卷 331-333页

作者：马英君小松原哲郎王守宇 Cederwall b Nyberg J 张玉虎古野兴平李容俊 Sletten g hagemann g Jensen H gjorup N 刘运祚吉林大学物理学院吉林长春130023 日本筑波大学串列加速器中心瑞典皇家技术研究所丹麦玻尔研究所串列加速器实验室中国科学院近代物理研究所甘肃兰州730000

通过116Cd(14N,5n),Ebeam=65MeV的核反应布居了125Cs的高自旋态.利用在束γ谱学实验方法,进行了γ γ符合测量,使已知的125Cs核能级纲图得到了扩展,并且修正了某些组态的带头激发能.

关键词：能级结构在束γ谱学 γ-γ符合测量能级纲图高自旋态激发能核反应带头扩展组态

Research and Practice of Flexibility in Distribution Systems:A Review

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CSEE Journal of Power and Energy Systems 2019年第3期5卷 285-294页

作者： Stefan Dalhues Yang Zhou Oliver Pohl Florian Rewald Fabian Erlemeyer Dennis Schmid Jannik Zwartscholten Zita hagemann Christian Wagner Daniel Mayorga gonzalez Hua Liu Mingmin Zhang Jiayan Liu Christian Rehtanz Yong Li Yijia Cao the TU Dortmund University Dortmund 44227Germany the College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Changsha University of Science and Technology Changsha 410114China.

Flexibility in energy systems can support the operation of the electricity grid by providing active and reactive power to avoid voltage limit violations or *** distribution networks can provide this flexibility by implementing systems to control distributed generators,storage or ***,power flow controlling devices can be used to implement operational flexibility in the energy *** paper presents concepts for planning and forecasting of flexibility,monitoring of energy systems and control of flexibility from active distribution networks(ADNs)to enable the use of flexibility in future power systems.

关键词： Active distribution networks distributed generation power flow control

Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro

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World Journal of Clinical Oncology 2012年第6期3卷 82-91页

作者： Feray Kockar Hatice Yildrim Rahsan Ilikci Sagkan Carsten hagemann Yasemin Soysal Jelena Anacker Ahmed Ayad Hamza Dirk Vordermark Michael Flentje Harun M Said Department of biology Faculty of Art and Science Balikesir University Department of Immunology and Allergy Diseases Gulhane Military Medical Academy Tumorbiology Laboratory Department of Neurosurgery University of Würzburg Faculty of Medicine Department of Medical Genetics Afyon Kocatepe University Department of Obstetrics and gynaecology University of Würzburg School of Medicine Southern Illinois University Department of Radiation Oncology University-Halle-Wittenberg Department of Radiation Oncology University of Wuerzburg

AIM: To study the expression of carbonic anhydrase(CA) 9 in human hepatocellular carcinoma(HCC) ***: We studied CA9 protein, CA9 m RNA and hypoxia-inducible factor-1 alpha(HIF-1α) protein levels in Hep3 b cells exposed in different parallel approaches. In one of these approaches, HCC cells were exposed to extreme in vitro hypoxia(24 h 0.1% O2) without or with interleukin(IL)-1, IL-6, tumor necrosis factoralpha(TNF-α) and transforming growth factor-beta(TgF-β) stimulation for the same hypoxic exposure time or exposed to normoxic oxygenation conditions without or with cytokine ***: The tumour cell line analysed showed a strong hypoxic CA9 m RNA expression pattern in response to prolonged severe hypoxia with cell-line specific patterns and a marked induction of CA9 protein in response to severe hypoxia. These results were paralleled by the results for HIF-1α protein under identical oxygenation conditions with a similar expression tendency to that displayed during the CA9 protein expression experimental series. Continuous stimulation with the cytokines, IL-1, IL-6, TNF-α and TgF-β, under normoxic conditions significantly increased the carbonic anhydrase 9 expression level at both the protein and m RNA level, almost doubling the CA9 m RNA and CA9 and HIF-1α protein expression levels found under hypoxia. The findings from these experiments indicated that hypoxia is a positive regulator of CA9 expression in HCC, and the four signal transduction pathways, IL-1, IL-6, TNF-α and TgF-β, positively influence CA9 expression under both normoxic and hypoxic ***: These findings may potentially be considered in the design of anti- cancer therapeutic approaches involving hypoxia-induced or cytokine stimulatory effects on expression. In addition, they provideevidence of the stimulatory role of the examined cytokine families resulting in an increase in CA9 expression under different oxygenation conditions in human cancer, especially HCC, and

关键词： Angiogenesis Carbonic anhydrase 9 Hypoxia Hypoxia-inducible factor-1 alpha Oxygen Radiotherapy Transforming growth factor-beta Tumour microenviroment

Neuroanatomy: 3D-Stereoscopic Atlas of the Human brain 1

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Neuroanatomy: 3D-Stereoscopic Atlas of the Human Brain

1999年

作者： Martin C. Hirsch Thomas Kramer C. Zinecker b. Harder T. hagemann C. Krasowski C. Schäfer M. Turtiainen M. gauer

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125Cs的能级结构

125Cs的能级结构

第十二届全国核物理大会

作者：马英君小松原哲郎王守宇 Cederwall b Nyberg J 张玉虎古野兴平李容俊 Sletten g hagemann g Jensen H gjorup N 刘运祚吉林大学物理学院日本筑波大学串列加速器中心吉林大学物理学院瑞典皇家技术研究所丹麦玻尔研究所串列加速器实验室RisφDK-400 Roskilde 中国科学院近代物理研究所日本筑波大学串列加速器中心吉林大学物理学院丹麦玻尔研究所串列加速器实验室Risφ DK-400 Roskilde 丹麦玻尔研究所串列加速器实验室Risφ DK-400 Roskilde 丹麦玻尔研究所串列加速器实验室Risφ DK-400 Roskilde 丹麦玻尔研究所串列加速器实验室Risφ DK-400 Roskilde 吉林大学物理学院

通过116Cd（14N 5n）,Ebestn=65 MeV的核反应布居了125Cs的高自旋态．利用在束γ谱学实验方法,进行了γ-γ符合测量,使已知的125Cs核能级纲图得到了扩展,并且修正了某些组态的带头激发能．

关键词：高自旋态能级纲图转动带 Nilsson单粒子组态

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125Cs的能级结构

125Cs的能级结构

Inhibition of N-Myc down regulated gene 1 in in vitro cultured human glioblastoma cells

第十二届全国核物理大会暨第七届会员代表大会

作者：马英君小松原哲郎 Cederwall b Nyberg J 张玉虎古野兴平王守宇李容俊 Sletten g hagemann g Jensen H gjorup N 刘运祚吉林大学物理学院日本筑波大学串列加速器中心瑞典皇家技术研究所丹麦波尔所中国科学院近代物理研究所

利用Cd(N,5n)E=65 MeV的核反应布居了奇质子核Cs的高自旋态,实验在丹麦波尔所完成。离线分析建立了该核的能级纲图。其部分能级纲图如下图所示。

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World Journal of Clinical Oncology 2012年第7期3卷 104-110页

作者： Harun M Said buelent Polat Susanne Stein Mathias guckenberger Carsten hagemann Adrian Staab Astrid Katzer Jelena Anacker Michael Flentje Dirk Vordermark Department of Radiation Oncology University of Wuerzburg 97080 Würzburg Germany Department of Hematology and Oncology Johannes Gutenberg University Ⅲ Medical School 55101 Mainz Germany Department of Neurosurgery Tumorbiology Laboratory University of Wuerzburg 97080 Würzburg Germany Department of Radiation Oncology Paul Scherer Institute CH-5100 Villingen Switzerland Department of gynaecology and Obstetrics University of Wuerzburg 97080 Würzburg Germany Department of Radiation Oncology University-Halle-Wittenberg 06110 Halle Germany

AIM: To study short ds RNA oligonucleotides(si RNA)as a potent tool for artificially modulating gene expression of N-Myc down regulated gene 1(NDRg1) gene induced under different physiological conditions(Normoxia and hypoxia) modulating NDRg1 transcription, m RNA stability and translation. METHODS: A cell line established from a patient with glioblastoma multiforme. Plasmid DNA for transfections was prepared with the Endofree Plasmid Maxi kit. From plates containing 5 × 107 cells, nuclear extracts were prepared according to previous protocols. The p SUPERNDRg1 vectors were designed, two sequences were selected from the human NDRg1 c DNA(5'-gCATTATTggCATgggAAC-3' and 5'-ATgCAgAgTAACgTggAAg-3'. reverse transcription polymerase chain reaction was performed using primers designed using published information on β-actin and hypoxia-inducible factor(HIF)-1α m RNA sequences in gen bank. NDRg1 m RNA and protein level expression results under different conditions of hypoxia or reoxygenation were compared to aerobic control conditions using the Mann-Whitney U test. Reoxygenation values were also compared to the NDRg1 levels after 24 h of hypoxia(P gnificant).RESULTS: si RNA- and iodoacetate(IAA)-mediated downregulation of NDRg1 m RNA and protein expression in vitro in human glioblastoma cell lines showed a nearly complete inhibition of NDRg1 expression when compared to the results obtained due to the inhibitory role of glycolysis inhibitor IAA. Hypoxia responsive elements bound by nuclear HIF-1 in human glioblastoma cells in vitro under different oxygenation conditions and the clearly enhanced binding of nuclear extracts from glioblastoma cell samples exposed to extreme hypoxic conditions confirmed the HIF-1 Western blotting results. CONCLUSION: NDRg1 represents an additional diagnostic marker for brain tumor detection, due to the role of hypoxia in regulating this gene, and it canrepresent a potential target for tumor treatment in human glioblastoma. T

关键词： N-Myc down regulated gene 1 Short dsRNA oligonucleotides Human cancer diseases brain cancer Radiotherapy