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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal Department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

新型冠状病毒引发全球卫生危机,需要科学解决方案和地方行动

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全球变化数据学报（中英文） 2020年第1期4卷 1-10,1-10页

作者： giles b.Sioen Peter Daszak Kristie Ebi Chadia Wannous brama Kone Kathryn bowen Franz W.gatzweiler Frances Harris Melanie boeckmann y Morse Chiho Watanabe Jouni J.K.Jaakkola g.briel O.Dida 马伟 The United Nations University Institute for the Advanced Study of Sustainability Tokyo 150-8925Japan The University of Tokyo Institute For Future InitiativesTokyo 150-8925Japan Future Earth Tokyo 150-8925Japan EcoHealth Alliance New York City 10001the United States of America University of Washington Seattle 98195the United States of America Towards A Safer World Network StockholmSweden UniversitéPéléforo gon Coulibaly KorhogoCôte d'Ivoire Centre Suisse de Recherches Scientifiques en Côte d'Ivoire AbidjanCôte d'Ivoire Australian National University Canberra 2600Australia 中国科学院城市环境研究所厦门361021 University of Hertfordshire Hatfield AL109ABUnited Kingdom bielefeld University School of Public HealthBielefeld D-33615Germany University of Liverpool Liverpool L18JXUnited Kingdom National Institute for Environmental Studies Tsukuba 305-8506Japan Center for Environmental and Respiratory Health Research University of OuluOulu FI-90014Finland The Technical University of Kenya Nairobi FI-90014Kenya 山东大学公共卫生学院流行病学系济南250012

根据《国际卫生条例(2005)》(IHR),世界卫生组织(WHO)宣布将新型冠状病毒肺炎(COVID-19)列为国际关注的突发公共卫生事件。系统性问题导致此次病毒暴发,该疫情全世界大流行对全球政治和社会系统产生了重大影响。虽然过去15年间科学界在... 详细信息

根据《国际卫生条例(2005)》(IHR),世界卫生组织(WHO)宣布将新型冠状病毒肺炎(COVID-19)列为国际关注的突发公共卫生事件。系统性问题导致此次病毒暴发,该疫情全世界大流行对全球政治和社会系统产生了重大影响。虽然过去15年间科学界在提高了公众对于疾病大流行的警觉方面做了大量的工作,但此次疫情依然暴发并已威胁全球人们的健康,影响经济发展。为了更好地应对这一事件,降低风险,有哪些做法可以改进?对政府、学术组织和个人有哪些科学建议?本文探讨在如何保障人民健康安全的同时,降低经济和社会成本,并号召世界科学家参加"未来地球健康领域知识行动网络"计划。

关键词：世界卫生组织(WHO) 新型冠状病毒肺炎突发公共卫生事件未来地球计划健康领域知识行动网络

On the pressure and stress singularities induced by steady flows of a pair of nonmiscible,incompressible,viscous fluids contacting a wall with slip

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Acta Mechanica Sinica 2020年第3期36卷 686-691页

作者： g.b.Sinclair Department of Mechanical Engineering Louisiana State UniversityBaton RougeLA 70803USA

An earlier asymptotic analysis identified the flow-induced power and log singularities present when two nonmiscible,incompressible,viscous fluids contact a wall with no slip *** a parallel asymptotic analysis identifies such singularities in pressures and stresses when slip is *** the singularity exponents for the two types of contact conditions are similar,the angles of interface impingement that have either power or log singularities are usually quite distinct.

关键词： Incompressible viscous fluids Slip conditions Fluid-structure interactions Singular stresses

On the pressure and stress singularities induced by steady flows of a pair of nonmiscible,incompressible,viscous fluids in contact with a wall

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Acta Mechanica Sinica 2010年第5期26卷 669-673页

作者： g.b.Sinclair Department of Mechanical Engineering Louisiana State University

Design for structural integrity requires an appreciation of where stress singularities can occur in structural configurations. While there is a rich literature devoted to the identification of such singular behavior in solid mechanics, only of late has there been much in the way of corresponding identifications of flow-induced stress singularities in fluid mechanics. These recent asymptotic identifications are for a single incompressible viscous fluid： Here the asymptotic approach is extended to apply to a configuration entailing two such fluids, For this configuration, various specifications leading to power or log singularities are determined. These results demonstrate that flow-induced stress singularities can occur in a structural container at a location where no singularities are identified within solid mechanics alone.

关键词： Incompressible viscous fluids - Navier-Stokes equations Fluid-structure interactions Stress singularities

Energy Savings Estimation of a Distribution System in Presence of Intelligent Volt-VAr Control based on IEEE Std.1547-2018

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CSEE Journal of Power and Energy Systems 2022年第5期8卷 1477-1486页

作者： Saran Satsangi g.b.Kumbhar Department of Electrical Engineering Indian Institute of Technology RoorkeeRoorkeeUttarakhandIndia

In the present scenario,many solar photovoltaic(SPV)systems have been installed in the distribution network,most of them are operating at the unity power factor,which does not provide any reactive power *** future distribution grids,there will be significant advances in operating strategies of SPV systems with the introduction of smart inverter *** new IEEE Std.1547-2018 incorporates dynamic Volt/VAr control(VVC)for smart *** smart inverters can inject or absorb reactive power and maintain voltages at points of common coupling(PCCs)based on local voltage *** multiple inverter-interfaced SPV systems connected to the grid,it becomes a necessary task to develop local,distributed or hybrid VVC algorithms for maximization of energy *** paper aims to estimate substation energy savings through centralized and decentralized control of inverters of SPV system alongside various VVC *** strategies of each SPV inverter have been accomplished in compliance with IEEE ***-series simulations are carried out on the modified IEEE-123 node test *** utilizing smart inverters in traditional SPV systems,considerable energy savings can be *** savings can be further increased by incorporating optimal intelligent VVC characteristics(IVVCC).Results show that just by allowing smart inverters on a predefined IVVCC(as per IEEE Std.1547-2018),a reduction of 11.69%in reactive demand and 5.63%in active demand have been acquired when compared with a conventional SPV *** energy demand is additionally reduced to 48.42%by considering centralized control of VVC devices alongside optimal IVVCC.

关键词： Conservation voltage reduction IEEE Std.1547-2018 smart inverter functions solar photovoltaic system Volt/VAr control Volt/VAr optimization

Thermal Entanglement in a Two-Qubit Ising Chain Subjected to Dzyaloshinsky–Moriya Interaction

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Chinese Physics Letters 2013年第12期30卷 5-8页

作者： b.g.Divyamani Sudha Department of Physics Kuvempu UniversityShankaraghattaShimoga-577451India Tunga Mahavidyalaya TirthahalliShimoga-577451India Inspire Institute Inc. AlexandriaVirginia22303USA

Thermal entanglement of a two-qubit Ising chain subjected to an external magnetic field and Dzyaloshinsky–Moriya(DM)interaction is *** effect of magnetic field,strength of DM interaction and temperature are analyzed by adopting negativity of partial transpose as the measure of *** is shown that when the DM interaction along the Ising axis is considerable,thermal entanglement can be sustained for a higher *** usefulness of longitudinal DM interaction over the one that is perpendicular to the Ising axis,in the manipulation and control of entanglement at a feasible temperature,is illustrated.

关键词： temperature Ising interaction

A derived grid-based model for simulation of pedestrian flow

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 209-220页

作者： günter bRWOLFF Hartmut SCHWANDT Institut für Mathematik Technische Universitt Berlin

We present a derived grid-based model for the simulation of pedestrian flow. Interactions among pedestrians are considered as the result of forces within a certain neig.bourhood. Unlike the social force model,the forces here,as in Newtonian physics,are proportional to the inverse of the square of the distance. Despite the notion of neig.bourhood and the underlying grid,this model differs from the existing cellular automaton(CA) models in that the pedestrians are treated as individuals. bresenham's algorithm for line rastering is applied in the step calculation.

关键词： bresenham's algorithm Cellular automaton (CA) Pedestrian dynamics Social force model

ANALYSIS OF DISCRETE-TIME QUEUES WITH bATCH RENEWAL INPUT AND MULTIPLE VACATIONS

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Journal of Systems Science & Complexity 2012年第3期25卷 486-503页

作者： Veena gOSWAMI g.b.MUND School of Computer Application KIIT University School of Computer Engineering KIIT University

This paper analyzes a discrete-time multiple vacations finite-buffer queueing system with batch renewal input in which inter-arrival time of batches are arbitrarily distributed. Service and vacation times are mutually independent and geometrically distributed. The server takes vacations when the system does not have any waiting jobs at a service completion epoch or a vacation completion epoch. The system is analyzed under the assumptions of late arrival system with delayed access and early arrival system. Using the supplementary variable and the imbedded Markov chain techniques, the authors obtain the queue-length distributions at pre-arrival, arbitrary and outside observer＇s ob- servation epochs for partial-batch rejection policy. The blocking probability of the first, an arbitrary- and the last-job in a batch have been discussed. The analysis of actual waiting-time distributions measured in slots of the first, an arbitrary- and the last-job in an accepted batch, and other performance measures along with some numerical results have also been investigated.

关键词： batch input discrete-time finite buffer multiple vacations partial-batch rejection.

Adaptation of real earthquake records for their reproduction by a shaking table with limited stroke

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Earthquake Engineering and Engineering Vibration 2010年第4期9卷 493-502页

作者： b blostotsky Y Ribakov g Agranovich Ariel University Center of Samaria

Shaking tables with moving platforms are widely used in laboratory testing of structural models and full-sized devices. In most cases, the platform＇s movement should reproduce real ground acceleration records. However, the stroke of the platform, required for reproduction of real records, is usually rather large. This limitation does not allow an accurate realization of the ground motion by the shaking table. Commonly, in order to overcome this problem, original records are modified, which causes a significant change in the acceleration records＇ spectra. That is why structural responses to the original and to the modified records are different. A new method for modification of original acceleration records is proposed, in which the original record is corrected by an additional artificial one that changes the shaking platform＇s displacement. The corrected record is obtained as a sequence of impulses, The magnitude and duration of each impulse, as well as their location on the time scale, are obtained by an optimization procedure. The optimization is implemented according to a performance index, aimed to minimize the influence of the correcting acceleration record on the specmam of the original one. The proposed method has higher reproduction accuracy, compared to other known methods. Its effectiveness is demonstrated by comparison of response spectra and dynamic behaviors of three multi-story structures subjected to natural and modified seismic excitations.

关键词： shaking table platform stroke earthquake record reproduction scaling optimization