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High-dose dexamethasone regulates microglial polarization via the gR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan zhuang Shenghua Lu Qianqian ge hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Unveiling the Initial Conditions of Open Star Cluster Formation

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Research in Astronomy and Astrophysics 2023年第7期23卷 288-299页

作者： C.J.hao Y.Xu L.g.Hou z.H.Lin Y.J.Li Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China

Open clusters(OCs)are infrequent survivors of embedded clusters gestated in molecular *** to now,little is known about the initial conditions for the formation of ***,we studied this issue using high-precision astrometric parameters provided by gaia data release *** statistics show that the peculiar motion velocities of OCs vary slightly from infancy to old age,providing a remarkable opportunity to use OCs to trace their *** a dynamical method,we derived the masses of the progenitor clumps where OCs were born,which have statistical characteristics comparable to previously known results for clumps observed in the ***,the masses of the progenitor clumps of OCs indicate they should be capable of gestating massive O-type *** fact,after inspecting the observed OCs and O-type stars,we found that there are many O-type stars in *** destructive stellar feedback from O-type stars may disintegrate the vast majority of embedded clusters,and only those sufficiently dense ones can survive as OCs.

关键词： galaxy:stellar content (galaxy:)open clusters and associations:general stars:formation stars:kinematics and dynamics

Microstructure and Mechanical Property of Hot-Rolled Mg-2Ag Alloy Prepared with Multi-pass Rolling

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Acta Metallurgica Sinica(English Letters) 2023年第2期36卷 335-342页

作者： H.zhang H.L.hao g.Y.Fu B.S.Liu R.g.Li R.z.Wu H.C.Pan School of Mechanical and Power Engineering Shenyang University of Chemical TechnologyShenyang110142China Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin150001China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Northeastern UniversityShenyang110819China

A conventional multi-pass rolling is designed to form different microstructures in a Mg-2Ag *** relationship between microstructure and mechanical property is *** result shows that twin-induced nucleation plays a prominent role for the dynamic recrystallization(DRX)behavior of the rolled Mg-2Ag *** DRXed grains distributed around elongated grains have random orientations but gradually turn to the concentrated orientation with strong basal texture when the rolling pass *** yield strength and ultimate tensile strength of rolled Mg-2Ag alloy gradually increase with increasing rolling *** elongation of rolled sample is gradually improved when the rolling pass increases from one to three,while a significant drop of elongation shows in the four-pass rolling *** strong basal texture,refined grains,high-density dislocations,and Ag segregation along grain boundaries are suggested to play a prominent role for enhancing the strength of Mg-Ag alloys,while the low-density dislocations,homogeneously fine-grained microstructure,and weak texture are critical for improving the ductility.

关键词： Magnesium alloy Conventional rolling Twinning Dynamic recrystallization Texture

NUMERICAL SIMULATION OF SUCCINONITRITE DENDRITIC gROWTH IN A FORCED FLOW

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Acta Metallurgica Sinica(English Letters) 2008年第6期21卷 444-450页

作者： z. Chen C.L. Chen L.M. hao School of Science Department of Applied Physics Shaanxi Key Laboratory of Condensed Matter Structures and Properties Northwestern Polytechnical University Xi＇an 710072 China School of Science Xi＇an University of Science ＆ Technology Xi＇an 710054 China

Numerical simulation based on phase field method is performed to describe solidification process of pure material in a free or forced flow. The evolution of the interface is showed, and the effects of mesh grid and flow velocity on succinonitrite shape are studied. These results indicate that crystal grows into an equiaxial dendrite in a free flow and into an asymmetrical dendritic in a forced flow. With increasing flow velocity, the upstream dendritic arm tip grows faster and the downstream arm grows slower. However, the evolution of the perpendicular tip has no significant change. In addition, mesh grid has no influence on dendritic growth shape when mesh grid is above 300×300.

关键词： Phase field method Forced flow Dendritic Succinonitrite Tip velocity

granger causal representation learning for groups of time series

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Science China(Information Sciences) 2024年第5期67卷 56-68页

作者： Ruichu CAI Yunjin WU Xiaokai HUANg Wei CHEN Tom z.J.FU zhifeng hao School of Computer Science Guangdong University of Technology Peng Cheng Laboratory College of Science Shantou University

Discovering causality from multivariate time series is an important but challenging *** existing methods focus on estimating the granger causal structures among multivariate time series,while ignoring the prior knowledge of these time series, e.g., the group of the time series. Focusing on discovering the granger causal structures among groups of time series, we propose a granger causal representation learning method to solve this problem. First, we use the multiset canonical correlation analysis method to learn the granger causal representation of each group of time series. Then, we model the granger causal relationships among the learned granger causal representations using a recurrent neural network with temporal information. Finally, we formulate the above two stages into one unified optimization problem, which is efficiently solved using the augmented Lagrangian method. We conduct extensive experiments on synthetic and real-world datasets to validate the correctness and effectiveness of the proposed method.

关键词： granger causal discovery granger causal representation learning time series data recurrent neural network multiset canonical correlation analysis

Nonlinear Transient Response of Functionally graded Material Sandwich Doubly Curved Shallow Shell Using New Displacement Field

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Acta Mechanica Solida Sinica 2018年第1期31卷 108-126页

作者： z.N.Li Y.X.hao W.zhang J.H.zhang College of Mechanical Engineering Beijing Information Science and Technology University College of Mechanical Engineering Beijing University of Technology

In this paper, the nonlinear transient dynamic response of functionally graded material （FgM） sandwich doubly curved shell with homogenous isotropic material core and functionally graded face sheet is analyzed using a new displacement field on the basis of Reddy＇s third-order shear theory for the first time. The equivalent material properties for the FgM face sheet are assumed to obey the rule of simple power law function in the thickness direction. Based on Reddy＇s theory of higher shear deformation, a new displacement field is developed by introducing the secant function into transverse displacement. Four coupled nonlinear differential equations are obtained by applying Hamilton＇s principle and galerkin method. It is assumed that the FgM sandwich doubly curved shell is subjected to step loading, air-blast loading, triangular loading, and sinusoidal loading, respectively. On the basis of double-precision variable- coefficient ordinary differential equation solver, a new program code in FORTRAN software is developed to solve the nonlinear transient dynamics of the system. The influences of core thickness, volume fraction, core-to-face sheet thickness ratio, width-to-thickness ratio and blast type on the transient response of the shell are discussed in detail through numerical simulation.

关键词： New displacement fields Functionally graded materials Sandwich doubly curvedshell Blast load Nonlinear transient response

NUMERICAL SIMULATION STUDY ON DEFORMATION UNIFORMITY OF EQUAL CROSS SECTION LATERAL EXTRUSION

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Acta Metallurgica Sinica(English Letters) 2004年第1期17卷 61-63页

作者： z.L.Chang J.L.Song N.H.hao Department of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 ChinaDepartment of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 ChinaDepartment of Materials Engineering Taiyuan Heavy Machinery Institute Taiyuan 030024 China

Equal cross section lateral extrusion (ECSLE) is an effective method realizing pure shear deformation. The influence of friction factor on the deformation uniformity of ECSLE was investigated with rigid plastic finite element method. The result shows that the non-uniform deformation in extrusion is caused mainly by the friction between workpiece and die. The higher the friction factor is, the more uneven plastic deformation resulted in extruded workpiece. The relation curve of deformation uniformity vs. friction factor was drawn based on the analysis result. The curve can be used as a basis of ECSLE process design.

关键词： equal cross section lateral extrusion strain finite element method

Frank-Kasper and related quasicrystal spherical phases in macromolecules

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Science China Chemistry 2018年第1期61卷 33-45页

作者： Mingjun Huang Kan Yue Jing Wang Chih-hao Hsu Linge Wang Stephen z.D.Cheng Department of Polymer Science The University of Akron South China Advanced Institute for Soft Matter Science and Technology South China University of Technology State Key Laboratory of Luminescent Materials and Devices School of Materials Science and Engineering South China University of Technology

Creation of diverse ordered nanostructures via self-assembly of macromolecules is a promising "bottom-up" approach towards next-generation nanofabrication technologies. It is therefore of critical importance to explore the possibilities to form new self-assembled phases in soft matter systems. In this review, we summarized recent advances on the identification of several unconventional spherical phases in the self-assembly of functional macromolecules, including Frank-Kasper(F-K) phases and quasicrystals originally observed in metal alloys. We believe that these results provide a new strategy towards the rational design of novel functional materials with hierarchically ordered structures.

关键词： self-assembly Frank-Kasper phase quasicrystal giant surfactant block copolymer dendrimer

STUDY ON THE THERMODYNAMICS OF CuO/Al IN SITU Al_2O_3 REINFORCED Al MATRIX COMPOSITES

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Acta Metallurgica Sinica(English Letters) 2004年第5期17卷 732-740页

作者： Y.Ma Y.hao S.z.Kou X.N.Lu StateKeyLab.ofAdvancedNonferrousMaterials LanzhouUniversityofTechnologyLanzhou730050China

Based on the experiment and the thermodynamics analysis for CuO/Al system, it is founded that the compounding reaction of CuO/Al under low temperature is available. The general equation of adiabatic temperature of the system is set up, and the influence of resultant concentration and temperature on adiabatic temperature is theoretically analyzed. The values of heat effect of CuO/Al system under different temperature are also caculated.

关键词： composites in situ thermodynamics CuO Al exothermic dispersion