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MR波谱检测遗传性平滑肌瘤病和肾细胞癌综合征的延胡索酸水合酶缺陷

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国际医学放射学杂志 2023年第1期46卷 111-111页

作者： g.y.wu g.Q.Liu J.F.Wang S.B.Pan y.S Luo y.Z.Xu 胡金玥

摘要无创性活体检测延胡索酸积聚,有助于确定遗传性平滑肌瘤病和肾细胞癌(HLRCC)综合征的延胡索酸水合酶缺陷。目的评估磁共振波谱(MRS)检测HLRCC相关肾癌

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Dietary supplementation with astragalus polysaccharide enhances ileal digestibilities and serum concentrations of amino acids in early-weaned piglets

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Dietary supplementation with astragalus polysaccharide enhan...

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

4th International Symposium on Animal Nutrition,Health and Feed Additive

作者： F.g yin~(1,4),y.L.Liu~2,y.L.yin~(1,2,*),X.F.Kong~1,R.L.Huang~1,T.J.Li~(1,4),g.y.wu~3 and y.Q.Hou~2 1 Key Laboratory for Agro-ecological Processes in Subtropical Region,Institute of Subtropical Agriculture,the Chinese Academy of Sciences,Changsha,Hunan 410125,China 2 Hubei Key Laboratory of Animal Nutrition and Feed Science,wuhan Polytechnic University, wuhan 430023,China 3 Department of Animal Science,Texas A&M University,College Station,TX 77843-2471,USA 4 The graduate School of the Chinese Academy of Sciences,Beijing 100049,China

Two experiments were conducted to evaluate the effects of dietary supplementation with astragalus polysaccharide(APS) growth performance,apparent ileal digestibilities (AID) of amino acids(AA),and their serum concentrations in early-weaned *** Exp.1,sixty pigs were weaned at 21 days of age(BW = 7.35±0.23 kg) and allocated to three treatments(20 pigs/treatment), representing supplementing 0.0%(control), 0.02%colistin(antibiotic),or 0.1%APS to a corn- and soybean meal-based *** daily gain(ADg),average daily feed intake (ADFI) and feed/gain ratio(F/g) were measured *** samples were obtained from five pigs selected randomly from each treatment for the measurement of serum free AA concentrations on Days 7,14 and *** Exp.2,twelve pigs were weaned at 21 day of age(BW = 7.64±0.71 kg),assigned to three treatment groups as in Exp.1,and surgically fitted with a simple T-cannula at the terminal *** digesta samples were obtained for the measurement of AID of AA on Days 7,14 and *** APS did not affect ADFI,but enhanced(Pg by 11%and 4.4%,and improved F/g by 5.6% and 8.4%,respectively,compared with the control and antibiotic *** of APS to the diet increased AID and serum concentrations of most nutritionally essential and nonessential AA(including arginine, proline,glutamate,lysine,methionine, tryptophan,and threonine) on Days 14 and 28. Circulating levels of total AA were affected by the age of pigs and treatment×time ***,these findings indicate that APS may ameliorate the digestive and absorptive function and regulate AA metabolism to beneficially increase the entry of dietary AA into the systemic circulation, which provide a mechanism to explain the growth-promoting effect of APS in early-weaned piglets.

关键词： Amino acids Astragalus polysaccharide Digestibilities Performance Pig

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun Li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

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gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt:Mechanistic and clinical implications

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World Journal of gastroenterology 2025年第3期31卷 134-137页

作者： Qi-Rong Jiang Da-wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

In this article,we provide commentary on the recent article by Zhao et *** focus on the shifts in the gut microbiota of patients with hepatitis B virus(HBV)-associated cirrhosis/portal hypertension(PH)following transjugular intrahepatic portosystemic shunt(TIPS)and the implications for understanding the mechanisms,diagnosis,and *** comparing the gut microbiota composition and dynamic changes before and after TIPS in patients with and without hepatic encephalopathy,the authors found an increase in non-probiotic bacteria in those who developed hepatic encephalopathy post-TIPS,with Morganella species present only in the hepatic encephalopathy *** gut microbiota changes post-TIPS among patients without the occurrence of hepatic encephalopathy suggest potential therapeutic benefits through prophylactic microbiome ***,the specific gut microbiota alterations may hold promise to predict the risk of hepatic encephalopathy in individuals undergoing TIPS for HBVrelated *** these promising findings,future studies are needed to address limitations,including a small sample size,a relatively short evaluation period for gut microbiota alterations,the absence of data on dynamic alterations in gut microbiota post-TIPS and their correlation with blood ammonia levels,and the lack of validation in animal *** conclusion,Zhao et al's study has shed new light on the link of gut microbiota with post-TIPS hepatic encephalopathy,potentially through the intricate gut-liver axis,and has important clinical implications for improving the management of patients with HBV-related PH.

关键词： Hepatitis B virus Cirrhosis Portal hypertension Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt gut microbiota

肾细胞癌肺转移抗血管生成靶向治疗的疗效评估:R2~*值作为预测标志物

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国际医学放射学杂志 2017年第6期 730-730页

作者： g.y.wu g.Q.Liu W.Kong J.X.Qu S.T.Suo X.S.Liu 张毓婧 Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University

摘要目的探究R~*mapping用于评估肺转移性肾细胞癌(m RCC)抗血管生成靶向治疗(a ATT)的效能和最佳时间点。方法试验组和验证组分别有22例和16例病人。MR R~*

关键词：抗血管生成靶向治疗 R2 疗效评估

Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

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World Journal of gastrointestinal Oncology 2025年第1期17卷 121-129页

作者： yang-gang Luo Mei wu Hong-guang Chen Pathology Department Xuanhan County People’s HospitalDazhou 636150Sichuan ProvinceChina

BACKgROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late *** the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment *** To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging *** We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our *** types were determined by histopathological examination of the surgical spe-cimens or biopsy *** imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic *** analyses were performed to identify significant associations between pathological types and specific imaging *** There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare *** imaging features were identified in each pathological *** ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural *** tumors often appear as hypervascular lesions in contrast-enhanced *** analysis revealed significant correlations between specific imaging features and pathological types(Py demonstrated a strong association between the pathological types of pancreatic cancer and imaging *** findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

关键词： Pancreatic cancer Pathological types Imaging features Retrospective analysis Diagnostic accuracy

Serum Metabolome is Altered in Arginine-Supplemented growing Pigs

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Serum Metabolome is Altered in Arginine-Supplemented Growing...

Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

4th International Symposium on Animal Nutrition,Health and Feed Additive

作者： Q.H.He,X.F.Kong,Z.R.Tang,g.y.wu,H.R.Tang,P.P.Ren,F.H. Hao,R.L.Huang,T.J.Li,B.E.Tan,y.N.wu,and y.L.yin 3 Key Laboratory for Agro-ecological Processes in Subtropical Region,Institute of Subtropical Agriculture,The Chinese Academy of Sciences,Changsha,Hunan 410125,P.R.China 4 National Institute for Nutrition and Food Safety,Chinese CDC,Beijing 100050 China 5 The graduate School of the Chinese Academy of Science,Beijing 100049,China 6 Department of Animal Science,Texas A&M University,College Station,TX,77843-2471 7 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,wuhan Centre for Magnetic Resonance,wuhan Institute of Physics and Mathematics,the Chinese Academy of Sciences,wuhan,Hubei 430071,China

Arginine plays an important role regulating nutrient metabolism,but the underlying mechanisms are largely *** study was conducted to determine the effect of dietary arginine supplementation on the metabolome in serum of growing pigs using H nuclear magnetic resonance spectroscopy. Sixteen pigs（48±4 kg） were randomly assigned to one of 2 groups,representing supplementation with 0 or 1.0%of L-arginine-HCl to corn- and soybean meal-based *** was collected after 46 d *** arginine supplementation decreased fat deposition and increased protein accretion in the body. Principal component analysis showed that serum concentrations of low-density lipoprotein,very-low-density lipoprotein,and urea were lower,but concentrations of creatinine,tricarboxylic-acid-cycle metabolites,alanine,ornithine,lysine and tyrosine were greater in arginine-supplemented than in control pigs. Additionally,the arginine treatment affected serum concentrations of lipid signalling molecules（glycerophosphorylcholine and myo-inositol） and intestinal bacterial metabolites（formate,ethanol,methylamine, dimethylamine,acetate,and propionate）. These novel findings suggest that dietary arginine supplementation alters the catabolism of fat and amino acids in the whole body, enhances protein synthesis in skeletal muscle, and modulates intestinal microbial metabolism in growing pigs.

关键词： arginine metabolomics serum pigs nuclear magnetic resonance spectroscopy

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World Journal of gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-Rong wu Xiao-Hong He yong-Fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： yingli gu Kijung Sung Chengbiao wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

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