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On the road towards the global analysis of human synapses

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Neural Regeneration Research 2017年第10期12卷 1586-1589页

作者： g.Aleph Prieto Carl w.Cotman Institute for Memory Impairments and Neurological Disorders University of CaliforniaIrvineCAUSA

Synapses are essential units for the flow of information in the *** the last 70 years,synapses have been widely studied in multiple animal models including worms,fruit flies,and *** comparison,the study of human synapses has evolved significantly slower,mainly because of technical ***,three novel methods allowing the analysis of molecular,morphological,and functional properties of human synapses may expand our knowledge of the human ***,we briefly describe these methods,and evaluate how the information provided by each unique approach may contribute to the functional and anatomical analysis of the synaptic component of human brain *** particular,using tissue from cryopreserved human brains,synaptic plasticity can be studied in isolated synaptosomes by fluorescence analysis of single-synapse long-term potentiation（FASS-LTP）,and subpopulations of synapses can be thoroughly assessed in the ribbons of brain tissue by array tomography（AT）.Currently,it is also possible to quantify synaptic density in the living human brain by positron emission tomography（PET）,using a novel synaptic ***,data provided by FASS-LTP,AT,and PET may significantly contribute to the global understanding of synaptic structure and function in both healthy and diseased human brains,thus directly impacting translational research.

关键词： fluorescence analysis of single-synapse long-term potentiation array tomography positron emission tomography synaptosomes flow cytometry microscopy [11C]UCB-J[(R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3 4 5-trifluorophenyl)pyrrolidin-2-one]

Effect of Sulfate on Adsorption of Zinc and Cadmium by Variable Charge Soils *1

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Pedosphere 1998年第3期8卷 245-250页

作者： ZHANggANgYA g．w．BRUMMER 等 InstituteofSoilScience theChineseAcademyofSciencesP.O.Box821Nanjing210008（China） DepartmentofsoilSc

SO 4 2- and Zn 2+ or Cd 2+ were added to three variable charge soils in different sequences. In one sequence sulfate was added first, and in the other, Zn 2+ or Cd 2+ ... 详细信息

SO 4 2- and Zn 2+ or Cd 2+ were added to three variable charge soils in different sequences. In one sequence sulfate was added first, and in the other, Zn 2+ or Cd 2+ first. The addition of sulfate to the system invariably caused an increase in adsorption of the heavy metal added, with the effect more remarkable when the soil reacted with the sulfate prior to the metal. The shift in pH 50 for both Zn and Cd adsorption was also comparatively larger in the first sequence of reactions. It was suggested that the increase in negative charge density and the resultant negative potential of the soil were the primary cause of the pronounced effect of sulfate on adsorption of Zn or Cd, and the formation of the ternary surface complex S SO 4 M might also play a role in the effect.

关键词： adsorption cadmium sulfate variable charge soil,zinc

Petrochemical Comparison of 3.5 ga Old Mafic Amphibolite Inclusions from Eastern Hebei Province with Archean Mafic-ultramafic Supracrustais of Uncertain Antiquity,Southern Jilin Eastern Liaoning Provinces,China

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Chinese Journal Of geochemistry 1989年第2期8卷 97-111页

作者： w.g.Ernst Institute of geophysics and Planetary Physics Department of Earth and Space Sciences University of California Los Angeles California 90024-1567

New major element data for coexisting minerals and bulk-rock REE analyses,combined with previously obtained petrologic/geologic information,allow comparison of Archean mafic-ultramafic meta-igneous rocks from adjacent portions of northeastern Sino-Korean shield .Isotope data published by previous workers document an Early Archean age of formation for metabasaltic rocks now occurring as mafic amphibolite inclusions in tonalitic gneisses west of Bohai Bay(area).Mafic-ultramafic mineral assemblages developed in tonalitic gneisses west of Bohai Bay(areaA).Mafic-ultramafic mineral assemblages developed in amphibolite facies Archean supracrustals east of Bohai Bay(areaB)are chemically similar ,but pre-existing phase associations have been overprinted by the effects of several later metamorphic ***0peridotitic area B protoliths appear to be more magnesian ,averaging-12wt.%MgO(versus-7wt.%for area A),and are slightly less fractionated in REE concentrations relative to chondrites(La-Lu=30-8X versus 37-14X for area A),thus perhaps being more mantle-like than area A metabasaltic *** basaltic-komatiitic series east of Bohai Bay probably represents the most ancient crust of that region,being invaded by Archean tonalities,which were subsequently converted to *** observations are compatible with the hypothesis that ,similar to area A metabasaltic rocks now found as amphibolitic inclusions in orthogneisses,are B mafic supracrustals were formed during Early of Middle Archean time ,prior to widespread isofacial amphibolite facies metamorphism(600-700℃,5-7kb,low αH2O).

关键词：岩石化学辽宁河北闪岩包裹体太古代铁镁质超基性岩地质构造

西藏高原中、北部断裂构造特征:INDEPTH(Ⅲ)-MT观测提供的依据

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地球科学（中国地质大学学报） 2006年第2期31卷 257-265页

作者：魏文博金胜叶高峰邓明谭捍东 Martyn Unsworth John booker Alan g. Jones LI Sheng-hui 地质过程与矿产资源国家重点实验室和地下信息探测技术与仪器教育部重点实验室北京100083 中国地质大学（北京）地球物理与信息技术学院北京100083 Department of Physics University of Albert Edmonton Alberta T6G3PS Canada geophysics Program University of Washington Seattle WA98 USA Dublin Institute of Advanced Studies 5 Merrion Squar Dublin Ireland

根据1998年和1999年INDEPTH(Ⅲ)MT在西藏中、北部所完成的德庆-龙尾错(500线)和那曲-格尔木(600线)超宽频带大地电磁深探测剖面数据研究西藏高原中北部断裂构造特征,有助于推进印度板块与亚洲板块碰撞、俯冲构造模式的研究.研究结果表明... 详细信息

根据1998年和1999年INDEPTH(Ⅲ)MT在西藏中、北部所完成的德庆-龙尾错(500线)和那曲-格尔木(600线)超宽频带大地电磁深探测剖面数据研究西藏高原中北部断裂构造特征,有助于推进印度板块与亚洲板块碰撞、俯冲构造模式的研究.研究结果表明,区内发育有F1～F10一系列深断裂.其中,F2向北倾斜是早期的主断裂,F1则是后期主逆冲断裂,它们共同构成空间结构复杂的嘉黎深断裂带.班公-怒江缝合带的主断裂系由略微向南陡倾的F3、F4和F5三组超壳深断裂构成;由于受后期构造运动强烈的改造,缝合带内发育多条延深不大的上地壳断层.唐古拉断裂带由F6、F7两组主断裂和一系列次级断裂构成;主断裂产状上陡、下缓,总体向南倾斜,向下延深达下地壳.而金沙江缝合带是由F8(金沙江断裂)和F9(可可西里断裂),以及它们之间存在的一系列上地壳次级断层共同组成的,是一组很宽的地块碰撞缝合带.F10即昆中断裂是产状陡立的超壳深断裂,是昆仑山断裂带的主体构造,它构成松潘-甘孜-可可西里地块的北部边界.从剖面电性结构特征分析,昆中断裂以南属于西藏高原主体;而以北地区是否还归属西藏高原?这有待更深入的讨论.值得特别关注的事实是,研究区内2组缝合带之下都存在向上地幔延伸的壳内高导体,它们可能反映区内壳幔热交换过程的痕迹.

关键词： INDEPTH-MT 大地电磁测深断裂特征壳幔热交换

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.w.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa gordon gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

ELECTROANALYTICAL APPLICATIONS OF CARBOXYL-MODIFIED CARBON NANOTUBE FILM ELECTRODES

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Acta Metallurgica Sinica(English Letters) 2003年第4期16卷 289-294页

作者： C.g.Hu w.L.wang K.J.Liao w.Zhu DepartmentofAppliedPhysics ChongqingUniversityChongqing400044China KeyLaboftheEducationMinistryforPhotoelectricTechnologyandSystem ChongqingUniversityChongqing400044China DepartmentofChemistry ChongqingUniversityChongqing400044ChinaManuscriptreceived25November2002

The electrochemical behavior of a carboxyl-modified carbon nanotube films was investigated to explore its possibility in electroanalytical applicaton. Cyclic voltammetry of quinone was conducted in 1mol/L Na2SO4, which showed a stable, quasi-reversible voltammetric response for quinone / hydroquinone, and the anodic and the cathodic peak potentials were 0.657V and -0.029V (vs. SCE) at a scan rate of 0.1V.s-1, respectively. Both anodic and cathodic peak currents depended linearly on the square root of the scan rate over the range of 0.01-0.5V.s-1, which suggested that the process of the electrode reactions was diffusion-controlled. Carboxyl-modified carbon nanotube electrodes made it possible to determine low level of dopamine selectively in the presence of a large excess of ascorbic acid in acidic media using derivative voltammetry. The results obtained were discussed in details. This work demonstrates the potential of carboxyl-modified carbon nanotube electrodes for electroanalytical applications.

关键词： carbon nanotube electrochemistry carboxyl modification dopamine

Modelling impacts of acid deposition and groundwater level on habitat quality and plant species diversity

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Ecological Processes 2016年第1期5卷 273-291页

作者： J.Kros J.P.Mol-Dijkstra g.w.w.wamelink g.J.Reinds Avan Hinsberg w.de Vries wageningen Environmental Research Wageningen University and ResearchP.O.Box 476700 AA WageningenThe Netherlands Netherlands Environmental Assessment Agency PO Box 3033720 BABilthovenWageningenThe Netherlands Environmental Systems Analysis group Wageningen University and ResearchP.O.Box 476700 AA WageningenThe Netherlands

Introduction:we quantified the effects of the site factors pH and nitrate(NO_(3))concentration in soil solution and groundwater level on the vegetation of terrestrial ecosystems for the Netherlands in response to changes in atmospheric nitrogen(N)and sulphur(S)deposition and groundwater level over the period *** assessment was made with the SMART2 model,a simple one-layer model including geochemical buffer processes,element cycling by litterfall,mineralisation and uptake,nitrogen transformation processes and element input through deposition,weathering and upward ***:To assess the effects of changes in abiotic site factors on the vegetation,we developed a simple plant diversity indicator for grassland,heathland and forest,based on the occurrence of target plant species and competing *** occurrence was calculated from the preferred ranges of each species for the NO_(3) concentration and pH in soil solution and mean spring groundwater *** in the plant diversity indicator were assessed from effects of changes in the occurrence of target and competing plant species in response to changes in mean spring groundwater level and in pH and NO_(3) concentration,as calculated with *** were made for combinations of five vegetation structure types(three forest types,semi-natural grassland and heathland)and seven soil types(three sandy soils,two clay soils,peat and loess soils)using a 250×250 m *** used data for atmospheric deposition and groundwater level in the past to assess trends between 1990 and 2010 and evaluated two future scenarios for the period 2010-2030:a Business as Usual and an Improved Environment ***:Comparison of model predictions on pH and NO_(3) with measured soil solution concentrations for forest showed a reasonable to good agreement for pH but rather poor for NO_(3).The largest impacts were found for the combination of the two Improved Environment ***:Reductions in N

关键词： Nutrient cycling Soil modelling Biodiversity Acidification Scenario analysis

A risk table to address concerns external to stock assessments when developing fisheries harvest recommendations

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Ecosystem Health and Sustainability 2020年第1期6卷 46-56,45页

作者： Martin w.Dorn Stephani g.Zador Resource Ecology and Fisheries Management Alaska Fisheries Science CenterSeattleWAUSA

This paper develops a risk table to facilitate incorporation of additional information into the fisheries stock assessment and management *** risk table is designed to evaluate unanticipated ecosystem and environmental impacts on marine resources that may require a rapid management *** risk table is a standardized framework to document concerns about the assessment model,population dynamics,and the ecosystem/environment that are not explicitly addressed within the stock assessment model.A scoring procedure is used to evaluate the severity of the *** concerns can then be evaluated in support for or against a reduction from the maximum Acceptable Biological Catch while providing reviewers and stakeholders transparent documentation of the *** risk table was applied successfully to several stocks on a trial basis during the 2018 groundfish assessment cycle for the North Pacific Fishery Management Council,and will be used for all full groundfish assessments in *** changes in climate are likely for Alaska marine ecosystems in coming decades,and these changes are not entirely ***,we avocate that the risk table approach should be included in the suite of management tools used to address the effects of climate change on Alaska marine resources.

关键词： Acceptable biological catch ecosystem-based management risk assessment stock assessment North Pacific Fishery Management Council

Object-Oriented Design for FDTD Visual Scientific Computing

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Journal of Systems Engineering and Electronics 2001年第3期12卷 71-75页

作者： Dong, X. wang, w. wang, g. Electromagnetic and Commun. Lab. Sch. of Electronic and Info. Eng. Xi'an Jiaotong University Xi'an 710049 China

A scheme for general purposed FDTD visual scientific computing software is introduced in this paper using object-oriented design (OOD) method. By abstracting the parameters of FDTD grids to an individual class and separating from the iteration procedure, the visual software can be adapted to more comprehensive computing problems. Real-time gray degree graphic and wave curve of the results can be achieved using DirectX technique. The special difference equation and data structure in dispersive medium are considered, and the peculiarity of parameters in perfectly matched layer are also discussed.

关键词： Computational methods Computer aided design Data structures Difference equations Finite difference method Iterative methods Natural sciences computing Object oriented programming Parameter estimation Three dimensional computer graphics Time domain analysis