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Effect of Equal Channel Angular Extrusion on the Microstructures and Properties of Two Extruded Al-Mg-Si Alloys

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Journal of Materials Science & Technology 2005年第5期21卷 623-629页

作者： g.w.Lorimer School of Materials The University of ManchesterGrosvenor StreetMl 7HS ManchesterUK

The effect of equal channel angular extrusion （ECAE） on the microstructure of two Al-Mg-Si extrusion alloys was investigated by high resolution electron backscattered diffraction （EBSD） using a field emission gun scanning electron microscope （FEg-SEM） and a transmission electron microscope （TEM）. Two contrasting alloys： a dilute alloy, based on alloy 6061 and a concentrated alloy, based on alloy 6069 were employed for this research. It has been found that prior ECAE to extrusion promotes high angle grain boundaries （HAgBs） in the extrusions, and the increase in HAgBs ratio is due to the large shear deformation involved in the process of ECAE. Tensile testing results show that a further ageing treatment strengthens the alloys after extrusion and the ECAE processed extrusions are more ductile than conventional extrusions.

关键词： Equal channel angular extrusion Electron backscattered diffraction Al-Mg-Si alloys

Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

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world Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew g garas Luis Calzadilla-Bertot Briohny w Smith Luc Delriviere Byron Jaques Lingjun Mou Leon A Adams gerry C MacQuillan george garas gary P Jeffrey Michael C wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BACKgROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of HCC recurrence is generally reported as 8%-20%in the *** predictors of HCC have already been researched,however,to our knowledge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of HCC recurrence in a contemporary western Australian LT *** we performed a retrospective cohort study of all liver transplants in patients with HCC at Sir Charles gairdner Hospital between 2006 and *** was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of HCC patients post-LT,stratified for recurrence,was calculated by Kaplan Meier *** and multivariate Cox regression was used to determine predictors of HCC recurrence *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with HCC.8.4%of subjects developed recurrent HCC after LT with median follow-up time of 5.4 *** median time to recurrence was 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(P=0.001),vascular invasion(P=0.003)and poorly differentiated HCC(P=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with HCC recurrence compared to those without HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank Pwas low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT *** studies are requir

关键词： Liver cancer Recurrence Liver transplantation Hepatocellular carcinoma Predictors Post-transplant survival Australian data

Secondary steady-state and time-periodic flows from a basic flow with square array of odd number of vortices

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Applied Mathematics and Mechanics(English Edition) 2023年第3期44卷 447-458页

作者： Zhimin CHEN w.g.PRICE School of Mathematics and Statistics Shenzhen UniversityShenzhen 518060Guangdong ProvinceChina Ship Science University of SouthamptonSouthampton SO171BJU.K.

In a magnetohydrodynamic(MHD)driven fluid cell,a plane non-parallel flow in a square domain satisfying a free-slip boundary condition is *** energy dissipation of the flow is controlled by the viscosity and linear *** latter arises from the influence of the Hartmann bottom boundary layer in a three-dimensional(3D)MHD experiment in a square bottomed *** basic flow in this fluid system is a square eddy flow exhibiting a network of N~2 vortices rotating alternately in clockwise and anticlockwise *** N is odd,the instability of the flow gives rise to secondary steady-state flows and secondary time-periodic flows,exhibiting similar characteristics to those observed when N=*** this reason,this study focuses on the instability of the square eddy flow of nine *** is shown that there exist eight bi-critical values corresponding to the existence of eight neutral eigenfunction ***,there exist non-real neutral eigenfunctions,which produce secondary time-periodic flows exhibiting vortices merging in an oscillatory *** Hopf bifurcation phenomenon has not been observed in earlier investigations.

关键词： two-dimensional(2D)Navier-Stokes equation non-parallel square vortex flow primary bifurcation secondary steady-state flow secondary time-periodic flow

Review of Late Jurassic-early Miocene sedimentation and plate-tectonic evolution of northern California:illuminating example of an accretionary margin

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Chinese Journal Of geochemistry 2015年第2期34卷 123-142页

作者： w.g.Ernst Department of geological & Environmental Sciences Stanford University

Production of voluminous igneous arc rocks,high-pressure/low-temperature(HP/LT) metamafic rocks,westward relative migration of the Klamath Mountains province,and U-Pb ages of deposition,sediment sources,and spatial locations of Jurassic and younger,detrital zirconbearing clastic rocks constrain geologic development of the northern California continental edge as follows:(1) At~ 175 Ma,transpressive plate underflow began to generate an Andean-type Klamath-Sierran arc along the margin.(2)Oceanic crustal rocks were metamorphosed under HP/LT conditions in an inboard,east-inclined subduction zone from~ 170-155 *** for the Red Ant blueschists,such Ethologies remained stored at depth;most HP/LT mafic tectonic blocks returned surfaceward only during mid- and Late Cretaceous time,chiefly entrained in circulating,buoyant Franciscan mud-matrix melange.(3) By ~ 165 Ma and continuing to ~ 150-140 Ma,erosion supplied volcanogenic debris to proximal Mariposa-galice ± Myrtle overlap strata.(4) At ~ 140,immediately prior to the onset of paired Franciscan and great Valley group(gVg) +Hornbrook deposition,the Klamath salient was deformed and displaced ~ 100-150 km westward relative to the Sierran arc,stranding pre-existing oceanic crust on the south as the Coast Range Ophiolite(CRO).(5) After the end-ofJurassic seaward step-out of the Farallon-North American convergent plate junction,terrigineous debris began to be deposited in the outboard Franciscan trench and intervening great Valley forearc.(6) Voluminous sedimentation and accretion of Franciscan Eastern + Central belts and gVg detritus took place during paroxysmal igneous activity and rapid,nearly orthogonal plate convergence at^125-80 Ma.(7) Sierran arc volcanism-plutonism ceased by^80 Ma in northern California,signaling a transition to shallow,nearly subhorizontal eastward plate underflow attending Laramide orogeny far to the east.(8) Presently exposed Paleogenelower Miocene Franciscan Coastal Belt sedimentary strata were

关键词：板块构造早中新世加利福尼亚州晚侏罗世增生保证金 U-Pb年龄地层沉积

A NUMERICAL METHOD FOR SIMULATINg NONLINEAR FLUID-RIgID STRUCTURE INTERACTION PROBLEMS

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Acta Mechanica Solida Sinica 2005年第2期18卷 95-109页

作者： Price w.g. The School of Engineering Sciences Ship ScienceUniversity of SouthamptonSouthampton SO17 1BJEngland

A numerical method for simulating nonlinear fluid-rigid structure interaction problems is developed. The structure is assumed to undergo large rigid body motions and the fluid flow is governed by nonlinear, viscous or non-viscous, field equations with nonlinear boundary conditions applied to the free surface and fluid-solid interaction interfaces. An Arbitrary-LagrangianEulerian (ALE) mesh system is used to construct the numerical model. A multi-block numerical scheme of study is adopted allowing for the relative motion between moving overset grids, which are independent of one another. This provides a convenient method to overcome the difficulties in matching fluid meshes with large solid motions. Nonlinear numerical equations describing nonlinear fluid-solid interaction dynamics are derived through a numerical discretization scheme of study. A coupling iteration process is used to solve these numerical equations. Numerical examples are presented to demonstrate applications of the model developed.

关键词： fluid-structure interaction nonlinear numerical analysis ALE description overset grids flow around bluff-body

Effect of monovalent charge compensators on the photoluminescence properties of Ca_(3)(PO_(4))_(2):Tb^(3+),A^(+)(A=Li,Na,K)phosphors

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Journal of Materials Science & Technology 2021年第23期82卷 187-196页

作者： g.w.Jung K.Park Faculty of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul05006Republic of Korea

Ca_(3-x)(PO_(4))_(2):xTb^(3+)(0.2≤x≤0.4),Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),0.35 A^(+)(A=Li,Na,K),and Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),yLi^(+)(0.35≤y≤0.455)phosphors were prepared by solid-state *** the prepared phosphors formed a rhombohedral unit cell with the R3c space *** improve the photoluminescence(PL)properties of the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)phosphor,monovalent charge compensators such as Li^(+),NA^(+),and K^(+)were added to the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)*** charge compensators acted as fluxes,so they improved the *** excitation and emission properties were significantly improved through the incorporation of charge *** particular,among the charge compensators,Li^(+)ion substantially enhanced the emission intensity and color ***,considering the evaporation of Li_(2)CO_(3)during the annealing process,we optimized the concentration of Li^(+)charge compensator to enhance its PL ***,the green emission intensity of the Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),0.385 Li^(+)phosphor was 260%higher than that of the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)*** believe that the effect of charge compensators on the PL properties and the optimum concentration of Li^(+)cha rge compensator are useful for the design of phosphors in light-emitting diodes.

关键词： Optical properties Ca_(3)(PO_(4))_(2) Emission Excitation Charge compensator

genomic regions underlying agronomic traits in linseed(Linum usitatissimum L.) as revealed by association mapping

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Journal of Integrative Plant Biology 2014年第1期56卷 75-87页

作者： Braulio J.Soto-Cerda Scott Duguid Helen booker gordon Rowland Axel Diederichsen Sylvie Cloutier Department of Plant Science University of Manitoba 66 Dafoe Road Cereal Research Center Agriculture and Agri-Food Canada 195 Dafoe Road Morden Research Station Agriculture and Agri-Food Canada 101 Route 100 Unit 100 Morden Department of Plant Sciences College of Agriculture and Bioresources University of Saskatchewan 51 Campus Drive Plant gene Resources of Canada Agriculture and Agri-Food Canada 107 Science Place

The extreme climate of the Canadian Prairies poses a major chal enge to improve yield. Although it is possible to breed for yield per se, focusing on yield-related traits could be advantageous because of their simpler genetic architecture. The Canadian flax core col ection of 390 accessions was genotyped with 464 simple sequence repeat markers, and phenotypic data for nine agronomic traits including yield, bol s per area, 1,000 seed weight, seeds per bol , start of flowering, end of flowering, plant height, plant branching, and lodging col ected from up to eight environments was used for association mapping. Based on a mixed model （principal component analysis （PCA） t kinship matrix （K））, 12 significant marker-trait associations for six agronomic traits were identi-fied. Most of the associations were stable across environments as revealed by multivariate analyses. Statistical simulation for five markers associated with 1000 seed weight indicated that the favorable al eles have additive effects. None of the modern cultivars carried the five favorable al eles and the maximum number of four observed in any accessions was mostly in＆amp;nbsp;breeding lines. Our results confirmed the complex genetic architecture of yield-related traits and the inherent difficulties associated with their identification while il ustrating the potential for improvement through marker-assisted selection.

关键词： Linum usitatissimum marker-assisted selection

Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

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Nano Research 2025年第1期18卷 628-641页

作者： Min Han Zishan Chen Shiying Zhou Zunde Liao Xiangting Yi Yao He Yiling Zhong Kam w.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Functional Nano and Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(ROS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

Dynamic Deformation of Frozen Soil at a High Strain Rate:Experiments and Damage-Coupled Constitutive Model

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Acta Mechanica Solida Sinica 2021年第6期34卷 895-910页

作者： Z.w.Zhu w.R.Tang g.Z.Kang Applied Mechanics and Structural Safety Key Laboratory of Sichuan Province School of Mechanics and EngineeringSouthwest Jiaotong UniversityChengdu610036China Northwest institute of Eco-Environment and Resources State Key Laboratory of Frozen Soil EngineeringChinese Academy of SciencesLanzhou730000China

The dynamic compressive deformation of frozen soil was investigated by conducting the split-Hopkinson pressure bar(SHPB)experiments at three temperatures and different high strain rates,and the dynamic stress–strain responses and failure modes of the frozen soil were *** experimental results demonstrate that the frozen soil exhibits evident dependence on the strain rate and temperature under the dynamic loading *** dynamic compressive stress–strain curve of the frozen soil was divided into three parts:the linear,nonlinear rising,and strain softening *** nonlinear rising and strain softening parts were both caused by the damage attributed to the debonding between the ice particles and soil matrix,from which a rate-dependent damage evolution equation was ***,a damage-coupled dynamic viscoelastic constitutive model of frozen soil at high strain rate was derived.A comparison between the theoretically predicted results and the experimental ones showed that the developed dynamic viscoelastic model could well describe the dynamic mechanical behavior of frozen soil at high strain rate.

关键词： Frozen soil Dynamic compression High strain rate Damage Constitutive model