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An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Diagnostic and therapeutic implications of the association between ferritin level and severity of nonalcoholic fatty liver disease

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World Journal of gastroenterology 2012年第29期18卷 3782-3786页

作者： Luca valenti Paola Dongiovanni Silvia Fargion Università degli Studi di Milano Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico20122 MilanoItaly

Nonalcoholic fatty liver disease(NAFLD),defined by excessive liver fat deposition related to the metabolic syndrome,is a leading cause of progressive liver disease,for which accurate non-invasive staging systems and effective treatments are still *** has shown that increased ferritin levels are associated with the metabolic insulin resistance syndrome,and higher hepatic iron and fat *** and iron stores have been associated with the severity of liver damage in NAFLD,and iron depletion reduced insulin resistance and liver ***,Kowdley et al demonstrated in a multicenter study in 628 adult patients with NAFLD from the NAFLD-clinical research network database with central re-evaluation of liver histology and iron staining that the increased serum ferritin level is an independent predictor of liver damage in patients with NAFLD,and is useful to identify NAFLD patients at risk of non-alcoholic steatohepatitis and advanced *** data indicate that incorporation of serum ferritin level may improve the performance of noninvasive scoring of liver damage in patients with NAFLD,and that iron depletion still represents an attractive therapeutic target to prevent the progression of liver damage in these patients.

关键词： Fibrosis Ferritin Iron overload Nonalcoholic fatty liver disease Steatohepatitis Steatosis

Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors

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World Journal of gastroenterology 2014年第36期20卷 12945-12955页

作者： Paola Dongiovanni Stefano Romeo Luca valenti Internal Medicine 1B Fondazione IRCCS Ca’ Granda Ospedale Policlinico 20122 Milano Italy Department of Pathophysiology and Transplantation Università degli Studi di Milano 20122 Milano Italy Wallenberg Laboratory Department of Molecular and Clinical Medicine University of Gothenburg 40530 Gothenburg Sweden Clinical Nutrition Unit Department of Medical and Surgical Sciences University Magna Graecia 88100 Catan-zaro Italy

Hepatocellular carcinoma(HCC) is the fourth cause of cancer related mortality, and its incidence is rapidly increasing. Viral hepatitis, alcohol abuse, and exposure to hepatotoxins are major risk factors, but nonalcoholic fatty liver disease(NAFLD) associated with obesity, insulin resistance, and type 2 diabetes, is an increasingly recognized trigger, especially in developed countries. Older age, severity of insulin resistance and diabetes, and iron overload have been reported to predispose to HCC in this context. Remarkably, HCCs have been reported in non-cirrhotic livers in a higher proportion of cases in NAFLD patients than in other etiologies. Inherited factors have also been implicated to explain the different individual susceptibility to develop HCC, and their role seems magnified in fatty liver, where only a minority of affected subjects progresses to cancer. In particular, the common I148 M variant of the PNPLA3 gene influencing hepatic lipid metabolism influences HCC risk independently of its effect on the progression of liver fibrosis. Recently, rare loss-of-function mutations in Apolipoprotein B resulting in very low density lipoproteins hepatic retention and in Telomerase reverse transcriptase influencing cellular senescence have also been linked to HCC in NAFLD. Indeed, hepatic stellate cells senescence has been suggested to bridge tissue aging with alterations of the intestinal microbiota in the pathogenesis of obesity-related HCC. A deeper understanding of the mechanisms mediating hepatic carcinogenesis during insulin resistance, and the identification of its genetic determinants will hopefully provide new diagnostic and therapeutic tools.

关键词： Nonalcoholic fatty liver disease Steatosis Hepatocellular carcinoma Cirrhosis Fibrogenesis Liver disease genetics Single nucleotide polymorphism Patatin-like phospholipase domain-containing 3

Importance and performance of streetscapes at a tourism destination in Indonesia:The residents’perspectives

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Frontiers of Architectural Research 2020年第3期9卷 641-655页

作者： Marly valenti Patandianan Hiroyuki Shibusawa Department of Architecture and Civil Engineering Toyohashi University of TechnolosvToyohoshiJapan

The present study examined the importance and performance of streetscapes at a tourism destination in Makassar,Indonesia,from the residents’perspectives using the importance-performance analysis ***,six attributes of the streetscapes in four segments of the old city district were identified and presented to 400 *** participants were then asked to rate the perception and preference of each *** of the attribute values were illustrated in a Cartesian *** indicate notable discrepancies between the perceptions and preferences of the ***,these attributes were inconsistent with their ***,the results showed that each segment should have different priorities for specific attributes to improve the performance of the ***,such data can be used by stakeholders,such as tourism developers and government policymakers,to make appropriate and informed decisions that will improve the attractiveness of this tourism destination and increase the number of visitors.

关键词： Streetscapes Tourism destination Importance-performance analysis Residents’perspectives

Building mass to prevent non-alcoholic fatty liver disease?

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Hepatobiliary Surgery and Nutrition 2019年第2期8卷 173-176页

作者： Serena Pelusi Luca valenti Department of Pathophysiology and Transplantation Università degli Studi di MilanoMilan Italy Translational Medicine Department of Transfusion Medicine and HematologyFondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico MilanoMilanItaly

While increased adiposity,generally estimated by high body mass index(BMI)is the major risk factor for non-alcoholic fatty liver disease(NAFLD),several studies have now reported an association between low skeletal muscle mass and this condition(1,2).In particular,sarcopenia has been associated with NAFLD in the general population,and with disease severity in patients who underwent liver biopsy(3-5).

关键词： NAFLD liver skeletal

NgM282: a step forward in the nonalcoholic steatohepatitis treatment landscape?

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 484-486页

作者： Luca valenti Valerio Nobili Internal Medicine and Metabolic Diseases Fondazione IRCCS Ca’Granda Ospedale Policlinico MilanoDepartment of Pathophysiology and TransplantationUniversitàdegli Studi di MilanoMilanItaly Hepatology Gastroenterology and Nutrition UnitIRCCS“Bambino Gesù”Children’s HospitalRomeItaly Department of Pediatric University“La Sapienza”RomeItaly

Nonalcoholic fatty liver disease(NAFLD)is becoming the leading cause of liver disease worldwide,and the prevalence is still increasing,especially during the developmental age(1-3).NAFLD is defined in the presence of increased hepatic fat content not explained by at risk alcohol intake,and is epidemiologically associated with obesity,insulin resistance and metabolic disorders.

关键词： NAFLD intake hepatic

Xiamen after 20 Years of Ecological Transformation

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China Today 2025年第1期74卷 66-68页

作者： ZACHARY g.LUNDQUIST 不详

The efforts Xiamen has made in ecological protection over the last 20 years have helped it become a beautiful and clean *** years ago,I had the opportunity to travel to the city of Xiamen in southeastern China’s Fujian ***,due to the fact that I was in a rush,I did not have the chance to see the whole *** memory of Xiamen was its pleasant climate and unforgettable beauty-I knew if I ever got the opportunity,I would revisit this *** years went by until I was able to return to this city *** emerging from the airport,I realized that I had grown older,while Xiamen was becoming increasingly youthful and *** exactly had given this city such vitality?

关键词： Ecological Xiamen Transformation