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Lig.t.based 3D printing of stimulus-responsive hydrogels forminiature devices:recent progress and perspective

Bio-Design and Manufacturing 2024年第5期7卷 721-746页

作者： Chen Xin Neng Xia Li zhang Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China Multi-Scale Medical Robotics Center Hong Kong Science ParkShatin NTHong Kong 999077China Chow Yuk Ho technology Center for Innovative Medicine The Chinese University of Hong KongHong Kong 999077China Department of Surgery The Chinese University of Hong KongHong Kong 999077China CUHK t Stone Robotics Institute The Chinese University of Hong KongHong Kong 999077China

Miniature devices comprising stimulus-responsive hydrogels with high environmental adaptability are now considered competitive candidates in the fields of biomedicine,precise sensors,and tunable *** and advanced fabricationmethods are critical formaximizing.t.e application capabilities ofminiature ***-based three-dimensional(3D)printing.t.chnology offers the advantages of a wide range of applicable materials,high processing accuracy,and strong 3D fabrication capability,which is suitable for the development of miniature devices with various *** paper summarizes and highlig.t. the recent advances in lig.t.based 3D-printed miniaturized devices,with a focus on the latest breakthroughs in lig.t.ased fabrication technologies,smart stimulus-responsive hydrogels,and tunable miniature devices for the fields of miniature cargo manipulation,targ.t.d drug and cell delivery,active scaffolds,environmental sensing,and optical ***,the challenges in the transition of tunable miniaturized devices from the laboratory to practical engineering applications are *** opportunities that will promote the development of tunable microdevices are elaborated,contributing.t. their improved understanding of these miniature devices and further realizing.t.eir practical applications in various fields.

关键词： 3D printing Stimulus-responsive hydrogels Miniature devices Shape-morphing

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Evaluation and Projection of Extreme High temperature Indices in Southwestern China Using NEX-gDDP-CMIP6

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Journal of Meteorological Research 2024年第1期38卷 88-107页

作者： Fen zhang Linxiao WEI Yonghua LI Hongyu tANg.t.anyu zhang Baogang YANg China Meteorological Administration Key Open Laboratory of transforming Climate Resource to Economy Chongqing Climate CentreChongqing 401147

Based on the recently released NASA Earth Exchange global Daily Downscaled Projections(NEX-gDDP)Coupled Model Intercomparison Project Phase 6(CMIP6) dataset and the gridded observational daily dataset CN05.1, this study evaluates the performance of 26 CMIP6 models in simulating extreme high temperature(EHt) indices in southwestern China and estimates future changes in the EHt indices under the Shared Socioeconomic Pathways(SSPs) SSP1-2.6, SSP2-4.5, and SSP5-8.5 using 11 optimal CMIP6 models. Five EHt indices are employed:annual maximum value of daily maximum temperature(tXX), high temperature days(t35), warm days(tX90P),heat wave frequency(HWF), and heat wave days(HWD). the main results are as follows.(1) NEX-gDDP-CMIP6 is highly capable of simulating.t.e spatial patterns of tXX and t35 in southwestern China but it presents a weaker ability to simulate the spatial patterns of tX90P, HWF, and HWD.(2) the simulated time series of t35, tX90P, HWF,and HWD in southwestern China exhibit consistent upward trends with the observations. the linear trends of increase in tX90P and HWD are much greater than those of increase in tXX, t35, and HWF.(3) the estimated increases in tXX and t35 in southwestern China are significantly greater in Chongqing and the adjacent areas of Sichuan than in the other regions. Spatial distributions of the increases in tX90P, HWF, and HWD generally show higher values in the west and lower values in the east.(4) In the three different scenarios, the projected future tXX,t35, tX90P, and HWD in southwestern China all display a continuous increase with time and radiative forcing levels, whereas HWF initially increases but then decreases under the SSP5-8.5 scenario. By the end of the 21st century, under the SSP5-8.5 scenario, tXX and t35 are projected to increase by 6.0℃ and 45.0 days, respectively. the duration of individual heat waves is also expected to increase.

关键词： NEX-gDDP-CMIP6 extreme high temperature(EHt) southwestern China evaluation projection

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Feeding prehistoric coastal community:A study of marine faunal remains at the Jingtoushan site

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Science China Earth Sciences 2024年第5期67卷 1574-1590页

作者： Endong WU guoping SUN Ying zhang School of Culture History and LanguageAustralian National UniversityCanberra 2600Australia Zhejiang Provincial Institute of Cultural Relics and Archaeology Hangzhou 310012China National Centre for Archaeology Beijing 100013China

this article examines the abundant marine mollusc,and fish remains at the Jingtoushan shell midden(8,300 to7,800 cal a BP)in Zhejiang Province,China,to investig.t. the fishing economy,community development,the palaeoenvironment,and their interactions among.t.e prehistoric populations in the lower Yangtze River Basin and southeastern coastal *** also attempts to explore the prosperity and decline of coastal settlements in China during.t.e Neolithic Age and the potential reasons for their rise and fall,*** on the ecological and biological principles of marine animals,standard zooarchaeological methods and radiocarbon dating analysis are used for sampling,identification,measurement,and *** show that at least 11 mollusc taxa and 14 fish taxa can be identified from the Jingtoushan faunal *** ancient Jingtoushan residents possibly lived in a settlement close to the coast and engaged in inshore and offshore fishing,hunting,and g.t.ering as their primary subsistence strategies,with low-level rice cultivation as a supplementary means of ***,the changes in the coastal environment could be one of the reasons why the Jingtoushan residents abandoned their *** research contributes to Chinese Neolithic archaeology with new evidence of the exploitation of marine resources around 8000 a BP in the eastern coastal areas and the relationship between Neolithic community development and environmental changes.

关键词： Neolithic Age Marine faunal remains Fishing economy Palaeoenvironment Community development

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Investig.t.on of the active ingredients and mechanism of Shuangling extract in dextran sulfate sodium salt induced ulcerative colitis mice based on network pharmacology and experimental verification

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Journal of traditional Chinese Medicine 2024年第3期44卷 478-488页

作者： CHU Mengzhen WANg Yu LIN Zhijian Lyu Jintao zhang Xiaomeng zhang Bing Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 102488China

OBJECtIVE: to explore the pharmacodynamic effects and potential mechanisms of Shuangling extract against ulcerative colitis(UC). MEtHODS: the bioinformatics method was used to predict the active ingredients and action targ.t. of Shuangling extract against UC in mice. And the biological experiments such as serum biochemical indexes and histopathological staining were used to verify the pharmacological effect and mechanism of Shuangling extract against UC in mice. RESULtS: the Shuangling extract reduced the levels of seruminterleukin-1β(IL-1β), tumor necrosis factor-α(tNF-N), interleukin-6(IL-6) and other inflammatory factors in UC mice and inhibited the inflammatory response. AKt Serine/threonine Kinase 1 and IL-6 may be the main targ.t. of the anti-UC action of Shuangling extract, and the tNF signaling pathway, Forkhead box O signaling pathway and t-cell receptor signaling pathway may be the main signaling pathways. CONCLUSION: the Shuangling extract could inhibit the inflammatory response induced by UC and regulate intestinal immune function through multiple targ.t. and multiple channels, which provided a new option and theoretical basis for anti-UC.

关键词： colitis ulcerative pharmacodynamic study network pharmacology molecular docking simulation Shuangling extract

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Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

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Cancer Biology & Medicine 2024年第4期21卷 312-330页

作者： Qian zhang Mingran Yang Peng zhang Bowen Wu Xiaosen Wei Shao Li Institute for tCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRISTDepartment of AutomationTsinghua UniversityBeijing 100084China

gastric cancer(gC), the fifth most common cancer globally, remains the leading cause of cancer deaths worldwide. Inflammation-induced tumorigenesis is the predominant process in gC development;therefore, systematic research in this area should improve understanding of the biological mechanisms that initiate gC development and promote cancer hallmarks. Here, we summarize biological knowledge regarding gastric inflammation-induced tumorigenesis, and characterize the multi-omics data and systems biology methods for investig.t.ng gC development. Of note, we highlig.t.pioneering studies in multi-omics data and state-of-the-art network-based algorithms used for dissecting.t.e features of gastric inflammation-induced tumorigenesis, and we propose translational applications in early gC warning biomarkers and precise treatment strategies. this review offers integrative insig.t. for gC research, with the goal of paving.t.e way to novel paradigms for gC precision oncology and prevention.

关键词： gastric cancer inflammation-induced tumorigenesis multi-omics artificial intelligence network-based methods

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Multi-modal visual tracking:Review and experimental comparison

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Computational Visual Media 2024年第2期10卷 193-214页

作者： Pengyu zhang Dong Wang Huchuan Lu Faculty of Electronic Information and Electrical Engineering Dalian University of TechnologyDalian 116024Chin

Visual object tracking has been drawing increasing attention in recent years,as a fundamental task in computer *** extend the range of tracking applications,researchers have been introducing information from multiple modalities to handle specific scenes,with promising research prospects for emerging methods and *** provide a thorough review of multi-modal tracking,different aspects of multi-modal tracking algorithms are summarized under a unified taxonomy,with specific focus on visibledepth(RgB-D)and visible-thermal(RgB-t)***,a detailed description of the related benchmarks and challenges is *** experiments were conducted to analyze the effectiveness of trackers on five datasets:PtB,VOt19-RgBD,gtOt,Rg.t.34,and ***,various future directions,including model design and dataset construction,are discussed from different perspectives for further research.

关键词： visual tracking object tracking multi-modal fusion RgB-t tracking RgB-D trackin

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Incubation temperature induced developmental plasticity of cold responsive physiological phenotypes in Japanese Quails

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Avian Research 2024年第3期15卷 385-394页

作者： Yingxin Kou Rongmiao zhang Xiaoqian Li Na Zhu Yihang Huang Shuping zhang College of Life and Environmental Sciences Minzu University of ChinaBeijing100081China

Embryonic development is a critical period for phenotype *** variation during embryonic development can induce changes in postnatal phenotypes of *** thyroxine secretion and aerobic metabolic activity of small birds are important phenotypes closely related to their winter *** the context of climate change,it is necessary to determine whether temperature variation during incubation in birds leads to developmental plasticity of these cold responsive *** incubated Japanese Quail(Coturnix japonica)eggs at 36.8℃,37.8℃,and 38.8℃,and raised the chicks to 35-day old at 22℃with same raising conditions,then all the quails were exposed to gradually temperature dropping environment(from 15℃to 0℃).After cold treatment,serum t3 level,resting metabolic rate,skeletal muscle and liver metabolomes of the birds were *** serum t3 levels were significantly lower in the 38.8℃group and significantly higher in the 36.8℃group compared to the 37.8℃*** metabolic rate in the 38.8℃group was significantly lower compared to the 37.8℃*** with the 37.8℃group,metabolites involved in the tricarboxylic acid cycle in the liver were significantly lower in the 38.8℃group,and metabolites related to lipid oxidation metabolism and fatty acid biosynthesis were significantly lower in the skeletal muscles in the 38.8℃group but significantly higher in the 36.8℃*** results indicate that incubation temperature variation can lead to developmental plasticity in cold responsive physiological *** incubation temperature may impair the capacity of birds coping with cold challenge.

关键词： Cold response Developmental plasticity Incubation temperature Metabolic rate Metabolomes Precocial bird thyroxin

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genome-wide identification and characterization of the PbrAtg family in Pyrus bretschneideri and functional analysis of PbrAtg1a in response to Botryosphaeria dothidea

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Horticultural Plant Journal 2024年第2期10卷 327-340页

作者： Yun Wang Xun Sun Zhenwu zhang Zhihua Xie Kaijie Qi Shaoling zhang Center of Pear Engineering.t.chnology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementCollege of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China

the pear is an economic fruit that is widely planted around the world and is loved by people for its rich nutritional value. Autophagy is a self-protection mechanism in eukaryotes, and its occurrence often accompanied by the degradation of damaged substances in cells and the recycling of nutrients. Autophagy is one of the mechanisms through which plants respond to environmental stress and plays an important role in plant development and stress resistance. Functional studies of autophagy-related genes (Atgs) have been performed on a variety of plant species, but little information is available on the Atg family in pear (Pyrus bretschneideri Rehd). therefore, we analyzed the evolutionary dynamics and performed a genome-wide characterization of the PbrAtg gene family. A total of 28 PbrAtg members were *** analysis showed that PbrAtgs were more closely related to Atgs of European pear and apple. Evolutionary analysis revealed that whole-genome duplication (WgD) and dispersed duplication events were the main driving forces of PbrAtg family *** analysis of different pear tissues showed that all the genes were expressed in different pear tissues, and different PbrAtgs are expressed at different times and in different locations. Moreover, all PbrAtgs also responded to different abiotic stresses, especially salt and droug.t.stress, which elicited the highest expression levels. Pear seedlings were subsequently infected with Botryosphaeria dothidea (***). the results showed that different PbrAtgs had different expression patterns at different infection stages. According.t. the gene expression data, PbrAtg1a was selected as a key autophagy gene for further analysis. Silencing of PbrAtg1a reduced the resistance of pear to B. dothidea, which resulted in increased lesions, reactive oxygen species (ROS) contents, antioxidant enzyme activity, and gene expression levels in the silenced pear seedlings after B. dothidea inoculation. In this s

关键词： Autophagy Pear PbrAtgs Abiotic stress Botryosphaeria dothidea PbrAtg1a

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geochemistry, zircon U–Pb geochronology, and Hf isotopes of S-type granite in the Baoshan block, constraints on the age and evolution of the Proto-tethys

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Acta geochimica 2024年第1期43卷 40-58页

作者： Jianjun zhang Chuanlong Mou Chendong Liu Yong zhang ting Chen Hualiang Li Institute of geological Survey East China University of TechnologyNanchang 330013China School of Earth Sciences East China University of TechnologyNanchang 330013China Chengdu geological Survey Center Chengdu 610081China School of Water Resources&Environmental Engineering East China University of TechnologyNanchang 330013China

geochemistry, zircon U–Pb geochronology, and Hf isotope data for the Early Paleozoic granites in the Baoshan Block reveal the Early Paleozoic tectonic evolution of the Proto-tethys. the samples are high-K, calcalkaline, strongly peraluminous rocks with A/CNK values of 1.37–1.46, are enriched in SiO2, K2O, and Rb, and are depleted in Nb, P, ti, Eu, and heavy rare earth elements,which indicates the crystallization fractionation of the granitic magma. Zircon U–Pb dating indicates that they formed in ca. 480 Ma. the Nansa granites have εHf(t) values ranging from-16.04 to 4.36 with corresponding.t. DMages of 2.10–0.81 ga, which suggests the magmas derived from the partial melting of ancient metasedimentary with minor involvement of mantle-derived components. A synthesis of data for the Early Paleozoic igneous rocks in the Baoshan block and adjacent(tengchong,Qiangtang, Sibumasu, Himalaya, etc.) blocks indicates that these blocks were all aligned along.t.e proto-tethyan margin of East gondwana in the Early Paleozoic. the Early Paleozoic S-type granites from Nansa were generated in a high-temperature and low-pressure(HtLP) extensional tectonic setting, which resulted from Andean-type orogeny instead of the final assembly of gondwana or crustal extension in a non-arc environment. In certain places, an expanding environment may exist in opposition to the tectonic backdrop of the lithosphere’s thickening and shortening, leading.t.e crust to melt and decompress,mantle-derived materials to mix, and a small quantity of peraluminous granite to emerge.

关键词： Baoshan block Early Paleozoic granite geochemistry Zircon geochronology Hf isotope

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tectonic geomorphology of türkiye and its insig.t. into the neotectonic deformation of the Anatolian Plate

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Earthquake Research Advances 2024年第1期4卷 23-35页

作者： Yuqiao Chang Yihui zhang Huiping zhang Yunnan Earthquake Agency Kunming650216China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing100029China

Quantitative geomorphic analyses are usually powerful in identifying active tectonics across global orogenic *** present study will focus on the Anatolian Plate which hosts a lot of recent catastrophic earthquakes in tü*** geomorphic indices for 100 sub-basins around türkiye have been computed including local relief,slope,normalized steepness index(k_(Sn)),hypsometric curve and integral(HI),transverse topographic symmetry factor(tf),and the basin asymmetry factor(Af).the averaged kSnand Af values have shown four high-value anomalous zones,suggesting relatively high uplift rates featured by high river incision and regional *** values of 0.35≤HIth S-shaped curves imply intensive tectonic activities along.t.e eastern part of the North Anatolian Fault Zone(NAFZ),the Northeast Anatolian Fault Zone(NEAFZ),the East Anatolian Fault Zone(EAFZ),and the Central Anatolian Fault Zone(CAFZ).All results of the geomorphic indices analysis suggest a relatively high degree of tectonic activity in the following four areas,the Isparta Angle,the Eastern Black Sea Mountains,the South-eastern Anatolia Region,and the Central Anatolian fault *** further suggest that the eastern part of the NAFZ,NEAFZ,EAFZ,and CAFZ will be more active in tectonic activities,with a greater potential for strong earthquake occurrence.

关键词： geomorphic indices Quantitative türkiye tectonic activity

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