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Microscopic colitis: A retrospective study of clinical presentation in 53 patients

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World Journal of gastroenterology 2005年第9期11卷 1351-1355页

作者： Zsolt Barta gabriella Mekkel István Csíp(o|") László Tóth szabolcs Szakáll gábor g.szabó gyula Bakó gyula Szegedi Margit Zeher Third Department of Medicine Department of Pathology

AIM: To evaluate the relationship between symptoms and microscopic colitis (MC) subtypes: to test whether collagenous colitis (CC) and/or lymphocytic colitis (LC)might be related to both constipation and ***: A cohort of patients with independently confirmed typical histopathological changes was investigated. Fifty-three patients with histologically proved MC (46 with CC, 7 with LC) were included. The existence of diarrhea or constipation and the co-existence of autoimmune diseases were also investigated and all data were retrospectively ***: Twenty-three (43.39%) of MC patients had chronic constipation (20 in CC, 3 in LC patients). Twentyfour(45.28%) of MC patients had autoimmune disease and the diagnosis of autoimmune disease was always prior to MC. Sjogren's syndrome was associated only with the constipation ***: The Janus face of MC resembles the subgroups of irritable bowel syndrome. The co-existence of autoimmune diseases and MC is confirmed in both the constipation and diarrhea subgroups.

关键词： Microscopic colitis Constipation Autoimmune

Hard life for sons in the nest?Sex-dependent offspring mortality in great Tits in urban and forest areas

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Avian Research 2024年第1期15卷 91-97页

作者： Nora Agh Henriett Anna Dalvári Krisztián szabó Ivett Pipoly András Liker HUN-REN-PE Evolutionary Ecology Research group University of PannoniaH-8200VeszpremPf.1158.Hungary Behavioral Ecology Research group Center for Natural SciencesUniversity of PannoniaH-8200Pf.1158.VeszpremHungary Molecular Ecology Research group Department of EcologyUniversity of Veterinary Medicine BudapestH-1400Pf.2.BudapestHungary Synlab Hungary Ltd. H-1211Weiss Manfr´ed Str.5-7BudapestHungary

Sex-biased mortality can occur in birds during development,for example due to sexual differences in energy requirement and/or environmental sensitivity,or the effects of sex hormones or sex differences in the expression of mutations linked to sex *** extent of sex-bias in mortality may also be related to environmental conditions that influence offspring development and *** areas often provide poorer conditions for nestling development resulting in higher offspring mortality compared to natural areas,which may accelerate sex differences in offspring mortality in *** test this hypothesis,we examined the sex ratio of dead offspring in great Tits(Parus major),using 427 samples of unhatched eggs and dead nestlings collected in two urban and two forest sites between 2013 and *** ratio of males in the whole sample of dead offspring(56.9%)was significantly higher than expected by an 1:1 ratio,and the strongest sex biases were detected in urban areas(57.6%males)and in young nestlings(g did not differ significantly among study sites and between offspring developmental stages.29.3%of unhatched eggs contained a visible embryo,and the proportion of embryo-containing unhatched eggs did not differ significantly between urban and forest study *** results suggest male-biased offspring mortality in great Tits,and highlight the need of large datasets to detect subtle differences between habitats and developmental stages.

关键词： great Tit Urbanization Nestling mortality Sex related differences

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微微秒分布反馈染料激光器

中国激光 1983年第Z1期 585-585页

作者： AlexanderMüler H.-PDorn Zs.Bor B.Rácz g.szab 德意志联邦共和国马-普生物物理化学研究所激光物理部德意志联邦共和国马-普生物物理化学研究所激光物理部匈牙利Jate 大学匈牙利Jate 大学匈牙利Jate 大学哥廷根哥廷根塞格德塞格德塞格德

分布反馈染料激光器(DFDL)建立了一个新的产生单个微微秒脉冲的方法。它根本不同于锁模,而是基于最近观察到的自调Q效应。分布反馈染料激光没有外部的腔,而是通过增益系数或折射率,或它们两者一起在空间的周期性调制使激活介质本身内部... 详细信息

分布反馈染料激光器(DFDL)建立了一个新的产生单个微微秒脉冲的方法。它根本不同于锁模,而是基于最近观察到的自调Q效应。分布反馈染料激光没有外部的腔,而是通过增益系数或折射率,或它们两者一起在空间的周期性调制使激活介质本身内部产生受激振荡所需的光学反馈。由泵浦束形成干涉条纹,去泵浦染料溶液就导致在DFDL中的分布反馈所需的周期性结构。当我们用衍射光栅代替平常所用的泵浦束分束器时,对泵浦激光的时间和空间相干性

关键词：锁模激光器激光液体激光器分布反馈泵浦束

Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： James K.Lugata Sawadi F.Ndunguru gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi gabriella gulyás Renáta Knop János Oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal Husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food Sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and Human Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,TETRA-SL layer hybrid(TSL)—commercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)DL-Met injected(DLM);and 4)L-Met injected(LM).The in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(Pgroup had significantly reduced crypt depth,glutathione(gSH)content,glutathione S-transferase 3 alpha(gST3),occludin(OCLN)gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group(Pgenotype has overexpressed insulin-like growth factor 1(IgF1)gene,tricellulin(MD2),occludin(OCLN),superoxide dismutase 1(SOD1),and gST3 genes than the TSL genotype(Pgs showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-Methionine L-Methionine In ovo injection Intestinal development Poultry

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Desorption isotherms and isosteric heat of anaerobic fermentation residues

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2510-2517页

作者： Tibor Poós Viktor szabó Department of Building Services and Process Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsBertalan Lajos u.4-6H-1111 BudapestHungary

This paper presents the equilibrium desorption isotherms and the isosteric heat of sorption of a mixture containing mechanically dewatered fermentation residue(obtained from a blend of chicken,swine and cattle manure)used in biogas plants and corn spoiled silage in a ratio of 2:*** moisture desorption isotherms of the fermentation residue were determined at 32°C,40°C and 80°C and in the relative humidity range of 0.057/1 using static gravimetric *** equations were used to analyze the desorption data of Modified Henderson,Modified Halsey,Modified Oswin,Modified Chung–Pfost and Modified gAB *** constants of the model equations were calculated by non-linear regression *** Modified Henderson model fitted to the desorption isotherm data *** the proposed function,the final moisture content of the material can be determined as long as it can be dried in infinite time with the drying gas in the given *** isosteric heat of desorption was calculated by using the Modified Henderson model in the studied temperature range based on the Clausius–Clapeyron *** isosteric heat varied between 46 k J·mol-1 and 67 k J·mol-1 at moisture levels 1.91 b XegH2O·kgdP-1 for the material.

关键词： Desorption Equilibrium Model Measurement Isosteric heat

Understanding the importance of autophagy in human diseases using Drosophila

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Journal of genetics and genomics 2019年第4期46卷 157-169页

作者： Arindam Bhattacharjee áron szabó Tamás Csizmadia Hajnalka Laczkó-Dobos gábor Juhász Institute of genetics Biological Research Centre of the Hungarian Academy of Sciences Department of Anatomy Cell and Developmental BiologyE€otv€os Loránd University

Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in the pathogenesis of various human diseases, either positively or negatively impacting disease outcomes depending on the specific context. The majority of medical conditions including cancer, neurodegenerative diseases, infections and immune system disorders and inflammatory bowel disease could probably benefit from therapeutic modulation of the autophagy machinery. Drosophila represents an excellent model animal to study disease mechanisms thanks to its sophisticated genetic toolkit, and the conservation of human disease genes and autophagic processes. Here, we provide an overview of the various autophagy pathways observed both in flies and human cells(macroautophagy, microautophagy and chaperone-mediated autophagy), and discuss Drosophila models of the above-mentioned diseases where fly research has already helped to understand how defects in autophagy genes and pathways contribute to the relevant pathomechanisms.

关键词： Drosophila Neurodegeneration Alzheimer’s disease Parkinson’s disease Cancer Inflammatory bowel disease Autophagy

Strategies in training deep learning models to extract building from multisource images with small training sample sizes

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International Journal of Digital Earth 2023年第1期16卷 1707-1724页

作者： Dávid Abriha Szilárd szabó Department of Physical geography and geoinformatics Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Building extraction from remote sensing data is an important topic in urban studies and the deep learning methods have an increasing role due to their minimal requirements in training data to reach outstanding *** aimed to investigate the original U-Net architecture’s efficiency in building segmentation with different number of training images and the role of data augmentation based on multisource remote sensing data with varying spatial and spectral resolutions(WorldView-2[WV2],WorldView-3[WV3]images and an aerial orthophoto[ORTHO]).When the trainings and predictions were conducted on the same image,U-Net provided good results with very few training images(validation accuracies:94-97%;192 images).Combining the ORTHO’s and WV2’s training data for prediction on WV3 provided poor results with low F1-score(0.184).However,the inclusion of only 48 WV3 training images significantly improved the F1-score(0.693),thus,most buildings were correctly ***,using only independent reference data(other than the target image)is not enough to train an accurate *** our case,the reference from WW2 and ORTHO images did not provide an acceptable basis to train a good model,but a minimal number of training images from the targeted WV3 improved the accuracy(F1-score:69%).

关键词： Building segmentation U-Net remote sensing urban analysis

Deductive way of reasoning about the internet AS level topology

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Chinese Physics B 2015年第11期24卷 633-642页

作者： Dávid szabó Attila Korsi József Bíró András gulyás High Speed Networks Laboratory Budapest University of Technology and Economics MTA-BME Information Systems Research group Budapest University of Technology and Economics MTA-BME Future Internet Research group Budapest University of Technology and Economics

Our current understanding about the AS level topology of the Internet is based on measurements and inductive-type models which set up rules describing the behavior （node and edge dynamics） of the individual ASes and generalize the consequences of these individual actions for the complete AS ecosystem using induction. In this paper we suggest a third, deductive approach in which we have premises for the whole AS system and the consequences of these premises are determined through deductive reasoning. We show that such a deductive approach can give complementary insights into the topological properties of the AS graph. While inductive models can mostly reflect high level statistics （e.g., degree distribution, clustering, diameter）, deductive reasoning can identify omnipresent subgraphs and peering likelihood. We also propose a model, called YEAS, incorporating our deductive analytical findings that produces topologies contain both traditional and novel metrics for the AS level Internet.

关键词： internet topology complex network analysis model

The effect of ethanol on the habit and in vitro aerodynamic results of dry powder inhalation formulations containing ciprofloxacin hydrochloride

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Asian Journal of Pharmaceutical Sciences 2021年第4期16卷 471-482页

作者： Edit Benke Christina Winter Piroska szabó-Révész Eva Roblegg Rita Ambrus Institute of Pharmaceutical Technology and Regulatory Affairs University of SzegedSzeged H-6720Hungary Institute of Pharmaceutical Sciences Pharmaceutical Technology and BiopharmacyUniversity of GrazUniversitätsplatz 1Graz A-8010Austria Research Center Pharmaceutical Engineering gmbH Inffeldgasse 13Graz A-8010Austria

In the case of dry powder inhalation systems(DPIs),the development of carrierfree formulations has gained increased ***,spray-drying is a promising technology and is widely used to produce carrier-free *** works have been published about the co-spray-drying of active ingredients with various solid excipients and their effect on the physicochemical characteristics and aerodynamic properties of the ***,only a few studies have been reported about the role of the solvents used in the stock solutions of spray-dried *** the present work,DPI microcomposites containing ciprofloxacin hydrochloride were prepared by spray-drying in the presence of different ethanol *** work expresses the roughness,depth and width of the dimples for particle size as a novel calculation possibility,and as a correlation between the MMAD/D_(0.5)ratio and correlating it with cohesion work,these new terms and correlations have not been published–to the best of our knowledge–which has resulted in gap-filling *** a result,different proportions of solvent mixtures could be interpreted and placed in a new perspective,in which the influence of different concentrations of ethanol on the habit of the DPI formulations,and thus on in vitro aerodynamic *** on these,it became clear why we obtained the best in vitro aerodynamic results for DPI formulation containing 30%ethanol in the stock solution.

关键词： Dry powder inhaler Ethanol Particle engineering Roughness Aerodynamic properties