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Capsule endoscopy:the road ahead

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World Journal of gastroenterology 2016年第1期22卷 369-378页

作者： Ana-Maria Singeap Carol stanciu Anca Trifan gastroenterology and Hepatology Institute “Gr.T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency Hospital700111 IasiRomania gastroenterology and Hepatology Institute “St.Spiridon”Emergency Hospital700111 IasiRomania

Since its introduction into clinical practice 15 years ago,capsule endoscopy(CE)has become the first-line investigation procedure in some small bowel pathologies,and more recently,dedicated esophageal and colon CE have expanded the fields of application to include the upper and lower gastrointestinal *** this time,CE has become increasingly popular among gastroenterologists,with more than 2 million capsule examinations performed worldwide,and nearly 3000Pub Med-listed studies on its different aspects *** huge interest in CE may be explained by its noninvasive nature,patient comfort,safety,and access to anatomical regions unattainable via conventional ***,CE has several limitations which impede its wider clinical applications,including the lack of therapeutic capabilities,inability to obtain biopsies and control its *** research groups are currently working to overcome these limitations,while novel devices able to control capsule movement,obtain high quality images,insufflate the gut lumen,perform chromoendoscopy,biopsy of suspect lesions,or even deliver targeted drugs directly to specific sites are under *** current limitations,especially as some of them have already been successfully surmounted,and based on the tremendous progress in technology,it is expected that,by the end of next 15years,CE able to perform both diagnostic and therapeutic procedures will remain the major form of digestive *** review summarizes the literature that prognosticates about the future developments of CE.

关键词： Capsule endoscopy Biopsy Drug deliverysystems Capsule endoscope locomotion Capsulelocalization

Ulcerated intussuscepted jejunal lipoma-uncommon cause of obscure gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3765-3771页

作者： Tudor Cuciureanu Laura Huiban Stefan Chiriac Ana-Maria Singeap Mihai Danciu Florin Mihai Carol stanciu Anca Trifan Nutu Vlad Department of gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of Pathology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of Radiology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of general Surgery “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania

BACKgROUND Intestinal lipomas are rare benign gastrointestinal(gI)tumors,usually asymptomatic,but may become symptomatic as the result of some complications such as intussusception,intestinal obstruction,volvulus or *** can occur at any site along the entire gI tract,more frequent in colon and rarely in small *** patient reported here is a very rare case of jejunal lipoma,ulcerated and intussuscepted,diagnosed in an adult investigated for a chronic iron deficiency anemia(IDA),and successfully managed by segmental jejunal *** SUMMARY A 63-year-old male was referred to“***”Hospital,Institute of gastroenterology and Hepatology,Iasi,to investigate an obscure gI bleeding with an *** upper gI endoscopy and colonoscopy were performed,excluding potentially bleeding lesions,videocapsule endoscopy was then carried out,revealing fresh blood and a protruding lesion in proximal jejunum,findings confirmed by a single-balloon *** biopsies were taken from the lesion,but histological results were ***,contrast-enhanced computed tomography was performed showing jejunal polypoid mass with homogenous fat density,suggestive for lipoma.A week later a laparotomy was performed revealing the intussuscepted jejunal segment which was resected enbloc,and sent for further histopathologic *** patient made an uneventful recovery and was discharged seven days later,and at six months follow-up he had no complains and his hemoglobin returned to normal *** Lipomas are very rarely located in the jejunum,usually asymptomatic,but they may lead to complications such as intussusception and *** resection remains the treatment of choice.

关键词： Lipoma Intussusception Computed tomography Video capsule endoscopy gastrointestinal bleeding Case report

QUALITY MANAgEMENT EVALUATION AND ASSESSMENT-MAIN WORLDWIDE AWARDS

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QUALITY MANAGEMENT EVALUATION AND ASSESSMENT-MAIN WORLDWIDE ...

Impact of time between meniscal injury and isolated meniscus repair on post-operative outcomes:A systematic review

The 14th IgWT Symposium

作者： ELENA CONDREA ANCA stanciu "Ovidius" University of Constanta Faculty of Economics 5 Dumbrava Rosie Str. 900613 ConstantaRomania "Ovidius" University of Constanta Faculty of Economics 5 Dumbrava Rosie Str. 900613 ConstantaRomania

＜正＞Awards and certification procedures provide frameworks, and quality auditing and assessment procedures provide control processes. The most prominent frameworks for quality management are the United States’ Malc...

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World Journal of Clinical Cases 2025年第7期13卷 39-45页

作者： Kashif Javid Xavier Akins Nicole g Lemaster Amer Ahmad Austin V Stone Department of Orthopaedic Surgery and Sports Medicine University of KentuckyLexingtonKY 40504United States

BACKgROUND Meniscal tears are one of the most common knee *** the diagnosis of a meniscal tear has been made,there are several factors physicians use to guide clinical *** influence of time between injury and isolated meniscus repair on patient outcomes is not well *** this relationship is important as it may influence clinical decision-making and can add to the preoperative patient education *** hypothesized that increasing the time from injury to meniscus surgery would worsen postoperative *** To investigate the current literature for data on the relationship between time between meniscus injury and repair on patient *** PubMed,Academic Search Complete,MEDLINE,CINAHL,and SPORTDiscus were searched for studies published between January 1,1995 and July 13,2023 on isolated meniscus *** criteria included concomitant ligament surgery,incomplete outcomes or time to surgery data,and *** demographics,time to injury,and postoperative outcomes from each study were abstracted and *** Five studies met all inclusion and exclusion *** were 204(121 male,83 female)patients *** of five(60%)studies determined that time between injury and surgery was not statistically significant for postoperative Lysholm scores(P=0.62),Tegner scores(P=0.46),failure rate(P=0.45,P=0.86),and International Knee Documentation Committee scores(P=0.65).Two of five(40%)studies found a statistically significant increase in Lysholm scores with shorter time to surgery(P=0.03)and a statistically significant association between progression of medial meniscus extrusion ratio(P=0.01)and increasing time to *** Our results do not support the hypothesis that increased time from injury to isolated meniscus surgery worsens postoperative ***-making primarily based on injury interval is thus not recommended.

关键词： Meniscus Meniscal Meniscus repair Meniscectomy Patient reported outcomes Postoperative outcomes Time to surgery Injury interval

Proton pump inhibitors therapy and risk of Clostridium difficile infection: Systematic review and meta-analysis

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World Journal of gastroenterology 2017年第35期23卷 6500-6515页

作者： Anca Trifan Carol stanciu Irina girleanu Oana Cristina Stoica Ana Maria Singeap Roxana Maxim Stefan Andrei Chiriac Alin Ciobica Lucian Boiculese Institute of gastroenterology and Hepatology “St.Spiridon”Hospital“Grigore T.Popa”University of Medicine and Pharmacy Institute of gastroenterology and Hepatology “St.Spiridon”Hospital Department of Research Faculty of Biology“Alexandru Ioan Cuza”University of Iasi Department of Preventive Medicine and Interdisciplinarity “Grigore.T.Popa”University of Medicine and Pharmacy

AIM To perform a systematic review and meta-analysis on proton pump inhibitors(PPIs) therapy and the risk of Clostridium difficile infection(CDI). METHODS We conducted a systematic search of MEDLINE/Pub Med and seven other databases through January 1990 to March 2017 for published studies that evaluated the association between PPIs and CDI. Adult case-control and cohort studies providing information on the association between PPI therapy and the development of CDI were included. Pooled odds ratios(ORs) estimates with 95% confidence intervals(CIs) were calculated using the random effect. Heterogeneity was assessed by I^2 test and Cochran's Q *** publication bias was evaluated via funnel plot, and quality of studies by the Newcastle-Otawa Quality Assessment Scale(NOS). RESULTS Fifty-six studies(40 case-control and 16 cohort) involving 356683 patients met the inclusion criteria and were analyzed. Both the overall pooled estimates and subgroup analyses showed increased risk for CDI despite substantial statistical heterogeneity among studies. Meta-analysis of all studies combined showed a significant association between PPI users and the risk of CDI(pooled OR = 1.99, CI: 1.73-2.30, P gnificant in subgroup analyses: by design-case-control(OR = 2.00, CI: 1.68-2.38, P ge ≥ 65 years(OR = 1.93, CI: 1.40-2.68, P gnificant differences were found in subgroup analyses(test for heterogeneity): P = 0.93 for case-control vs cohort, P = 0.85 for adjusted vs unadjusted, P = 0.24 for unicenter vs multicenter, P = 0.86 for age ≥ 65 years and gnificant hetero

关键词： Proton pump inhibitors Clostridium difficile infection Risk Systematic review Meta-analysis

Did the severe acute respiratory syndrome-coronavirus 2 pandemic cause an endemic Clostridium difficile infection?

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World Journal of Clinical Cases 2021年第33期9卷 10180-10188页

作者： Camelia Cojocariu Irina girleanu Anca Trifan Andrei Olteanu Cristina Maria Muzica Laura Huiban Stefan Chiriac Ana Maria Singeap Tudor Cuciureanu Catalin Sfarti Carol stanciu Department of gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”University HospitalInstitute of Gastroenterology and HepatologyIasi 700115Romania

BACKgROUND Clostridium difficile infection(CDI)has increased in prevalence during the last *** coronavirus disease 2019(COVID-19)pandemic has negatively influenced patient *** majority of the severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2)-infected patients received antibiotics during *** To analyze the factors that influenced CDI development after SARS-CoV-2 *** Between March 2020 to December 2020,we performed a prospective observational study including 447 patients diagnosed with CDI who were admitted to our tertiary referral university *** diagnosis of CDI was based on the presence of diarrhea(≥3 watery stools within 24 h)associated with Clostridium difficile toxins A or *** excluded patients with other etiology of acute *** Among the total 447(12.5%)patients with CDI,most were male(54.3%)and mean age was 59.7±10.8 ***-six(17.0%)had history of COVID-19,most being elderly(COVID-19:62.6±14.6 years vs non-COVID-19:56.8±17.6 years,P=0.007),with history of alcohol consumption(43.4%vs 29.4%,P=0.017),previous hospitalizations(81.6%vs 54.9%,Pg higher doses of vancomycin and prone to recurrent disease(25.0%vs 13.1%,P=0.011).Age over 60 years[odds ratio(OR):2.591,95%confidence interval(CI):1.452-4.624,P=0.001],urban residence(OR:2.330,95%CI:1.286-4.221,P=0.005),previous antibiotic treatments(OR:1.909,95%CI:1.083-3.365,P=0.025),previous hospitalizations(OR:2.509,95%CI:1.263-4.986,P=0.009)and alcohol consumption(OR:2.550,95%CI:1.459-4.459,P=0.001)were risk factors of CDI in *** CDI risk is unrelated to history of SARS-CoV-2 ***,previous COVID-19 may necessitate higher doses of vancomycin for CDI.

关键词： COVID-19 infection Clostridium difficile infection Risk factors Antibiotic use Pandemic Recurrence

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Differential diagnosis of uterine vascular anomalies:Uterine pseudoaneurysm as a cause of massive hemorrhage

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World Journal of Clinical Cases 2025年第9期13卷 60-64页

作者： Teresa gastañaga-Holguera Isabel Campo gesto Laura gómez-Irwin Marta Calvo Urrutia Department of Obstetrics and gynecology San Carlos Clinical HospitalMadrid 28040Spain Department of gastroenterology University Hospital of CrucesBaracaldo 48903BizkaiaSpain

In this article,we comment on the paper by Kakinuma et al published *** focus specifically on the diagnosis of uterine pseudoaneurysm,but we also review other uterine vascular anomalies that may be the cause of life-threating hemorrhage and the different causes of uterine *** artery pseudoaneurysm is a complication of both surgical gynecological and nontraumatic *** hemorrhage is the consequence of the rupture of the *** artery pseudoaneurysm can develop after obstetric or gynecological procedures,being the most frequent after cesarean or vaginal deliveries,curettage and even during ***,there are several cases described unrelated to pregnancy,such as after conization,hysteroscopic surgery or laparoscopic *** is the clinical manifestation and it can be life-threatening so suspicion of this vascular lesion is essential for early diagnosis and ***,there are other uterine vascular anomalies that may be the cause of severe hemorrhage,which must be taken into account in the differential *** tomography angiography and embolization is supposed to be the first therapeutic option in most of them.

关键词： Uterine artery pseudoaneurysm Vascular anomaly Uterine vascular malformation Massive hemorrhage Postpartum hemorrhage Angiography Uterine embolization Transarterial embolization

Association of the glycemic background patterns and the diabetes management efficacy in poorly controlled type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 74-90页

作者： Ayşe N Erbakan Müzeyyen Arslan Bahadır FatoşN Kaya Büşra güleç MiraçVural Keskinler Ümmügülsüm AktemurÇelik Özge Faydalıel Banu Mesçi Aytekin Oğuz Department of Internal Medicine Prof Dr Suleyman Yalcin City HospitalIstanbul Medeniyet UniversityIstanbul 34722Türkiye Department of Family Medicine Istanbul Medeniyet UniversityIstanbul 34722Türkiye

BACKgROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic *** To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic *** This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 *** were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as *** analysis focused on the success rates of good glycemic control and the associated factors within each *** The study showed significant improvements in HbA1c levels in all *** most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,*** one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and *** In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored ***

关键词： Type 2 diabetes mellitus glycated hemoglobin glycemic control Patient-centered care Diabetes management glycemic background