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Present status and future directions:Apexification

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World Journal of Methodology 2025年第1期15卷 26-32页

作者： Sachin Chauhan Radha Chauhan Prashant Bhasin Bhavna g Sharaf Department of Conservative Dentistry and Endodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia Department of Prosthodontics and Crown and Bridge and Oral Implantology Mahatma Gandhi Dental College&HospitalJaipur 302022RajasthanIndia Department of Pedodontics and Preventive Dentistry Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia

The success rate of apexification is primarily determined by multiple factors,including the material used,the size of the open apex compared to the length of the root,and the technique used in each *** main objective of this review was to provide an update on the present management of open apex to identify factors and circumstances that may influence the success of apexification using different materials and *** research on apexification should focus on how to treat open apices with wide periapical lesions without ***,the predictability of these parameters with non-surgical procedures was uncertain,but now,with the use of a dental operating microscope,it has become more *** reason could be that extra visits are no longer required due to major advances in the armamentarium and materials used for apexification.

关键词： Bioceramics Magnification Biodentine Mineral trioxide aggregate Apexification Open apex

Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia

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World Journal of Clinical Cases 2025年第1期13卷 11-15页

作者： Aidan K Tirpack Danyaal g Buttar Mandeep Kaur Department of Psychiatry Campbell University School of Osteopathic MedicineBuies CreekNC 27506United States Department of Psychiatry and Behavioral Health Mercyhealth Hospital and Trauma CenterJanesvilleWI 53548United States

Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental *** utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant *** have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human *** this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and *** et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as *** et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and *** two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.

关键词： Schizophrenia Magnetic resonance imaging Biomarkers Neurotransmitters Psychiatric disorders

Mechanical transduction by ion channels: A cautionary tale

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World Journal of Neurology 2015年第3期5卷 74-87页

作者： Frederick sachs UB School of Medicine and Biomedical Sciences Physiology and Biophysics

Mechanical transduction by ion channels occurs in all cells. The physiological functions of these channels have just begun to be elaborated, but if we focus on the upper animal kingdom, these channels serve the common sensory services such as hearing and touch,provide the central nervous system with information on the force and position of muscles and joints, and they provide the autonomic system with information about the filling of hollow organs such as blood vessels. However, all cells of the body have mechanosensitive channels(MSCs), including red cells. Most of these channels are cation selective and are activated by bilayer tension. There are also K+ selective MSCs found commonly in neurons where they may be responsible for both general anesthesia and knockout punches in the boxing ring by hyperpolarizing neurons to reduce excitability. The cationic MSCs are typically inactive under normal mechanical stress, but open under pathologic stress. The channels are normally inactive because they are shielded from stress by the cytoskeleton. The cationic MSCs are specifically blocked by the externally applied peptide gs Mtx4(aka, AT-300). This is the first drug of its class and provides a new approach to many pathologies since it is nontoxic, non-immunogenic, stable in a biological environment and has a long pharmacokinetic lifetime. Pathologies involving excessive stress are common. They produce cardiac arrhythmias, contraction in stretched dystrophic muscle, xerocytotic and sickled red cells, etc. The channels seem to function primarily as "fire alarms", providing feedback to the cytoskeleton that a region of the bilayer is under excessive tension and needs reinforcing. The eukaryotic forms of MSCs have only been cloned in recent years and few people have experience working with them. "Newbies" need to become aware of the technology, potential artifacts, and the fundamentals of mechanics. The most difficult problem in studying MSCs is that the actual stimulus, the f

关键词： Channel Mechanical Patch Force Tension Bilayer Domain Osmotic Transduction Biomechanics

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世界向多极化、多货币体系发展

国际金融研究 2020年第1期 16-20页

作者： Jeffrey sachs 哥伦比亚大学

世界经济金融体系正在发生深刻变革。以中国、日本、韩国、东盟十国为代表的东方经济体具有超越西方经济体经济总量的潜力。在此背景下,需要倡导更积极的国际合作,共同致力于消除贫困、保护环境、消除收入分配不平等、应对人口结构变化... 详细信息

世界经济金融体系正在发生深刻变革。以中国、日本、韩国、东盟十国为代表的东方经济体具有超越西方经济体经济总量的潜力。在此背景下,需要倡导更积极的国际合作,共同致力于消除贫困、保护环境、消除收入分配不平等、应对人口结构变化挑战及加强国际和平领域合作等。此外,推动世界经济的可持续发展具有重要意义,特别是在能源结构转型、粮食生态保护、教育质量、饮食健康、城市建设及数字经济等领域。未来,世界将向多极化政治经济格局、多货币体系发展,建立更为合理的世界秩序。中国的经济发展及人民币国际化进程将有利于新格局的建立。

关键词：经济金融体系地缘政治可持续发展多极化

BRIC welcome South Africa as its newest member

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ChinAfrica 2011年第2期3卷 10-11页

作者： goldman sachs

Multicenter experience with photoselective vaporization of the prostate on men taking novel oral anticoagulants

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Asian Journal of Urology 2020年第4期7卷 340-344页

作者： Brooke sachs Vincent Misrai Shahin Tabatabaei Henry H.Woo Bankstown-Lidcombe Hospital SydneyAustralia Clinique Pasteur ToulouseFrance Massacheussets general Hospital BostonUSA The Chris O’Brien Lifehouse Hospital SydneyAustralia

Objective:Photoselective vaporization of the prostate(PVP)is a widely performed surgical procedure for benign prostatic *** approach has become particular favoured for men on anti-platelet and anticoagulation agents such as clopidogrel and warfarin but there is minimal published experience in the setting of novel oral anticoagulants(NOACs).This study was to examine the perioperative outcomes in men on NOACs undergoing PVP,with particular reference to perioperative ***:A retrospective analysis of PVP datasets was undertaken from three centres in Sydney(Australia),Toulouse(France)and Boston(USA).Subjects who had been treated whilst on NOACs without discontinuation or bridging were *** outcomes and treatment parameters were examined and morbidity recorded according to Clavien-Dindo(CD)***:There were a total of 20 subjects who had undergone PVP whilst NOACs had been continued during the perioperative *** mean age was 776.5 *** mean prostate volume,energy utilization and vaporisation time was 9456 mL,301211 kJ,and 3521 min *** mean postoperative duration of catheterization and duration of hospitalization was 2.22.4 days and 2.42.4 days *** was a single episode of urinary tract infection and four subjects required re-catheterisation for non-hematuric ***:This study supports the safety of men on NOACs undergoing *** this study represents the largest experience of PVP in these men,larger studies are necessary to confirm the safety of PVP in this group of men undergoing BPH-related surgery.

关键词： Benign prostatic hyperplasia Benign prostatic obstruction Photoselective vaporisation of the prostate Non-vitamin K oral anticoagulants Novel oral anticoagulants

Seizing Sustainable Solutions China sets the standard for alleviating poverty and promoting ongoing growth

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China Report ASEAN 2019年第8期4卷 61-63页

作者： Jeffrey sachs Center for International Development at Harvard University

I first visited China almost40 years ago. In 1981, whenI toured Beijing, Shanghai andguangdong Province, thingswere still pretty basic. Over theyears, I have witnessed much ofthe remarkable transformationof China from... 详细信息

关键词： Sustainable extreme poverty

Catching Up Peacefully

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Beijing Review 2019年第20期62卷 34-35页

作者： Jeffrey sachs Center for Sustainable Development at Columbia University

The most fundamental change in the world economy over the past 40 years has been China, which is effectively catching up in a smart, normal, peaceful and rule-based way, said Jeffrey sachs, Director of the Center for Sustainable Development at Columbia University and senior United Nations advisor, during a keynote speech at an event co-hosted by the China general Chamber of Commerce-USA and the Standard Chartered Bank in New York City on May 2.

关键词： fundamental change effectively catching China general Chamber

“世界经济与中国2022:聚焦全球经济金融体系的未来”国际观点荟萃

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国际金融研究 2022年第1期 7-12页

作者： Joseph Stiglitz Jeffrey sachs 哥伦比亚大学

回顾2021年,新冠肺炎疫情仍未得到有效控制,发达经济体货币政策转向导致跨境资本流动波动性增强,国际金融市场风险增大,全球价值链面临重塑,各经济体复苏仍面临诸多不确定因素。为促进对国际及国内经济金融形势和重大经济金融热点问题... 详细信息

回顾2021年,新冠肺炎疫情仍未得到有效控制,发达经济体货币政策转向导致跨境资本流动波动性增强,国际金融市场风险增大,全球价值链面临重塑,各经济体复苏仍面临诸多不确定因素。为促进对国际及国内经济金融形势和重大经济金融热点问题的探讨,中国国际金融学会举办了以"世界经济与中国2022:聚焦全球经济金融体系的未来"为主题的学术年会,邀请众多国内外知名专家学者共同探讨后疫情时代全球经济复苏面临的新挑战,展望未来经济金融发展新趋势和新变化。本刊从国际嘉宾演讲中择发有代表性的演讲,分别从新冠肺炎疫情冲击及全球政治经济格局重塑视角展望全球与中国经济金融形势,希望以此推动经济金融相关问题的学术研究。

关键词：新冠肺炎疫情气候风险绿色增长国际合作