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Sum-Based Meta-Analytical Enrichment of gene Expression Data to Identify Pathway Signatures of Cancers

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Journal of Cancer Therapy 2010年第1期1卷 36-42页

作者： Kavishwar Wagholikar Prasanna Venkatraman sundararajan Vijayraghavan Chandan Kumar-Sinha Advanced Centre for Treatment Research and Education in Cancer Navi Mumbai India Interdisciplinary School of Scientific Computing University of Pune Pune India Michigan Center for Translational Pathology Department of Pathology University of Michigan Ann Arbor MI USA

A new method for analysis of microarray gene expression experiments referred to as Sum-based Meta-analytical Enrichment?(SME) is proposed in this manuscript. SME is a combined enrichment and meta-analytical approach to infer?on the association of gene sets with particular phenotypes. SME allows enrichment to be performed across datasets,?which to our knowledge was not earlier possible. As a proof of concept study, this technique is applied to datasets from?Oncomine, a publicly available cancer microarray database. The genes that are significantly up-/down-regulated?(p-value ≤ 10-4) in various cancer types in Oncomine were listed. These genes were assigned to biological processes?using gO annotations. The SME algorithm was applied to identify a list of gO processes most deregulated in 4 major?cancer types. For validation we examined whether the processes predicted by SME were already documented in *** method identified several known processes for the 4 cancer types and identified several novel processes?which are biologically plausible. Nearly all the pathways identified by SME as common to the 4 cancers were found to?contribute to processes which are widely regarded as cancer hallmarks. SME provides an intuitive yet objective ‘process-centric’ interpretation of the ‘gene-centric’ output of individual microarray comparison studies. The methods described?here should be applicable in the next-generation sequencing based gene expression analysis as well.

关键词： gene Expression Microarray Enrichment Meta-Analysis

Optical, Thermal and Nonlinear Properties of Tristhiourea Lanthanum Nitrate

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Journal of Minerals and Materials Characterization and Engineering 2015年第3期3卷 118-124页

作者： V. S. Kumar R. S. sundararajan Department of Physics Swami Dayananda College of Arts and Science Manjakkudi Tamilnadu India Department of Physics Government Arts College (Autonomous) Kumbakonam Tamilnadu India

The single crystals of tristhiourea lanthanum nitrate (TTLaN) have been grown by solution growth using slow evaporation technique. The optical study revealed that the crystal has high transmission with lower cut-off wavelength of 235.78 nm. The EDAX analysis confirmed the grown compound elements. The presence of functional groups was identified through Fourier transform-infrared technique. The thermal stability of the crystal was determined from thermo gravimetric and differential thermal analysis curve. The second harmonic generation behavior of TTLaN crystal was tested by Kurtz-Perry powder technique. This single novel semiorganic crystal of TTLaN showed very good optical transmission property, high thermal stability and large non-linearity nature.

关键词： Nonlinear Optical Tristhiourea Lanthanum Nitrate Second Harmonic generation Thermo gravimetric Analysis Differential Thermal Analysis

Application of ANN and MLR Models on groundwater Quality Using CWQI at Lawspet, Puducherry in India

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Journal of geoscience and Environment Protection 2017年第3期5卷 99-124页

作者： N. Suresh Nathan R. Saravanane T. sundararajan Department of Civil Engineering Pondicherry Engineering College Puducherry India

With respect to groundwater deterioration from human activities a unique situation of co-disposal of non-engineered Municipal Solid Waste (MSW) dumping and Secondary Wastewater (SWW) disposal on land prevails simultaneously within the same campus at Puducherry in India. Broadly the objective of the study is to apply and compare Artificial Neural Network (ANN) and Multi Linear Regression (MLR) models on groundwater quality applying Canadian Water Quality Index (CWQI). Totally, 1065 water samples from 68 bore wells were collected for two years on monthly basis and tested for 17 physio-chemical and bacteriological parameters. However the study was restricted to the pollution aspects of 10 physio-chemical parameters such as EC, TDS, TH, , Cl-, , Na+, Ca2+, Mg2+ and K+. As there is wide spatial variation (2 to 3 km radius) with ground elevation (more than 45 m) among the bore wells it is appropriate to study the groundwater quality using Multivariate Statistical Analysis and ANN. The selected ten parameters were subjected to Hierarchical Cluster Analysis (HCA) and the clustering procedure generated three well defined clusters. Cluster wise important physio-chemical attributes which were altered by MSW and SWW operations, are statistically assessed. The CWQI was evolved with the objective to deliver a mechanism for interpreting the water quality data for all three clusters. The ANOVA test results viz., F-statistic (F = 134.55) and p-value (p = 0.000 2, low RMSE and MAE values but in Cluster 3 only ANN model fared well. Thus this study will be very useful to decision makers in solving water quality problems.

关键词： Canadian Water Quality Index Multi-Linear Regression Artificial Neural Network Simulation Comparison

Fabrication and Research of a Novel NLO Material: Tristhiourea Lanthanum Bromide

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Natural Science 2015年第5期7卷 248-254页

作者： V. S. Kumar R. S. sundararajan Department of Physics Swami Dayananda College of Arts and Science Manjakkudi Tiruvarur Dt. Tamilnadu India Department of Physics Government Arts College (Autonomous) Kumbakonam Tamilnadu India

The single crystals of tristhiourea lanthanum bromide (TTLaB) have been grown by solution growth using slow evaporation technique. The grown crystals were characterized by single crystal X-ray diffraction (XRD) to study the crystal structure. The presence of functional groups was identified through Fourier transform-infrared technique. The optical study exposed that the crystal has high transmission with lower cut off wavelength of 237.43 nm. The Elemental analysis confirmed atoms present in the grown compound. The NLO (Non Linear Optical) behavior of TTLaB crystal was tested by Kurtz-Perry powder technique. This novel semi-organic single crystal of TTLaB exhibited very good optical transmission property, high mechanical strength and large non-linearity nature.

关键词： Nonlinear Optical Tristhiourea Lanthanum Bromide Second Harmonic generation Fourier Transform Infrared spectrum

Studies on the Effect of Zinc Chloride Mixing on Bisthiourea Cadmium Chloride Crystals

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Journal of Minerals and Materials Characterization and Engineering 2013年第6期1卷 315-320页

作者： R. S. sundararajan M. Senthilkumar C. Ramachandraraja Department of Physics Government Arts College (Autonomous) Kumbakonam India

Nonlinear optical Zinc mixed bisthiourea Cadmium chloride (BTCC) crystals were synthesized and grown by slow evaporation method. The FTIR analysis reveals that the C-N stretching frequencies of thiourea are shifted towards the higher frequencies for pure and Zinc mixed BTCC and the C = S stretching frequencies are shifted towards the lower frequencies for pure and Zinc mixed BTCC crystals. These observations suggest that the metals coordinate with thiourea through sulphur. UV-Vis-NIR spectra were recorded to study the optical transparency of the grown crystals. The lower cutoff wavelength is observed at 233 nm for the pure BTCC crystals. There is no comparable change in the lower cutoff wavelength for the Zinc mixed BTCC crystals. The Nonlinear Optical (NLO) efficiency of the pure BTCC crystal decreases with the increase percentage mixing of Zinc. The SHg output for BTCC mixed with 1% zinc chloride is almost 9 times greater than the SHg output obtained for Pottasium Dihydrogen Phosphate (KDP) crystal. Vicker’s microhardness test done on the experimental crystals proves their greater physical strength.

关键词： Zinc BTCC Crystals Nonlinear Optical (NLO)

Spatial Variability of ground Water Quality Using HCA, PCA and MANOVA at Lawspet, Puducherry in India

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Computational Water, Energy, and Environmental Engineering 2017年第3期6卷 243-268页

作者： N. Suresh Nathan R. Saravanane T. sundararajan Department of Civil Engineering Pondicherry Engineering College Puducherry India

In ground water quality studies multivariate statistical techniques like Hierarchical Cluster Analysis (HCA), Principal Component Analysis (PCA), Factor Analysis (FA) and Multivariate Analysis of Variance (MANOVA) were employed to evaluate the principal factors and mechanisms governing the spatial variations and to assess source apportionment at Lawspet area in Puducherry, India. PCA/FA has made the first known factor which showed the anthropogenic impact on ground water quality and this dominant factor explained 82.79% of the total variance. The other four factors identified geogenic and hardness components. The distribution of first factor scores portray high loading for EC, TDS, Na+ and Cl−(anthropogenic) in south east and south west parts of the study area, whereas other factor scores depict high loading for HCO3−, Mg2+, Ca2+ and TH (hardness and geogenic) in the north west and south west parts of the study area. K+ and SO42−(geogenic) are dominant in south eastern direction. Further MANOVA showed that there are significant differences between ground water quality parameters. The spatial distribution maps of water quality parameters have rendered a powerful and practical visual tool for defining, interpreting, and distinguishing the anthropogenic, hardness and geogenic factors in the study area. Further the study indicated that multivariate statistical methods have successfully assessed the ground water qualitatively and spatially with a more effective step towards ground water quality management.

关键词： HCA PCA FA MANOVA Spatial Variability Puducherry India

growth and Characterization of Bisthiourea Nickel Bromide—New Semiorganic Nonlinear Optical Crystal

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Journal of Crystallization Process and Technology 2013年第2期3卷 56-59页

作者： R. S. sundararajan M. Senthilkumar C. Ramachandraraja Department of Physics Government Arts College (Autonomous) Kumbakonam India

A new semiorganic nonlinear optical crystal of bisthiourea nickel bromide (BTNB) was grown successfully by slow evaporation technique using water as solvent. The lattice parameters of the grown crystal have been determined by X-ray diffraction studies. Vibrational spectrum is recorded to determine symmetries of molecular vibrations. Optical absorbance spectrum recorded revealed that this crystal has good transparency in the visible region. The second harmonic generation test of BTNB confirmed the nonlinear nature of the crystal. The BTNB crystal was analyzed by a differential thermal analysis and thermogravimetric analysis (DTA-TgA) to obtain its thermal stability. Vickers microhardness test done on the crystal shows that the crystal has greater physical strength.

关键词： BTNB—Bisthiourea Nickel Bromide SHg—Second Harmonic generation TgA/DTA NLO—Nonlinear Optical

Study on geometric Factors Influencing Saturation Flow Rate at Signalized Intersections under Heterogeneous Traffic Conditions

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Journal of Transportation Technologies 2017年第1期7卷 83-94页

作者： B. g. Savitha R. Satya Murthy H. S. Jagadeesh H. S. Sathish T. sundararajan Department of Civil Engineering KS School of Engineering & Management Bangalore India Department of Civil Engineering BMS Engineering College Bangalore India Department of Civil Engineering Pondicherry Engineering College Pondicherry India

The main objective of intersection design is to facilitate the convenience, comfort, and safety of people traversing the intersection by enhancing the efficient movement of road users. The intersections on urban roads in India generally cater to heterogeneous motorized traffic, along with slow-moving traffic including pedestrians. It is therefore necessary to consider saturation flow for mixed traffic conditions to evaluate the overall operation of signalized intersections. A proper traffic model must consider varying characteristics of all the road users to effectively design and efficiently manage signalized intersections. This paper presents the results of the study on analyses of saturation flow rate conducted at signalized intersections with mixed traffic conditions in the city of Bangalore, India. Studies were carried out at 15 signalized intersections in the city of Bangalore with varying geometric factors such as width of road (w), gradient of the road (g), and turning radius (r) for right turning vehicles. Saturation flow rate computed as per Highway Capacity manual (HCM: 2000), Indonesian highway capacity manual (IHCM), and IRC SP: 41-1994 was compared with the field observations. The geometric factors, which affect the saturation flow, have been considered in this study and accordingly a new model has been proposed for determining saturation flow. It has been shown that by the introduction of the suggested adjustment factors in this paper, the saturation flow rate can give better picture of the field conditions, especially under heterogeneous traffic conditions of an urban area.

关键词： Saturation Flow Capacity Signalized Intersections Heterogeneous Traffic

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